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Janne Grønli

Associate Professor, Head of Bergen Stress and Sleep Group
  • E-mailJanne.Gronli@uib.no
  • Phone+47 55 58 60 03+47 922 96 559
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7807
    5020 BERGEN
  • The regulation and function of sleep
  • The relationship between sleep, circadian rhythms, stress and brain function
    • How can stress influence the sleep; quality, regulation and function
    • How can stress influence circadian rhythms
    • The influence of stress on behavior
    • Consequences of stress on the neurobiology
       
  • Consequences of simulated shiftwork on sleep, circadian rhythms, biological clocks and metabolism
     
  • How light influence wakefulness and sleep
    • e-reading before bedtime
    • blocking blue light as additive treatment for mania
    • blocking blue light as treatment to ease sleep disturbances during pregnancy
    • consequences of short day versus long day

 

Methods:

  • Polysomnography (PSG)
  • Actigraphy
  • Radar
  • Circadian rhythms
  • Light laboratory
  • Blue-blocking glasses
  • Simulated shift work, in men and rodents
  • Animal models of depression
  • Behavioral tests in rodents

Sleep - elegantly designed for us to be awake (in Norwegian)
http://innsikt.bt.no/author/janneg/

Can dogs dream? (in Norwegian)
https://tv.nrk.no/serie/newton/dmpv74002312/30-09-2012 fra kl 16.07

Reading from a tablet before bed may affect sleep quality
http://www.reuters.com/article/us-health-sleep-ipad-reading-idUSKCN0WD1Z5

 

Course coordinator:

Biological psychology PROPSY303
Sleep, circadian rhythms and behavior PSYK115
Circadian rhythms and sleep their role in mental and physical health, safety and productivity (NRSN summer school 2017: https://www.ntnu.edu/nrsn/summer-school)
Polysomnography (PSG) - scoring of sleep and sleep related events; beginners and advanced level

Some topics that I teach:

