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Gunnar Mellgren

Professor
  • E-mailGunnar.Mellgren@uib.no
  • Phone+47 55 97 43 66
  • Visitor Address
    Haukeland University Hospital
    N-5021 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen

Diabetes and obesity

Hormones and breast cancer

Molecular endocrinology

http://www.uib.no/en/rg/hormonelaboratory

Endocrinology and Medical Biochemistry

Books
  • Mellgren, Gunnar; Angelsen, Anders; Eikesdal, Hans Petter; Geisler, Jürgen. 2016. MEDIKAMENTELL KREFTBEHANDLING - CYTOSTATIKABOKEN Kapittel 19 - Hormoner og antihormoner. 661 pages. ISBN: 978-82-992331-4-9.
Journal articles
  • Aadland, Eli Kristin; Graff, Ingvild Eide; Lavigne, Charles; Eng, Øyvin Andre Solberg; Paquette, Martine; Holthe, Asle; Mellgren, Gunnar; Madsen, Lise; Jacques, Hélène; Liaset, Bjørn. 2016. Lean seafood intake reduces postprandial c-peptid and lactate concentrations in healthy adults in a randomized controlled trial with a crossover design. Journal of Nutrition. 146: 1027-1034. doi: 10.3945/jn.115.229278
  • Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre; Katz, Betina; Kellmann, Ralf; Gauthier-Landry, louis; Fazli, Ladan; Krobert, Kurt Allen; Wang, Wanzhong; Levy, Finn Olav; Bjartell, Anders; Berge, Viktor; Rennie, Paul S.; Mellgren, Gunnar; Mælandsmo, Gunhild; Svindland, Aud; barbier, olivier; Tasken, Kristin Austlid. 2016. Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism. OncoTarget. 7: 1878-1894. doi: 10.18632/oncotarget.6479
  • Flågeng, Marianne Hauglid; Larionov, Alexey; Geisler, Jürgen; Knappskog, Stian; Prestvik, Wenche S; Bjørkøy, Geir; Lilleng, Peer Kåre; Dixon, JM; Miller, William R.; Lønning, Per Eystein; Mellgren, Gunnar. 2016. Treatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers. Journal of Steroid Biochemistry and Molecular Biology. 165. Published 2016-06-22. doi: 10.1016/j.jsbmb.2016.06.011
  • Hagen, Ingrid Valheim; Helland, Anita; Bratlie, Marianne; Brokstad, Karl Albert; Rosenlund, Grethe; Sveier, Harald; Mellgren, Gunnar; Gudbrandsen, Oddrun Anita. 2016. High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: A randomised trial. British Journal of Nutrition. 116: 648-657. doi: 10.1017/S0007114516002555
  • Jacobsen, Rhian Gaenor; Gavgani, Fatemeh Mazloumi; Mellgren, Gunnar; Lewis, Aurelia Eva. 2016. DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells. Cellular Signalling. 28: 1593-1603. doi: 10.1016/j.cellsig.2016.07.002
  • Johansson, Harriet; Gandini, Sara; Serrano, Davide; Gjerde, Jennifer; Lattanzi, Monia; Macis, Debora; Guerrieri-Gonzaga, Aliana; Aristarco, Valentina; Mellgren, Gunnar; Lien, Ernst Asbjørn; Decensi, Andrea; Bonanni, Bernardo. 2016. A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen. Breast Cancer Research and Treatment. 159: 97-108. doi: 10.1007/s10549-016-3932-7
  • Madsen, Andre Greger; Bjune, Jan Inge; Bjørkhaug, Lise; Mellgren, Gunnar; Sagen, Jørn V. 2016. The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. Molecular and Cellular Endocrinology. 419: 92-101. doi: 10.1016/j.mce.2015.10.003
