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UiB
- E-mailBengt-Erik.Haug@uib.no
- Phone+47 55 58 34 68
- Visitor AddressAllégaten 41Realfagbygget5007 BergenRoom4055a
- Postal AddressPostboks 78035020 Bergen
We are interested in research questions that lie on the interface of chemistry and biology. The research projects that we are involved in are rooted within medicinal chemistry and biological chemistry, and we apply synthetic organic chemistry to address our research questions. The group has been instrumental for the establishment of the Laboratory for High-throughput experimentation - HTE@UiB, which is lead by Professor Haug. Several of our projects require access to synthetic peptides, and the group has established and runs the Peptide synthesis laboratory at the Department of Chemistry.
The group is part of the research group on Bioresources and Pharmaceutical Chemistry.
Academic article
- (2024). Investigating Polypharmacology through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3. Journal of Chemical Information and Modeling. 621-626.
- (2023). Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80. Frontiers in Chemistry.
- (2022). Identification of a phage display-derived peptide interacting with the N-terminal region of factor VII activating protease (FSAP) enables characterization of zymogen activation. ACS Chemical Biology. 2631-2642.
- (2021). Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy. Theranostics. 6044-6057.
- (2021). CytoCy5S™, a compound of many structures. in vitro and in vivo evaluation of four near-infrared fluorescent substrates of nitroreductase (NTR). Dyes and pigments. 1-11.
- (2021). Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model. Molecular Imaging and Biology. 144-155.
- (2021). An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics . ChemMedChem. 2715.
- (2020). Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements. Chemical Science. 12081-12088.
- (2020). Total synthesis of phorbazole B. Molecules. 1-10.
- (2019). Kinase chemodiversity from the Arctic: the breitfussins. Journal of Medicinal Chemistry. 10167-10181.
- (2018). Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proceedings of the National Academy of Sciences of the United States of America. 4405-4410.
- (2018). Aldol condensations on a 3-alkylidene-2,5-diketopiperazine - synthesis of two marine natural products. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 1303-1306.
- (2017). Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism. Tetrahedron. 3866-3877.
- (2017). Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model. Oncoimmunology. 1-13.
- (2017). LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment. Future Medicinal Chemistry. 1339-1344.
- (2017). Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorganic & Medicinal Chemistry. 646-657.
- (2016). Discovery of a 9-mer cationic peptide (LTX-315) as a potential first in class oncolytic peptide. Journal of Medicinal Chemistry. 2918-2927.
- (2016). Crystal structure of the Golgi-associated human N-alpha acetyltransferase 60 (Naa60/NatF) reveals the molecular determinants for substrate-specific acetylation. Structure. 1044-1056.
- (2015). Pseudoaeruginosins, nonribosomal peptides in nodularia spumigena. ACS Chemical Biology. 725-733.
- (2015). Probing the molecular interactions between CXC chemokine receptor 4 (CXCR4) and an arginine-based tripeptidomimetic antagonist (KRH-1636). Journal of Medicinal Chemistry. 8141-8153.
- (2015). Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila. Journal of Medicinal Chemistry. 8402-8412.
- (2015). A concise total synthesis of breitfussin A and B. Organic Letters. 122-125.
- (2014). Reversible ketomethylene-based inhibitors of human neutrophil proteinase 3. Journal of Medicinal Chemistry. 9396-9408.
- (2014). In silico design, synthesis, and assays of specific substrates for proteinase 3: Influence of fluorogenic and charged groups. Journal of Medicinal Chemistry. 1111-1115.
- (2014). Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorganic & Medicinal Chemistry. 4759-4769.
- (2013). Synthesis and docking of novel piperidine renin inhibitors. Monatshefte für Chemie. 479-494.
- (2013). Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. Cancer Research. 1276-1286.
- (2012). The relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determines their cytotoxicity. Journal of Biological Chemistry. 233-244.
- (2012). Interaction of local anaesthetic articaine enantiomers with brain lipids: A Langmuir monolayer study. European Journal of Pharmaceutical Sciences. 394-401.
- (2012). Debenzylation of Functionalized 4-and 5-substituted 1,2,3-fTriazoles. Synthesis (Stuttgart). 2070-2078.
- (2012). 1,3-Dipolar cycloaddition of benzyl azide to two highly functionalized alkynes. Monatshefte für Chemie. 505-512.
- (2011). Synthesis of trans-4-Triazolyl-Substituted 3-Hydroxypiperidines. Synthesis (Stuttgart). 749-754.
- (2011). Intramolecular hydrogen bonding in articaine can be related to superior bone tissue penetration: A molecular dynamics study. Biophysical Chemistry. 18-25.
- (2008). Synthetic antimicrobial peptidomimetics with therapeutic potential. Journal of Medicinal Chemistry. 4306-4314.
- (2008). Antimicrobial Peptides with Stability toward Tryptic Degradation. Biochemistry. 3777-3788.
