Alignment of chromo domains colour coded according to conserved sequence similarity. The upper group of sequences contains the classical chromo domains and the lower group is the chromo shadow domains. The domain positions in the protein sequences are indicated next to their names. The numbers in parentheses refer to the positions in the DNA sequence database entries when no protein sequence is available. Frameshifted and ambiguous positions are indicated with '?' and the domains which end at the protein C-termini are ended with '*'. A consensus common to both the classical and shadow chromo domains is shown: %, semi-conserved hydrophobicity; #, strongly conserved hydrophobicity; -, conserved acidic residues; +, conserved basic residues. <28> and <29> denotes the number of residues of MoCHD1 and CeC29H12, respectively, not included in the alignment. A secondary structure prediction generated with the program phd (written by Burkhard Rost, EMBL, Heidelberg) is shown. The alignment was created with Clustal W (J.D Thompson, D.G. Higgins, and T.J. Gibson, EMBL, Heidelberg) ) edited with the GDE multiple sequence alignment editor (S. Smith, Harvard University, USA) and colour coded with COLORMASK (J.D Thompson and T.J. Gibson, EMBL, Heidelberg).