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Aurora Martinez

Professor
  • E-mailAurora.Martinez@uib.no
  • Phone+47 55 58 64 27
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Books
  • Helle, Karen Blaauw; Martinez, Aurora; Reed, Rolf K. 2013. Fra Allégaten via Årstadvollen til Ulrikens Fot 1963–2013. Bodoni forlag. 169 pages. ISBN: 978-82-90952-62-9.
  • Pey, Angel; Thorolfsson, Matthias; Erlandsen, Heidi; Stevens, Raymond c.; Ugarte, Magdalena; Desviat, Lourdes R.; Perez, Belen; Martinez, Aurora. 2004. Thermodynamic parameters for the binding of tetrahydrobiopterin to human phenylalanine hydroxylase. 6 pages.
Journal articles
  • Anikster, Yair; Haack, Tobias B.; Vilboux, Thierry; Pode-Shakked, Ben; Thöny, Beat; Shen, Nan; Guarani, Virginia; Meissner, Thomas; Mayatepek, Ertan; Trefz, Friedrich K.; Marek-Yagel, Dina; Martinez, Aurora; Huttlin, Edward L.; Paulo, Joao A.; Berutti, Riccardo; Benoist, Jean-François; Imbard, Apolline; Dorboz, Imen; Heimer, Gali; Landau, Yuval; Ziv-Strasser, Limor; Malicdan, May Christine V.; Gemperle-Britschgi, Corinne; Cremer, Kirsten; Engels, Hartmut; Meili, David; Keller, Irene; Bruggmann, Rémy; Strom, Tim M.; Meitinger, Thomas; Mullikin, James C.; Schwartz, Gerard; Ben-Zeev, Bruria; Gahl, William A.; Harper, J. Wade; Blau, Nenad; Hoffmann, Georg F.; Prokisch, Holger; Opladen, Thomas; Schiff, Manuel. 2017. Biallelic mutations in DNAJC12 cause hyperphenylalaninemia, dystonia, and intellectual disability. American Journal of Human Genetics. 100: 257-266. doi: 10.1016/j.ajhg.2017.01.002
  • Lyu, Chuang; Lyu, Gong-Wei; Martinez, Aurora; Shi, Tie-Jun. 2017. Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult Bax-deficient mice. Journal of Pain Research. 10: 2079-2087. doi: 10.2147/JPR.S133087
  • Waløen, Kai; Kleppe, Rune; Martinez, Aurora; Haavik, Jan. 2017. Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease. Expert opinion on therapeutic targets. 21: 167-180. doi: 10.1080/14728222.2017.1272581
  • Yuste-Checa, Patricia; Brasil, Sandra; Gamez, Alejandra; Underhaug, Jarl; Desviat, Lourdes Ruiz; Ugarte, Magdalena; Pérez-Cerdá, Celia; Martinez, Aurora; Pérez, Belén. 2017. Pharmacological Chaperoning: A Potential Treatment for PMM2-CDG. Human Mutation. 38: 160-168. doi: 10.1002/humu.23138
  • Baumann, Anne; Jorge Finnigan, Ana; Kunwar, Jung K. C.; Sauter, Alexander; Horvath, Istvan; Morozova-Roche, Ludmilla A.; Martinez, Aurora. 2016. Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity. Scientific Reports. 6:39488. doi: 10.1038/srep39488
  • Bezem, Maria Teresa; Baumann, Anne; Skjærven, Lars; Meyer, Romain; Kursula, Petri; Martinez, Aurora; Flydal, Marte Innselset. 2016. Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme. Scientific Reports. 6:60390. 14 pages. Published 2016-07-27. doi: 10.1038/srep30390
  • Hole, Magnus; Jorge Finnigan, Ana; Underhaug, Jarl; Teigen, Knut; Martinez, Aurora. 2016. Pharmacological chaperones that protect Tetrahydrobiopterin dependent aromatic amino acid hydroxylases through different mechanisms. Current Drug Targets. 17: 1515-1526. doi: 10.2174/1389450117666160307143512
  • Hole, Magnus; Underhaug, Jarl; Diez, Hector; Ying, Ming; Røhr, Åsmund Kjendseth; Jorge-Finnigan, Ana; Fernàndez-Castillo, Noèlia; Garcia-Cazorla, Àngels; Kristoffer Andersson, K.; Teigen, Knut; Martinez, Aurora. 2016. Erratum: Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms (Biochimica et Biophysica Acta - Proteins and Proteomics (2015) 1854:9 (1078-1089) DOI: 10.1016/j.bbapap.2015.04.030). Biochimica et Biophysica Acta - Proteins and Proteomics. 1864: 317. doi: 10.1016/j.bbapap.2015.11.008
  • Aubi Catevilla, Oscar; Flydal, Marte Innselset; Zheng, Huaixin; Skjærven, Lars; Rekand, Illimar; Leiros, Hanna-Kirsti S.; Haug, Bengt Erik; Cianciotto, Nicholas P.; Martinez, Aurora; Underhaug, Jarl. 2015. Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila. Journal of Medicinal Chemistry. 58: 8402-8412. doi: 10.1021/acs.jmedchem.5b01589
  • Hole, Magnus; Underhaug, Jarl; Diez, Hector; Ying, Ming; Røhr, Åsmund Kjendseth; Jorge Finnigan, Ana; Fernàndez-Castillo, Noèlia; García-Cazorla, Angels; Andersson, K. Kristoffer; Teigen, Knut; Martinez, Aurora. 2015. Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms. Biochimica et Biophysica Acta - Proteins and Proteomics. 1854: 1078-1089. doi: 10.1016/j.bbapap.2015.04.030
  • Korner, Germaine; Noain, Daniela; Ying, Ming; Hole, Magnus; Flydal, Marte Innselset; Scherer, Tanja; Allegri, Gabriella; Rassi, Anahita; Fingerhut, Ralph; Becu-Villalobos, Damasia; Pillai, Samyuktha; Wueest, Stephan; Konrad, Daniel; Lauber-Biason, Anna; Baumann, Christian R.; Bindoff, Laurence; Martinez, Aurora; Thöny, Beat. 2015. Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency. Brain. 138: 2948-2963. doi: 10.1093/brain/awv224
  • Loer, Curtis M.; Calvo, Ana C; Watschinger, Katrin; Werner-Felmayer, Gabriele; O'Rourke, Delia; Stroud, Dave; Tong, Amy; Gotenstein, Jennifer R.; Chisholm, Andrew D.; Hodgkin, Jonathan; Werner, Ernst R.; Martinez, Aurora. 2015. Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4). Genetics. 200: 237-253. doi: 10.1534/genetics.114.174110
  • Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. 2015. Arc is a flexible modular protein capable of reversible self-oligomerization. Biochemical Journal. 468: 145-158. doi: 10.1042/BJ20141446