  • The regulation of sleep and circadian rhythms
  • Sleep, sleep disturbances and mental health
  • Chronobiological treatment of psychiatric diseases
  • The use of actigraphy and PSG
  • The interpretaion of actogram and hypnogram
  • Endocrinology
  • Immunology
  • Psychoendocrinology/psychoimmunology
  • Sexual reproduction and differentiation
Journal articles
  • Grønli, Janne; Melinder, Annika Maria D; Ousdal, Olga Therese; Pallesen, Ståle; Endestad, Tor; Milde, Anne Marita. 2017. Life Threat and Sleep Disturbances in Adolescents: A Two-Year Follow-Up of Survivors From the 2011 Utøya, Norway, Terror Attack. Journal of Traumatic Stress. 219-228. doi: 10.1002/jts.22196
  • Steine, Iris Mulders; Winje, Dagfinn; Krystal, John H.; Bjorvatn, Bjørn; Milde, Anne Marita; Grønli, Janne; Nordhus, Inger Hilde; Pallesen, Ståle. 2017. Cumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse. International Journal of Child Abuse & Neglect. 65: 99-111. doi: 10.1016/j.chiabu.2017.01.008
  • Steine, Iris Mulders; Winje, Dagfinn; Skogen, Jens Christoffer; Krystal, John H; Milde, Anne Marita; Bjorvatn, Bjørn; Nordhus, Inger Hilde; Grønli, Janne; Pallesen, Ståle. 2017. Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study. International Journal of Child Abuse & Neglect. 67: 280-293. doi: 10.1016/j.chiabu.2017.03.002
  • Blågestad, Tone Fidje; Nordhus, Inger Hilde; Grønli, Janne; Engesæter, Lars B.; Ruths, Sabine; Ranhoff, Anette Hylen; Bjorvatn, Bjørn; Pallesen, Ståle. 2016. Prescription trajectories and effect of total hip arthroplasty on the use of analgesics, hypnotics, antidepressants, and anxiolytics: Results from a population of total hip arthroplasty patients. Pain. 157: 643-651. Published 2015-11-14. doi: 10.1097/j.pain.0000000000000414
  • Blågestad, Tone Fidje; Pallesen, Ståle; Grønli, Janne; Tang, Nicole K.Y.; Nordhus, Inger Hilde. 2016. How perceived pain influence sleep and mood more than the reverse: A novel, exploratory study with patients awaiting total hip arthroplasty. Frontiers in Psychology. 7. 11 pages. doi: 10.3389/fpsyg.2016.01689
  • Blågestad, Tone Fidje; Pallesen, Ståle; Grønli, Janne; Tang, Nicole K.Y.; Nordhus, Inger Hilde. 2016. Relationships between pain, sleep and mood: Perceptions of symptom interaction in patients awaiting total hip arthroplasty. Journal of Sleep Research. 25: 224-224. Published 2016-08-29. doi: 10.1111/jsr.12446
  • Grønli, Janne. 2016. What does shift work do to sleep, circadian function and regulation of metabolism? Controlled studies with a rodent model. Journal of Sleep Research. 25: 27-27. Published 2016-08-29. doi: 10.1111/jsr.12446
  • Grønli, Janne; Byrkjedal, Ida Kristiansen; Bjorvatn, Bjørn; Nødtvedt, Øystein Ottesen; Hamre, Børge; Pallesen, Ståle. 2016. Reading from an iPad or from a book in bed: the impact on human sleep. A randomized controlled crossover trial. Sleep Medicine. 21: 86-92. doi: 10.1016/j.sleep.2016.02.006
  • Grønli, Janne; Clegern, William C.; Schmidt, Michelle A.; Nemri, Rahmi S.; Rempe, Michael J.; Gallitano, Amelia L.; Wisor, Jonathan. 2016. Sleep homeostatic and waking behavioral phenotypes in Egr3-deficient mice associated with serotonin receptor 5-HT2 deficits. Journal of Sleep Research. 25: 103-104. Published 2016-08-29. doi: 10.1111/jsr.12446
  • Grønli, Janne; Clegern, William C.; Schmidt, Michelle A.; Nemri, Rahmi S.; Rempe, Michael J.; Gallitano, Amelia L.; Wisor, Jonathan P. 2016. Sleep homeostatic and waking behavioral phenotypes in Egr3-deficient mice associated with serotonin receptor 5-Ht2 deficits. Sleep. 39: 2189-2199. Published 2016-12-01. doi: 10.5665/sleep.6324
  • Grønli, Janne; Meerlo, Peter; Pedersen, Torhild; Pallesen, Ståle; Skrede, Silje; Marti, Andrea Rørvik; Wisor, Jonathan; Murison, Robert; Henriksen, Tone Elise Gjøtterud; Rempe, Michael J.; Mrdalj, Jelena. 2016. A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Journal of Biological Rhythms. doi: 10.1177/0748730416675460
  • Grønli, Janne; Rempe, Michael J.; Clegern, William C.; Schmidt, Michelle; Wisor, Jonathan. 2016. Beta EEG reflects sensory processing in active wakefulness and homeostatic sleep drive in quiet wakefulness. Journal of Sleep Research. 25: 257-268. doi: 10.1111/jsr.12380
  • Henriksen, Tone Elise Gjøtterud; Skrede, Silje; Fasmer, Ole Bernt; Schøyen, Helle Kristine; Leskauskaite, Ieva; Bjørke-Bertheussen, Janette; Assmus, Jörg; Hamre, Børge; Grønli, Janne; Lund, Anders. 2016. Blue-blocking glasses as additive treatment for mania: A randomized placebo-controlled trial. Bipolar Disorders. 18: 221-232. doi: 10.1111/bdi.12390
