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James B. Lorens

Professor
  • E-mailJim.Lorens@uib.no
  • Phone+47 55 58 67 76+47 975 57 112
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Ferreira, Bibiana I.; Lie, Maria Kolnes; Svendsen, Agnete; Machado, Susana; Link, Wolfgang; Lorens, James. 2017. Adaptive mechanisms of resistance to anti-neoplastic agents. MedChemComm. 8: 53-66. doi: 10.1039/c6md00394j
  • Hodneland Nilsson, Linn Iren; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie; Micklem, David Robert; Dale, Hege Avsnes; Røsland, Gro Vatne; Lorens, James; Tronstad, Karl Johan. 2016. Corrigendum: A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports. doi: 10.1038/srep30527
  • Hellesøy, Monica; Lorens, James. 2015. Cellular context-mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis. Molecular Biology of the Cell. 26: 2698-2711. doi: 10.1091/mbc.E14-09-1378
  • Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie; Micklem, David Robert; Dale, Hege Avsnes; Røsland, Gro Vatne; Lorens, James; Tronstad, Karl Johan. 2015. A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports. 5:17217. doi: 10.1038/srep17217
  • Kirane, Amanda; Ludwig, Kathleen F.; Sorrelle, Noah; Haaland, Gry Sandvik; Sandal, Tone; Ranaweera, Renate; Toombs, Jason E.; Wang, Miao; Dineen, Sean P.; Micklem, David Robert; Dellinger, Michael T.; Lorens, James; Brekken, Rolf A. 2015. Warfarin blocks Gas6-mediated Axl activation required for pancreatic cancer epithelial plasticity and metastasis. Cancer Research. 75: 3699-3705. doi: 10.1158/0008-5472.CAN-14-2887-T
  • Lorens, James. 2015. The immortality two-step. Cell Cycle. 14. 798 pages. doi: 10.1080/15384101.2015.1006560
  • Ocal, Ozhan; Pashkov, Victor; Kollipara, Rahul K.; Zolghadri, Yalda; Cruz, Victoria H.; Hale, Michael A.; Heath, Blake R.; Artyukhin, Alex B.; Christie, Alana L.; Tsoulfas, Pantelis; Lorens, James; Swift, Galvin H.; Brekken, Rolf A.; Wilkie, Thomas M. 2015. A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics. Disease Models and Mechanisms. 8: 1201-1211. doi: 10.1242/dmm.020933
  • Virtakoivu, Reetta; Mai, Anja; Mattila, Elina; de Franceschi, Nicola; Imanishi, Susumu Y.; Corthals, Garry; Kaukonen, Riina; Saari, Markku; Cheng, Fang; Torvaldson, Elin; Kosma, Veli-Matti; Mannermaa, Arto; Muharram, Ghaffar; Gilles, Christine; Eriksson, John; Soini, Ylermi; Lorens, James; Ivaska, Johanna. 2015. Vimentin-ERK signaling uncouples slug gene regulatory function. Cancer Research. 75: 2349-2362. doi: 10.1158/0008-5472.CAN-14-2842
  • Ellensen, Vegard Skalstad; Abrahamsen, Iren; Lorens, James; Jonung, Torbjörn. 2014. Auswirkungen von enoxaparin und dalteparin auf die proliferation und migration humaner vaskulärer glatter muskelzellen aus einem patientenkollektiv. VASA. 43: 124-131. doi: 10.1024/0301-1526/a000338
  • Ellensen, Vegard Skalstad; Abrahamsen, Iren; Lorens, James; Jonung, Torbjörn. 2014. Effects of enoxaparin and dalteparin on proliferation and migration of patient-derived vascular smooth muscle cells. VASA. 43: 124-131. doi: 10.1024/0301-1526/a000338
  • Hellesøy, Monica; Blois, Anna; Tiron, Crina Elena; Mannelqvist, Monica; Akslen, Lars A.; Lorens, James. 2014. Akt1 activity regulates vessel maturation in a tissue engineering model of angiogenesis. Tissue Engineering. Part A. 20: 2590-2603. doi: 10.1089/ten.tea.2013.0399
