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Erling Andre Høivik's picture

Erling Andre Høivik

Researcher
  • E-mailErling.Hoivik@uib.no
  • Phone+47 55 97 07 23
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Berg, Anna; Gulati, Ankush; Ytre-Hauge, Sigmund; Fasmer, Kristine Eldevik; Mauland, Karen Klepsland; Høivik, Erling Andre; Husby, Jenny Hild Aase; Tangen, Ingvild Løberg; Trovik, Jone; Halle, Mari Kyllesø; Stefansson, Ingunn; Akslen, Lars A.; Woie, Kathrine; Bjørge, Line; Salvesen, Helga; Salvesen, Øyvind; Werner, Henrica Maria Johanna; Haldorsen, Ingfrid S.; Krakstad, Camilla. 2017. Preoperative imaging markers and PDZ-binding kinase tissue expression predict low-risk disease in endometrial hyperplasias and low grade cancers. OncoTarget. 8: 68530-68541. doi: https://doi.org/10.18632/oncotarget.19708
  • Halle, Mari Kyllesø; Ojesina, Akinyemi I; Engerud, Hilde Renate; Woie, Kathrine; Tangen, Ingvild Løberg; Holst, Frederik; Høivik, Erling Andre; Kusonmano, Kanthida; Haldorsen, Ingfrid S.; Vintermyr, Olav Karsten; Trovik, Jone; Bertelsen, Bjørn; Salvesen, Helga; Krakstad, Camilla. 2017. Clinicopathologic and molecular markers in cervical carcinoma: a prospective cohort study. American Journal of Obstetrics and Gynecology. 217: 432.e1-432.e17. doi: 10.1016/j.ajog.2017.05.068
  • Karlsson, Thomas; Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Pollock, Pamela M.; Salvesen, Helga; Lewis, Aurelia Eva. 2017. Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation. OncoTarget. 8: 3881-3894. Published 2017-01-17. doi: 10.18632/oncotarget.13989
  • Kopperud, Reidun Kristin; Rygh, Cecilie Brekke; Karlsen, Tine Veronica; Krakstad, Camilla; Kleppe, Rune; Høivik, Erling Andre; Bakke, Marit; Tenstad, Olav; Selheim, Frode; Liden, Åsa; Madsen, Lise; Pavlin, Tina; Taxt, Torfinn; kristiansen, k; Curry, FE; Reed, Rolf K.; Doskeland, Stein Ove. 2017. Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiologica. 219: 441-452. doi: 10.1111/apha.12697
  • Mjøs, Siv; Werner, Henrica Maria Johanna; Birkeland, Even; Holst, Frederik; Berg, Anna; Halle, Mari Kyllesø; Tangen, Ingvild Løberg; Kusonmano, Kanthida; Mauland, Karen Klepsland; Øyan, Anne Margrete; Kalland, Karl-Henning; Lewis, Aurelia Eva; Mills, Gordon B.; Krakstad, Camilla; Trovik, Jone; Salvesen, Helga; Høivik, Erling Andre. 2017. PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. Scientific Reports. 7:10240: 1-12. doi: 10.1038/s41598-017-10717-z
  • Nygaard, Gyrid; Herfindal, Lars; Sivertsen Åsrud, Kathrine; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Oveland, Eystein; Berven, Frode; Myhren, Lene Elisabeth; Høivik, Erling Andre; Lunde, Turid Helen Felli; Bakke, Marit; Doskeland, Stein Ove; Selheim, Frode. 2017. Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 7:8725: 1-15. doi: 10.1038/s41598-017-08975-y
  • Berg, Anna; Fasmer, Kristine Eldevik; Mauland, Karen Klepsland; Ytre-Hauge, Sigmund; Høivik, Erling Andre; Husby, Jenny Hild Aase; Tangen, Ingvild Løberg; Trovik, Jone; Halle, Mari Kyllesø; Woie, Kathrine; Bjørge, Line; Bjørnerud, Atle; Salvesen, Helga; Werner, Henrica Maria Johanna; Krakstad, Camilla; Haldorsen, Ingfrid S. 2016. Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer. OncoTarget. 7: 69844-69856. doi: 10.18632/oncotarget.12004
  • Edland, Ravn Fritdtjov; Wergeland, Anita; Kopperud, Reidun Kristin; Sivertsen åsrud, Kathrine; Høivik, Erling Andre; Witsø, Solveig Lund; Æsøy, Reidun; Madsen, Lise; Kristiansen, K; Bakke, Marit; Doskeland, Stein Ove; Jonassen, Anne K. 2016. Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. Nutrition & Metabolism. 13: 1-11. doi: 10.1186/s12986-016-0147-1