  • Hossain, Jubayer; Ystaas, Lars Andreas Rømo; Mrdalj, Jelena; Välk, Kristjan; Riecken, Kristoffer; Fehse, Boris; Bjerkvig, Rolf; Grønli, Janne; Miletic, Hrvoje. 2016. Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells. Journal of Gene Medicine. 18: 234-243. doi: 10.1002/jgm.2895
  • Marti, Andrea Rørvik; Meerlo, Peter; Grønli, Janne; Hasselt, Sjoerd van; Mrdalj, Jelena; Pallesen, Ståle; Pedersen, Torhild; Henriksen, Tone Elise Gjøtterud; Skrede, Silje. 2016. Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. Nutrients. 8:712: 1-13. doi: 10.3390/nu8110712
  • Marti, Andrea Rørvik; Mrdalj, Jelena; Skrede, Silje; Pedersen, Torhild Thue; Meerlo, Peter; van Hasselt, Sjoerd Johan; Henriksen, Tone Elise Gjøtterud; Pallesen, Ståle; Murison, Robert; Grønli, Janne. 2016. Simulated night work alters clock gene expression in central and peripheral tissue in rats. Journal of Sleep Research. 25: 57-57. Published 2016-08-29. doi: 10.1111/jsr.12446
  • Mrdalj, Jelena; Murison, Robert; Soule, Jonathan; Kinn Rød, Anne Marie; Milde, Anne Marita; Pallesen, Ståle; Grønli, Janne. 2016. Mild daily stressors in adulthood may counteract behavioural effects after constant presence of mother during early life. Physiology and Behavior. 165: 313-321. doi: 10.1016/j.physbeh.2016.08.018
  • Pallesen, Ståle; Bjorvatn, Bjørn; Grønli, Janne. 2016. Behandling av mareritt : en oversikt over randomiserte behandlingsstudier. Tidsskrift for Norsk Psykologforening. 53: 716-726.
  • Pallesen, Ståle; Grønli, Janne. 2016. The impact of e-reading on sleep. Sleep Medicine. 23: 109-110. Published 2016-08-03. doi: 10.1016/j.sleep.2016.07.005
  • Rempe, Michael J.; Pedersen, Torhild Thue; Meerlo, Peter; Mrdalj, Jelena; Pallesen, Ståle; Marti, Andrea Rørvik; Wisor, Jonathan; Murison, Robert; Henriksen, Tone Elise Gjøtterud; Grønli, Janne. 2016. A rat model for shiftwork: Effects on sleep architecture and sleep homeostasis. Journal of Sleep Research. 25: 248-249. Published 2016-08-29. doi: 10.1111/jsr.12446
  • Steine, Iris Mulders; Winje, Dagfinn; Nordhus, Inger Hilde; Milde, Anne Marita; Bjorvatn, Bjørn; Grønli, Janne; Pallesen, Ståle. 2016. Langvarig taushet om seksuelle overgrep : prediktorer og korrelater hos voksne som opplevde seksuelle overgrep som barn. Tidsskrift for Norsk Psykologforening. 53: 889-899.
  • Steine, Iris Mulders; Zayats, Tetyana; Stansberg, Christine; Pallesen, Ståle; Mrdalj, Jelena; Håvik, Bjarte; Soule, Jonathan; Haavik, Jan; Milde, Anne Marita; Skrede, Silje; Murison, Robert; Krystal, John H; Grønli, Janne. 2016. Implication of NOTCH1 Gene in Susceptibility to Anxiety and Depression among Sexual Abuse Victims. Translational psychiatry. doi: 10.1038/tp.2016.248
  • Bjorvatn, Bjørn; Pallesen, Ståle; Grønli, Janne; Sivertsen, Børge; Lehmann, Sverre. 2014. Prevalence and correlates of insomnia and excessive sleepiness in adults with obstructive sleep apnea symptoms. Perceptual and Motor Skills. 118: 571-586. doi: 10.2466/15.06.PMS.118k20w3
  • Grønli, Janne; Soule, Jonathan; Bramham, Clive R. 2014. Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. Frontiers in Behavioral Neuroscience. 7:224. 18 pages. doi: 10.3389/fnbeh.2013.00224
  • Henriksen, Tone Elise Gjøtterud; Skrede, Silje; Fasmer, Ole Bernt; Hamre, Børge; Grønli, Janne; Lund, Anders. 2014. Blocking blue light during mania - markedly increased regularity of sleep and rapid improvement of symptoms: A case report. Bipolar Disorders. 16: 894-898. doi: 10.1111/bdi.12265
  • Kinn Rød, Anne Marie; Murison, Robert; Mrdalj, Jelena; Milde, Anne Marita; Jellestad, Finn Konow; Øvernes, Leif Arvid; Grønli, Janne. 2014. Effects of social defeat on sleep and behaviour: Importance of the confrontational behaviour. Physiology and Behavior. 127: 54-63. doi: 10.1016/j.physbeh.2014.01.010
  • Mrdalj, Jelena; Mattson, Åse Lundegaard; Murison, Robert; Jellestad, Finn Konow; Milde, Anne Marita; Pallesen, Ståle; Ursin, Reidun; Bjorvatn, Bjørn; Grønli, Janne. 2014. Hypothermia after chronic mild stress exposure in rats with a history of postnatal maternal separations. Chronobiology International. 31: 252-264. doi: 10.3109/07420528.2013.846351
  • Bjorvatn, Bjørn; Flo, Elisabeth; Fiske, Eldbjørg; Grønli, Janne. 2013. Ulik forekomst av søvnlidelser mellom fylker og mellom by og land. SØVN. 5: 22-25.