  • Sauter, Alexander; Mc Duffie, Yvonne; Böhm, Heike; Martinez, Aurora; Spatz, Joachim P.; Appel, Silke. 2015. Surface-mediated priming during in vitro generation of monocyte-derived dendritic cells. Scandinavian Journal of Immunology. 81: 56-65. doi: 10.1111/sji.12246
  • Skjærven, Lars; Cuéllar, Jorge; Martinez, Aurora; Valpuesta, José María. 2015. Dynamics, flexibility, and allostery in molecular chaperonins. FEBS Letters. 589: 2522-2532. doi: 10.1016/j.febslet.2015.06.019
  • Wettstein, Sara; Underhaug, Jarl; Perez, Belen; Marsden, Brian D.; Yue, Wyatt W.; Martinez, Aurora; Blau, Nenad. 2015. Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuria. European Journal of Human Genetics. 23: 302-309. doi: 10.1038/ejhg.2014.114
  • Fossbakk, Agnete; Kleppe, Rune; Knappskog, Per; Martinez, Aurora; Haavik, Jan. 2014. Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia. Human Mutation. 35: 880-890. doi: 10.1002/humu.22565
  • Hritz, Jozef; Byeon, In-Ja L.; Krzysiak, Troy; Martinez, Aurora; Sklenar, Vladimir; Gronenborn, Angela M. 2014. Dissection of binding between a phosphorylated tyrosine hydroxylase peptide and 14-3-3ζ: A complex story elucidated by NMR. Biophysical Journal. 107: 2185-2194. doi: 10.1016/j.bpj.2014.08.039
  • Kleppe, Rune; Ghorbani, Sadaf; Martinez, Aurora; Haavik, Jan. 2014. Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins. FEBS Letters. 588: 92-98. doi: 10.1016/j.febslet.2013.11.012
  • Kleppe, Rune; Rosati, Sara; Jorge Finnigan, Ana; Alvira, Sara; Ghorbani, Sadaf; Haavik, Jan; Valpuesta, José María; Heck, Albert J.R.; Martinez, Aurora. 2014. Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ. Molecular & Cellular Proteomics. 13: 2017-2030. doi: 10.1074/mcp.M113.035709
  • Skjevik, Åge Aleksander; Mileni, Mauro; Baumann, Anne; Halskau, Øyvind; Teigen, Knut; Raymond C., Stevens; Martinez, Aurora. 2014. The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. Journal of Molecular Biology. 426: 150-168. doi: 10.1016/j.jmb.2013.09.012
  • Szczepanski, Claudia; Tenstad, Olav; Baumann, Anne; Martinez, Aurora; Myklebust, Reidar; Bjerkvig, Rolf; Prestegarden, Lars. 2014. Identification of a novel lytic peptide for the treatment of solid tumours. Genes & cancer. 5: 186-200.
  • Bustad, Helene J.; Vorland, Marta; Rønneseth, Eva; Sandberg, Sverre; Martinez, Aurora; Toska, Karen. 2013. Conformational stability and activity analysis of two hydroxymethylbilane synthase mutants, K132N and V215E, with different phenotypic association with acute intermittent porphyria. Bioscience Reports. 33: 617-U203. doi: 10.1042/BSR20130045
  • Flydal, Marte Innselset; Martinez, Aurora. 2013. Phenylalanine hydroxylase: Function, structure, and regulation. IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology. 65: 341-349. doi: 10.1002/iub.1150
  • Jorge Finnigan, Ana; Brasil, Sandra; Underhaug, Jarl; Ruiz-Sala, Pedro; Amerinero, Begoña; Banerjee, Ruma; Desviat, Lourdes R.; Ugarte, Magdalena; Martinez, Aurora; Pérez, Belén. 2013. Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type. Human Molecular Genetics. 22: 3680-3689. doi: 10.1093/hmg/ddt217
  • Leiros, Hanna-Kirsti S.; Flydal, Marte Innselset; Martinez, Aurora. 2013. Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila. FEBS Open Bio. 3: 370-378. doi: 10.1016/j.fob.2013.08.006
  • Martin, Ianire; Underhaug, Jarl; Celaya, Garbiñe; Moro, Fernando; Teigen, Knut; Martinez, Aurora; Muga, Arturo. 2013. Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. Journal of Medicinal Chemistry. 56: 7177-7189. doi: 10.1021/jm400499k
  • Sauter, Alexander; Richter, Gunther; Micoulet, Alexandre; Martinez, Aurora; Spatz, Joachim P.; Appel, Silke. 2013. Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. Biointerphases. 8:14. 12 pages. doi: 10.1186/1559-4106-8-14
  • Totland, Cecilie; Ying, Ming; Haugen, Mette; Mazengia, Kibret Yimer; Storstein, Anette; Aarseth, Jan Harald; Martinez, Aurora; Vedeler, Christian A. 2013. Avidity of onconeural antibodies is of clinical relevance. Cancer Immunology and Immunotherapy. 62: 1393-1396. doi: 10.1007/s00262-013-1442-6
  • Baumann, Anne; Gjerde, Anja Underhaug; Ying, Ming; Svanborg, Catharina; Holmsen, Holm A; Glomm, Wilhelm; Martinez, Aurora; Halskau jr, Øyvind. 2012. HAMLET forms annular oligomers when deposited with phoshpolipid monolayers. Journal of Molecular Biology. 418: 90-102. doi: 10.1016/j.jmb.2012.02.006
  • Bustad, Helene J.; Skjærven, Lars; Ying, Ming; Halskau jr, Øyvind; Baumann, Anne; Rodriguez-Larrea, David; Costas, Miguel; Underhaug, Jarl; Sanchez-Ruiz, Jose Manuel; Martinez, Aurora. 2012. The peripheral binding of 14-3-3gamma to membranes involves isoform-specific histidine residues. PLoS ONE. 7. doi: 10.1371/journal.pone.0049671
  • Flydal, Marte Innselset; Chatfield, Christa H.; Zheng, Huaiixing; Gunderson, Felizza F.; Aubi Catevilla, Oscar; Cianciotto, Nicholas P.; Martinez, Aurora. 2012. Phenylalanine hydroxylase from legionella pneumophila is a thermostable enzyme with a major functional role in pyomelanin synthesis. PLoS ONE. 7. 13 pages. doi: 10.1371/journal.pone.0046209
  • Heintz, Caroline; Troxler, Heinz; Martinez, Aurora; Thöny, Beat; Blau, Nenad. 2012. Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry. Molecular Genetics and Metabolism. 105: 559-565. doi: 10.1016/j.ymgme.2011.12.025
  • Sarkissian, Christineh N.; Ying, Ming; Scherer, Tanja; Thöny, Beat; Martinez, Aurora. 2012. The mechanism of BH4-responsive hyperphenylalaninemia-as it Occurs in the ENU1/2 genetic mouse model. Human Mutation. 33: 1464-1473. doi: 10.1002/humu.22128
