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Karl Johan Tronstad's picture

Karl Johan Tronstad

Professor
  • E-mailKarl.Tronstad@uib.no
  • Phone+47 55 58 64 33
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen

For an updated publication list see Pubmed.

(The links below may not be completely updated)

Journal articles
  • Lindquist, Carine; Bjørndal, Bodil; Rossmann, Christine Renate; Tusubira, Deusdedit; Svardal, Asbjørn M.; Røsland, Gro Vatne; Tronstad, Karl Johan; Hallstrõm, Seth; Berge, Rolf Kristian. 2017. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. Journal of Lipid Research. 58: 1362-1373. doi: 10.1194/jlr.M074849
  • Chang, Jui-Chih; Wu, Shey-Lin; Hoel, Fredrik; Cheng, Yu-Shan; Liu, Ko-Hung; Hsieh, Mingli; Hoel, August; Tronstad, Karl Johan; Yan, Kuo-Chia; Hsieh, Ching-Liang; Lin, Wei-Yong; Kuo, Shou-Jen; Su, Shih-Li; Liu, Chin-San. 2016. Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function. Scientific Reports. 6:30436. doi: 10.1038/srep30436
  • Fluge, Øystein; Mella, Olav; Bruland, Ove; Risa, Kristin; Dyrstad, Sissel Elisabeth; Alme, Kine; Rekeland, Ingrid Gurvin; Sapkota, Dipak; Røsland, Gro Vatne; Fosså, Alexander; Ktoridou-Valen, Irini; Lunde, Sigrid; Sørland, Kari; Lien, Katarina; Herder, Ingrid; Thurmer, Hanne; Gotaas, Merete E; Baranowska, Katarzyna Anna; Bohnen, Louis M.L.J.; Schäfer, Christoph; Mccann, Adrian; Sommerfelt, Kristian; Helgeland, Lars; Ueland, Per Magne; Dahl, Olav; Tronstad, Karl Johan. 2016. Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. JCI Insight. 1. doi: 10.1172/jci.insight.89376
  • Hodneland Nilsson, Linn Iren; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie; Micklem, David Robert; Dale, Hege Avsnes; Røsland, Gro Vatne; Lorens, James; Tronstad, Karl Johan. 2016. Corrigendum: A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports. doi: 10.1038/srep30527
  • Talasila, Krishna Mukharji; Røsland, Gro Vatne; Hagland, Hanne Røland; Eskilsson, Eskil; Flønes, Irene Hana; Fritah, Sabrina; Azuaje, Francisco; Atai, Nadia A; Harter, Patrick N.; Mittelbronn, Michel; Vareecal Joseph, Justin; Hossain, Jubayer; Vallar, Laurent; van Noorden, Cornelis J.F.; Niclou, Simone Pierrette; Thorsen, Frits; Tronstad, Karl Johan; Tzoulis, Charalampos; Bjerkvig, Rolf; Miletic, Hrvoje; Andersen, Michael Borenste. 2016. The angiogenic switch leads to a metabolic shift in human glioblastoma. Neuro-Oncology. 19: 383-393. doi: 10.1093/neuonc/now175
  • Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie; Micklem, David Robert; Dale, Hege Avsnes; Røsland, Gro Vatne; Lorens, James; Tronstad, Karl Johan. 2015. A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports. 5:17217. doi: 10.1038/srep17217
  • Van Linden, Magali R; Dölle, Christian; Pettersen, Ina Katrine Nitschke; Kulikova, Veronika; Niere, Marc; Agrimi, Gennaro; Dyrstad, Sissel Elisabeth; Palmieri, Ferdinando; Nikiforov, Andrey; Tronstad, Karl Johan; Ziegler, Mathias. 2015. Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. Journal of Biological Chemistry. 290: 27644-27659. Published 2015-11-13. doi: 10.1074/jbc.M115.654129
