Harleen Grewal

Professor, Senior consultant (Haukeland hospital)

Department of Clinical Science

E-mailHarleen.Grewal@uib.no
Phone+47 55 97 46 31+47 994 50 554
Visitor Address
Haukeland universitetssykehus, Laboratoriebygget

5009 Bergen
Postal Address
Postboks 7804

5020 Bergen

Publications

Academic article

Show author(s) (2024). Diagnostic Stewardship in Community-Acquired Pneumonia with Syndromic Molecular Testing: A Randomized Clinical Trial. JAMA Network Open. E240830.

Show author(s) (2023). The diagnostic utility of microscopic quality assessment of sputum samples in the era of rapid syndromic PCR testing. Microbiology spectrum.
Show author(s) (2023). Seroprevalence of SARS-CoV-2 antibodies in a prospective cohort of patients admitted to an acute psychiatric ward in Norway during the initial months of the COVID-19 pandemic. Nordic Journal of Psychiatry.
Show author(s) (2023). Host blood-based biosignatures for subclinical TB and incipient TB: A prospective study of adult TB household contacts in Southern India. Frontiers in Immunology. 17 pages.
Show author(s) (2023). Diagnostic utility of oropharyngeal swabs as an alternative to lower respiratory tract samples for PCR-based syndromic testing in patients with community-acquired pneumonia. Journal of Clinical Microbiology. 11 pages.

Show author(s) (2022). The changing spectrum of microbial aetiology of respiratory tract infections in hospitalized patients before and during the COVID-19 pandemic. BMC Infectious Diseases. 1-11.
Show author(s) (2022). Rapid syndromic PCR testing in patients with respiratory tract infections reduces time to results and improves microbial yield. Scientific Reports.
Show author(s) (2022). Improving Assignments for Therapeutic and Prophylactic Treatment Within TB Households. A Potential for Immuno-Diagnosis? Frontiers in Immunology. 11 pages.
Show author(s) (2022). Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR). Trials.
Show author(s) (2022). Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools. Biomarker Insights. 1-8.
Show author(s) (2022). Comparison of rapid molecular testing methods for detecting respiratory viruses in emergency care: a prospective study. Infectious Diseases. 247-254.

Show author(s) (2021). The Magnitude of Interferon Gamma Release Assay Responses in Children with Household Tuberculosis Contact Is Associated with Tuberculosis Exposure and Disease Status. The Pediatric Infectious Disease Journal. 763-770.
Show author(s) (2021). Prevalence of Mycobacterium tuberculosis infection as measured by the QuantiFERONTB Gold assay and ESAT-6 free IGRA among adolescents in Mwanza, Tanzania. PLOS ONE. 11 pages.
Show author(s) (2021). Host blood RNA transcript and protein signatures for sputum-independent diagnostics of tuberculosis in adults. Frontiers in Immunology. 1-10.
Show author(s) (2021). A 2-Dose AERAS-402 Regimen Boosts CD8+ Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients. Frontiers in Immunology. 1-15.

Show author(s) (2020). Typing and classification of non-tuberculous mycobacteria isolates [. F1000 Research. 1-32.
Show author(s) (2020). Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations. BMC Infectious Diseases. 1-11.
Show author(s) (2020). Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes. Communications Biology. 1-10.

Show author(s) (2018). Incidence of tuberculosis and the influence of surveillance strategy on tuberculosis case-finding and all-cause mortality: A cluster randomised trial in Indian neonates vaccinated with BCG. BMJ Open Respiratory Research. 1-9.

Show author(s) (2017). Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children. Scientific Reports. 1-9.

Show author(s) (2016). The effect of deworming on tests of tuberculosis infection in children with recent tuberculosis exposure a randomized controlled trial. The Pediatric Infectious Disease Journal. 622-627.
Show author(s) (2016). Incidence of tuberculosis among school-going adolescents in South India. BMC Public Health. 11 pages.
Show author(s) (2016). High prevalence of primary drug resistance in children with intrathoracic tuberculosis in India. Paediatrics and International Child Health. 214-218.
Show author(s) (2016). BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome. Scientific Reports. 1-11.
Show author(s) (2016). Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum. Scientific Reports.
Show author(s) (2016). Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis - Specific Immunity in Young Children. The Pediatric Infectious Disease Journal.