  • Schallreuter, Karin U.; Salem, Mohamed A.E.L.; Gibbons, Nick C.J.; Martinez, Aurora; Slominski, Radomir; Lüdemann, Jürgen; Rokos, Hartmut. 2012. Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: epidermal H2O2/ONOO--mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels. The FASEB Journal. 26: 2457-2470. doi: 10.1096/fj.11-197137
  • Skjærven, Lars; Muga, Arturo; Reuter, Nathalie; Martinez, Aurora. 2012. A dynamic model of long-range conformational adaptations triggered by nucleotide binding in GroEL-GroES. Proteins: Structure, Function, and Genetics. 80: 2333-2346. doi: 10.1002/prot.24113
  • Underhaug, Jarl; Aubi, Oscar; Martinez, Aurora. 2012. Phenylalanine hydroxylase misfolding and pharmacological chaperones. Current Topics in Medicinal Chemistry. 12: 2534-2545. doi: 10.2174/1568026611212220008
  • Calvo, Ana C; Pey, Angel L.; Miranda-Vizuete, Antonio; Døskeland, Anne Paulus; Martinez, Aurora. 2011. Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine. Biochemical Journal. 434: 133-141. doi: 10.1042/BJ20101561
  • Dao, Khanh Kim; Pey, Angel L.; Gjerde, Anja Underhaug; Teigen, Knut; Byeon, In-Ja L.; Doskeland, Stein Ove; Gronenborn, Angela M.; Martinez, Aurora. 2011. The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. PLoS ONE. 6. 10 pages. doi: 10.1371/journal.pone.0017602
  • Johannessen, Helene Bustad; Underhaug, Jarl; Halskau jr, Øyvind; Martinez, Aurora. 2011. The binding of 14-3-3 gamma to membranes studied by intrinsic fluorescence spectroscopy. FEBS Letters. 585: 1163-1168. doi: 10.1016/j.febslet.2011.03.027
  • Kleppe, Rune; Martinez, Aurora; Doskeland, Stein Ove; Haavik, Jan. 2011. The 14-3-3 proteins in regulation of cellular metabolism. Seminars in Cell and Developmental Biology. 22: 713-719. doi: 10.1016/j.semcdb.2011.08.008
  • Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut; Jensen, Vidar Remi. 2011. Substrate Hydroxylation by the Oxido-Iron Intermediate in Aromatic Amino Acid Hydroxylases: A DFT Mechanistic Study. European Journal of Inorganic Chemistry. 17. 2720-2732. doi: 10.1002/ejic.201001218
  • Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut; Jensen, Vidar Remi. 2011. Formation of the Iron-Oxo Hydroxylating Species in the Catalytic Cycle of Aromatic Amino Acid Hydroxylases. Chemistry - A European Journal. 17: 3746-3758. doi: 10.1002/chem.201002910
  • Skjærven, Lars; Grant, Barry; Muga, Arturo; Teigen, Knut; McCammon, Andrew; Reuter, Nathalie; Martinez, Aurora. 2011. Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations. PloS Computational Biology. 7. doi: 10.1371/journal.pcbi.1002004
  • Skjærven, Lars; Martinez, Aurora; Reuter, Nathalie. 2011. Principal component and normal mode analysis of proteins; a quantitative comparison using the GroEL subunit. Proteins: Structure, Function, and Genetics. 79: 232-243. doi: 10.1002/prot.22875
  • Skjærven, Lars; Reuter, Nathalie; Martinez, Aurora. 2011. Dynamics, flexibility and ligand induced conformational changes in biological macromolecules: a computational approach. Future Medicinal Chemistry. 3: 2079-2100. doi: 10.4155/FMC.11.159
  • Szczepanski, C; Bjerkvig, Rolf; Tenstad, Olav; Thorsen, Frits Alan; Wendelbo, Ingvild Haukaas; Martinez, Aurora; Baumann, Anne; Prestegarden, Lars. 2011. Treatment of Solid Cancers Using a New Cationic Cytolytic Peptide. European Journal of Cancer. 47: S148-S148.
  • Bustad, Helene J.; Rønneseth, Eva; Toska, Karen; Underhaug, Jarl; Martinez, Aurora; Sandberg, Sverre. 2010. Characterization of the molecular basis of acute intermittent porphyria. The FEBS Journal. 277: 76-76.
  • Byeon, In-Ja L.; Dao, Khanh Kim; Jung, Jinwon; Keen, Thomas Jeffrey; Leiros, Ingar; Doskeland, Stein Ove; Martinez, Aurora; Gronenborn, Angela M. 2010. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. Journal of Biological Chemistry. 285: 14062-14070. doi: 10.1074/jbc.M110.106666
  • Calvo, Ana C; Scherer, Tanja; Pey, Rodroguez Angel Luis; Ying, Ming; Winge, Ingeborg; Mc Kinney, Jeffrey Alan; Haavik, Jan; Thöny, Beat; Martinez, Aurora. 2010. Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2. Journal of Neurochemistry. 114: 853-863. doi: 10.1111/j.1471-4159.2010.06821.x
  • Flydal, Marte Innselset; Mohn, Tonje Cecilie; Pey, Rodroguez Angel Luis; Siltberg-Liberles, Jessica; Teigen, Knut; Martinez, Aurora. 2010. Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications. Amino Acids. 39: 1463-1475. doi: 10.1007/s00726-010-0611-6
  • Halskau jr, Øyvind; Volden, Sondre; Calvo, Ana C; Martinez, Aurora; Glomm, Wilhelm. 2010. Adsorption and bioactivity of tyrosine hydroxylase on gold surfaces and nanoparticles. Protein peptide letters. 17: 1376-1382.
  • Johannessen, Helene Bustad; Rxnneseth, E; Underhaug, Jarl; Skjærven, Lars; Toska, Karen; Martinez, Aurora; Sandberg, Sverre. 2010. CHARACTERIZATION OF THE MOLECULAR BASIS OF ACUTE INTERMITTENT PORPHYRIA. Journal of Inherited Metabolic Disease. 33: S177-S177.
  • Jorge-Finnigan, A; Underhaug, Jarl; Desviat, Lourdes R.; Martinez, Aurora; Ugarte, Magdalena; Perez, Belen. 2010. POTENTIAL PHARMACOLOGYCAL CHAPERONE THERAPY FOR ISOLATED METHYLMALONIC ACIDURIA cbIB TYPE. Journal of Inherited Metabolic Disease. 33: S40-S40.
  • Martinez, Aurora; Calvo, Ana C; Scherer, Tanja; Pey, Rodroguez Angel Luis; Ying, Ming; Winge, Ingeborg; Mc Kinney, Jeffrey Alan; Haavik, Jan; Thöny, Beat. 2010. PHARMACOLOGICAL CHAPERONES FOR THE AROMATIC AMINO ACID HYDROXYLASES. Journal of Inherited Metabolic Disease. 33: S163-S163.