  • Schmedes, Mette; Aadland, Eli Kristin; Sundekilde, Ulrik Kræmer; Jacques, Hélène; Lavigne, Charles; Graff, Ingvild Eide; Eng, Øyvin Andre Solberg; Holthe, Asle; Mellgren, Gunnar; Young, Jette Feveile; Bertram, Hanne Christine; Liaset, Bjørn; Clausen, Morten Rahr. 2016. Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study. Molecular Nutrition & Food Research. 60: 1661-1672. doi: 10.1002/mnfr.201500785
  • Svingen, Gard Frodahl Tveitevåg; Schartum-Hansen, Hall; Pedersen, Eva Ringdal; Ueland, Per Magne; Tell, Grethe Seppola; Mellgren, Gunnar; Njølstad, Pål Rasmus; Seifert, Reinhard; Strand, Elin; Karlsson, Therese; Nygård, Ottar. 2016. Prospective associations of systemic and urinary choline metabolites with incident type 2 diabetes. Clinical Chemistry. 62: 755-765. doi: 10.1373/clinchem.2015.250761
  • Aadland, Eli Kristin; Lavigne, Charles; Graff, Ingvild Eide; Eng, Øyvin Andre Solberg; Paquette, Martine; Holthe, Asle; Mellgren, Gunnar; Jacques, Hélène; Liaset, Bjørn. 2015. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. American Journal of Clinical Nutrition. 102: 582-592. doi: 10.3945/ajcn.115.112086
  • Bozickovic, Olivera; Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Helland, Thomas; Skartveit, Linn; Ouchida, Mamoru; Mellgren, Gunnar; Sagen, Jørn V. 2015. Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells. Biochimica et Biophysica Acta. Molecular Cell Research. 1853: 2383-2391. doi: 10.1016/j.bbamcr.2015.05.016
  • Christensen, Monika; Fenne, Ingvild Sveinsgjerd; Nordbø, Yngve; Varhaug, Jan Erik; Nygård, Ottar; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2015. Novel inflammatory biomarkers in primary hyperparathyroidism. European Journal of Endocrinology. 173: 9-17. doi: 10.1530/EJE-14-1038
  • Claussnitzer, Melina; Dankel, Simon N; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S.; Beaudry, Jacqueline L.; Puviindran, Vijitha; Abdennur, Nezar A.; Liu, Jannel; Svensson, Per-Arne; Hsu, Yi-Hsiang; Drucker, Daniel J.; Mellgren, Gunnar; Hui, Chi-Chung; Hauner, Hans; Kellis, Manolis. 2015. FTO obesity variant circuitry and adipocyte browning in humans. New England Journal of Medicine. 373: 895-907. doi: 10.1056/NEJMoa1502214
  • Falorni, Alberto; Bini, Vittorio; Betterle, Corrado; Brozzetti, Annalisa; Castaño, Luis; Fichna, Marta; Kämpe, Olle; Mellgren, Gunnar; Peterson, Pärt; Chen, Shu; Rönnelid, Johan; Seissler, Jochen; Tiberti, Claudio; Uibo, Raivo; Yu, Liping; Lernmark, Ake; Husebye, Eystein Sverre. 2015. Determination of 21-hydroxylase autoantibodies: Inter-laboratory concordance in the Euradrenal International Serum Exchange Program. Clinical Chemistry and Laboratory Medicine. 53: 1761-1770. doi: 10.1515/cclm-2014-1106
  • Flågeng, Marianne Hauglid; Knappskog, Stian; Gjerde, Jennifer; Lønning, Per Eystein; Mellgren, Gunnar. 2015. Estrogens correlate with PELP1 expression in ER positive breast cancer. PLoS ONE. 10:e0134351. 12 pages. doi: 10.1371/journal.pone.0134351
  • Helland, Thomas; Gjerde, Jennifer; Dankel, Simon N; Fenne, Ingvild Sveinsgjerd; Skartveit, Linn; Drangevåg, Andreas; Bozickovic, Olivera; Flågeng, Marianne Hauglid; Søiland, Håvard; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2015. The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. PLoS ONE. 10. 19 pages. doi: 10.1371/journal.pone.0122339