  • Kvestad, Hilde; Evensen, Lasse; Lorens, James; Bruserud, Øystein; Hatfield, Kimberley Joanne. 2014. In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia: Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells. Leukemia Research and Treatment. 2014. doi: 10.1155/2014/143479
  • LaBarge, Mark A.; Parvin, Bahram; Lorens, James. 2014. Molecular deconstruction, detection, and computational prediction of microenvironment-modulated cellular responses to cancer therapeutics. Advanced Drug Delivery Reviews. 69-70: 123-131. doi: 10.1016/j.addr.2014.02.009
  • Micklem, David Robert; Blø, Magnus; Bergström, Petra; Hodneland, Erlend; Tiron, Crina Elena; Høiby, Torill; Gjerdrum, Christine; Hammarsten, Ola; Lorens, James. 2014. Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets. BMC Biotechnology. 14:57. doi: 10.1186/1472-6750-14-57
  • Nikolaisen, Julie; Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke; Willems, Peter H.G.M.; Lorens, James; Koopman, Werner J.H.; Tronstad, Karl Johan. 2014. Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties. PLoS ONE. 9. doi: 10.1371/journal.pone.0101365
  • Pedersen, Torbjørn Østvik; Blois, Anna; Xue, Ying; Xing, Zhe; Sun, Yang; Finne-Wistrand, Anna; Lorens, James; Fristad, Inge; Leknes, Knut N.; Mustafa, Kamal Babikeir Eln. 2014. Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation. Stem Cell Research & Therapy. 5. doi: 10.1186/scrt412
  • Pelissier, Fanny; Garbe, James C.; Ananthanarayanan, Badriprasad; Miyano, Masaru; Lin, ChunHan; Jokela, Tiina; Kumar, Sanjay; Stampfer, Martha R.; Lorens, James; LaBarge, Mark A. 2014. Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors. Cell reports. 7: 1926-1939. doi: 10.1016/j.celrep.2014.05.021
  • Abrahamsen, Iren; Lorens, James. 2013. Evaluating extracellular matrix influence on adherent cell signaling by cold trypsin phosphorylation-specific flow cytometry. BMC Cell Biology. 14. 7 pages. doi: 10.1186/1471-2121-14-36
  • Ben Batalla, I; Schultze, A; Wroblewski, Mark; Erdmann, R; Heuser, M; Riecken, Kristoffer; Binder, M; Cubas-Cordova, M; Janning, M; Wellbrock, J; Fehse, B; Hagel, C; Krauter, J; Ganser, A; Lorens, James; Fiedler, W; Carmeliet, P; Pantel, K; Bokemeyer, C; Loges, S. 2013. Axl, a therapeutic target in AML mediates stroma-induced chemoresistance. Onkologie (Basel). 36: 44-44.
  • Ben-Batalla, Isabel; Schultze, Alexander; Wroblewski, Mark; Erdmann, Robert; Heuser, Michael; Waizenegger, Jonas S.; Riecken, Kristoffer; Binder, Mascha; Schewe, Denis; Sawall, Stefanie; Witzke, Victoria; Cubas-Cordova, Miguel; Janning, Melanie; Wellbrock, Jasmin; Fehse, Boris; Hagel, Christian; Krauter, Jürgen; Ganser, Arnold; Lorens, James; Fiedler, Walter; Carmeliet, Peter; Pantel, Klaus; Bokemeyer, Carsten; Loges, Sonja. 2013. Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma. Blood. 122: 2443-2452. doi: 10.1182/blood-2013-03-491431
  • Evensen, Lasse; Odlo, Kristin; Micklem, David Robert; Littlewood-Evans, Amanda; Wood, Jeanette; Kuzniewski, Christian; Altmann, Karl-Heinz; Hansen, Trond Vidar; Lorens, James. 2013. Contextual compound screening for improved therapeutic discovery. ChemBioChem (Print). 14: 2512-2518. doi: 10.1002/cbic.201300409
  • Kirane, Amanda R.; Dellinger, Michael T.; Toombs, Jason E.; Schwarz, Roderich E.; Lorens, James; Brekken, Rolf A. 2013. Warfarin blocks Gas6-mediated Axl activation required for pancreatic tumor EMT and metastasis. Annals of Surgical Oncology. 20: S133-S133.
