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Øystein Fluge

Researcher
  • E-mailOystein.Fluge@uib.no
  • Phone+47 55 97 35 87
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Dale, Jon Espen; Sebjørnsen, Sigrunn; Leh, Sabine Maria; Røsler, Cornelia; Aaserud, Stein; Møller, Bjørn; Fluge, Øystein; Erichsen, Christian; Nadirpour, Saied; Kørner, Hartwig; Pfeffer, Frank; Dahl, Olav. 2016. Multimodal therapy is feasible in elderly anal cancer patients. Acta Oncologica. 56: 81-87. doi: 10.1080/0284186X.2016.1244356
  • Fluge, Øystein; Mella, Olav; Bruland, Ove; Risa, Kristin; Dyrstad, Sissel Elisabeth; Alme, Kine; Rekeland, Ingrid Gurvin; Sapkota, Dipak; Røsland, Gro Vatne; Fosså, Alexander; Ktoridou-Valen, Irini; Lunde, Sigrid; Sørland, Kari; Lien, Katarina; Herder, Ingrid; Thurmer, Hanne; Gotaas, Merete E; Baranowska, Katarzyna Anna; Bohnen, Louis M.L.J.; Schäfer, Christoph; Mccann, Adrian; Sommerfelt, Kristian; Helgeland, Lars; Ueland, Per Magne; Dahl, Olav; Tronstad, Karl Johan. 2016. Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. JCI Insight. 1. doi: 10.1172/jci.insight.89376
  • Fluge, Øystein; Thurmer, Hanne. 2016. Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. JCI Insight. 1. doi: 10.1172/jci.insight.89376
  • Kiserud, Cecilie E.; Fagerli, Unn-Merete; Smeland, Knut Bjøro; Fluge, Øystein; Bersvendsen, Hanne; Kvaløy, Stein Olav; Holte, Harald; Dahl, Alv A. 2016. Pattern of employment and associated factors in long-term lymphoma survivors 10 years after high-dose chemotherapy with autologous stem cell transplantation. Acta Oncologica. 55: 547-553. doi: 10.3109/0284186X.2015.1125015
  • Loebel, Madlen; Grabowski, Patricia; Heidecke, Harald; Bauer, Sandra; Hanitsch, Leif G.; Wittke, Kirsten; Meisel, Christian; Reinke, Petra; Volk, Hans-Dieter; Fluge, Øystein; Mella, Olav; Scheibenbogen, Carmen. 2016. Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome. Brain, behavior, and immunity. 52: 32-39. doi: 10.1016/j.bbi.2015.09.013
  • Lunde, Sigrid; Kristoffersen, Einar Klæboe; Sapkota, Dipak; Risa, Kristin; Dahl, Olav; Bruland, Ove; Mella, Olav; Fluge, Øystein. 2016. Serum BAFF and APRIL levels, T-lymphocyte subsets, and immunoglobulins after B-cell depletion using the monoclonal anti-CD20 antibody rituximab in myalgic encephalopathy/chronic fatigue syndrome. PLoS ONE. 11:e0161226. doi: 10.1371/journal.pone.0161226
  • Smeland, Knut Bjøro; Kiserud, Cecilie E.; Lauritzsen, Grete Fossum; Blystad, Anne Kirsti; Fagerli, Unn-Merete; Falk, Ragnhild Sørum; Fluge, Øystein; Fosså, Alexander; Kolstad, Arne; Loge, Jon Håvard; Maisenhölder, Martin; Østenstad, Bjørn; Kvaløy, Stein Olav; Holte, Harald. 2016. A national study on conditional survival, excess mortality and second cancer after high dose therapy with autologous stem cell transplantation for non-Hodgkin lymphoma. British Journal of Haematology. 173: 432-443. doi: 10.1111/bjh.13965
  • Fluge, Øystein; Risa, Kristin; Lunde, Sigrid; Alme, Kine; Rekeland, Ingrid Gurvin; Sapkota, Dipak; Kristoffersen, Einar Klæboe; Sørland, Kari; Bruland, Ove; Dahl, Olav; Mella, Olav. 2015. B-lymphocyte depletion in myalgic encephalopathy/chronic fatigue syndrome. An open-label phase II study with rituximab maintenance treatment. PLoS ONE. 10:e0129898. doi: 10.1371/journal.pone.0129898