  • Lehmann, Ulrike; Gjessing, Hanne Rosendahl; Hirche, Frank; Müller-Belecke, Andreas; Gudbrandsen, Oddrun Anita; Ueland, Per Magne; Mellgren, Gunnar; Lauritzen, Lotte; Lindqvist, Helen; Hansen, Anita Lill; Erkkilä, Arja T.; Pot, Gerda K.; Stangl, Gabriele I.; Dierkes, Jutta. 2015. Efficacy of fish intake on Vitamin D status: A meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition. 102: 837-847. doi: 10.3945/ajcn.114.105395
  • Madsen, Andre Greger; Bozickovic, Olivera; Bjune, Jan Inge; Mellgren, Gunnar; Sagen, Jørn V. 2015. Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2). Scientific Reports. 5:16430. doi: 10.1038/srep16430
  • McCulloch, Laura J.; Rawling, Tom J.; Sjöholm, Kajsa; Franck, Niclas; Dankel, Simon N; Price, Emily J.; Knight, Bridget; Liversedge, Neil H.; Mellgren, Gunnar; Nyström, Fredrik; Carlsson, Lena M.; Kos, Katarina. 2015. COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology. 156: 134-146. doi: 10.1210/en.2014-1042
  • Pedersen, Eva Ringdal; Tuseth, Nora; Eussen, Simone; Ueland, Per Magne; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Midttun, Øivind; Meyer, Klaus; Mellgren, Gunnar; Ulvik, Arve; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Nygård, Ottar. 2015. Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. Arteriosclerosis, Thrombosis and Vascular Biology. 35: 455-462. doi: 10.1161/ATVBAHA.114.304674
  • Svingen, Gard Frodahl Tveitevåg; Schartum-Hansen, Hall; Ueland, Per Magne; Pedersen, Eva Ringdal; Seifert, Reinhard; Ebbing, Marta; Bønaa, Kaare Harald; Mellgren, Gunnar; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Øyen, Jannike; Nygård, Ottar. 2015. Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease. European Journal of Preventive Cardiology. 22: 743-752. Published 2014-03-26. doi: 10.1177/2047487314529351
  • Christensen, Monika; Fenne, Ingvild Sveinsgjerd; Flågeng, Marianne Hauglid; Almås, Bjørg; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2014. Estradiol determines the effects of PTH on ERα-dependent transcription in MC3T3-E1 cells. Biochemical and Biophysical Research Communications - BBRC. 450: 360-365. doi: 10.1016/j.bbrc.2014.05.109
  • Claussnitzer, Melina; Dankel, Simon E Nitter; Klocke, Bernward; Grallert, Harald; Glunk, Viktoria; Berulava, Tea; Lee, Heekypung; Oskolkov, Nikolay; Fadista, João; Ehlers, Kerstin; Wahl, Simone; Hoffmann, Christoph; Qian, Kun; Rönn, Tina; Riess, Helene; Müller-Nurasyid, Martina; Bretschneider, Nancy; Schroeder, Timm; Skurk, Thomas; Horsthemke, Bernhard; Spieler, Derek; Klingenspor, Martin; Seifert, Martin; Kern, Michael J.; Mejhert, Niklas; Dahlman, Ingrid; Hansson, Ola; Hauck, Stefanie M.; Blüher, Matthias; Arner, Peter; Groop, Leif; Illig, Thomas; Suhre, Karsten; Hsu, Yi-Hsiang; Mellgren, Gunnar; Hauner, Hans; Laumen, Helmut. 2014. Leveraging cross- species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 156: 343-358. doi: 10.1016/j.cell.2013.10.058
  • Dankel, Simon E Nitter; Degerud, Eirik Magnus Meek; Borkowski, Kamil; Fjære, Even; Midtbø, Lisa Kolden; Haugen, Christine; Solsvik, Margit; Lavigne, Ann Marie; Liaset, Bjørn; Sagen, Jørn V.; Kristiansen, Karsten; Mellgren, Gunnar; Madsen, Lise. 2014. Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. 306: E210-E224. doi: 10.1152/ajpendo.00188.2013