  • McCormack, Emmet; Silden, Elisabeth; West, Richard M.; Pavlin, Tina; Micklem, David Robert; Lorens, James; Haug, Bengt Erik; Cooper, Michael E.; Gjertsen, Bjørn Tore. 2013. Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. Cancer Research. 74: 1276-1286. doi: 10.1158/0008-5472.CAN-12-2649
  • Olsen, Jan Roger; Øyan, Anne Margrete; Rostad, Kari; Hellem, Margrete Reime; Liu, Jie; Li, Lisha; Micklem, David Robert; Haugen, Hallvard; Lorens, James; Rotter, Varda; Ke, Xisong; Lin, Biaoyang; Kalland, Karl-Henning. 2013. p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS ONE. 8. 12 pages. doi: 10.1371/journal.pone.0062547
  • Pedersen, Torbjørn Østvik; Blois, Anna; Xing, Zhe; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Akslen, Lars A.; Lorens, James; Leknes, Knut N.; Fristad, Inge; Mustafa, Kamal Babikeir Eln. 2013. Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs. Stem Cell Research & Therapy. 4. 10 pages. doi: 10.1186/scrt202
  • Raddum, Aase Merethe; Evensen, Lasse; Hollås, Hanne; Grindheim, Ann Kari; Lorens, James; Vedeler, Anni. 2013. Domains I and IV of annexin A2 affect the formation and integrity of in vitro capillary-like networks. PLoS ONE. 8. 12 pages. doi: 10.1371/journal.pone.0060281
  • Christodoulou, Michael S; Zunino, Franco; Zuco, Valentina; Borrelli, Stella; Comi, Daniella; Fontana, Gabriele; Martinelli, Marisa; Lorens, James; Evensen, Lasse; Sironi, Maurizio; Pieraccini, Stefano; Dalla Via, Lisa; Gia, Ornella Maria; Passarella, Daniele. 2012. Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation. ChemMedChem. 7: 2134-2143. doi: 10.1002/cmdc.201200322
  • Hatfield, Kimberley Joanne; Evensen, Lasse; Reikvam, Håkon; Lorens, James; Bruserud, Øystein. 2012. Soluble mediators released by acute myeloid leukemia cells increase capillary-like networks. European Journal of Haematology. 89: 478-490. doi: 10.1111/ejh.12016
  • McCormack, Emmet Martin; Haaland, Ingvild; Venås, Gurid; Forthun, Rakel Brendsdal; Huseby, Sjur; Gausdal, Gro; Knappskog, Stian; Micklem, David Robert; Lorens, James; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2012. Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. Leukemia. 26: 910-917. doi: 10.1038/leu.2011.315
  • Oveland, Eystein; Wergeland, Line; Hovland, Randi; Lorens, James; Gjertsen, Bjørn Tore; Fladmark, Kari Espolin. 2012. Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. Cell Biology and Toxicology. 28: 201-212. doi: 10.1007/s10565-012-9216-z
  • Pedersen, Torbjørn; Blois, Anna; Xue, Ying; Xing, Zhe; Cottler-Fox, Michele; Fristad, Inge; Leknes, Knut N.; Lorens, James; Mustafa, Kamal Babikeir Eln. 2012. Osteogenic stimulatory conditions enhance growth and maturation of endothelial cell microvascular networks in culture with mesenchymal stem cells. Journal of Tissue Engineering. 3. doi: 10.1177/2041731412443236
  • Radi, Marco; Evensen, Lasse; Dreassi, Elena; Zamperini, Claudio; Caporicci, Marialessandra; Falchi, Federico; Musumeci, Francesca; Schenone, Silvia; Lorens, James; Botta, Maurizio. 2012. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation. Bioorganic & Medicinal Chemistry Letters. 22: 5579-5583. doi: 10.1016/j.bmcl.2012.07.014