  • Flo, Elisabeth; Pallesen, Ståle; Åkerstedt, Torbjørn; Magerøy, Nils; Moen, Bente Elisabeth; Grønli, Janne; Nordhus, Inger Hilde; Bjorvatn, Bjørn. 2013. Shift-related sleep problems vary according to work schedule. Occupational and Environmental Medicine. 70: 238-245. doi: 10.1136/oemed-2012-101091
  • Grønli, Janne. 2013. Søvnproblemer hos små barn – hvordan behandle det? SØVN. 5: 10-13.
  • Grønli, Janne. 2013. Redaktørens hjørne. SØVN. 5: 3.
  • Grønli, Janne. 2013. Markus og Mille – en natt på søvnlaboratoriet. SØVN. 5: 10-13.
  • Grønli, Janne. 2013. Søvnlaboratoriet ved Lovisenberg Diakonale sykehus. Et søvnsenter for barn – og voksne. SØVN. 5: 26-29.
  • Mrdalj, Jelena; Pallesen, Ståle; Milde, Anne Marita; Jellestad, Finn Konow; Murison, Robert; Ursin, Reidun; Bjorvatn, Bjørn; Grønli, Janne. 2013. Early and later life stress alter brain activity and sleep in rats. PLoS ONE. 8. Published 2013-07-26. doi: 10.1371/journal.pone.0069923
  • Saxvig, Ingvild W.; Grønli, Janne. 2013. Sesongvariasjoner, døgnrytmeforstyrrelser og AD/HD. SØVN. 5: 5-7.
  • Skeie, Bente Sandvei; Wang, Jian; Dodoo, Ernest; Heggdal, Jan Ingemann; Grønli, Janne; Sleire, Linda; Bragstad, Sidsel Marit; Ganz, Jeremy Christopher; Chekenya, Martha; Mørk, Sverre; Pedersen, Paal-Henning; Enger, Per Øyvind. 2013. Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model. Biomedical research. 2013. 9 pages. doi: 10.1155/2013/139674
  • Bjorvatn, Bjørn; Fiske, Eldbjørg; Grønli, Janne. 2012. Interaktiv spørreundersøkelse om søvn på nett. SØVN. 2. 6-9.
  • Blagestad, T.; Pallesen, Ståle; Lunde, Linn-Heidi; Sivertsen, Børge; Nordhus, Inger Hilde; Grønli, Janne. 2012. Medication use and its relation to measures on sleep, pain, depression and anxiety in older chronic pain patients. Journal of Sleep Research. 21: 370-370.
  • Blågestad, Tone Fidje; Pallesen, Ståle; Lunde, Linn-Heidi; Sivertsen, Børge; Nordhus, Inger Hilde; Grønli, Janne. 2012. Sleep in older chronic pain patients: a comparative polysomnographic study. The Clinical Journal of Pain. 28: 277-283. doi: 10.1097/AJP.0b013e3182313899
  • Flo, Elisabeth; Bjorvatn, Bjørn; Folkard, Simon; Moen, Bente Elisabeth; Grønli, Janne; Nordhus, Inger Hilde; Pallesen, Ståle. 2012. A reliability and validity study of the Bergen shift work sleep questionnaire in nurses working three-shift rotations. Chronobiology International. 29: 937-946. doi: 10.3109/07420528.2012.699120
  • Flo, Elisabeth; Pallesen, Ståle; Magerøy, Nils; Moen, Bente Elisabeth; Grønli, Janne; Nordhus, Inger Hilde; Bjorvatn, Bjørn. 2012. Shift work disorder in nurses - assessment, prevalence and related health problems. PLoS ONE. 7. 9 pages. doi: 10.1371/journal.pone.0033981
  • Grønli, Janne. 2012. Hva drømmer du om? SØVN. 2. 20-21.
  • Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita; Murison, Robert; Bramham, Clive R. 2012. Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Behavioural Brain Research. 235: 251-262. doi: 10.1016/j.bbr.2012.08.008
  • Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita; Murison, Robert; Bramham, Clive R. 2012. Chronic mild stress abolishes a relationship between sleep architecture and translational control. Journal of Sleep Research. 21: 41-41.
  • Kinn Rød, Anne Marie; Milde, Anne Marita; Grønli, Janne; Jellestad, Finn Konow; Sundberg, Håkan; Murison, Robert. 2012. Long-term effects of footshock and social defeat on anxiety-like behaviours in rats: Relationships to pre-stressor plasma corticosterone concentration. Stress. 15: 658-670. doi: 10.3109/10253890.2012.663836
  • Kinn Rød, Anne Marie; Mrdalj, Jelena; Milde, Anne Marita; Jellestad, Finn Konow; Murison, Robert; Øvernes, Leif Arvid; Grønli, Janne. 2012. Sleep architecture, behaviour, corticosterone and acoustic startle response after double exposure to social defeat in rats. Journal of Sleep Research. 21: 212-212.
  • Steine, Iris Mulders; Harvey, Allison G.; Krystal, John H; Milde, Anne Marita; Grønli, Janne; Bjorvatn, Bjørn; Nordhus, Inger Hilde; Eid, Jarle; Pallesen, Ståle. 2012. Sleep disturbances in sexual abuse victims: A systematic review. Sleep Medicine Reviews. 16: 15-25. doi: 10.1016/j.smrv.2011.01.006
  • Steine, Iris Mulders; Krystal, John H; Nordhus, Inger Hilde; Bjorvatn, Bjørn; Harvey, Allison G.; Eid, Jarle; Grønli, Janne; Milde, Anne Marita; Pallesen, Ståle. 2012. Insomnia, nightmare frequency, and nightmare distress in victims of sexual abuse: the role of perceived social support and abuse characteristics. Journal of Interpersonal Violence. 27: 1827-1843. doi: 10.1177/0886260511430385