  • Mossberg, Ann-Kristin; Puchades, Maja; Halskau jr, Øyvind; Baumann, Anne; Lanekoff, Ingela; Chao, Yinxia; Martinez, Aurora; Svanborg, Catharina; Karlsson, Roger. 2010. HAMLET interacts with lipid membranes and perturbs their structure and integrity. PLoS ONE. 5. 10 pages. doi: 10.1371/journal.pone.0009384
  • Olsson, Elaine; Teigen, Knut; Martinez, Aurora; Jensen, Vidar Remi. 2010. The aromatic amino acid hydroxylase mechanism: A perspective from computational chemistry. Advances in Inorganic Chemistry. 62: 437-500. doi: 10.1016/S0898-8838(10)62011-9
  • Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut; Jensen, Vidar Remi. 2010. Water dissociation and dioxygen binding in phenylalanine hydroxylase. European Journal of Inorganic Chemistry. 3. 351-356. doi: 10.1002/ejic.200900489
  • Pey, Angel L.; Martinez, Aurora; Sanchez-Ruiz, Jose Manuel; Salido, EC. 2010. PARTIALLY FOLDED STATES OF A MISTARGETING VARIANT OF THE HUMAN ALANINE: GLYOXYLATE AMINOTRANSFERASE STABLY INTERACT WITH HSC70 CHAPERONES. Journal of Inherited Metabolic Disease. 33: S174-S174.
  • Stevens, Raymond C.; Sancho, Javier; Martinez, Aurora. 2010. Rescue of misfolded proteins and stabilization by small molecules. Methods in Molecular Biology. 648: 313-324. doi: 10.1007/978-1-60761-756-3_22
  • Ying, Ming; Pey, Rodroguez Angel Luis; Aarsaether, Niels; Martinez, Aurora. 2010. Phenylalanine hydroxylase expression in primary rat hepatocytes is modulated by oxygen concentration. Molecular Genetics and Metabolism. 101: 279-281. doi: 10.1016/j.ymgme.2010.06.013
  • Balague, O; Valera, S; Martinez, A; Colomo, L; Delabie, Jan; Macolscy, A; Campo, E. 2009. Plasmablastic Lymphomas (PBL) Are Genetically Characterized by Frequent MYC Translocations. Laboratory Investigation. 89: 255A-255A.
  • Dobrowolski, Steven Francis; Pey, Angel; Koch, Richard; Levy, Harvey; Ellingson, Clint C.; Naylor, Edwin W.; Martinez, Aurora. 2009. Biochemical characterization of mutant phenylalanine hydroxylase enzymes and correlation with clinical presentation in hyperphenylalaninaemic patients. Journal of Inherited Metabolic Disease. 32: 10-21. doi: 10.1007/s10545-008-0942-6
  • Flydal, Marte Innselset; Mohn, TC; Pey, Angel; Martinez, Aurora. 2009. Using the nematode enzyme as template for elucidating regulatory mechanism of phenylalanine hydroxylase. The FEBS Journal. 276: 365-365.
  • Halskau jr, Øyvind; Muga, Arturo; Martinez, Aurora. 2009. Linking new paradigms in protein chemistry to reversible membrane-protein interactions. Current protein and peptide science. 10: 339-359.
  • Halskau jr, Øyvind; Ying, Ming; Baumann, Anne; Kleppe, Rune; Rodriguez-Larrea, David; Almås, Bjørg; Haavik, Jan; Martinez, Aurora. 2009. Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase and negatively charged membranes. Journal of Biological Chemistry. 284: 32758-32769. doi: 10.1074/jbc.M109.027706
  • Martinez, Aurora; Calvo, Ana C; Teigen, Knut; Pey, Angel. 2009. Rescuing proteins of low kinetic stability by chaperones and natural ligands; phenylketonuria, a case study. Progress in Nucleic Acid Research and Molecular Biology. 83: 89-134. doi: 10.1016/S0079-6603(08)00603-X
  • Pey, Rodroguez Angel Luis; Martinez, Aurora. 2009. Iron binding effects on the kinetic stability and unfolding energetics of a thermophilic phenylalanine hydroxylase from Chloroflexus aurantiacus. Journal of Biological Inorganic Chemistry. 14: 521-531. doi: 10.1007/s00775-009-0467-y
  • Siltberg-Liberles, Jessica; Flydal, Marte Innselset; Teigen, Knut; Martinez, Aurora. 2009. Evolution of regulation, structure and function in phenylalanine hydroxylase. Pteridines. 20: 42-50.
  • Siltberg-Liberles, Jessica; Martinez, Aurora. 2009. Searching distant homologs of the regulatory ACT domain in phenylalanine hydroxylase. Amino Acids. 36: 235-249. doi: 10.1007/s00726-008-0057-2
  • Skjevik, Åge Aleksander; Teigen, Knut; Martinez, Aurora. 2009. Overview of computational methods employed in early-stage drug discovery. Future Medicinal Chemistry. 1: 49-63. doi: 10.4155/FMC.09.7
  • Calvo, Ana C; Pey, Angel; Thöny, Beat; Martinez, Aurora. 2008. Natural chaperone ligands as new therapies for the treatment of genetic diseases related to catecholamine synthesis. The FEBS Journal. 275: 445-445.
  • Calvo, Ana C; Pey, Angel; Ying, Ming; Loer, Curtis M.; Martinez, Aurora. 2008. Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans. The FASEB Journal. 22. doi: 10.1096/fj.08-108522
  • Halskau jr, Øyvind; Perez-Jimenez, Raul; Ibarra-Molero, Beatriz; Underhaug, Jarl; Muñoz, Victor; Martinez, Aurora; Sanchez-Ruiz, Jose Manuel. 2008. Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics. Proceedings of the National Academy of Sciences of the United States of America. 105: 8625-8630. doi: 10.1073/pnas.0709881105
  • Lenz, G; Wright, G; Dave, SS; Xiao, W; Powell, J; Zhao, H; Xu, W; Tan, B; Goldschmidt, N; Iqbal, J; Vose, J; Bast, M; Fu, K; Weisenburger, DD; Greiner, TC; Armitage, JO; Kyle, A; May, L; Gascoyne, RD; Connors, JM; Troen, Gunhild; Holte, Harald; Kvaløy, Stein; Dierickx, D; Verhoef, G; Delabie, Jan; Smeland, Erlend B; Jares, P; Martinez, A; Lopez-Guillermo, A; Montserrat, E; Campo, E; Braziel, RM; Miller, TP; Rimsza, LM; Cook, J R.; Pohlman, B; Sweetenham, J; Tubbs, RR; Fisher, RI; Hartmann, E; Rosenwald, A.; Ott, G; Muller-Hermelink, HK; Wrench, D; Lister, TA; Jaffe, ES; Wilson, WH; Chan, WC; Staudt, LM. 2008. Stromal Gene Signatures in Large-B-Cell Lymphomas. New England Journal of Medicine. 359: 2313-2323.
  • Pey, Angel; Ying, Ming; Cremades, Nunilo; Velazquez-Campoy, Adrian; Scherer, Tanja; Thöny, Beat; Sancho, Javier; Martinez, Aurora. 2008. Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria. Journal of Clinical Investigation. 118: 2858-2867. doi: 10.1172/JCI34355
  • Siltberg-Liberles, Jessica; Steen, Ida Helene; Svebak, Randi Myrseth; Martinez, Aurora. 2008. The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene. 427: 86-92. doi: 10.1016/j.gene.2008.09.005
  • Thöny, Beat; Calvo, Ana C; Scherer, Tanja; Svebak, Randi Myrseth; Haavik, Jan; Blau, Nenad; Martinez, Aurora. 2008. Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase. Journal of Inherited Metabolic Disease. 31: 138-138.