  • Dankel, Simon E Nitter; Svärd, Jessica; Matthä, Simone; Claussnitzer, Melina; Klöting, Nora; Glunk, Viktoria; Fandalyuk, Zinayida; Grytten, Elise; Solsvik, Margit; Nielsen, Hans Jørgen; Busch, Christian; Hauner, Hans; Blüher, Matthias; Skurk, Thomas; Sagen, Jørn V.; Mellgren, Gunnar. 2014. COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 22: 1807-1813. doi: 10.1002/oby.20758
  • Gudbrandsen, Oddrun Anita; Kodama, Yosuke; Mjøs, Svein Are; Zhao, Chun-Mei; Johannesen, Helene; Brattbakk, Hans-Richard; Haugen, Christine; Kulseng, Bård Eirik; Mellgren, Gunnar; Chen, Duan. 2014. Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats. Nutrition and Diabetes. 4. 6 pages. doi: 10.1038/nutd.2014.22
  • Ussar, Siegfried; Lee, Kevin; Dankel, Simon N; Boucher, Jeremie; Haering, Max-Felix; Kleinridders, Andre; Thomou, Thomas; Xue, Ruidan; Macotela, Yazmin; Cypess, Aaron; Tseng, Yu-Hua; Mellgren, Gunnar; Kahn, C. Ronald. 2014. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine. 6. Published 2014-06-30. doi: 10.1126/scitranslmed.3008490
  • Våge, Villy; Sande, Vetle Aaberge; Mellgren, Gunnar; Laukeland, Camilla; Behme, Jan Horst; Andersen, John Roger. 2014. Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: A two-year follow-up study. BMC Surgery. 14. Published 2014-02-11. doi: 10.1186/1471-2482-14-8
  • Christensen, Monika; Apalset, Ellen M; Nordbø, Yngve; Varhaug, Jan Erik; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2013. 1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism apa1 influence bone mineral density in primary hyperparathyroidism. PLoS ONE. 8. 8 pages. doi: 10.1371/journal.pone.0056019
  • Fenne, Ingvild Sveinsgjerd; Helland, Thomas; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Mellgren, Gunnar; Sagen, Jørn V. 2013. Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLoS ONE. 8. 10 pages. doi: 10.1371/journal.pone.0070096
  • Flågeng, Marianne Hauglid; Knappskog, Stian; Haynes, Ben P.; Lønning, Per Eystein; Mellgren, Gunnar. 2013. Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue. PLoS ONE. 8. 12 pages. doi: 10.1371/journal.pone.0074618
  • Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Madsen, Andre Greger; Bozickovic, Olivera; Johannessen, Mona; Bergsvåg, Mari; Lien, Ernst Asbjørn; Stallcup, Michael R.; Sagen, Jørn V.; Moens, Ugo; Mellgren, Gunnar. 2013. cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 154: 1513-1527. doi: 10.1210/en.2012-2049
  • Lien, Ernst Asbjørn; Søiland, Håvard; Lundgren, Steinar; Aas, Turid; Steen, Vidar Martin; Mellgren, Gunnar; Gjerde, Jennifer. 2013. Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment. Breast Cancer Research and Treatment. 141: 243-248. doi: 10.1007/s10549-013-2677-9
  • Madsen, Arve; Bjune, Jan Inge; Mellgren, Gunnar; Sagen, Jørn V. 2013. AICAR regulates G6Pase independently of SRC-2/ROR alpha. Diabetologia. 56: S281-S281.
  • Methlie, Paal; Dankel, Simon E Nitter; Myhra, Tone Sæterdal; Christensen, Bjørn Jostein; Gjerde, Jennifer; Fadnes, Dag Jone Stokke; Våge, Villy; Løvås, Kristian; Mellgren, Gunnar. 2013. Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. Obesity. 21: 2495-2503. doi: 10.1002/oby.20449
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Mellgren, Gunnar. 2013. Steroid reseptor koaktivatorer, HER-2 og hormonbehandling ved brystkreft. Bestpractice : dialog mellom leger. 8-13.