Show author(s) (2015). Xpert MTB/RIF assay can be used on archived gastric aspirate and induced sputum samples for sensitive diagnosis of paediatric tuberculosis. BMC Microbiology.
Show author(s) (2015). Optimizing the detection of recent tuberculosis infection in children in a high tuberculosis-HIV burden setting. American Journal of Respiratory and Critical Care Medicine. 820-830.

Show author(s) (2014). Vitamin D levels in Indian children with intrathoracic tuberculosis. Indian Journal of Medical Research (IJMR). 531-537.
Show author(s) (2014). The tuberculin skin test in school going adolescents in South India: associations of socio-demographic and clinical characteristics with TST positivity and non-response. BMC Infectious Diseases.
Show author(s) (2014). The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy Indian adolescents. PLOS ONE.
Show author(s) (2014). TB Trials Study Group: Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles. Genes and Immunity. 265-274.
Show author(s) (2014). Influence of age and nutritional status on the performance of the tuberculin skin test and QuantiFERON®-TB Gold In-Tube in young children evaluated for tuberculosis in southern India. The Pediatric Infectious Disease Journal. e260-e269.
Show author(s) (2014). Increased level of acute phase reactants in patients infected with modern mycobacterium tuberculosis genotypes in mwanza, tanzania. BMC Infectious Diseases.
Show author(s) (2014). Effect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis management. PLoS Neglected Tropical Diseases.
Show author(s) (2014). Effect of micronutrient supplementation on treatment outcomes in children with intrathoracic tuberculosis: a randomized controlled trial. American Journal of Clinical Nutrition. 1287-1297.
Show author(s) (2014). Effect of micronutrient deficiency on QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood intrathoracic tuberculosis. European Journal of Clinical Nutrition. 38-42.
Show author(s) (2014). Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles. Genes and Immunity. 265-274.

Show author(s) (2013). Two-step tuberculin skin testing in school-going adolescents with initial 0-4 millimeter responses in a high tuberculosis prevalence setting in South India. PLOS ONE. 10 pages.
Show author(s) (2013). TB Trials Study Group; Two-step tuberculin skin testing in school-going adolescents with initial 0-4 millimeter responses in a high tuberculosis prevalence setting in South India. PLOS ONE. e71470.
Show author(s) (2013). Role of the QuantiFERON (R)-TB Gold In-Tube test in the diagnosis of intrathoracic childhood tuberculosis. The International Journal of Tuberculosis and Lung Disease. 1383-1388.
Show author(s) (2013). Identification of biomarkers for Mycobacterium tuberculosis infection and disease in BCG-vaccinated young children in Southern India. Genes and Immunity. 356-364.
Show author(s) (2013). Does Neutralization of Gastric Aspirates from Children with Suspected Intrathoracic Tuberculosis Affect Mycobacterial Yields on MGIT Culture? Journal of Clinical Microbiology. 1753-1756.
Show author(s) (2013). Diabetes is a strong predictor of mortality during tuberculosis treatment: a prospective cohort study among tuberculosis patients from Mwanza, Tanzania. Tropical medicine & international health. 822-829.
Show author(s) (2013). Ambulatory gastric lavages provide better yields of mycobacterium tuberculosis than induced sputum in children with intrathoracic tuberculosis. The Pediatric Infectious Disease Journal. 1313-1317.

Show author(s) (2012). Well-quantified tuberculosis exposure is a reliable surrogate measure of tuberculosis infection. The International Journal of Tuberculosis and Lung Disease. 1033-1039.
Show author(s) (2012). The effect of energy-protein supplementation on weight, body composition and handgrip strength among pulmonary tuberculosis HIV-co-infected patients: randomised controlled trial in Mwanza, Tanzania. British Journal of Nutrition. 263-271.
Show author(s) (2012). Mycobacterium tuberculosis Mcel protein complex initiates rapid induction of transcription of genes involved in substrate trafficking. Genes and Immunity. 496-502.
Show author(s) (2012). Effect of Ascaris Lumbricoides specific IgE on tuberculin skin test responses in children in a high-burden setting: a cross-sectional community-based study. BMC Infectious Diseases. 8 pages.
Show author(s) (2012). CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection. BMC Infectious Diseases. 7 pages.
Show author(s) (2012). Baseline Predictors of Sputum Culture Conversion in Pulmonary Tuberculosis: Importance of Cavities, Smoking, Time to Detection and W-Beijing Genotype. PLOS ONE. 7 pages.

