SAND domain

This is a www-page under construction which will serve as an appendix to a manuscript.
Since these pages changes a lot during these days, - it's allways wise to RELOAD each page to be sure you see the most recent version.

The SAND domain:
a probable DNA-binding domain found in human Sp100, AIRE-1, NucP41/P75 and the Drosophila DEAF-1 transcription factor.

a web page with additional information to the paper:

The APECED polyglandular autoimmune syndrome protein, AIRE-1,
contains the SAND domain and is probably a transcription factor.

by Toby J. Gibson(1), Chenna Ramu(1), Christine Gemund (1)
and Rein Aasland (2),

(1) EMBL, Heidelberg, Germany,
(2) Department of Molecular Biology, University of Bergen, Bergen, Norway.

published in Trends Biochem. Sci. 23(7):242-244; a journal published by Elsevier

On these pages you find:

Additional information on the SAND domain and SAND domain proteins.
Alignment of SAND domains
Alignment of N-terminal domains from Sp100 group proteins
Both alignments as a PDF file (you need Adobe Acrobat to read this)
A cartoon of SAND domain proteins.
Unrooted Neighbour-Joining tree for the SAND domain.
A hyperlinked table of SAND domain proteins
Full text from TiBS ONline

Links to other related material on the web:

The Finnish-German APECED consortium web-pages.
Read OMIM entry for APECED

You can contact us:
E-mail: Toby.Gibson@EMBL-Heidelberg.de
E-mail: Aasland@mbi.uib.no,
or take a look at other stuff on Rein's web pages.

This page was made by Rein Aasland APRIL 27. 1998; Last updated MAY 26. 1998

The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor.

The APECED polyglandular autoimmune syndrome protein, AIRE-1,
contains the SAND domain and is probably a transcription factor.