  • Sapkota, Dipak; Costea, Daniela Elena; Blø, Magnus; Bruland, Ove; Lorens, James B.; Vasstrand, Endre N.; Ibrahim, Salah Osman. 2012. S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. Oral Oncology. 48: 219-225. doi: 10.1016/j.oraloncology.2011.10.001
  • Hegen, Anja; Blois, Anna; Tiron, Crina Elena; Hellesøy, Monica; Micklem, David Robert; Nör, Jacques E; Akslen, Lars A.; Lorens, James. 2011. Efficient in vivo vascularization of tissue-engineering scaffolds. Journal of Tissue Engineering and Regenerative Medicine. 5: E52-E62. doi: 10.1002/term.336
  • Napolitano, Carmela; Natoni, Alessandro; Santocanale, Corrado; Evensen, Lasse; Lorens, James; Murphy, Paul V. 2011. Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 21: 1167-1170. doi: 10.1016/j.bmcl.2010.12.100
  • Tiron, Crina Elena; Gjerdrum, Christine; Høiby, Torill; Maugen, Hallvard; Stefansson, Ingunn Marie; Sandal, Tone; Collett, Karin; Li, Shan; McCormack, Emmet Martin; Gjertsen, Bjørn Tore; Micklem, David Robert; Akslen, Lars A.; Glackin, Carlotta A.; Lorens, James. 2011. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Clinical and Experimental Metastasis. 28: 234-235.
  • Vuoriluoto, Karoliina; Haugen, Hallvard; Kiviluoto, Santeri; Mpindi, John-Patrick; Nevo, Jonna; Gjerdrum, Christine; Tiron, Crina Elena; Lorens, James; Ivaska, Johanna. 2011. Vimentin regulates EMT induction by Slug and oncogenic H-ras and migration by governing Axl expression in breast cancer. Oncogene. 30: 1436-1448. doi: 10.1038/onc.2010.509
  • Wang, Jian; Daphu, Inderjit Kaur; Pedersen, Paal-Henning; Miletic, Hrvoje; Hovland, Randi; Mørk, Sverre; Bjerkvig, Rolf; Tiron, Crina Elena; McCormack, Emmet Martin; Micklem, David Robert; Lorens, James; Immervoll, Heike; Thorsen, Frits Alan. 2011. A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. Neuropathology and Applied Neurobiology. 37: 189-205. doi: 10.1111/j.1365-2990.2010.01119.x
  • Evensen, Lasse; Link, Wolfgang; Lorens, James. 2010. Image-based high-throughput screening for anti-angiogenic drug discovery. Current pharmaceutical design. 16: 3958-3963. doi: 10.2174/138161210794455030
  • Evensen, Lasse; Micklem, David Robert; Link, Wolfgang; Lorens, James. 2010. A novel imaging-based high-throughput screening approach to anti-angiogenic drug discovery. Cytometry. 77A: 41-51. doi: 10.1002/cyto.a.20808
  • Gjerdrum, Christine; Tiron, Crina Elena; Høiby, Torill; Stefansson, Ingunn Marie; Haugen, Hallvard; Sandal, Tone; Collett, Karin; Li, Shan; McCormack, Emmet Martin; Gjertsen, Bjørn Tore; Micklem, David Robert; Akslen, Lars A.; Glackin, Carlotta A.; Lorens, James. 2010. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proceedings of the National Academy of Sciences of the United States of America. 107: 1124-1129. doi: 10.1073/pnas.0909333107
  • Napolitano, Carmela; Natoni, Alessandro; Santocanale, Corrado; Evensen, Lasse; Lorens, James; Murphy, Paul V. 2010. Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcyclic acid lactone series and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 21: 1167-1170. doi: 10.1016/j.bmcl.2010.12.100
