The AIRE protein also has a SAND domain just N-terminally to the PHD fingers (Gibson et al. 1998). We speculate that the SAND domain may be a DNA binding domain.
| December 1997 |
Nagamine et al. (1997) and A Finnish-German APECED Consortium (1997) have identified a novel gene AIRE (AutoImmune REgulator) located on chromosome 21q22.3 which is mutated in Autoimmune polyglandular syndrome type I (APS 1, also called APECED). The protein encoded by the AIRE gene carries two PHD fingers and several LXXLL-motifs. The function of the protein is unknown. The AIRE protein also has a SAND domain just N-terminally to the PHD fingers (Gibson et al. 1998). We speculate that the SAND domain may be a DNA binding domain.
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| October 1997 |
Gibbons et al. (1997)
and Gibbons et al. (1995) have recently identified mutations in the PHD finger of the ATRX gene as the most likely cause of the Alpha-Thalassemia/mental Retardation syndrome, X-linked (ATR-X). The ATRX gene encodes a protein with two PHD fingers and a putative helicase domain. The function of the protein is unknown.
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| April 1998 | Cardoso et al. (1998) finds that the PHD-finger/Helicase ATRX interacts with the E(z) homologue, EZH2 - see also my E(z) web-pages . |
| June 1998 | Wade et al. (1998) (Curr. Biol. 8:843-846.) shows that a Xenopus homologue of the Mi-2 protein is part of a multiprotein complex which contains in addition: Rpd3, RbAp48/p46 and copurifies with a histone deacetylase activity. Mi-2 has two PHD fingers, two chromo domains and a putative "DNA helicase"-like ATPase domain. Mi-2 was identified as an autoantigen in dermatomyositis.
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