  • Thöny, Beat; Calvo, Ana C; Scherer, Tanja; Svebak, Randi Myrseth; Haavik, Jan; Blau, Nenad; Martinez, Aurora. 2008. Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase. Journal of Neurochemistry. 106: 672-681. doi: 10.1111/j.1471-4159.2008.05423.x
  • Fedøy, Anita-Elin; Fedoy, AE; Yang, Nannan; Martinez, A; Leiros, Hanna-Kirsti S.; Steen, IH. 2007. Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability. Journal of Molecular Biology. 372: 130-149. doi: 10.1016/j.jmb.2007.06.040
  • Leiros, Hanna-Kirsti S.; Pey, AL; Innselset, M; Innselset, Marte; Moe, Elin; Leiros, Ingar; Steen, IH; Martinez, A. 2007. Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Journal of Biological Chemistry. 282. doi: 10.1074/jbc.M610174200
  • Pey, Angel L.; Stricher, Francois; Serrano, Luis; Martinez, Aurora. 2007. Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases. American Journal of Human Genetics. 81: 1006-1024. doi: 10.1086/521879
  • Pey, Angel; Martinez, Aurora. 2007. Tetrahydrobiopterin for patients with phenylketonuria. The Lancet. 370: 462-463. doi: 10.1016/S0140-6736(07)61209-4
  • Teigen, Knut; Mckinney, Jeffrey Alan; Haavik, Jan; Martinez, Aurora. 2007. Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Current Medicinal Chemistry. 14: 455-467. doi: 10.2174/092986707779941023
  • Dao, Khanh Kim; Teigen, Knut; Kopperud, Reidun Kristin; Hodneland, Erlend; Schwede, Frank; Mellgren, Anne Elisabeth Christensen; Martinez, Aurora; Doskeland, Stein Ove. 2006. Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. Journal of Biological Chemistry. 281: 21500-21511. doi: doi:10.1074/jbc.M603116200
  • Martinez, Aurora; Loer, Curtis M.; Pey, Angel. 2006. Characterization of phenylalanine hydroxylase from Caenorhabditis elegans. Insights into the evolution of human activity and regulation. The FASEB Journal. 20: A52-A52.
  • Pey, Angel; Martinez, Aurora; Charubala, Ramamurthy; Maitland, Derek J.; Teigen, Knut; Calvo, Ana; Pfleiderer, Wolfgang; Wood, John M.; Schallreuter, Karin U. 2006. Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. The FASEB Journal. 20: 2130-2132. doi: 10.1096/fj.06-5835fje
  • Reigstad, Laila Johanne; Martinez, Aurora; Varhaug, Jan Erik; Lillehaug, Johan. 2006. Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines. Experimental Cell Research. 312: 782-795. doi: 10.1016/j.yexcr.2005.11.035
  • Halskau, Øyvind; Underhaug, Jarl; Frøystein, Nils Åge; Martinez, Aurora. 2005. Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity. Journal of Molecular Biology. 349: 1072-1086. doi: 10.1016/j.jmb.2005.04.020
  • Liberles, Jessica; Thorolfsson, Matthias; Martinez, Aurora. 2005. Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism. Amino Acids. 28: 1-12. doi: 10.1007/s00726-004-0152-y
  • Liberles, Jessica; Thorolfsson, Matthias; Martinez, Aurora. 2005. Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism. Amino Acids. 28: 1-12. doi: 10.1007/s00726-004-0152-y
  • Miranda, Frederico Faro; Kolberg, Matthias; Andersson, K.Kristoffer; Geraldes, Carlos F.G.C.; Martinez, Aurora. 2005. The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase. Journal of Inorganic Biochemistry. 99: 1320-1328.
  • Perez, Belen; Desviat, Lourdes R.; Gomez-Puertas, Paulino; Martinez, Aurora; Stevens, Raymond C; Ugarte, Magdalena. 2005. Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients. Molecular Genetics and Metabolism. 86: S11-S16. doi: 10.1016/j.ymgme.2005.06.009
  • Pey, Angel; Martinez, Aurora. 2005. The activity of wild-type and mutant phenylalanine hydroxylase and its regulation by phenylalanine and tetrahydrobiopterin at physiological and pathological concentrations: An isothermal titration calorimetry study. Molecular Genetics and Metabolism. 86: S43-S53. doi: 10.1016/j.ymgme.2005.04.008
  • Rødland, Ingunn; Halskau, Øyvind; Martinez, Aurora; Holmsen, Holm A. 2005. alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1717: 11-20.
  • Rødland, Ingunn; Halskau, Øyvind; Martinez, Aurora; Holmsen, Holm A. 2005. α-Lactalbumin binding and membrane integrity – effect of charge and degree of unsaturation of glycerophospholipids. Biochimica et Biophysica Acta - Biomembranes. 1717: 11-20. doi: 10.1016/j.bbamem.2005.09.004
  • Scavelli, Rossana; Ding, Zhaobing; Blau, Nenad; Haavik, Jan; Martinez, Aurora; Thöny, Beat. 2005. Stimulation of hepatic phenylalanine hydroxylase activity but not Pah-mRNA expression upon oral loading of tetrahydrobiopterin in normal mice. Molecular Genetics and Metabolism. 86: S153-S155. doi: 10.1016/j.ymgme.2005.09.015
  • Teigen, Knut; Jensen, Vidar Remi; Martinez, Aurora. 2005. The reaction mechanism of phenylalanine hydroxylase. A question of coordination. Pteridines. 16: 27-34.
  • Erlandsen, Heidi; Pey, Angel; Gamez, Alejandra; Perez, Belen; Desviat, Lourdes R.; Aguado, C.; Koch, Richard; Surendran, Sankar; Tyring, Stephen; Matalon, Reuben; Scriver, Charles R.; Ugarte, Magdalena; Martinez, Aurora; Stevens, Raymond c. 2004. Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proceedings of the National Academy of Sciences of the United States of America. 101: 16903-16908.
  • McKinney, J; Mckinney, Jeffrey Alan; Knappskog, Per; Pereira, J.; Ekern, Trude; Toska, Karen; Kuitert, B.B.; Levine, David; Gronenborn, Angela m.; Martinez, Aurora; Haavik, Jan. 2004. Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastoris. Protein Expression and Purification. 33: 185-194.
  • Miranda, Frederico F.; Thorolfsson, Matthias; Teigen, Knut; Sanchez-Ruiz, Jose Manuel; Martinez, Aurora. 2004. Structural and stability effects of phosphorylation � Localized structural changes in phenylalanine hydroxylase. Protein Science. 13: 1219-1226.
