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Centre for Cancer Biomarkers CCBIO

CCBIO Seminar

CCBIO Seminar - Neil C. Henderson

Neil C. Henderson - Targeting of pericytes and tissue myofibroblasts during organ fibrogenesis

Apart from the interesting talks, the CCBIO seminars are a good way to meet CCBIO members and associates. Please feel free to circulate the invitation as all are welcome!

Neil C. Henderson, MRC Centre for Inflammation Research, University of Edinburgh, UK.

Title: Targeting of pericytes and tissue myofibroblasts during organ fibrogenesis

Abstract:

My lab studies concern the cellular and molecular mechanisms that drive organ fibrosis. Myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis, however the paucity of tools for reliable inactivation of genes in myofibroblasts in vivo has greatly impeded progress in dissecting the molecular mechanisms driving fibrosis, thereby slowing the discovery of novel, mechanistically targeted anti-fibrotic treatments. I will describe the development of a novel strategy (Pdgfrb-Cre) to genetically manipulate myofibroblasts in the liver and other organs, and discuss the use of transgenic fluorescent reporter mice and cell sorting to fully characterise this system. Using this strategy we identified a key role for myofibroblast αv integrins in the regulation of fibrosis and then validated our approach by using a small molecule to target αv integrins, thereby identifying a novel and targeted approach to treat fibrosis. Towards the end of my talk I will also discuss some of the cutting-edge imaging modalities, such as multiphoton microscopy that we are currently employing to further study cellular and molecular mechanisms of fibrogenesis in vivo.

Time: 14.30, 28.05.2015

Host: Donald Gullberg, CCBIO

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