  • Steine, Iris Mulders; Milde, Anne Marita; Bjorvatn, Bjørn; Grønli, Janne; Nordhus, Inger Hilde; Mrdalj, Jelena; Pallesen, Ståle. 2012. Forekomsten av seksuelle overgrep i et representativt befolkningsutvalg i Norge. Tidsskrift for Norsk Psykologforening. 49: 950-957.
  • Øines, Eliann; Murison, Robert; Mrdalj, Jelena; Grønli, Janne; Milde, Anne Marita. 2012. Neonatal maternal separation in male rats increases intestinal permeability and affects behavior after chronic social stress. Physiology and Behavior. 105: 1058-1066. doi: 10.1016/j.physbeh.2011.11.024
  • Flo, Elisabeth; Steine, Iris Mulders; Blågestad, Tone; Grønli, Janne; Pallesen, Ståle; Portas, Chiara Maria. 2011. Transient changes in frontal alpha asymmetry as a measure of emotional and physical distress during sleep. Brain Research. 1367: 234-249. Published 2011-01-07. doi: 10.1016/j.brainres.2010.09.090
  • Grønli, Janne; Saxvig, Ingvild W. 2011. Hvordan sover vi - egentlig? SØVN. 3: 10-12.
  • Milde, Anne Marita; Grønli, Janne. 2011. Trygg nok til å sove? SØVN. 3: 6-9.
  • Bjorvatn, Bjørn; Grønli, Janne; Pallesen, Ståle. 2010. Prevalence of different parasomnias in the general population. Sleep Medicine. 11: 1031-1034. doi: 10.1016/j.sleep.2010.07.011
  • Grønli, Janne. 2010. Akkreditering av søvnspesialister og søvnsentre i Norge. SØVN. 4: 20.
  • Grønli, Janne. 2010. Hva er status vedrørende akkreditering i Norge? SØVN. 4. 21.
  • Grønli, Janne. 2010. Europeisk søvnkongress i Lisboa. SØVN. 4. 11.
  • Grønli, Janne; Milde, Anne Marita. 2010. Dyremodeller for søvn og stress - implikasjoner for mentale lidelser. SØVN. 4. 8-10.
  • Bjorvatn, Bjørn; Grønli, Janne; Pallesen, Ståle. 2009. Parasomnier. Tidsskrift for Den norske legeforening. 129: 1892-1894.
  • Grønli, Janne. 2009. Beste søvnartikkel i 2009. SØVN. 3. 15.
  • Grønli, Janne. 2009. Behandling av søvnapné – pustemaske, bittskinne eller kirurgi? SØVN. 2.
  • Grønli, Janne; Ursin, Reidun. 2009. Basale søvnmekanismer. Tidsskrift for Den norske legeforening. 129: 1758-1761. doi: 10.4045/tidsskr.08.0465
  • Bjorvatn, Bjørn; Grønli, Janne; Pallesen, Ståle. 2008. Prevalence of possible parasomnias in the general population. Journal of Sleep Research. 17: P48.
  • Fiske, Eldbjørg; Portas, Chiara Maria; Grønli, Janne; Sørensen, Eli; Bjorvatn, Bjørn; Bjørkum, Alvhild Alette; Ursin, Reidun. 2008. Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats. Acta Physiologica. 193: 89-97. doi: 10.1111/j.1748-1716.2007.01792.x
  • Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita; Murison, Robert; Portas, Chiara Maria; Bramham, Clive R. Evjen. 2008. Sleep deprivation as an antidepressant treatment following chronic mild stress: effects on translation factor EIF4E and EEF2 activity. Journal of Sleep Research. 17: 221-221.
  • Kinn, Anne Marie; Grønli, Janne; Fiske, Eldbjørg; Kuipers, Sjoukje; Ursin, Reidun; Murison, Robert; Portas, Chiara Maria. 2008. A double exposure to social defeat induces sub-chronic effects on sleep and open field dehaviour in rats. Physiology and Behavior. 95: 553-561. doi: 10.1016/j.physbeh.2008.07.031
  • Saxvig, Ingvild W.; Lundervold, Astri; Grønli, Janne; Ursin, Reidun; Bjorvatn, Bjørn; Portas, Chiara Maria. 2008. The effect of a REM sleep deprivation procedure on different aspects of memory function in humans. Psychophysiology. 45: 309-317. doi: 10.1111/j.1469-8986.2007.00623.x
  • Bjorvatn, Bjørn; Grønli, Janne. 2007. Nasjonalt Kompetansesenter for Søvnsykdommer. Paraplyen. Tidsskrift for Hordaland og Sogn og Fjordane legeforeninger. 20-21.
  • Fiske, Eldbjørg; Portas, Chiara Maria; Grønli, Janne; Sørensen, Eli; Bjorvatn, Bjørn; Bjørkum, Alvhild Alette; Ursin, Reidun. 2007. Increased extracellular 5-HT but no change of sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleous of rats. Acta Physiologica.
  • Grønli, Janne; Fiske, Eldbjørg; Murison, Robert; Bjorvatn, Bjørn; Sørensen, Eli; Ursin, Reidun; Portas, Chiara Maria. 2007. Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats. A microdialysis study over the sleep/wake cycle in an animal model of depression. Sleep and Biological Rhythms.
  • Grønli, Janne; Fiske, Eldbjørg; Murison, Robert; Bjorvatn, Bjørn; Sørensen, Eli; Ursin, Reidun; Portas, Chiara Maria. 2007. Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats. - A microdialysis study in an animal model of depression. Behavioural Brain Research. 181: 42-51. doi: 10.1016/j.bbr.2007.03.018