- (2007). Application of the Suzuki-Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials. Bioorganic & Medicinal Chemistry Letters.
- (2005). Facile degradative lactonization of Gln-Arg and Gln-Phe hydroxyethylene dipeptide derivatives. Journal of Peptide Research.
- (2004). Synthesis of a Gln-Phe hydroxyethylene dipeptide isostere. Organic Letters. 4783-4786.
- (2004). Bulky nonproteinogenic amino acids permit the design of very small and effective cationic antibacterial peptides. Journal of Medicinal Chemistry. 4159-4162.
- (2003). The Pharmacophore of Short Cationic Antibacterial Peptides. Journal of Medicinal Chemistry. 1567-1570.
- (2003). Enhanced antitumor activity of 15-residue bovine lactoferricin derivatives containing bulky aromatic amino acids and lipophilic N-terminal modifications. Journal of Peptide Science. 510-517.
- (2002). Synthesis of a 2-arylsulphonylated tryptophan: the antibacterial activity of bovine lactoferricin peptides containing Trp(2-Pmc). Journal of Peptide Science. 307-313.
- (2002). Simple parameterization of non-proteinogenic amino acids for QSAR of antibacterial peptides. Journal of Peptide Science. 302-306.
- (2001). The effects of charge and lipophilicity on the antibacterial activity of undecapeptides derived from bovine lactoferricin. Journal of Peptide Science. 425-432.
- (2001). The Role of Tryptophan in the Antibacterial Activity of a 15-Residue Bovine Lactoferricin Peptide. Journal of Peptide Science. 190-196.
- (2001). Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity. International Journal of Biochemistry and Cell Biology.
- (2001). Bulky Aromatic Amino Acids Increase the Antibacterial Activity of Bovine Lactoferricin Peptides. Journal of Peptide Science. 425-432.
- (2000). Fargestoffer i Sopp. Kjemi.
Lecture
- (2014). Havet - vårt nye medisinskap?
Popular scientific lecture
- (2016). Peptider, peptidomimetika og legemiddelutvikling.
- (2013). Hvordan lager man legemiddelmolekyler?
- (2012). The Nobel Prize in Chemistry 2012.
- (2012). Peptider og legemiddelutvikling.
- (2012). Hvordan lager man et legemiddel?
- (2007). Antimikrobielle peptider - En kilde til utvikling av fremtidenslegemidler mot mikrober og kreft?
Academic lecture
- (2023). Phospholipid membrane interactions of model peptides and depth of insertion investigated via solid-state NMR.
- (2023). A fragment to bind them all: Characterising phorbazole fragments as pan-kinase inhibitor.
- (2022). TARGETING A PSEUDOMONAS AERUGINOSA β-KETOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE WITH COVALENT INHIBITORS INSPIRED BY CERULENIN.
- (2022). Innovative molecular imaging technique for Granzyme-B characterization as an emerging biomarker for radio-immunotherapy combinations.
- (2022). Biogas Residues as Feedstock for Hydrothermal Conversion: Bio-Oil Yield Optimisation and Fate of Drugs.
- (2021). Targeting Bacterial Fatty Acid Synthesis using Fragment-Based Drug Design.
- (2020). Synthesis and Biological Activity of the Breitfussins.
- (2016). Discovery of LTX-315 - A potential first-in-class oncolytic peptide.
- (2016). BIOSNet - From marine natural products to commercial leads.
- (2015). Total synthesis of breitfussin A and B.
- (2014). Design and synthesis of substrates and inhibitors for Proteinase 3.
- (2014). Design and synthesis of ketomethylene-based inhibitors of human neutrophil Proteinase 3.
- (2012). Synthesis of piperidine derivatives.
- (2012). Novel Renin Inhibitors.
- (2012). Hvordan lager man et legemiddel?
- (2010). [3+2] Cycloaddition of benzyl azide to two highly functionalized alkynes.
- (2009). Synthesis of biologically active peptides and peptidomimetics.
- (2006). Synthesis of a Gln-Phe hydroxyethylene dipeptide isostere.
- (2001). Antibacterial Activity of 15-Residues Bovine Lactoferricin Derivatives Employing non-coded Aromatic Amino Acids, Peptides 2000.
- (2000). Increased Antibacterial activity of 15-residues Bovine Lactoferricin Derivatives employing non-coded Aromatic Amino Acids,.
Other product
- (2001). Antimicrobial compounds and formulations.
Compendium
- (2010). IUPAC ICOS-18 Proceedings.
Popular scientific article
- (2001). FARGESTOFFER I SOPP. Blekksoppen. 16-19.
Feature article
- (2024). Kjemi og beredskap. Stavanger Aftenblad. 52-52.
Doctoral dissertation
- (2016). Synthesis of Bicyclic CXCR4 Antagonists .
- (2014). Synthesis of serine protease inhibitors.
- (2012). Synthesis of novel renin inhibitors.
- (2012). Synthesis of Some Nitrogen Heterocycles of Medicinal Relevance.