  • Nikolaisen, Julie; Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke; Willems, Peter H.G.M.; Lorens, James; Koopman, Werner J.H.; Tronstad, Karl Johan. 2014. Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties. PLoS ONE. 9. doi: 10.1371/journal.pone.0101365
  • Tronstad, Karl Johan; Nooteboom, Marco; Hodneland, Linn I.; Nikolaisen, Julie; Sokolewicz, Maciek; Grefte, Sander; Pettersen, Ina Katrine Nitschke; Dyrstad, Sissel Elisabeth; Hoel, Fredrik; Willems, Peter H.G.M.; Koopman, Werner J.H. 2014. Regulation and quantification of cellular mitochondrial morphology and content. Current pharmaceutical design. 20: 5634-5652. doi: 10.2174/1381612820666140305230546#sthash.ysSUnETy.dpuf
  • Hagland, Hanne; Hodneland, Linn I.; Burri, Lena; Nikolaisen, Julie; Berge, Rolf Kristian; Tronstad, Karl Johan. 2013. Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA). Biochemical and Biophysical Research Communications - BBRC. 430: 573-578. doi: 10.1016/j.bbrc.2012.11.111
  • Nilsson, L I H; Nikolaisen, Julie; Hagland, Hanne; Tronstad, Karl Johan. 2012. A mitochondrial reporter system for studies on NRF-1/AMPK activity and regulation in viable cells. Biochimica et Biophysica Acta - Bioenergetics. 1817: S70-S70. doi: 10.1016/j.bbabio.2012.06.197
  • Svendsen, Agnete; Verhoeff, Joost JC; Immervoll, Heike; Brøgger, Jan C; Kmiecik, Justyna; Poli, Aurélie; Netland, Inger Anne; Prestegarden, Lars; Planaguma, Jesus; Torsvik, Anja; Kjersem, Anneli Bohne; Sakariassen, Per Øystein; Heggdal, Jan Ingemann; van Furth, Wouter R; Bjerkvig, Rolf; Lund-Johansen, Morten; Enger, Per Øyvind; Felsberg, Joerg; Brons, Nicolas H.C.; Tronstad, Karl Johan; Waha, Andreas; Chekenya, Martha. 2011. Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathologica. 122: 495-510. doi: 10.1007/s00401-011-0867-2
  • Chekenya, Martha; Netland, Inger Anne; Verhoeff, Joost JC; Svendsen, Agnete; Brøgger, Jan; Immervoll, Heike; Planaguma, Jesus; Kjersem, Anneli Bohne; Sakariassen, Per Øystein; Bjerkvig, Rolf; Heggedal, JI; Enger, Per Øyvind; Tronstad, Karl Johan; van Furth, Wouter R. 2010. NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. Neuro-Oncology. 12: 8-8.
  • Erikstein, Bjarte Skoe; Hagland, Hanne; Nikolaisen, Julie; Kulawiec, Marion; Singh, Keshav K.; Gjertsen, Bjørn Tore; Tronstad, Karl Johan. 2010. Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment. Journal of Cellular Biochemistry. 111: 574-584. doi: 10.1002/jcb.22741
  • Erikstein, Bjarte Skoe; McCormack, Emmet Martin; Tronstad, Karl Johan; Schwede, Frank; Berge, Rolf Kristian; Gjertsen, Bjørn Tore. 2010. Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB. Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. 34: 77-84. doi: 10.1016/j.leukres.2009.09.005
  • Foss, Brynjar; Tronstad, Karl Johan; Bruserud, Øystein. 2010. Connexin-based signaling in acute myelogenous leukemia (AML). Biochimica et Biophysica Acta - Biomembranes. 1798: 1-8. doi: 10.1016/j.bbamem.2009.10.014
  • Bredholt, Therese; Dimba, Elisabeth Anne Okumu; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell O.; Tronstad, Karl Johan; Johannessen, Anne Chr.; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore. 2009. Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Molecular Cancer. 8. doi: 10.1186/1476-4598-8-101