  • Viste, Kristin; Grytaas, Marianne Aardal; Jørstad, Melissa; Jøssang, Dag Eirik; Høyden, Eivind Næss; Fotland, Solveig Simmenes; Jensen, Dag Kjartan; Løvås, Kristian; Thordarson, Hrafnkell B; Almås, Bjørg; Mellgren, Gunnar. 2013. Efficacy of adrenal venous sampling is increased by point of care cortisol analysis. Endocrine Connections. 2: 236-242. Published 2013-09-15. doi: 10.1530/EC-13-0063
  • Våge, Villy; Nilsen, Roy Miodini; Berstad, Arnold; Behme, Jan Horst; Sletteskog, Nils; Gåsdal, Stein Ronny; Laukeland, Camilla; Mellgren, Gunnar. 2013. Predictors for remission of major components of the metabolic syndrome after biliopancreatic diversion with duodenal switch (BPDDS). Obesity Surgery. 23: 80-86. doi: 10.1007/s11695-012-0775-0
  • Christensen, Monika; Pedersen, Eva Kristine Ringdal; Nordbø, Yngve; Varhaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Nygård, Ottar; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2012. Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism. Journal of Internal Medicine. 272: 583-591. doi: 10.1111/j.1365-2796.2012.02570.x
  • Gjerde, Jennifer; Gandini, Sara; Guerrieri-Gonzaga, Aliana; Moi, Line Leonore Haugan; Aristarco, Valentina; Mellgren, Gunnar; Decensi, Andrea; Lien, Ernst Asbjørn. 2012. Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. Breast Cancer Research and Treatment. 134: 693-700. doi: 10.1007/s10549-012-2074-9
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Gjerde, Jennifer; Madsen, Andre Greger; Røst, Therese Halvorsen; Gudbrandsen, Oddrun Anita; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2012. Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer. BMC Cancer. 12. 12 pages. doi: 10.1186/1471-2407-12-247
  • Veum, Vivian Lohmann; Dankel, Simon E Nitter; Gjerde, Jennifer; Nielsen, Hans Jørgen; Solsvik, Margit Hildershavn; Haugen, Christine; Christensen, Bjørn Jostein; Hoang, Tuyen; Fadnes, Dag Jone Stokke; Busch, Christian; Våge, Villy; Sagen, Jørn V.; Mellgren, Gunnar. 2012. The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 36: 1195-1202. doi: 10.1038/ijo.2011.240
  • Christensen, Monika; Dankel, Simon E Nitter; Nordbø, Yngve; Varhaug, Jan Erik; Almås, Bjørg; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. PLoS ONE. 6. 10 pages. doi: 10.1371/journal.pone.0020481
  • Dankel, Simon E Nitter; Staalesen, Vidar; Bjørndal, Bodil; Berge, Rolf Kristian; Mellgren, Gunnar; Burri, Lena. 2011. Tissue-specific effects of bariatric surgery including mitochondrial function. International Journal of Obesity. 2011: 435245. doi: 10.1155/2011/435245
  • Liaset, Bjørn; Hao, Qin; Jørgensen, Henry; Hallenborg, Philip; Du, Zhen-yu; Ma, Tao; Marschall, Hanns-Ulrich; Kruhøffer, Mogens; Li, Ruiqiang; Li, Quibin; Yde, Christian Clement; Criales, Gabriel Cabrera; Bertram, Hanne C.; Mellgren, Gunnar; Øfjord, Erik Snorre; Lock, Erik-Jan; Espe, Marit; Frøyland, Livar; Madsen, Lise; Kristiansen, Karsten. 2011. Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome. Journal of Biological Chemistry. 286: 28382-28395. doi: 10.1074/jbc.M111.234732
  • Serrano, Davide; Lazzeroni, Matteo; Zambon, Carlo–Federico; Macis, Debora; Maisonneuve, Patrick; Johansson, Harriet Ann; Guerrieri-Gonzaga, Aliana; Plebani, Mario; Basso, Daniela; Gjerde, Jennifer; Mellgren, Gunnar; Rotmensz, Nicole; Decensi, Andrea; Bonanni, Bernardo. 2011. Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial. The Pharmacogenomics Journal. 11: 100-107. doi: 10.1038/tpj.2010.17
  • Aumo, Linda; Rusten, Marte; Mellgren, Gunnar; Bakke, Marit; Lewis, Aurelia. 2010. Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. Endocrinology. 151: 2151-2161. doi: 10.1210/en.2009-1139
  • Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen; Veum, Vivian Lohmann; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. 57: S429-S429.
  • Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen; Veum, Vivian Lohmann; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2010. Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS ONE. 5. 12 pages. doi: 10.1371/journal.pone.0011033
  • Dankel, Simon E Nitter; Hoang, Tuyen; Flågeng, Marianne Hauglid; Sagen, Jørn V.; Mellgren, Gunnar. 2010. cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. Biochimica et Biophysica Acta. Molecular Cell Research. 1803: 1013-1019. doi: 10.1016/j.bbamcr.2010.05.008
  • Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar; Ekse, Dagfinn; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2010. Effects of CYP2C19 genotype on tamoxifen and estrogen metabolism. European Journal of Cancer. 8: 60-60.
  • Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar; Ekse, Dagfinn; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2010. Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer. BMC Cancer. 10. 13 pages. doi: 10.1186/1471-2407-10-313
  • Hoang, Tuyen; Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Veum, Vivian Lohmann; Våge, Villy; Steen, Vidar Martin; Sagen, Jørn V.; Mellgren, Gunnar. 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 31. 1 pages.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Gandini, Sara; Guerrieri-Gonzaga, Aliana; Bonanni, Bernardo; Lazzeroni, Matteo; Gjerde, Jennifer; Lien, Ernst Asbjørn; De Censi, Andrea; Mellgren, Gunnar. 2010. Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. Clinical Cancer Research. 16: 2176-2186. doi: 10.1158/1078-0432.CCR-09-1859
  • Bratland, Eirik; Bredholt, Geir; Mellgren, Gunnar; Knappskog, Per; Mozes, Edna; Husebye, Eystein Sverre. 2009. The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: The major autoantigen in autoimmune Addison's disease. Journal of Autoimmunity. 33: 58-67. doi: 10.1016/j.jaut.2009.02.018
  • Flageng, MH; Hauglid, Marianne; Moi, Line Leonore Haugan; Dixon, J. Michael; Geisler, Jurgen; Lien, Ernst Asbjørn; Miller, William Russell; Lonning, PE; Lønning, Per Eystein; Mellgren, Gunnar. 2009. Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors. British Journal of Cancer. 101: 1253-1260. doi: 10.1038/sj.bjc.6605324
  • Liaset, Bjørn; Madsen, Lise; Hao, Qin; Criales, Gabriel Cabrera; Mellgren, Gunnar; Marschall, Hanns-Ulrich; Hallenborg, Philip; Espe, Marit; Frøyland, Livar; Kristiansen, Karsten. 2009. Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1791: 254-262. doi: 10.1016/j.bbalip.2009.01.016
  • Røst, Therese Halvorsen; Moi, Line Leonore Haugan; Berge, Kjetil; Staels, Bart; Mellgren, Gunnar; Berge, Rolf Kristian. 2009. A pan-PPAR ligand induces hepatic fatty acid oxidation in PPAR alpha-/- mice possibly through PGC-1 mediated PPAR delta coactivation. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1791: 1076-1083. doi: 10.1016/j.bbalip.2009.06.005
  • Fenne, Ingvild Sveinsgjerd; Hoang, Tuyen; Hauglid, Marianne; Sagen, Jørn V.; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2008. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology. 149: 4336-4345. doi: 10.1210/en.2008-0037
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Hauglid, M; Breilid, Harald; Lundgren, S.; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2008. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Annals of Oncology. 19: 56-61. doi: 10.1093/annonc/mdm434
  • Gjerde, Jennifer Fernandez; Geisler, Jurgen; Lundgren, Steinar; Ekse, Dagfinn; Breilid, Harald; Hauglid, Marianne; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lønning, Per Eystein; Lien, Ernst Asbjørn. 2007. A study of associations between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferase 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady state tamoxifen treatment. Breast Cancer Research and Treatment. S106.