  • Fiske, Eldbjørg; Grønli, Janne; Bjorvatn, Bjørn; Ursin, Reidun; Portas, Chiara Maria. 2006. The effect of GABA(A) antagonist bicuculline on dorsal raphe nucleus and frontal cortex extracellular serotonin: A window on SWS and REM sleep modulation. Pharmacology, Biochemistry and Behavior. 83. doi: 10.1016/j.pbb.2006.02.014
  • Grønli, Janne; Bjorvatn, Bjørn. 2006. SOV:no: Nasjonalt Kompetansesenter for Søvnsykdommer. Medisinsk informasjon. 1. 28-29.
  • Grønli, Janne; Bramham, Clive R. Evjen; Murison, Robert; Kanhema, Tambudzai; Fiske, Eldbjørg; Bjorvatn, Bjørn; Ursin, Reidun; Portas, Chiara Maria. 2006. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacology, Biochemistry and Behavior. 85: 842-849. doi: 10.1016/j.pbb.2006.11.021
  • Grønli, Janne; Kinn, Anne Marie; Ursin, Reidun; Portas, Chiara Maria. 2006. Modest changes in sleep and open field behaviour in rats exposed to social defeats. Journal of Sleep Research. 15: 127-127.
  • Kinn, Anne Marie; Grønli, Janne; Ursin, Reidun; Portas, Chiara Maria. 2006. Social defeats induce modest changes in sleep and open field behaviour in rats. Sleep. 29: A17-A17.
  • Lecca, D; Cacciapaglia, F; Valentini, V; Grønli, Janne; Spiga, S; Di Chiara, G. 2006. Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administration. Psychopharmacology. 184: 335-346.
  • Grønli, Janne; Murison, Robert; Fiske, Eldbjørg; Bjorvatn, Bjørn; Sørensen, Eli; Portas, Chiara Maria; Ursin, Reidun. 2005. Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions. Physiology and Behavior. 84: 571-577. doi: 10.1016/j.physbeh.2005.02.007
  • Grønli, Janne; Murison, Robert; Kanhema, Tambudzai; Fiske, Eldbjørg; Bjorvatn, Bjørn; Sørensen, Eli; Portas, Chiara Maria; Bramham, Clive R. Evjen; Ursin, Reidun. 2005. Chronic mild stress, an animal model of depression, affects the expression of BDNF and 5-HT levels over the sleep/wake cycle in hippocampus in rats. Sleep. 28.
  • Fischer, Walter; Gustafsson, Lotta; Mossberg, Ann-Kristin; Grønli, Janne; Mørk, Sverre; Bjerkvig, Rolf; Svanborg, Catharina. 2004. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Research. 64: 2105-2112.
  • Fiske, Eldbjørg; Grønli, Janne; Hamre, Frøydis; Portas, Chiara Maria; Ursin, Reidun. 2004. Dose-related effect of bicuculline perfused in DRN. Journal of Sleep Research. 13. 236-236.
  • Saxvig, Ingvild; Lundervold, Astri Johansen; Grønli, Janne; Portas, Chiara Maria. 2004. The effect of rem sleep deprivation on different memory tasks in humans. Journal of Sleep Research. 13. 1 pages.
  • Bjorvatn, Bjørn; Grønli, Janne; Hamre, Frøydis; Sørensen, Eli; Fiske, Eldbjørg; Bjørkum, Alvhild A; Portas, Chiara Maria; Ursin, Reidun. 2002. Effects of sleep deprivation on extracellular serotonin in the hippocampus and frontal cortex of the rat. Neuroscience. 113: 323-330.
  • Sørensen, Eli; Grønli, Janne; Bjorvatn, Bjørn; Bjørkum, Alvhild A; Ursin, Reidun. 2001. Sleep and waking following microdialysis perfusion of the selective 5-HT 1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat. Brain Research. 897: 122-130.
  • Sørensen, Eli; Grønli, Janne; Bjorvatn, Bjørn; Ursin, Reidun. 2001. The selective 5-HT 1A receptor antagonist p-MPPI antagonizes sleep-waking and behavioural effects of 8-OH-DPAT in rats. Behavioural Brain Research. 121: 181-187.
  • Portas, CM; Bjorvatn, Bjørn; Fagerland, Snorre; Grønli, Janne; Mundal, V; Sørensen, Eli; Ursin, Reidun. 1998. On-line detection of extracellular levels of serotonin in dosal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat. Neuroscience. 83: 807-814.
  • Portas, Chiara Maria; Bjorvatn, Bjørn; Fagerland, Snorre; Grønli, Janne; Mundal, Vibeke; Sørensen, Eli; Ursin, Reidun. 1998. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving ra. Neuroscience. 83: 807-814.
Reports and theses
  • Grønli, Janne. 2006. Chronic mild stress an anmial model of depression. From behavior to molecules.
  • Grønli, Janne. 1996. Vekselvirkninger mellom polyelektrolytt og ioniske surfaktanter i vandig fase og på _a-alumina studert ved ledningsevnemålinger og adsorpsjonsisotermer. UiB. 141 pages.
Book sections
  • Portas, Chiara Maria; Grønli, Janne. 2008. Involvement of the 5-HT1A and the 5-HT1B receptor in the regulation of sleep and waking. 12. In:
    • Monti, J.M.; Pandi-Perumal, S.R.; Jacobs, B-L-; Nutt, D.J. 2008. Serotonin and Sleep: Molecular, Functional and Clinical Aspects. Birkhäuser Verlag. 621 pages. ISBN: 978-3-7643-8560-6.