  • Riva, Elena; Comi, Daniella; Borrelli, Stella; Colombo, Francesco; Danieli, Bruno; Borlak, Jurgen; Evensen, Lasse; Lorens, James; Fontana, Gabriele; Gia, Ornella Maria; Via, Lisa Dalla; Passarella, Daniele. 2010. Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20. Bioorganic & Medicinal Chemistry. 18: 8660-8668. doi: 10.1016/j.bmc.2010.09.069
  • Zanella, Fabian; Lorens, James; Link, Wolfgang. 2010. High content screening: seeing is believing. Trends in Biotechnology. 28: 237-245. doi: 10.1016/j.tibtech.2010.02.005
  • Evensen, Lasse; Micklem, David Robert; Blois, Anna; Berge, Sissel Vik; Aarsaether, Niels; Littlewood-Evans, A; Wood, J.; Lorens, James. 2009. Mural cell associated VEGF is required for organotypic vessel formation. PLoS ONE. 4. doi: 10.1371/journal.pone.0005798
  • Evensen, Lasse; Micklem, David Robert; Link, W; Lorens, James. 2009. A novel imaging-based high-throughput screening approach to anti-angiogenic drug discovery. Cytometry Part A. 77: 41-51.
  • Gjerdrum, Christine; Tiron, Crina Elena; Haugen, Hallvard; Berge, Sissel Vik; Micklem, D; Høiby, Torill; Holland, S; Hitoshi, Y; Bruserud, O; Glackin, Carlotta A.; Lorens, James. 2009. The receptor tyrosine kinase Axl controls breast carcinoma cell invasiveness and tumor formation by regulating E-cadherin. Clinical and Experimental Metastasis. 26: 863-863.
  • Parlati, F; Lee, S; Aujay, M; Levitsky, K; Lorens, James; Lu, Yan; Micklem, David Robert; Rurrs, P; Shenk, K; Sun, Chenping; Suzuki, E; Sylvain, C; Bennett, Mark K. 2009. CARFILZOMIB: A SELECTIVE INHIBITOR OF THE CHYMOTRYPSIN-LIKE ACTIVITY OF THE CONSTITUTIVE PROTESOME AND IMMUNOPROTEASOME HAS ANTI-TUMOR ACTIVITY ON MULTIPLE MYELOMA, LYMPHOMA AND LEUKEMIA CELLS WITH MINIMAL EFFECTS ON NORMAL CELLS. Haematologica. 94: 148-149.
  • Parlati, Francesco; Lee, Susan J.; Aujay, Monette; Suzuki, Erika; Levitsky, Konstantin; Lorens, James; Micklem, David Robert; Ruurs, Paulina; Sylvain, Catherine; Lu, Yan; Shenk, Kevin D.; Bennett, Mark K. 2009. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood. 114: 3439-3447. doi: 10.1182/blood-2009-05-223677
  • Blø, Magnus; Micklem, David Robert; Lorens, James. 2008. Enhanced gene expression from retroviral vectors. BMC Biotechnology. 8. 6 pages. doi: 10.1186/1472-6750-8-19
  • Myklebust, Line Merethe; Bjørndal, Bodil; Rosendal, Ken Roger; Myromslien, Frøydis Deinboll; Lorens, James; Nolan, Gary; Bruland, Ove; Lillehaug, Johan. 2008. The scaffold protein RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells. The FEBS Journal. 275: 315-315.
  • Bjørndal, Bodil; Myklebust, Line Merethe; Rosendal, Ken Roger; Myromslien, Frøydis Deinboll; Lorens, James; Nolan, Gary P; Bruland, Ove; Lillehaug, Johan. 2007. RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells. International Journal of Cancer. 120: 961-969. doi: 10.1002/ijc.22373
  • Blø, Magnus; Bogenberger, Jakob M.; Swift, Susan E.; Micklem, David Robert; Lorens, James. 2007. Expanding the spectrum of genetic elements transferable by retroviral vectors. DNA and Cell Biology. 26: 773-779. doi: 10.1089/dna.2007.0574
  • Blø, Magnus; Micklem, David Robert; Lorens, James. 2007. Target discovery using retroviruses. Expert Opinion on Drug Discovery. 2: 1285-1300.