  • Pulczynski, Elisa J.; Kuittinen, Outi; Erlanson, Martin; Hagberg, Hans; Fosså, Alexander; Eriksson, Mikael; Nordström, Marie; Østenstad, Bjørn; Fluge, Øystein; Leppä, Sirpa; Fiirgaard, Bente; Bersvendsen, Hanne; Fagerli, Unn-Merete. 2015. Successful change of treatment strategy in elderly patients with primary central nervous system lymphoma by de-escalating induction and introducing temozolomide maintenance: results from a phase II study by the Nordic Lymphoma Group. Haematologica. 100: 534-540. doi: 10.3324/haematol.2014.108472
  • Smeland, Knut Halvor Bjøro; Kiserud, Cecilie E.; Lauritzsen, Grete Fossum; Fagerli, Unn-Merete; Falk, Ragnhild Sørum; Fluge, Øystein; Fosså, Alexander; Kolstad, Arne; Loge, Jon Håvard; Maisenhölder, Martin; Kvaløy, Stein Olav; Holte, Harald. 2015. Conditional survival and excess mortality after high-dose therapy with autologous stem cell transplantation for adult refractory or relapsed Hodgkin lymphoma in Norway. Haematologica. 100: e240-e243. doi: 10.3324/haematol.2014.119214
  • Taskinen, Minna; Louhimo, Riku; Koivula, Satu; Chen, Ping; Rantanen, Ville; Holte, Harald; Delabie, Jan; Karjalainen-Lindsberg, Marja-Liisa; Björkholm, Magnus; Fluge, Øystein; Pedersen, Lars Møller; Fjordén, Karin; Jerkeman, Mats; Eriksson, Mikael; Hautaniemi, Sampsa; Leppä, Sirpa. 2014. Deregulation of COMMD1 is associated with poor prognosis in diffuse large B-cell lymphoma. PLoS ONE. 9. doi: 10.1371/journal.pone.0091031
  • Holte, Harald; Leppä, Sirpa; Bjørkholm, Mikaela; Fluge, Øystein; Jyrkkio, S.; Delabie, Jan; Sundström, C.; Karjalainen-Lindsberg, Marja-Liisa; Erlanson, M.; Kolstad, Arne; Fosså, Alexander; Østenstad, Bjørn; Löfvenberg, E.; Nordstrøm, Marianne; Janes, R.; Pedersen, L.M.; Anderson, H.; Jerkeman, M.; Eriksson, M. 2013. Dose-densified chemoimmunotherapy followed by systemic central nervous system prophylaxis for younger high-risk diffuse large B-cell/follicular grade 3 lymphoma patients: results of a phase II Nordic Lymphoma Group study. Annals of Oncology. 24: 1385-1392. doi: 10.1093/annonc/mds621
  • Knudsen-Baas, Kristin Marie; Moen, Gunnar; Fluge, Øystein; Storstein, Anette. 2013. Pseudoprogression in high-grade glioma. Acta Neurologica Scandinavica. 127: 31-37. doi: 10.1111/ane.12047
  • Smeland, Knut Halvor Bjøro; Kiserud, Cecilie E.; Lauritzsen, Grete Fossum; Blystad, Anne Kirsti; Fagerli, Unn-Merete; Fluge, Øystein; Fosså, Alexander; Hammerstrøm, Jens; Kolstad, Arne; Loge, Jon Håvard; Maisenhölder, Martin; Østenstad, Bjørn; Kvaløy, Stein Olav; Holte, Harald. 2013. High dose therapy with autologous stem cell support for lymphoma in Norway 1987-2008. Tidsskrift for Den norske legeforening. 133: 1704-1709. doi: 10.4045/tidsskr13.0243
  • Leppä, Sirpa; Taskinen, Minna; Koivula, Satu; Chen, Ping; Louhimo, Riku; Delabie, Jan; Karjalainen-Lindsberg, Marja-Liisa; Björkholm, Magnus; Fluge, Øystein; Pedersen, Lars Moeller; Rydström, Karin; Jerkeman, Mats; Eriksson, Mikael; Hautaniemi, Sampsa; Holte, Harald. 2012. Use of exon-based transcriptome profiling to identify novel signaling pathways and survival-associated genes in diffuse large B-cell lymphoma. Journal of Clinical Oncology. 30. 1 pages.