Show author(s) (2011). Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene. 140-147.
Show author(s) (2011). The effect of vitamin A and zinc supplementation on treatment outcomes in pulmonary tuberculosis: a randomized controlled trial. American Journal of Clinical Nutrition. 93-100.
Show author(s) (2011). Modulation of transcriptional and inflammatory responses in murine macrophages by the mycobacterium tuberculosis mammalian cell entry (Mce) 1 complex. PLOS ONE. 11 pages.
Show author(s) (2011). How participatory is parental consent in low literacy rural settings in low income countries? Lessons learned from a community based study of infants in South India. BMC Medical Ethics. 9 pages.
Show author(s) (2011). Environmental tobacco smoke exposure increases Mycobacterium tuberculosis infection risk in children. The International Journal of Tuberculosis and Lung Disease. 1490-1496.
Show author(s) (2011). Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV-uninfected but not HIV-Infected patients in Mwanza, Tanzania. Journal of Nutrition. 685-691.

Show author(s) (2010). Determination of the susceptibility of Mycobacterium tuberculosis to pyrazinamide in liquid and solid media assessed by a colorimetric nitrate reductase assay. Journal of Antimicrobial Chemotherapy. 704-712.
Show author(s) (2010). BCG vaccination status may predict sputum conversion in patients with pulmonary tuberculosis: a new consideration for an old vaccine? Thorax. 1072-1076.

Show author(s) (2009). Short-Term Reproducibility of a Commercial Interferon Gamma Release Assay. Clinical and Vaccine Immunology. 1170-1175.
Show author(s) (2009). Predominance of mycobacterium tuberculosis EAI and Beijing lineages in Yangon, Myanmar. Journal of Clinical Microbiology. 335-344.
Show author(s) (2009). Isoniazid and rifampicin resistance-asTisociated mutations in Mycobacterium tuberculosis isolates from Yangon, Myanmar: implications for rapid molecular testing. Journal of Antimicrobial Chemotherapy. 694-701.
Show author(s) (2009). In-depth molecular characterization of Mycobacterium tuberculosis from New Delhi--predominance of drug resistant isolates of the 'modern' (TbD1) type. PLOS ONE.
Show author(s) (2009). High diversity of Mycobacterium tuberculosis genotypes in South Africa and preponderance of mixed infections among ST53 isolates. Journal of Clinical Microbiology. 1848-1856.
Show author(s) (2009). Direct detection of mycobacterial species in pulmonary specimens by two rapid amplification tests, the gen-probe amplified mycobacterium tuberculosis direct test and the genotype mycobacteria direct test. Journal of Clinical Microbiology. 3635-3639.

Show author(s) (2008). Pyrazinamide resistance among South African multidrug-resistant Mycobacterium tuberculosis isolates. Journal of Clinical Microbiology. 3459-3464.
Show author(s) (2008). Genomic Diversity among Beijing and non-Beijing Mycobacterium tuberculosis Isolates from Myanmar. PLOS ONE. e1973.
Show author(s) (2008). Effect of high dose oral zinc in mice with severe infection with Streptococcus pneumoniae. Scandinavian Journal of Infectious Diseases. 363-367.

Show author(s) (2006). Evaluation of the nitrate-based colorimetric method for testing the susceptibility of Mycobacterium tuberculosis to streptomycin and ethambutol in liquid cultures. Journal of Antimicrobial Chemotherapy. 987-991.

Show author(s) (2005). Tuberculosis in contacts need not indicate disease transmission. Thorax. 136-137.
Show author(s) (2005). Drug-resistant tuberculosis in Yangon, Myanmar. Scandinavian Journal of Infectious Diseases. 846-851.

Show author(s) (2004). Identification and molecular characterization of the gene encoding coli surface antigen 20 of enterotoxigenic Escherichia coli. FEMS Microbiology Letters. 131-138.