More information in national current research information system (CRIStin)

Publications in 2017:

Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study.
Steine IM, Winje D, Skogen JC, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Grønli J, Pallesen S.
Child Abuse Negl. 2017 Mar 16;67:280-293. doi: 10.1016/j.chiabu.2017.03.002. PMID: 28327414

Cumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse.
Steine IM, Winje D, Krystal JH, Bjorvatn B, Milde AM, Grønli J, Nordhus IH, Pallesen S.
Child Abuse Negl. 2017 Mar;65:99-111. doi: 10.1016/j.chiabu.2017.01.008. Epub 2017 Jan 26. PMID: 28131947

A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances.
Grønli J, Meerlo P, Pedersen TT, Pallesen S, Skrede S, Marti AR, Wisor JP, Murison R, Henriksen TEG, Rempe MJ, Mrdalj J.
J Biol Rhythm, 2017 Feb;32(1):48-63. doi: 10.1177/0748730416675460. Epub 2016 Dec 14

Publications in 2016:

Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shift work. A rat model.
Marti AR, Meerlo P, Grønli J, van Hasselt SJ, Mrdalj J, Pallesen S, Pedersen TT, Henriksen TEG, Skrede S.
Nutrients, 2016 Nov 8;8(11). pii: E712

Implication of NOTCH1 Gene in Comorbid Anxiety and Depression Symptoms in a Sample of Sexual Abuse Victims.
Steine I., Zayats, T. Stansberg C, Pallesen S, Mrdalj J, Håvik  B, Murison R, Haavik  J, Krystal JH, Milde AM, Skrede S, Grønli J
Translational Psychiatry, 2016 Dec 13;6(12):e977. doi: 10.1038/tp.2016.248.

Sleep homeostatic and waking behavioral phenotypes in Egr3-deficient mice associated with serotonin receptor 5-HT2 deficits.
Gronli J, Clegern WC, Schmidt MA, Nemri RS, Rempe MJ, Gallitano AL, Wisor JP.
SLEEP, 2016 Dec 1;39(12):2189-2199. doi: 10.5665/sleep.6324

How Perceived Pain Influence Sleep and Mood More Than The Reverse: A Novel, Exploratory Study with Patients Awaiting Total Hip Arthroplasty.
Blågestad T, Pallesen S, Grønli J, Tang NKY, Nordhus IH.
Frontiers in Psychology 7(1689) · October 2016 DOI: 10.3389/fpsyg.2016.0168

Beta EEG reflects sensory processing in active wakefulness and homeostatic sleep drive in quiet wakefulness.
Grønli J, Rempe MJ, Clegern WC, Schmidt M, Wisor JP.
J Sleep Res. 2016 Jun;25(3):257-68.

Reading on an Ipad or in a book in bed– the impact on human sleep. A randomized controlled crossover trial.
Grønli J, Byrkjedal Kristiansen I, Bjorvatn B, Nødtvedt Ø, Hamre B, Pallesen S.
Sleep Med. 2016 May;21:86-92

Blue-blocking glasses as additive treatment for mania: a randomized placebo-controlled trial.
Henriksen TE, Skrede S, Fasmer OB, Schoeyen H, Leskauskaite I, Bjørke-Bertheussen J, Assmus J, Hamre B, Grønli J, Lund A.
Bipolar Disord. 2016 May;18(3):221-32.