  • Myklebust, Mette Pernille; Fluge, Øystein; Immervoll, Heike; Skarstein, Arne; Balteskard, Lise; Bruland, Ove; Dahl, Olav. 2012. Expression of DSG1 and DSC1 are prognostic markers in anal carcinoma patients. British Journal of Cancer. 106: 756-762. doi: 10.1038/bjc.2011.548
  • Myklebust, Mette Pernille; Li, Zhiping; Tran, Thai H.; Rui, Hallgeir; Knudsen, Erik S.; Elsaleh, Hany; Fluge, Øystein; Vonen, Barthold; Myrvold, Helge Elliot; Leh, Sabine; Tveit, Magne Kjell; Pestell, Richard G.; Dahl, Olav. 2012. Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer. British Journal of Cancer. 107: 1684-1691. doi: 10.1038/bjc.2012.463
  • Riihijärvi, Sari; Nurmi, Heidi; Holte, Harald; Björkholm, Magnus; Fluge, Øystein; Pedersen, Lars Møller; Rydström, Karin; Jerkeman, Mats; Eriksson, Mikael; Leppä, Sirpa. 2012. High serum vascular endothelial growth factor level is an adverse prognostic factor for high-risk diffuse large B-cell lymphoma patients treated with dose-dense chemoimmunotherapy. European Journal of Haematology. 89: 395-402. doi: 10.1111/ejh.12005
  • Eide, Marianne Brodtkorb; Lauritzsen, Grete Fossum; Kvalheim, Gunnar; Kolstad, Arne; Fagerli, Unn-Merete; Maisenhölder, Martin; Østenstad, Bjørn; Fluge, Øystein; Delabie, Jan; Aarset, Harald; Liestøl, Knut; Holte, Harald. 2011. High dose chemotherapy with autologous stem cell support for patients with histologically transformed B-cell non-Hodgkin lymphomas. A Norwegian multi centre phase II study. British Journal of Haematology. 152: 600-610. doi: 10.1111/j.1365-2141.2010.08519.x
  • Fluge, Øystein; Bruland, Ove; Risa, Kristin; Storstein, Anette; Kristoffersen, Einar Klæboe; Sapkota, Dipak; Næss, Halvor; Dahl, Olav; Nyland, Harald Inge; Mella, Olav. 2011. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLoS ONE. 6. 13 pages. doi: 10.1371/journal.pone.0026358
  • Holte, Harald; Bogsrud, Trond; Leppa, S.; Laukka, M.; Bjørkholm, Mikaela; Jacobsson, H.; Jyrkkio, S.; Seppanen, M.; Jerkeman, Mats; Brun, E.; Fluge, Øystein; Pedersen, Lone Møller. 2011. (18)FDG PET/CT AFTER INTENSIFIED CHEMO-IMMUNOTHERAPY IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL), AGED 18-65 YEARS WITH AAIPI 2-3. POSITIVE OR INDETERMINATE LESIONS HAVE A LOW POSITIVE PREDICTIVE VALUE. A NORDIC PHASE II SUBSTUDY. Annals of Oncology. 22: 159-159.