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald; Lundgren, Steinar; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2007. Effect of CYP2D6 and SULT1A1 genotypes on the serum concentration of 4-hydroxytamoxifen and 4-hydroxy-N-demethyltamoxifen during steady state treatment of breast cancer patients. Breast. 16: S15-S15.
  • Gjerde, Jennifer; Geisler, Jurgen; Lundgren, Steinar; Ekse, Dagfinn; Breilid, H; Hauglid, M; Varhaug, Jan Erik; Mellgren, G; Steen, VM; Lønning, Per Eystein; Lien, Ernst A. 2007. A study of association between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferae 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady sate tamoxifen treatment. Breast Cancer Research and Treatment. 106: S144-S144. Published 2007-10-24. doi: 10.1007/s10549-007-9793-3
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald; Lundgren, Steinar; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2005. Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients. Breast Cancer Research and Treatment. 94: S236-S237.
  • Gjerde, Jennifer Fernandez; Kisanga, Elton Richard; Hauglid, Marianne; Holm, Pål Ivar; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2005. Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A. 1082: 6-14. doi: 10.1016/j.chroma.2005.01.004
  • Kisanga, Elton Richard; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2005. Excretion of hydroxylated metabolites of tamoxifen in human bile and urine. Anticancer Research. 25: 4487-4492.
  • Kisanga, Elton Richard; Moi, Line Leonore Haugan; Gjerde, Jennifer; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2005. Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats. Journal of Steroid Biochemistry and Molecular Biology. 94: 489-498. doi: 10.1016/j.jsbmb.2004.12.037
  • Bøe, Anette Susanne; Bredholt, Geir; Knappskog, Per; Hjelmervik, Trond Ove; Mellgren, Gunnar; Winqvist, Ola; Kämpe, Olle; Husebye, Eystein S.Junior. 2004. Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1. European Journal of Endocrinology. 150: 49-56.
  • Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Cook, Carol Ann; Børud, Bente; Bakke, Marit; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2004. cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. Journal of Biological Chemistry. 279: 49120-49130.
  • Lund, Johan; Jacob, Anne Lilybert J.; Aesöy, R.; Yri, Olav Erich; Mellgren, Gunnar. 1998. Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17. Endocrine Research. 24: 497-504.
  • Fladmark, Kari Espolin; Gjertsen, Bjørn Tore; Molven, Anders; Mellgren, Gunnar; Vintermyr, Olav Karsten; Døskeland, Stein Ove. 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 25: 847-855.
  • Flatmark, K.E.; Gjertsen, B.T.; Molven, Anders; Mellgren, Gunnar; Vintermyr, Olav Karsten; Døskeland, S.O. 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 25: 847-855.
  • Lund, Johan; Bakke, Marit; Mellgren, Gunnar; Morohashi, K.; Døskeland, Stein Ove. 1997. Transcriptional regulation of the bovine CYP17 gene by cAMP. Steroids. 62: 43-45.
  • Mellgren, Gunnar; Bruland, T; Døskeland, A.P; Flatmark, Torgeir; Vintermyr, Olav Karsten; Døskeland, Stein Ove. 1997. Synergistic antiproliferative actions of cyclic adenosine 3',5'-monophosphate, interleukin-1beta, and activators of Ca%2%+/calmodulin-dependent protein kinase in primary hepatocytes. Endocrinology. 138: 4373-4383.