Prescription trajectories and effect of total hip arthroplasty on the use of analgesics, hypnotics, antidepressants and anxiolytics: Results from a population of total hip arthroplasty patients.
Blågestad TF, Nordhus IH, Grønli J, Engesæter LB, Ruths S, Ranhoff AH, Bjorvatn B, Pallesen S.
PAIN, 2016 Mar;157(3):643-51

  
Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells.
Hossain JA, Ystaas LR, Mrdalj J, Välk K, Riecken K, Fehse B, Bjerkvig R, Grønli J, Miletic H.    
J Gene Med. 2016 Sep;18(9):234-43. doi: 10.1002/jgm.2895.

Mild daily stressors in adulthood may counteract behavioural effects after constant presence of mother during early life.
Mrdalj J, Murison R, Soulé J, Kinn Rød AM, Milde AM, Pallesen S, Grønli J.
Physiol Behav. 2016 Oct 15;165:313-21. doi: 10.1016/j.physbeh.2016.08.018. PMID: 27546213

The impact of e-reading on sleep.
Pallesen S, Grønli J.
Editorial in Sleep Med. 2016 Jul;23:109-110. PMID: 27522403

Behandling av mareritt. En systematisk narrativ oversikt over randomiserte behandlingsstudier.
Pallesen S, Bjorvatn B, Grønli J.
Tidsskrift for Norsk Psykologforening. Vol 53, nummer 9, 2016, 716-726

2011- : Associate professor, Department of Biological and Medical Psychology, University of Bergen
2014-2016: Assistant research professor, Washington State University, Spokane, WA, USA
2013: Somnologist – sleep scientist. European certification
2009-2014: Editor of the Norwegian journal 'SLEEP'
2007-2011: Postdoctor, Department of Biological and Medical Psychology, University of Bergen
2004-2014: Center Coordinator, Norwegian Competence Center for Sleep Disorders
2006 and 2011: Registered Polysomnographic Technologist (RPSGT). American certification
2006: PhD, Department of Biomedicine, University of Bergen
2005: Resacher, CEE grant, EU project 'Cellular and Molecular Mechanisms of Nicotine Dependence', Cagliari, Italia
1996: Master of Science, Cand. Scient., Department of Chemistry, University of Bergen.

 

 

 

Early Life Stress: A Translational Study of Affective and Behavioral Outcomes and Genetic Modulation

The primary objective of this project is to establish translational research on early life stress with affective, behavioral outcome as well as genetic modulation, with a strong gender perspective.

The secondary obejctivesare: 1) to explore the impact of negative experiences in childhood, 2) to explore the impact of positive support as a moderator of risk to develop later anxiety and depression and 3) to identify high-probability candidate genes which may interact with early life stress making the individual more vulnerable or resilient to later stress experience. The latter point represents an innovative approach to the exploration of genetic vulnerability and resilience of early life stress.

Projectleaders: Janne Grønli and Ståle Pallesen
Institution: UoB.
From: 2010.
End of the project: 2012.


Prosjektleader: Ståle Pallesen
Title: LISA – longitudinal investigation of sexual abuse
Institution: UoB.
From: 2008.
End of the project: 2019.

Prosjektleader: Robert Murison.
Title: Social defeat – as a model of anxiety
Institution: UoB.
From: 2006.
End of the project: 2012.

Prosjektleader: Anne Marita Milde
Title: Maternal separation effects on behaviour, stress responsivity and the
gastrointestinal system: translational studies of the concept “attachment” on health.
Institution: UoB.
From: 2008.
End of the project: 2012.

Prosjektleader: Bjørn Bjorvatn
Title: Questionnaire on shiftwork, sleep and health among nurses
Ansvarlig institusjon: Helse Bergen/Uib.
Oppstartsår: 2010.
Forventet prosjektslutt: 2012.

Prosjektleader: Jonathan Soule
Title: State-dependent control of LTP consolidation
Institution: UoB.
From: 2009.
End of the project: 2012.

Prosjektleader: Sjoukje Kuipers
Title: BDNF and Neurogenesis in Mood Disorders:
ARCing the Gap from Psychopathology to Treatment
Institution: Bergen Medical Research fundation/UoB.
From: 2010.
End of the project: 2013.

Prosjektleader: Inger Hilde Nordhus
Title: Pain in the elderly – sleep and effects on sleeptreatment
Institution: UoB.
From: 2005.
End of the project: 2011.

Prosjektleader: Bjørn Bjorvatn.
Title: Sleep, shiftwork and health among nurses in hospitals.
Institution: Helse Bergen/UoB.
From: 2007.
End of the project: 2017.

Prosjektleader: Bjørn Bjorvatn.
Title: Prevalence of sleep apnea, insomnia and sleepiness in the Norwegian population.
Institution: UoB.
From: 2010.
End of the project: 2012.