  • Myklebust, Mette Pernille; Bruland, Ove; Fluge, Øystein; Skarstein, Arne; Balteskard, Lise; Dahl, Olav. 2011. MicroRNA-15b is induced with E2F-controlled genes in HPV-related cancer. British Journal of Cancer. 105: 1719-1725. doi: 10.1038/bjc.2011.457
  • Dresemann, Gregor; Weller, Michael; Rosenthal, Mark A.; Wedding, Ulrich; Wagner, Wolfgang; Engel, Erik; Heinrich, Bernhard; Mayer-Steinacker, Regine; Karup-Hansen, Anders; Fluge, Øystein; Nowak, Anna; Mehdorn, Maximillian; Schleyer, Eberhard; Krex, Dietmar; Olver, Ian N.; Steinbach, Joachim P.; Hosius, Christian; Sieder, Christian; Sorenson, Greg; Parker, Richard D.; Nikolova, Zariana. 2010. Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. Journal of Neuro-Oncology. 96: 393-402. doi: 10.1007/s11060-009-9976-3
  • Holte, Harald; Leppä, Sirpa; Björkholm, Magnus; Fluge, Øystein; Jyrkkio, Sirkku; Delabie, Jan; Sundström, Christer; Karjalainen-Lindsberg, Marja-Liisa; Erlanson, Martin; Kolstad, Arne; Fosså, Alexander; Østenstad, Bjørn; Löfvenberg, Eva; Nordström, Marie; Pedersen, Lars Møller; Anderson, Harald; Jerkeman, Mats; Eriksson, Mikael. 2010. R-CHOEP-14 x 6 Followed by Systemic CNS Prophylaxis for Diffuse Large B-Cell Lymphoma/Follicular Lymphoma Grade 3 with Age Adjusted IPI Score 2-3: Final Results of a Nordic Lymphoma Group Phase 2 Study Including 156 Patients Aged 18-65 Years. Blood. 116: 1157-1157.
  • Koivula, Satu; Taskinen, Minna; Chen, Ping; Holte, Harald; Delabie, Jan; Karjalainen-Lindsberg, Marja-Liisa; Björkholm, Magnus; Fluge, Øystein; Pedersen, Lars Møller; Jerkeman, Mats; Eriksson, Mikael; Hautaniemi, Sampsa; Leppä, Sirpa. 2010. Exon-Based Transcriptome Profiling Reveals Genes That Have Prognostic Impact on the Survival of Young High Risk Diffuse Large B-Cell/Follicular Grade 3 Lymphoma Patients Treated with Dose-Dense Chemoimmuno-therapy and CNS Prophylaxis. Results From a Nordic Lymphoma Group Phase II Study. Blood. 116: 1281-1281.
  • Koivula, Satu; Taskinen, Minna; Chen, Ping; Holte, Harald; Delabie, Jan; Karjalainen-Lindsberg, Marja-Liisa; Björkholm, Magnus; Fluge, Øystein; Pedersen, Lars Møller; Jerkeman, Mats; Eriksson, Mikael; Hautaniemi, Sampsa; Leppä, Sirpa. 2010. Exon Based Transcriptome Profiling Reveals Genes That Have Prognostic Impact on the Survival of Young High Risk Diffuse Large B Cell/Follicular Grade 3 Lymphoma Patients Treated with Dose-Dense Chemoimmuno-therapy and CNS Prophylaxis. Results From a Nordic Lymphoma Group Phase II Study. Blood. 116: 1281-1281.
  • Riihijärvi, Sari; Nyman, Heidi; Holte, Harald; Björkholm, Magnus; Fluge, Øystein; Pedersen, Lars Møller; Jerkeman, Mats; Eriksson, Mikael; Leppä, Sirpa. 2010. High Serum Vascular Endothelial Growth Factor (VEGF) Level Is An Adverse Prognostic Factor In High Risk Diffuse Large B-Cell Lymphoma (DLBCL) Patients Treated with Dose-Dense Chemoimmunotherapy and Systemic CNS Prophylaxis. Results From a Nordic Phase II Study. Blood. 116: 1686-1686.