Show author(s) (1998). Mucosal antibodies can be measured in air-dried samples of saliva and feces. Journal of Immunological Methods (JIM). 163-172.
Show author(s) (1998). Mucosal antibodies can be measured in air-dried samples of saliva and feces. Journal of Immunological Methods (JIM). 163-172.

Show author(s) (1997). Expression of colonization factor antigen I fimbriae by enterotoxigenic Escherichia coli; influence by growth conditions and a recombinant positive regulatory gene. APMIS - Journal of Pathologiy, Microbiology and Immunology. 247-254.
Show author(s) (1997). Expression of colonization factor antigen I by enterotoxigenic Escherichia coli; influence of growth conditions and a recombinant positive regulatory gene. APMIS - Journal of Pathologiy, Microbiology and Immunology. 247-254.
Show author(s) (1997). Detection and characterization of the coli surface antigen 6 of enterotoxigenic Escherichia coli by using monoclonal antibodies. Journal of Clinical Microbiology. 867-872.
Show author(s) (1997). Detection and characterisation of the coli surface antigen 6 of enterotoxigenic Escherichia coli by using monoclonal antibodies. Journal of Clinical Microbiology. 867-872.
Show author(s) (1997). A new putative colonization factor, CS19, of human enterotoxigenic Escherichia coli. Infection and Immunity. 507-513.
Show author(s) (1997). A new fimbrial putative colonization factor, CS19 in human enterotoxigenic Escherichia coli. Infection and Immunity. 507-13.

Show author(s) (1994). Genotypic and phenotypic identification of coli surface antigen 6-positive enterotoxigenic Escherichia coli. Journal of Clinical Microbiology. 1295-1301.

Show author(s) (1993). Induction of Colonization Factor Antigen I and Coli Surface Antigen 4 of enterotoxigenic Escherichia coli. Vaccine. 221-226.

Show author(s) (1992). Use of nonradioactive DNA Hybridization for the identification of enterotoxigenic Escherichia coli harboring genes for colonization factor antigen/1, coli surface antigen 4 and putative colonization factor 0166. Journal of Clinical Microbiology. 1823-1828.
Show author(s) (1992). Genetic relationship of putative colonization factor 0166 to colonization factor antigen I and coli surface antigen 4 of enterotoxigenic Escherichia coli. Infection and Immunity. 3799-3806.
Show author(s) (1992). Colonization factor antigen I, coli surface antigen 4 and putative colonization factor 0166 of enterotoxigenic Escherichia coli are genetically related. Vaccine. 289-289.

Show author(s) (1991). Presence of cfaD-homologous sequences and expression of coli surface antigen 4 on enterotoxigenic Escherichia coli; relevance for diagnostic procedures. Microbial Pathogenesis. 297-304.

Lecture

Show author(s) (2018). ADVANCES IN THE DIAGNOSIS AND TREATMENT OF TUBERCULOSIS IN CHILDREN- a decade of collaboration.

Show author(s) (2016). Vaccines for TB.
Show author(s) (2016). The future for diagnostics for TB with a focus on children.
Show author(s) (2016). MPT64 Antigen test.

Show author(s) (2015). Biomarkers of TB disease and treatment response in children with intrathoracic TB in India.

Popular scientific lecture

Show author(s) (1998). Molecular microbiological and immunological studies of childhood diarrhea in India and Guinea-Bissau - relevance for vaccine development.

Academic lecture

Show author(s) (2018). Biomarkers of TB disease and treatment response in children.

Show author(s) (2015). Biomarkers of TB disease and treatment response in Indian children,.

Show author(s) (2014). TB Vaccines; Presented at the AIIMS Conferenceon Childhood Tuberculosis, New Delhi, India 16th November 2014.
Show author(s) (2014). TB Trials:Development of a TB clinical trial site in Southern India; presented at the TBVI conference on: A new horizon for preventive vaccines against TB. Spain, 7-8 May 2014 .
Show author(s) (2014). Immune responses to TB in children;presented at theAll India Institute of Medical Science Conference on Childhood Tuberculosis, NewDelhi, India 15th November 2014.