  • Pey, Angel; Perez, Belen; Desviat, Lourdes R.; Martinez, M.A.; Aguado, C.; Erlandsen, Heidi; Gamez, Alejandra; Stevens, Raymond c.; Thorolfsson, Matthias; Ugarte, Magdalena; Martinez, Aurora. 2004. Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations. Human Mutation. 24: 388-399.
  • Pey, Angel; Thorolfsson, Matthias; Teigen, Knut; Ugarte, Magdalena; Martinez, Aurora. 2004. Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase. Journal of the American Chemical Society. 126: 13670-13678.
  • Rodríguez-Aranda, Claudia; Casey, B.J.; Davidson, M.C; Hara, Y; Thomas, K.M.; Martinez, A; Galvan, A; Halperin, J.M.; Tottenham, Nim. 2004. Early development of subcortical regions involved in non-cued attention switching. Developmental Science. 7: 534-542.
  • Teigen, Knut; Dao, Khanh Kim; Mckinney, Jeffrey Alan; Gorren, A.C.F.; Mayer, B.; Frøystein, Nils Åge; Haavik, Jan; Martinez, Aurora. 2004. Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity. Journal of Medicinal Chemistry. 47: 5962-5971.
  • Thöny, Beat; Ding, Zhaobing; Martinez, Aurora. 2004. Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: Implications for tetrahydrobiopterin-responsive hyperphenylalaninemia. FEBS Letters. 577: 507-511.
  • Agasøster, Armelle, V.; Halskau, Øyvind; Fuglebakk, Edvin; Frøystein, Nils Å.; Muga, Arturo; Holmsen, Holm A; Martinez, Aurora. 2003. The interaction of peripheral proteins and membranes studied with alpha-lactalbumin and phospholipid bilayers of various compositions. Journal of Biological Chemistry. 278: 21790-21797.
  • Christensen, Anne Elisabeth; Selheim, Frode; de Rooij, Johan; Dremier, Sarah; Schwede, Frank; Dao, Khanh Kim; Martinez, Aurora; Maenhaut, Carine; Bos, Johanes L.; Genieser, H.-G.; Døskeland, Stein Ove. 2003. cAMP analog mapping of Epac1 and camp kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. Journal of Biological Chemistry. 278: 35394-35402.
  • Reigstad, Laila Johanne; Sande, Hege M; Fluge, Øystein; Bruland, Ove; Muga, Arturo; Varhaug, Jan Erik; Martinez, Aurora; Lillehaug, Johan. 2003. Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure. Journal of Biological Chemistry. 278: 17114-17120.
  • Teigen, Knut; Martinez, Aurora. 2003. Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics. 20: 733-740.
  • Thorolfsson, Matthias; Teigen, Knut; Martinez, Aurora. 2003. Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237. Biochemistry. 42: 3419-3428.
  • Halskau, Øyvind; Frøystein, Nils Å.; Martinez, Aurora. 2002. Detaljer i utilgjengelig systemer – membran-protein vekselvirkninger. NBS-nytt. 26: 16-19.
  • Halskau, Øyvind; Frøystein, Nils Å.; Muga, Arturo; Martinez, Aurora. 2002. The Membrane-bound Conformation of a-Lactalbumin Studied by NMR-monitored 1H Exchange. Journal of Molecular Biology. 321: 99-110.
  • Miranda, Frederiko; Teigen, Knut; Thorolfsson, Matthias; Svebakk, Randi; Knappskog, Per Morten; Flatmark, Torgeir; Martinez, Aurora. 2002. Phosphorylation and mutations of Ser16 in human phenylalanine hydroxylase. Kinetic and structural effects. Journal of Biological Chemistry. 277: 40937-40943.
  • Thorolfsson, Matthias; Døskeland, Anne Paulus; Muga, Arturo; Martinez, Aurora. 2002. The binding of tyrosine hydroxylase to negatively charged lipid bilayers involves the N-terminal region of the enzyme. FEBS Letters. 519: 221-226.
  • Thorolfsson, Matthias; Ibarra-Molero, Beatriz; Fojan, Peter; Peterssen, Steffen, B.; Sanchez-Ruiz, Jose M.; Martinez, Aurora. 2002. L-Phenylalanine binding and domain organization in human phenylalanine hydroxylase. A differential scanning calorimetry study. Biochemistry. 41: 7573-7585.
  • Hagedoorn, Peter-L.; Schmidt, Peter P.; Andersson, K.Kristoffer; Hagen, Wilfred R.; Flatmark, Torgeir; Martinez, Aurora. 2001. The effect of substrate, dihydrobiopterin and dopamine on the EPR spectroscopic properties and the midpoint potential of the catalytic iron in recombinant human phenylalanine hydroxylase. Journal of Biological Chemistry. 276: 22850-22856.
  • Martinez, Aurora; Knappskog, Per M.; Haavik, Jan. 2001. A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis. Current Medicinal Chemistry. 8: 1077-91 + cover.
  • McKinney, Jeffrey Alan; Teigen, Knut; Frøystein, Nils Å.; Knappskog, Per M.; Martinez, Aurora; Haavik, Jan. 2001. The structure of tryptophan hydroxylase structure of tryptophan hydroxylase enzyme substrate complexes as determined by NMR spectroscopy and molecular modeling. Pteridines. 12: 61-62.
  • McKinney, Jeffrey Alan; Teigen, Knut; Frøystein, Nils Å.; Salaun, Clotilde; Knappskog, Per M.; Haavik, Jan; Martinez, Aurora. 2001. Conformation of the substrate and pterin cofactor bound to human tryptophan hydroxylase. Important role of Phe313 in substrate specificity. Biochemistry. 40: 15591-15601.
  • Almås, Bjørg; Toska, Karen; Teigen, Knut; Groehn, Viola; Pfleiderer, Wolfgang; Martinez, Aurora; Flatmark, Torgeir; Haavik, Jan. 2000. A kinetic and conformational study on the interaction of tetrahydropteridines with tyrosine hydroxylase. Biochemistry. 39: 13676-13686.
  • Martinez, Aurora; Dao, K.K.; Mckinney, Jeffrey Alan; Teigen, K.; Frøystein, N.Å. 2000. The conformation of 5,6,7,8-tetrahydrobiopterin and 7,8-dihydrobiopterin in solution: A 1H NMR study. Pteridines. 11: 32-33.
  • Martinez, Aurora; Dao, Khanh Kim; McKinney, Jeffrey Alan; Teigen, Knut; Frøystein, Nils Å. 2000. The conformation of 5,6,7,8-tetrahydrobiopterin and 7,8-dihydrobiopterin in solution: A 1H NMR study. Pteridines. 11: 32-33.
  • Thorolfsson, Matthias; Fojan, P.; Petersen, Steffen B; Martinez, Aurora. 2000. The effect of tetrahydrobiopterin on the thermostability of human phenylalanine hydroxylase as studied by circular dichroism spectroscopy. Pteridines. 11: 29-31.