  • Gibson, William J.; Høivik, Erling Andre; Halle, Mari Kyllesø; Taylor-Weiner, Amaro; Cherniack, Andrew D.; Berg, Anna; Holst, Frederik; Zack, Travis I.; Werner, Henrica Maria Johanna; Staby, Kjersti M.; Rosenberg, Mara; Stefansson, Ingunn; Kusonmano, Kanthida; Chevalier, Aaron; Mauland, Karen Klepsland; Trovik, Jone; Krakstad, Camilla; Giannakis, Marios; Hodis, Eran; Woie, Kathrine; Bjørge, Line; Vintermyr, Olav Karsten; Wala, Jeremiah A.; Lawrence, Michael S.; Getz, Gad; Carter, Scott L.; Beroukhim, Rameen; Salvesen, Helga. 2016. The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. Nature Genetics. 48: 848-855. doi: 10.1038/ng.3602
  • Holst, Frederik; Høivik, Erling Andre; Gibson, William J.; Taylor-Weiner, Amaro; Schumacher, Steven E.; Asmann, Yan W.; Grossmann, Patrick; Trovik, Jone; Necela, Brian M.; Thompson, E. Aubrey; Meyerson, Matthew; Beroukhim, Rameen; Salvesen, Helga; Cherniack, Andrew D. 2016. Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth. Scientific Reports. 6. doi: 10.1038/srep25521
  • Mauland, Karen Klepsland; Wik, Elisabeth; Høivik, Erling Andre; Kusonmano, Kanthida; Halle, Mari Kyllesø; Berg, Anna; Haugland, Hans Kristian; Øyan, Anne Margrete; Kalland, Karl-Henning; Stefansson, Ingunn; Akslen, Lars A.; Krakstad, Camilla; Trovik, Jone; Werner, Henrica Maria Johanna; Salvesen, Helga. 2016. Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. OncoTarget. 8: 9696-9707. doi: 10.18632/oncotarget.14201
  • Painter, Jodie N.; Kaufmann, Susanne; O'Mara, Tracy A.; Hillman, Kristine M.; Sivakumaran, Haran; Darabi, Hatef; Cheng, Timothy H.T.; Pearson, John; Kazakoff, Stephen; Waddell, Nicola; Høivik, Erling Andre; Goode, Ellen L.; Scott, Rodney J.; Tomlinson, Ian; Dunning, Alison M.; Easton, Douglas F.; French, Juliet D.; Salvesen, Helga; Pollock, Pamela M.; Thompson, Deborah J.; Spurdle, Amanda B.; Edwards, Stacey L. 2016. A common variant at the 14q32 endometrial cancer risk locus activates AKT1 through YY1 binding. American Journal of Human Genetics. 98: 1159-1169. doi: 10.1016/j.ajhg.2016.04.012
  • Berg, Anna; Høivik, Erling Andre; Mjøs, Siv; Holst, Frederik; Werner, Henrica Maria Johanna; Tangen, Ingvild Løberg; Taylor-Weiner, Amaro; Gibson, William J.; Kusonmano, Kanthida; Wik, Elisabeth; Trovik, Jone; Halle, Mari Kyllesø; Øyan, Anne Margrete; Kalland, Karl-Henning; Cherniack, Andrew D; Beroukhim, Rameen; Stefansson, Ingunn; Mills, Gordon B.; Krakstad, Camilla; Salvesen, Helga. 2015. Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients. OncoTarget. 6: 1327-1339.
  • Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Halle, Mari Kyllesø; Berg, Anna; Werner, Henrica Maria Johanna; Ræder, Maria B; Kusonmano, Kanthida; Zou, June; Øyan, Anne Margrete; Stefansson, Ingunn; Trovik, Jone; Kalland, Karl-Henning; Chen, Hong-Wu; Salvesen, Helga. 2015. ATAD2 overexpression links to enrichment of B-MYBtranslational signatures and development of aggressive endometrial carcinoma. OncoTarget. 6: 28440-28452. doi: 10.18632/oncotarget.4955
  • Høivik, Erling Andre; Kusonmano, Kanthida; Halle, Mari Kyllesø; Berg, Anna; Wik, Elisabeth; Werner, Henrica Maria Johanna; Petersen, Kjell; Øyan, Anne Margrete; Kalland, Karl-Henning; Krakstad, Camilla; Trovik, Jone; Widschwendter, Martin; Salvesen, Helga. 2014. Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. OncoTarget. 5: 1052-1061.