Abstract
- (2012). Synthesis and docking of 4-triazolyl substituted piperidine derivatives as novel renin inhibitors. Journal of Peptide Science. S125-S125.
- (2011). SAR and Binding Mode for CXCR4 Antagonists Based on an Arg-Arg-Nal Tripeptide Motif. Biopolymers. 492-492.
Poster
- (2022). Structure-based hit discovery for riboswitch ligands.
- (2022). A P. AERUGINOSA FATTY ACID SYNTHESIS PROTEIN CRYSTALLOGRAPHIC FRAGMENT SCREEN AND ATTEMPTED OPTIMIZATION OF A HIT.
- (2020). Inhibition of the Actin N-terminal acetyltransferase NAA80.
- (2018). naa10 knockdown and NatA inhibition point to role for the NatA complex in zebrafish dorsoventral axis formation .
- (2018). Inhibition of the Actin N-terminal acetyltransferase NAA80.
- (2017). Synthesis of the natural product (3Z,6Z)-3-((1H-imidazol-5-yl)methylene)-6-(2-methylpropylidene)-piperazine-2,5-dione.
- (2017). Halogenation of electron rich heterocycles: Where does it go?
- (2016). Total Synthesis of Breitfussin A and B.
- (2016). Synthesis of a Challenging Amide.
- (2016). Synthesis of Analogues of the Bioactive Compound Barettin.
- (2016). Scaffold-based tripeptidomimetic CXCR4 antagonists.
- (2015). Synthetic studies towards peptidomimetic CXCR4 antagonists.
- (2015). Synthetic studies towards nitroreductase-activated fluorescent probes.
- (2015). Synthetic studies towards CXCR4 antagonists.
- (2014). Synthetic studies towards CXCR4 antagonists.
- (2014). Synthetic studies towards CXCR4 antagonists.
- (2014). Synthesis and biological evaluation of pseudopeptide inhibitors of Proteinase 3.
- (2012). Synthesis of a Ketomethylene Dipeptide Isostere.
- (2012). Synthesis and docking of 4-triazolyl substituted piperidine derivatives as novel renin inhibitors.
- (2012). Local Anesthetic Articaine Enantiomers interaction with Brain Lipids.
- (2011). Synthesis of 3,4-disubstituted piperidines.
- (2011). Synthesis of 3,4-disubstituted piperidines.
- (2009). Cycloaddition with highly functionalized terminal alkynes.
- (2006). Novel Antibacterial Tripeptides.
- (2001). Preparation of (2S)-3-amino-(2,2,5,7,8-pentamethyl-chroman-6-sulfonyl)-1H-indol-3-yl)-propionic acid and its incorporation into antibacterial lactoferricin peptides.
Academic literature review
- (2015). Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists. Future Medicinal Chemistry. 1261-1283.
- (2007). The medicinal chemistry of short lactoferricin-based antibacterial peptides. Current Medicinal Chemistry. 1-18.
More information in national current research information system (CRIStin)
Addressing the need for new antibiotics through underexplored bacterial targets
The group in involved in several research projects where novel targets for future antibiotics are investigated. Our focus is on processes that are essential in bacteria and in our work, we address several different riboswitches, which are non-coding structural elements in mRNA that regulate gene expression by binding to small organic molecules, in addition to key enzymes within the fatty acid synthesis machinery in bacteria.
Early drug discovery
The group is partner in the RESPOND3 project on responsible early digital drug discovery within the Centre for Digital Life Norway. This project focuses on developing better computational approaches and responsible innovation strategies in early drug discovery with applications to antibiotics targeting riboswitches and inflammatory lung diseases.
Molecular imaging
The group is part of the Tracer Development Center of the Norwegian Nuclear Medicine Consortium.
Inhibitors of N-terminal acetyl transferases
Proteins constitute an essential part of the machinery of life and display enormous variation in both structure and function. In addition to the diversity inferred by the 20 coded amino acids, proteins are often covalently modified during or after biosynthesis, which adds additional layers of complexity.
Acetylation is one of the most common co- or post-translational protein modifications and occurs either on the amino group of lysine side chains (K-acetylation) or on the alpha-amino group of N-terminal residues (Nt-acetylation).
Nt-acetylation of proteins is extremely common and occurs on more than 80% of all human proteins. Biochemically it consists of transfer of an acetyl group from acetyl coenzyme A (Ac-CoA) to the protein substrate and is catalyzed by the N-terminal acetyltransferase (NAT) group of enzymes.
Although our understanding of the NATs has increased in recent years, there are fundamental questions that remain unanswered in the field:- What are the cellular roles of NAT enzymes (and thus Nt-acetylation)?- Can NATs be targeted for therapeutic intervention in cancer and other diseases?
Access to specific and potent NAT inhibitors is a prerequisite to answer these questions, and we are working toward equipping the scientific community with these molecular tools in collaboration with the Arnesen group at UiB.
Fields of competence