  • Borkamo, Erling Dahl; Dahl, Olav; Bruland, Ove; Fluge, Øystein. 2009. Kinetics study on markers of the immune system by gene expression profiling of an in vivo heated tumor. International Journal of Hyperthermia. 25: 41-46. doi: 10.1080/02656730802397955
  • Dahl, Olav; Fluge, Øystein; Carlsen, Erik; Wiig, Johan N; Myrvold, Helge E; Vonen, Barthold; Podhorny, Nina; Bjerkeset, Ottar; Eide, Tor Jacob; Halvorsen, T; Tveit, Kjell Magne. 2009. Final results of a randomised phase III study on adjuvant chemotherapy with 5 FU and levamisol in colon and rectum cancer stage II and III by the Norwegian Gastrointestinal Cancer Group. Acta Oncologica. 48: 368-376. doi: 10.1080/02841860902755244
  • Fluge, Øystein; Gravdal, K; Carlsen, E; Carlsen, Erik; Vonen, Barthold; Kjellevold, K; Refsum, S; Lilleng, R; Eide, Tor J.; Halvorsen, TB; Tveit, KM; Tveit, Kjell Magne; Otte, AP; Akslen, LA; Dahl, O. 2009. Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis. British Journal of Cancer. 101: 1282-1289. doi: 10.1038/sj.bjc.6605333
  • Fluge, Øystein; Mella, Olav. 2009. Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series. BMC Neurology. 9. 7 pages. doi: 10.1186/1471-2377-9-28
  • Borkamo, Erling Dahl; Dahl, Olav; Bruland, Ove; Fluge, Øystein. 2008. Global gene expression analyses reveal changes in biological processes after hyperthermia in a rat glioma model. International Journal of Hyperthermia. 24: 425-441. doi: 10.1080/02656730802081997
  • Borkamo, Erling Dahl; Fluge, Øystein; Mella, Olav; Akslen, Lars A.; Bruland, Ove; Dahl, Olav. 2008. Hyperthermia improves the antitumour effect of metronomic cyclophosphamide in a rat transplantable brain tumour. Radiotherapy and Oncology. 86: 435-442. doi: 10.1016/j.radonc.2008.01.022
  • Bruland, Ove; Fluge, Øystein; Immervoll, Heike; Balteskard, Lise; Myklebust, Mette Pernille; Skarstein, Arne; Dahl, Olav. 2008. Gene expression reveals two distinct groups of anal carcinomas with clinical implications. British Journal of Cancer. 98: 1264-1273. doi: 10.1038/sj.bjc.6604285
  • Dahl, Olav; Borkamo, Erling Dahl; Fluge, Øystein. 2008. Current status of antivascular therapy and targeted treatment in the clinic. International Journal of Hyperthermia. 24: 97-110. doi: 10.1080/02656730701824406
  • Dahl, Olav; Fluge, Øystein. 2008. Analkreft. Tidsskrift for Den norske legeforening. 128: 198-200.
  • Fluge, Øystein; Bruland, Ove; Akslen, Lars A.; Lillehaug, Johan; Varhaug, Jan Erik. 2006. Gene expression in poorly differentiated papillary thyroid carcinomas. Thyroid. 16: 161-175.
  • Fluge, Øystein; Omenaas, Ernst; Eide, Geir Egil; Gulsvik, Amund. 1998. Fish consumption and respiratory symptoms among young adults in a Norwegian community. European Respiratory Journal. 12: 336-340.
  • Svanes, Cecilie; Omenaas, Ernst; Eide, Geir Egil; Fluge, Øystein; Gulsvik, Amund. 1998. Hospitalization for lung disease in early childhood and asthma symptoms in young adulthood. Respiratory Medicine. 92: 1003-1009.
Reports and theses
  • Fluge, Øystein. 2004. Gene expression in papillary thyroid carcinomas, with special reference to tyrosine kinase receptors and growth factors.
Book sections
  • Christoffersen, Thoralf; Bruserud, Øystein; Fluge, Øystein; Lehne, Gustav; Dahl, Olav. 2016. Kreftbiologi og medikamentell terapi. Kapittel 1, pages 13-46. In:
    • Dahl, Olav; Lehne, Gustav; Christoffersen, Thoralf. 2016. Medikamentell kreftbehandling - Cytostatikaboken 8. utgave 2016. 661 pages. ISBN: 978-82-992331-4-9.
  • Christoffersen, Thoralf; Fluge, Øystein; Lehne, Gustav; Dahl, Olav. 2009. Kreftceller og kjemoterapi. Kapittel 1, pages 13-37. In:
    • Dahl, Olav; Lehne, Gustav; Baksaas, Ingebjørg; Kvaløy, Stein Olav; Christoffersen, Thoralf. 2009. Medikamentell kreftbehandling. 495 pages. ISBN: 978-829923312-5.
  • Lillehaug, Johan; Fluge, Øystein; Varhaug, Jan Erik. 2006. Thyroid Cancer: Molecular Biology and Clinical Aspects. 20, pages 431-444. In:
    • Warshawsky, David; Landolph, Joseph R. 2006. Molecular carcinogenesis and the molecular biology of human cancer. CRC Press. 576 pages. ISBN: 0-8493-1167-5.

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