  • Ojesina, Akinyemi; Lichtenstein, Lee; Freeman, Samuel S.; Pedamallu, Chandra Sekhar; Imaz-Rosshandler, I; Pugh, Trevor J.; Cherniack, Andrew D.; Ambrogio, Lauren; Cibulskis, Kristian; Bertelsen, Bjørn; Romero-Cordoba, S; Treviño, Victor; Vazquez-Santillan, K; Guadarrama, Alberto Salido; Wright, Alexi A.; Rosenberg, Mara W.; Duke, Fujiko; Kaplan, Bethany; Wang, Rui; Nickerson, Elizabeth; Walline, Heather M; Lawrence, Michael S.; Stewart, Chip; Carter, Scott L.; McKenna, Aaron; Rodriguez-Sanchez, Iram P.; Espinosa-Castilla, Magali; Woie, Kathrine; Bjørge, Line; Wik, Elisabeth; Halle, Mari Kyllesø; Høivik, Erling Andre; Krakstad, Camilla; Gabiño, Nayeli Belem; Gómez-Macías, Gabriela; Valdez-Chapa, Lezmes D.; Garza-Rodríguez, Maria Lourdes; Maytorena, German; Vazquez, Jorge; Rodea, Carlos; Cravioto, Adrian; Cortes, Maria L.; Greulich, Heidi; Crum, Christopher P.; Neuberg, Donna S.; Hidalgo-Miranda, Alfredo; Escareno, Claudia Rangel; Akslen, Lars A.; Carey, Thomas E.; Vintermyr, Olav Karsten; Gabriel, Stacey B.; Barrera-Saldana, Hugo A.; Melendez-Zajgla, Jorge; Getz, Gad; Salvesen, Helga Birgitte; Meyerson, Matthew. 2014. Landscape of genomic alterations in cervical carcinomas. Nature. 506: 371-375. doi: 10.1038/nature12881
  • Tangen, Ingvild Løberg; Werner, Henrica Maria Johanna; Berg, Anna; Halle, Mari Kyllesø; Kusonmano, Kanthida; Trovik, Jone; Høivik, Erling Andre; Mills, Gordon B.; Krakstad, Camilla; Salvesen, Helga. 2014. Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions. European Journal of Cancer. 50: 3003-3010. doi: 10.1016/j.ejca.2014.09.003
  • Wik, Elisabeth; Trovik, Jone; Kusonmano, Kanthida; Birkeland, Even; Ræder, Maria B; Pashtan, I; Høivik, Erling Andre; Krakstad, Camilla; Werner, Henrica Maria Johanna; Holst, Frederik; Mjøs, Siv; Halle, Mari Kyllesø; Mannelqvist, Monica; Mauland, Karen Klepsland; Øyan, Anne Margrete; Stefansson, Ingunn; Petersen, Kjell; Simon, R; Cherniack, AD; Meyerson, M; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga Birgitte. 2014. Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations. Gynecologic Oncology. 134: 599-606. doi: 10.1016/j.ygyno.2014.06.026
  • Zhao, Yu; Yang, Yihua; Trovik, Jone; Sun, Kun; Zhou, Liang; Jiang, Peiyong; Lau, Tat-San; Høivik, Erling Andre; Salvesen, Helga; Sun, Hao; Wang, Huating. 2014. A novel Wnt regulatory axis in endometrioid endometrial cancer. Cancer Research. 74: 5103-5117. doi: 10.1158/0008-5472.CAN-14-0427
  • Æsøy, Reidun; Gradin, Katarina; Åsrud, Kathrine Sivertsen; Høivik, Erling Andre; Ruas, Jorge Lira; Poellinger, Lorenz; Bakke, Marit. 2014. Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways. Molecular Cancer. 13. doi: 10.1186/1476-4598-13-54
  • Høivik, Erling Andre; Bjånesøy, Trine Elholm; Bakke, Marit. 2013. Epigenetic regulation of the gene encoding steroidogenic factor-1. Molecular and Cellular Endocrinology. 371: 133-139. doi: 10.1016/j.mce.2012.12.028
  • Høivik, Erling Andre; Witsø, Solveig Lund; Bergheim, Inger Riise; Xu, Yunjian; Jakobsson, Ida; Tengholm, Anders; Doskeland, Stein Ove; Bakke, Marit. 2013. DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms. PLoS ONE. 8. 12 pages. doi: 10.1371/journal.pone.0067925
  • Wik, Elisabeth; Birkeland, Even; Trovik, Jone; Werner, Henrica Maria Johanna; Høivik, Erling Andre; Mjøs, Siv; Krakstad, Camilla; Kusonmano, Kanthida; Mauland, Karen Klepsland; Stefansson, Ingunn Marie; Holst, Frederik; Petersen, Kjell; Øyan, Anne Margrete; Simon, Roland; Kalland, Karl-Henning; Ricketts, William; Akslen, Lars A.; Salvesen, Helga Birgitte. 2013. High phospho-stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition. Clinical Cancer Research. 19: 2331-2341. doi: 10.1158/1078-0432.CCR-12-3413