  • McCormack, Emmet Martin; Micklem, David Robert; Pindard, Lars Erik; Silden, Elisabeth; Gallant, Pascal; Belenkov, Alexandre; Lorens, James; Gjertsen, Bjørn Tore. 2007. In vivo optical Imaging of acute myeloid leukemia by green fluorescent protein: Time-domain autofluorescence decoupling, fluorophore quantification, and localization. Molecular Imaging. 6: 193-204. doi: 10.2310/7290.2007.00016
  • Micklem, David Robert; Lorens, James. 2007. RNAi screening for therapeutic targets in human malignancies. Current Pharmaceutical Biotechnology. 8: 337-343. doi: 10.2174/138920107783018426
  • Parlati, Francesco; Aujay, Monette; Bedringaas, Siv Lise; Demo, Susan; Gjertsen, Bjørn Tore; Goldstein, Eileen; Jiang, Jing; Kirk, Christopher; Laidig, Guy; Lorens, James; Lu, Yan; Micklem, David Robert; Ruurs, Paulina; Shenk, Kevin; Sylvain, Catherine; Sun, Congcong; Woo, Tina; Zhou, Han-Jie; Bennett, Mark. 2007. Anti-tumor activity of immunoproteasome selective inhibitors. Blood. 110: 477A-478A.
  • Skaftnesmo, Kai Ove; Prestegarden, Lars; Micklem, David Robert; Lorens, James. 2007. MicroRNAs in tumorigenesis. Current Pharmaceutical Biotechnology. 8: 320-325. doi: 10.2174/138920107783018390
  • Stapnes, Camilla I; Døskeland, Anne Paulus; Hatfield, Kimberley Joanne; Ersvær, Elisabeth; Ryningen, Anita; Lorens, James; Gjertsen, Bjørn Tore; Bruserud, Øystein. 2007. The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. British Journal of Haematology. 136: 814-828. doi: 10.1111/j.1365-2141.2007.06504.x
  • Hitoshi, Y; Demo, SD; Masuda, E; Payan, DG; Lorens, James. 2004. Isolation of Genetic Effectors using the Tetracycline-Regulatable System. Genomu Igaku : Genome Medicine. 4.
  • Lorens, James; Pearsall, DM; Swift, SE; Peelle, B; Armstrong, R; Demo, SD; Ferrick, DA; Hitoshi, Y; Payan, DG; Anderson, D. 2004. Stable, stoichiometric delivery of diverse protein functions. Journal of Biochemical and Biophysical Methods. 58: 101-110.
  • Oppen-Berntsen, Dag Oscar; Arukwe, Augustine; Yadetie, Fekadu; Lorens, James; Male, Rune. 1999. Salmon Eggshell Protein Expression: A Marker for Environmental Estrogens. Marine Biotechnology. 1: 252-260.
  • Oppen-Berntsen, Dag Oskar; Arukwe, Augustine; Yadetie, Fekadu; Lorens, James; Male, Rune. 1999. Salmon eggshell protein expression: A marker for environmental estrogens. Marine Biotechnology. 1: 252-260.
  • Amirthalingam, K.; Lorens, James; Sætre, B. O.; Salaneck, E.; Fjose, Anders. 1995. Embryonic expression and DNA-binding properties of zebrafish pax-6. Biochemical and Biophysical Research Communications - BBRC. 215: 122-128.
  • Lorens, James; Nerland, Audun H.; Aasland, Rein; Lossius, Ivar; Male, Rune. 1993. Expression of growth hormone genes in Atlantic salmon. Journal of Molecular Endocrinology. 11: 167-179.