  • Flatmark, Torgeir; Almås, Bjørg; Knappskog, Per; Berge, SV; Svebak, RM; Chenin, Roseana; Muga, A; Martinez, Aurora. 1999. Tyrosine hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity as shown by kinetic analysis and surface plasmon resonance detection. European Journal of Biochemistry. 262: 1-11.
  • Olafsdottir, S; Martinez, Aurora. 1999. The accessibility of the iron at the active site of recombinant human phenylalanine hydroxylase to water as studied by <SUP>1</SUP>H-N paramagnetic relaxation. Effect of L-Phe and comparison with the rat enzyme. Journal of Biological Chemistry. 274: 6280-6284.
  • Teigen, Knut; Frøystein, Nils Åge; Martinez, Aurora. 1999. The structural Basis of the Recognition of Phenylalanine and Pterine Cofactors by Phenylalanine Hydroxylase. Implications for the Catalytic Mechanism. Journal of Molecular Biology. 294: 807-823.
  • Teigen, Knut; Frøystein, Nils Åge; Martinez, Aurora. 1999. The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase. Implications for the catalytic mechanism. Journal of Molecular Biology. 294: 807-823.
  • Erlandsen, H; Fusetti, F; Martinez, Aurora; Hough, E; Flatmark, Torgeir; Stevens, R.C. 1997. Crystal structure of the catalytic domain of human phenylalanine hydroxylase at 2.0 Å resolution reveals the structural basis for phenylketonuria. Nature Structural Biology. 4: 995-1000.
  • Erlandsen, H; Martinez, Aurora; Knappskog, Per; Haavik, Jan; Hough, E; Flatmark, Torgeir. 1997. Crystallization and preliminary diffraction analysis of a truncated homodimer of human phenylalanine hydroxylase. FEBS Letters. 406: 171-174.
  • Knappskog, Per; Martinez, Aurora. 1997. Effect of mutations at cys 237 on the activation state and activity of human phenylalanine hydroxylase. FEBS Letters. 409: 7-11.
  • Knappskog, Per; Martinez, Aurora. 1997. Effect of mutations at Cys 237 on the activation state and activity of human phenylalanine hydroxylase. FEBS Letters. 409: 7-11.
  • Muga, M; Arrondo, J.L.R; Martinez, Aurora; Flatmark, Torgeir; Haavik, Jan. 1997. The effect of phosphorylation at Ser-40 on the structure and thermal stability of tyrosine hydroxylase. Advances in Pharmacology. 42: 15-18.
  • Waters, P.J; Hewson, A.C; Scriver, C.R; Treacy, E.P; Martinez, Aurora; Knappskog, Per; Parniak, M.A. 1997. Comparative analysis of phenylalanine hydroxylase A104D mutant, associated with variant phenylketonuria, and wild-type enzyme. Biochemical Society Transactions. 25: S362.
  • Døskeland, Anne Paulus; Martinez, Aurora; Knappskog, Per; Flatmark, Torgeir. 1996. Phosphorylation of recombinant human phenylalanine hydroxylase. Effect on catalytic activity, substrate activation and protection against non-spesific cleavage of the fusion protein by restriction protease. The Biochemical journal. 319: 409-414.
  • Døskeland, Anne Paulus; Martinez, Aurora; Knappskog, Per; Flatmark, Torgeir. 1996. Phosphorylation of recombinant human phenylalanine hydroxylase. Effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease. Biochemical Journal. 319: 409-414.
  • Døskeland, Anne Paulus; Martinez, Aurora; Knappskog, Per; Flatmark, Torgeir. 1996. Phosphorylation of recombinant human phenylalanine hydroxylase. Effect on catalytic activity, substrate activation and protection against non-spesific cleavage of the fusion protein by restriction protease. The Biochemical journal. 319: 409-414.
  • Knappskog, Per; Eiken, Hans Geir; Martinez, Aurora; Bruland, O.; Apold, Jaran; Flatmark, Torgeir. 1996. PKU mutation (D143G) associated with an apparent high residual enzyme activity: Expression of a kinetic variant form of phenylalanine hydroxilase in three different systems. Human Mutation. 8: 236-246.
  • Knappskog, Per; Eiken, Hans Geir; Martinez, Aurora; Bruland, O.; Apold, Jaran; Flatmark, Torgeir. 1996. PKU mutation (D143G) associated with an apparent high residual enzyme activity: Expression of a kinetic variant form of phenylalanine hydroxilase in three different systems. Human Mutation. 8: 236-246.
  • Knappskog, Per; Flatmark, Torgeir; Aarden, J. M.; Haavik, Jan; Martinez, Aurora. 1996. Structure-function relationship in human phenylalanine hydroxylase . Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme. European Journal of Biochemistry. 242: 813-821.
  • Martinez, Aurora; Haavik, Jan; Flatmark, Torgeir. 1996. Conformational properties and stability of tyrosine hydroxylase studied by infrared spectroscopy. Effect of iron/catecholamine binding and phosphorylation. Journal of Biological Chemistry. 271: 19737-19742.
  • Meyer, W.; Shünemann, V.; Winkler, H.; Trautwein, A. X.; Bill, E.; Haavik, Jan; Martinez, Aurora; Flatmark, Torgeir; Nolting, H.F. 1996. Characterization of the iron environment in human tyrosine hydroxylase, using M#"ossbauer-, EPR-, and EXAFS-spectroscopy. Conf Proc Ital Phys Soc. 50: 819-822.
  • Knappskog, Per; Eiken, Hans Geir; Martinez, Aurora; Flatmark, Torgeir; Apold, Jaran. 1995. The PKU mutation S349P causes complete loss of catalytic activity in the recombinant phenylalanine hydroxylase enzyme. Hum Genet. 95: 171-173.
  • Martinez, Aurora. 1995. Evidence for a functionally important histidine residue in human tyrosine hydroxylase. Amino Acids. 9: 285-292.
  • Martinez, Aurora; Knappskog, Per; Olafsdottir, S; Døskeland, AP; Eiken, Hans Geir; Svebak, RM; Bozzini, M.; Apold, Jaran; Flatmark, Torgeir. 1995. Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme. Biochemical Journal. 306: 589-597.
  • Martinez, Aurora; Knappskog, Per; Olafsdottir, S; Døskeland, AP; Eiken, Hans Geir; Svebak, RM; Bozzini, ML; Apold, Jaran; Flatmark, Torgeir. 1995. Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Biochemical Journal. 306: 589-597.
  • Knappskog, Per; Eiken, Hans Geir; Martinez, Aurora; Flatmark, Torgeir; Motzfeldt, K.; Apold, Jaran. 1994. The PKU mutation S349P causes complete loss of catalytic activity in the recombinant phenylalanine hydroxylase enzyme. Hum Genet. 94: 171-173.
  • Martinez, Aurora; Abeygunawardana, C.; Haavik, Jan; Flatmark, Torgeir; Mildvan, A. S. 1993. Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR. Biochemistry. 32: 6381-6390.