Show author(s) (2010). Nutritional intervention and novel diagnostics to improve community-based control of tuberculosis.
Show author(s) (2010). Interferon gamma release assays for TB.
Show author(s) (2010). Frequency and clinical outcome of patients with mixed Mycobacterium tuberculosis infections.
Show author(s) (2010). DIAGNOSTIC UTILITY OF THE QUANTIFERON GOLD IN-TUBE ASSAY IN PAEDIATRIC INTRATHORACIC TB PATIENTS.
Show author(s) (2010). A comparison of the QuantiFERON Gold In-Tube assay with the tuberculin skin test in infants.

Show author(s) (2008). Childhood Tuberculosis and HIV: epidemiology and research priorities.

Show author(s) (2007). • Role of intestinal pathogens in necrotizing enterocolitis, International conference on Necrotizing enterocolitis, EUPSA (European Pediatric Surgeons Association).
Show author(s) (2007). Preparing for tuberculosis vaccine efficacy trials.

Show author(s) (2005). The Host-pathogen interaction in TB with a special focus on the infecting strain.

Show author(s) (2004). Levels of antibodies against enterotoxigenic Escherichia coli and Vibrio cholerae in young childrenin Bhanktapur, Nepal.

Show author(s) (2001). Applications of microarrays. Department of epidemiology and International health, University of Barcelona, Spain.
Show author(s) (2001). Applications of microarrays in microbiology. Norwegian Annual society of microbiology meeting, Ullevål hospital, Oslo, 10th October 2001.

Show author(s) (1998). Measurement of specific IgA in fecal extracts and in intestinal lavage fluid for monitoring of mucosal immune responses after rectal and gastric immunization.
Show author(s) (1998). Measurement of specific IgA in fecal extracts and in intestinal lavage fluid for monitoring of mucosal immune responses after rectal and gastric immunization.

Show author(s) (1997). The colonization factor antigen I like group of fimbrial proteins of human enterotoxigenic Escherichia coli.
Show author(s) (1997). The colonization factor antigen I like group of fimbrial proteins of human enterotoxigenic Escherichia coli.
Show author(s) (1997). Air-dried saliva and feces can be used for analyses of mucosal antibodies.
Show author(s) (1997). Air-dried saliva and feces can be used for analyses of mucosal antibodies.

Editorial

Show author(s) (2008). Opportunistic pathogens in AIDS: trends, diagnosis and priorities. Expert Review of Anti-Infective Therapy. 163-166.

Reader opinion piece

Show author(s) (2013). BCG protects against tuberculosis irrespective of HIV status: a matched case-control study in Mwanza, Tanzania. Thorax. 288-289.

Show author(s) (2011). Isoniazid and rifampicin resistance-associated mutations in Mycobacterium tuberculosis isolates from Yangon, Myanmar: implications for rapid molecular testing-authors' response. Journal of Antimicrobial Chemotherapy. 687-687.

Non-fiction book

Show author(s) (2006). The Role of Nutrition in Tuberculosis. In: Practical Approach to Tuberculosis Management. Jaypee Brothers Medical Publishers,(P) Ltd., New Delhi, India.

Masters thesis

Show author(s) (2012). Diagnostic utility of the tuberculin skin test and QuantiFERON-TB Gold In-Tube assay in children with probable intra-thoracic tuberculosis in India.
Show author(s) (2012). Assessment of the utility of repeat tuberculin testing: a prospective study of adolescents in a high tuberculosis prevalence setting in South India.

Show author(s) (2011). Feasibility, utility and acceptability of gastric aspiration and induced sputum sampling in young children for the diagnosis of mycobacterial infections; study conducted as part of the development of a TB vaccine site in South India.
Show author(s) (2011). Comparison of Tuberculin Skin Test and QuantiFERON TB Gold In-tube Assay for the diagnosis of tuberculosis infection and disease in young children; study conducted as part of the development of a TB vaccine site in Southern India.

Show author(s) (2009). Predictors of sputum conversion among pulmonary tuberculosis patients in Mwanza, Tanzania.

Show author(s) (2005). Pyrazinamide resistance among multi-drug resistant M. tuberculosis isolates from South African pulmonary tuberculosis patients.

Show author(s) (2004). Drug resistant tuberculosis in Yangon, Myanmar.
Show author(s) (2004). Drug resistant tuberculosis in Yangon, Myanmar.

Research groups

Research group for Infection and Microbiology