  • Male, Rune; Lorens, James; Nerland, Audun H.; Slinde, E. 1993. Biotechnology in Aquaculture, with Special Reference to Transgenic Salmon. Biotechnology & Genetic Engineering Reviews. 11: 31-56.
  • Male, Rune; Nerland, Audun H.; Lorens, James; Telle, Wenche; Lossius, Ivar; Totland, Geir Kåre. 1992. The complete nucleotide sequence of the Atlantic salmon growth hormone I gene. Biochimica et Biophysica Acta. 1130: 345-348.
Reports and theses
  • Lorens, James. 1993. Molecular studies on the gene structure and expression of Atlantic salmon growth hormone. (dr.scient).
Book sections
  • Evensen, Lasse; Link, Wolfgang; Lorens, James. 2013. Image-based high-throughput screening for inhibitors of angiogenesis. -, pages 139-151. In:
    • Taatjes, Douglas J.; Roth, Jürgen. 2013. Cell Imaging Techniques. Springer Science+Business Media B.V.. ISBN: 978-1-62703-055-7.
  • Mora-Blanco, Lorena E.; Lorens, James; LaBarge, Mark A. 2013. The Tumor Microenvironment as a Transient Niche: A Modulator of Epigenetic States and Stem Cell Funct. -, pages 463-478. In:
    • Resende, Rodrigo R; Ulrich, Henning. 2013. Trends in Stem Cell Proliferation and Cancer Research2013, XVIII, 661 p. 77 illus., 58 illus. in color. Springer. ISBN: 978-94-007-6210-7.
  • Gjertsen, Bjørn Tore; Lorens, James. 2008. Comprehensive Analysis of Gene Function: RNA interference and Chemical Genomics. Kapittel 16, pages 193-205. In:
    • Willard, Huntington F.; Ginsburg, Geoffrey S. 2008. Genomic and personalized medicine. Academic Press. 1478 pages. ISBN: 978-0-12-369420-1.
  • Lossius, Ivar; Kryvi, Harald; Lorens, James; Male, Rune; Nerland, Audun H.; Olsen, L.; Telle, Wenche; Totland, Geir Kåre; Aasland, Rein. 1993. Cloning and characterization of growth regulating genes from Atlantic salmon: A strategy for increasing growth rate by microinjection of a modified growth hormone gene into fertilized salmon eggs. 40-46. In:
    • [Mangler etternavn], [Mangler fornavn]. 1993. Physiol and Biochem of Marine Fish Larvae. (Red.: Walther, B. T., Fyhn, H. J.).

More information in national current research information system (CRIStin)

A full bibliography is available here

Prof. Lorens completed undergraduate studies at Carleton College (USA) and University of Bergen (UiB), and graduate studies in chemistry (MS) and molecular biology (PhD) at UiB in 1993. He did postdoctoral work with Prof. Garry Nolan at Stanford University studying tumor and immune cell apoptosis mechanisms, before joining Rigel Pharmaceuticals in 1997. As one of the first scientists at Rigel, Prof. Lorens led technology development and was later Director of Oncology R&D. He returned to UiB as a Professor in the Medical Faculty, starting his academic laboratory in the Dept. Biomedicine in 2004 to focus on cancer research. Prof. Lorens founded BerGenBio AS in 2008 to facilitate clinical translation of his group’s pioneering research on the Axl receptor tyrosine kinase. He continues to serve as Chief Scientific Officer. BerGenBio’s Axl inhibitor (BGB324) is currently in Phase I/II clinical trials to treat cancer.

In addition to his university research, teaching and supervisory activities, Prof. Lorens serves on the Editorial Board of Cancer Research and is an Affiliate at Lawrence Berkeley National Laboratory (USA). He has held several research administration and scientific advisory positions, including a current appointment to the board of the Research Council Division of Innovation. He has received several awards recognizing his achievements in innovation and holds several patents. A full bibliography is available here

Research groups