  • Brustugun, OT; Mellgren, Gunnar; Gjertsen, BT; Bjerkvig, Rolf; Døskeland, SO. 1995. Sensitive and rapid detection of _b-galactosidase expression in intact cells by microinjection of fluorescent substrate. Experimental Cell Research. 219: 372-378.
  • Gjertsen, BT; Mellgren, Gunnar; Otten, A; Maronde, E; Genieser, HG; Jastorff, B; McKnight, GS; Døskeland, SO. 1995. Novel Rp-cAMPS analogs as tools for inhibition of type I cAMP-dependent protein kinase in cell culture. Basal cAMP-kinase activity modulates hepatocyte DNA replication and interleukin-1_b action. Journal of Biological Chemistry. 270: 22599-20607.
  • Houge, G; Robaye, B; Eikholm, TS; Goldstein, J; Mellgren, Gunnar; Gjertsen, BT; Lanotte, M; Døskeland, SO. 1995. Fine mapping of 28S rRNA sites specifically cleaved in cells undergoing apoptosis. Molecular and Cellular Biology. 15: 2051-2062.
  • Mellgren, Gunnar; Vintermyr, Olav Karsten; Døskeland, SO. 1995. Okadaic acid, cAMP, and selected nutrients inhibit hepatocyte proliferation at different stages in G%b: Modulation of the cAMP effect by phosphatase inhibitors and nutrients. Journal of Cellular Physiology. 163: 232-240.
  • Jensen, P. H.; Cressey, L.; Gjertsen, Bjørn Tore; Madsen, P.; Mellgren, Gunnar; Hokland, P.; Gliemann, J.; Døskeland, Stein Ove; Lanotte, M.; Vintermyr, Olav Karsten. 1994. Cleaved intracellular plasminogen activator inhibitor-2 is a marker of apoptosis present in human myeloid leukemia cells. British Journal of Cancer. 70: 834-840.
  • Mellgren, Gunnar; Vintermyr, Olav Karsten; Bøe, Ragnar; Døskeland, Stein Ove. 1993. Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. Exp Cell Res. 205: 293-301.
Reports and theses
  • Mellgren, Gunnar. 2004. Endokrinologi. Kompendium for studenter i biokjemi II. Universitetet i Bergen. Instututt for indremedisin. Seksjon for endokrinologi, Hormonlaboratoriet., Bergen. 167 pages.
  • Mellgren, Gunnar. 1996. Hepatocyte growth inhibition by cAMP-dependent protein kinase and other signaling pathways. Dr.med.. -.
Book sections
  • Gjerde, Jennifer; Moi, Line Leonore Haugan; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2012. Tamoxifen metabolism and biological activity. chapter 2, pages 7-28. In:
    • de Mello, R.A. 2012. Tamoxifen concepts and cancer: New paradigms. 196 pages. ISBN: 978-1-62081-520-5.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Hoang, Tuyen; Gjerde, Jennifer; Sagen, Jørn V.; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 2, pages 35-66. In:
    • Bates, Margaret K; Kerr, Regina M. 2011. Nuclear Receptors. Nova Science Publishers, Inc.. 174 pages. ISBN: 978-1-61209-980-4.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Fenne, Ingvild Sveinsgjerd; Gjerde, Jennifer; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer. 35, pages 715-732. In:
    • Gunduz, Mehmet; Gunduz, Esra. 2011. Breast Cancer - Carcinogenesis, Cell Growth and Signalling Pathways. INTECH. 732 pages. ISBN: 978-953-307-714-7.
  • Brustugun, Odd Terje; Mellgren, Gunnar; Gjertsen, Bjørn Tore; Bjerkvig, Rolf; Døskeland, Stein Ove. 1996. Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate. In:
    • Slavik, J. 1996. Fluorecence microscopy and fluorescent probes.

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Specialist in Internal medicine, Endocrinology, and Medical biochemistry