  • Wik, Elisabeth; Ræder, Maria B; Krakstad, Camilla; Trovik, Jone; Birkeland, Even; Høivik, Erling Andre; Mjøs, Siv; Werner, Henrica Maria Johanna; Mannelqvist, Monica; Stefansson, Ingunn Marie; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga Birgitte. 2013. Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. Clinical Cancer Research. 19: 1094-1105. doi: 10.1158/1078-0432.CCR-12-3039
  • Birkeland, Even; Wik, Elisabeth; Mjøs, Siv; Høivik, Erling Andre; Trovik, Jone; Werner, Henrica Maria Johanna; Kusonmano, Kanthida; Petersen, Kjell; Ræder, Maria B; Holst, Frederik; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Simon, R; Krakstad, Camilla; Salvesen, Helga Birgitte. 2012. KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer. British Journal of Cancer. 107: 1997-2004. doi: 10.1038/bjc.2012.477
  • Krakstad, Camilla; Birkeland, Even; Seidel, Danila; Kusonmano, Kanthida; Petersen, Kjell; Mjøs, Siv; Høivik, Erling Andre; Wik, Elisabeth; Halle, Mari Kyllesø; Øyan, Anne Margrete; Kalland, Karl-Henning; Werner, Henrica Maria Johanna; Trovik, Jone; Salvesen, Helga Birgitte. 2012. High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated. PLoS ONE. 7. doi: 10.1371/journal.pone.0052795
  • Høivik, Erling Andre; Bjånesøy, Trine Elholm; Mai, Oliver; Okamoto, Shiki; Minokoshi, Yasuhiko; Shima, Yuichi; Morohashi, Ken-Ichirou; Boehm, Ulrich; Bakke, Marit. 2011. DNA methylation of intronic enhancers directs tissue- specific expression of steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP). Endocrinology. 152: 2100-2112. doi: 10.1210/en.2010-1305
  • Høivik, Erling Andre; Bjånesøy, Trine Elholm; Witsø, Solveig Lund; Bakke, Marit. 2010. Tissue Specific Methylation of Intronic Enhancers in the Gene Encoding Steroidogenic Factor 1. Endocrine reviews. 31. 1 pages.
  • Høivik, Erling Andre; Lewis, Aurelia; Aumo, Linda; Bakke, Marit. 2010. Molecular aspects of steroidogenic factor 1 (SF-1). Molecular and Cellular Endocrinology. 315: 27-39. doi: 10.1016/j.mce.2009.07.003
  • Høivik, Erling Andre; Aumo, Linda; Æsøy, Reidun; Lillefosse, Haldis Haukås; Lewis, Aurelia; Perrett, Rebecca; Stallings, Nancy; Hanley, Neil; Bakke, Marit. 2008. Deoxyribonucleic acid methylation controls cell type-specific expression of steroidogenic factor 1. Endocrinology. 149: 5599-5609. doi: 10.1210/en.2008-0104
  • Lewis, Aurelia; Rusten, Marte; Høivik, Erling Andre; Vikse, Elisabeth Lea; Hansson, Magnus L.; Wallberg, Annika E.; Bakke, Marit. 2008. Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7. Molecular Endocrinology. 22: 91-104. doi: 10.1210/me.2006-0478
  • Ellingsen, Ståle; Laplante, Mary; Kønig, Melanie; Furmanek, Tomasz Michal; Kikuta, Hiroshi; Høivik, Erling Andre; Becker, Thomas S. 2005. Large-scale enhancer detection in the zebrafish genome. Development. 132: 3799-3811. doi: 10.1242/dev.01951
  • Haugland, Gyri Teien; Høivik, Erling Andre. 2004. Gendoping av idrettsutøvere. Naturen. 6. 314-320.
  • Høivik, Erling Andre; Haugland, Gyri Teien. 2004. Modifiserte retrovirus som biologisk verktøy. Naturen. 6. 321-330.
Reports and theses
  • Høivik, Erling Andre. 2008. Steroidogenic Factor-1 (SF-1): Regulation of gene expression and transcriptional activity.

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