  • Haavik, Jan; Martinez, Aurora; Olafsdottir, S.; Mallet, J.; Flatmark, Torgeir. 1992. The incorporation of divalent metal ions into recombinant human tyrosine hydroxylase apoenzymes studied by intrinsic fluorescence and 1H-NMR spectroscopy. European Journal of Biochemistry. 210: 23-31.
  • Martinez, Aurora; Olafsdottir, S.; Flatmark, Torgeir. 1992. The cooperative binding of phenylalanine to phenylalanine 4-monooxygenase studied by %1H-NMR relaxation enhancement: changes in water accessibility to the iron at the active site upon substrate binding. European Journal of Biochemistry. 211: 259-266.
  • Martinez, Aurora; Olafsdottir, S.; Haavik, Jan; Flatmark, Torgeir. 1992. Interaction of phenylalanine hydroxylase by reducing agents in vitro. Biochemical and Biophysical Research Communications - BBRC. 182: 92-98.
  • Haavik, Jan; Bourdelles, B. Le; Martinez, Aurora; Flatmark, Torgeir; Mallet, J. 1991. Recombinant human tyrosine hydroxylase isozymes. Reconstruction with iron and inhibitory effect of other metal ions. European Journal of Biochemistry. 199: 371-378.
  • Martinez, Aurora; Andersson, K. K.; Haavik, Jan; Flatmark, Torgeir. 1991. EPR and %1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates inhibitors. European Journal of Biochemistry. 198: 675-682.
Book sections
  • Skjærven, Lars; Teigen, Knut; Martinez, Aurora. 2014. Structure–Function Relationships in the Aromatic Amino Acid Hydroxylases Enzyme Family: Evolutionary Insights. http://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0025581/abstract. In:
    • Bynum, William F. 2014. eLS. John Wiley & Sons. ISBN: 9780470015902.
  • Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut; Jensen, Vidar Remi. 2010. The aromatic amino acid hydroxylase mechanism: a perspective from computational chemistry. 62, pages 437-500. In:
    • van Eldik, Rudi; Harvey, Jeremy. 2010. Theoretical and Computational Inorganic Chemistry. Elsevier. 500 pages. ISBN: 978-0-12-380874-5.
  • McKinney, Jeffrey Alan; Teigen, Knut; Frøystein, Nils Å.; Knappskog, Per, M.; Haavik, Jan; Martinez, Aurora. 2002. Role of Phe313/Trp326 in determining substrate specificity in tryptophan and phenylalanine hydroxylases. 97-102. In:
    • Milstien, Sheldon; Kapatos, G.; Levine, R. A.; Shane,, B. 2002. Chemistry and Biology of Pteridines and Folates: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17-22, 2001. 677 pages. ISBN: 0-7923-7675-7.
  • Teigen, Knut; Dao, Khanh Kim; Frøystein, Nils Å.; Gorren, Antonius, C.F.; Mayer, Bernd; McKinney, Jeffrey Alan; Haavik, Jan; Martinez, Aurora. 2002. The conformation of tetrahydrobiopterin free and bound to aromatic amino acid hydroxylases. 67-72. In:
    • Milstien, Sheldon; Kapatos, G.; Levine, R. A.; Shane,, B. 2002. Chemistry and Biology of Pteridines and Folates: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17-22, 2001. 677 pages. ISBN: 0-7923-7675-7.
  • Thorolfsson, Matthias; Muga, Arturo; Martinez, Aurora. 2002. The N-terminus of human tyrosine hydroxylase is responsible for its association with phospholipid bilayers. 115-120. In:
    • Milstien, Sheldon; Kapatos, G.; Levine, R. A.; Shane,, B. 2002. Chemistry and Biology of Pteridines and Folates: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17-22, 2001. 677 pages. ISBN: 0-7923-7675-7.
  • Garcia-Domingo, D; Leonardo, E; Grandien, A; Martinez, C; Albar, JP; Izpisua-Belmonte, JC; Martinez, Aurora. 1999. DIO-1 is a novel gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. 7992-7997. In:
    • [Mangler etternavn], [Mangler fornavn]. 1999. Proceedings of the National Academy of Sciences of the USA.
  • Flatmark, Torgeir; Knappskog, Per; Bjørgo, Elisa; Martinez, Aurora. 1997. Molecular characterization of disease related mutant forms of human phenylalanine hydroxylase and tyrosine hydroxylase. 503-508. In:
    • Pfleiderer, Wolfgang; Rokos, Hartmut. 1997. Chemistry and biology of pteridines and folates: Proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15-20, 1997. Blackwell Publishing. 894 pages. ISBN: 3-8263-3185-0.
  • Flatmark, Torgeir; Knappskog, Per; Bjørgo, Elisa; Martinez, Aurora. 1997. Molecular (-en 1) characterization of disease related mutant forms of human phenylalanine hydroxylase and tyrosine hydroxylase. 58-58. In:
    • [Mangler etternavn], [Mangler fornavn]. 1997. Pteridines 8.
  • Haavik, Jan; Bill, E.; Lengen, M.; Martinez, Aurora; Flatmark, Torgeir; Trautwein, A. K. 1993. Characterization of the iron environment in recombinant human tyrosine hydroxylase. 71-76. In:
    • Ayling, June E.; Nair, M.G.; Baugh, C.M. 1993. Chemistry and Biology of Pteridines and Folates. Proceedings of the Tenth International Symposium on Chemistry and Biology of Pteridines, held March 21 - 26, 1993, in Orange Beach, Alabama. 825 pages. ISBN: 0306445816.
  • Knappskog, Per; Eiken, Hans Geir; Martinez, Aurora; Olafsdottir, S.; Haavik, Jan; Flatmark, Torgeir; Apold, Jaran. 1993. Expression of recombinant wild type and mutant forms of human phenylalanine hydroxylase in E. coli. In:
    • Ayling, June E.; Nair, M.G.; Baugh, C.M. 1993. Chemistry and Biology of Pteridines and Folates. Proceedings of the Tenth International Symposium on Chemistry and Biology of Pteridines, held March 21 - 26, 1993, in Orange Beach, Alabama. 825 pages. ISBN: 0306445816.
  • Knappskog, Per; Eiken, Hans Geir; Martinez, Aurora; Olafsdottir, S.; Haavik, Jan; Flatmark, Torgeir; Apold, Jaran. 1993. Expression of wild type and mutant forms of human phenylalanine hydroxylase in E.Coli. 50-62. In:
    • [Mangler etternavn], [Mangler fornavn]. 1993. Adv Exp Med Biol.
  • Martinez, Aurora; Abeygunawardana, C.; Haavik, Jan; Flatmark, Torgeir; Mildvan, A. S. 1993. Interaction of substrate and pterin cofactor with the metal of human tyrosine hydroxylase as determined by %1H-NMR. 77-80. In:
    • Ayling, June E.; Nair, M.G.; Baugh, C.M. 1993. Chemistry and Biology of Pteridines and Folates. Proceedings of the Tenth International Symposium on Chemistry and Biology of Pteridines, held March 21 - 26, 1993, in Orange Beach, Alabama. 825 pages. ISBN: 0306445816.

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