  • Moen, Ingrid; Tronstad, Karl Johan; Kolmannskog, Odd; Salvesen, Gerd Signe; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug. 2009. Hyperoxia increases the uptake of 5-FU in mammary tumors independently of cganges in interstitial pressure and tumor stroma. BMC Cancer. 17. doi: 10.1186/1471-2407-9-446
  • Moen, Ingrid; Øyan, Anne Margrete; Kalland, Karl-Henning; Tronstad, Karl Johan; Akslen, Lars A.; Chekenya, Martha; Sakariassen, Per Øystein; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug. 2009. Hyperoxic treatment induces mesenchymal to epithelial transition in a rat adenocarcinoma model. PLoS ONE. 4. doi: 10.1371/journal.pone.0006381
  • Hagland, Hanne; Nikolaisen, Julie; Hodneland, Linn I.; Tronstad, Karl Johan. 2008. Mitochondrial function in cancer cell line models. Biochimica et Biophysica Acta - Bioenergetics. 1777: S41-S41. doi: 10.1016/j.bbabio.2008.05.164
  • Wergedahl, Hege; Berge, Kjetil; Bohov, Pavol; Tronstad, Karl Johan; Madsen, Lise; Berge, Rolf Kristian. 2008. Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats. Drug Metabolism Letters. 2: 138-145.
  • Erikstein, Bjarte Skoe; Tronstad, Karl Johan; McCormack, Emmet Martin; Schwede, Frank; Berge, Rolf Kristian; Gjertsen, Bjørn Tore. 2007. Synergistic anti-leukemic effect of protein kinase a activator and PPAR7agonist is independent of Bcl-2 status. Blood. 110: 117B-117B.
  • Hagland, Hanne; Nikolaisen, Julie; Hodneland, Linn Iren; Gjertsen, Bjørn Tore; Bruserud, Øystein; Tronstad, Karl Johan. 2007. Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. Expert opinion on therapeutic targets. 11: 1055-1069. doi: 10.1517/14728222.11.8.1055
  • Bruserud, Øystein; Stapnes, Camilla I; Tronstad, Karl Johan; Ryningen, Anita; Ånensen, Nina; Gjertsen, Bjørn Tore. 2006. Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML. Expert opinion on therapeutic targets. 10: 51-68. doi: 10.1517/14728222.10.1.51
  • Bruserud, Øystein; Tronstad, Karl Johan; McCormack, Emmet Martin; Gjertsen, Bjørn Tore. 2006. Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia? Cancer Immunology and Immunotherapy. 55: 221-228. doi: 10.1007/s00262-005-0032-7
  • Iversen, Per O.; Sørensen, Dag R.; Tronstad, Karl Johan; Gudbrandsen, Oddrun; Rustan, Arild C.; Berge, Rolf Kristian; Drevon, Christian A. 2006. A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia. Clinical Cancer Research. 12: 3525-3531. doi: 10.1158/1078-0432.CCR-05-2802
  • Berge, Rolf Kristian; Tronstad, Karl Johan; Berge, Kjetil; Røst, Therese Halvorsen; Wergedahl, Hege; Gudbrandsen, Oddrun Anita; Skorve, Jon Andreas. 2005. The metabolic syndrome and the hepatic fatty acid drainage hypothesis. Biochimie. 87: 15-20. doi: 10.1016/j.biochi.2004.11.011
  • Bruserud, Øystein; Tronstad, Karl Johan; Berge, Rolf Kristian. 2005. In vitro culture of human osteosarcoma cell lines: a comparison of functional characteristics for cell lines cultured in medium without and with fetal calf serum. Journal of Cancer Research and Clinical Oncology. 131: 377-384. doi: 10.1007/s00432-004-0650-z
  • Fernø, Johan; Ræder, Maria Therese Barøy; Vik-Mo, Audun Osland; Skrede, Silje; Glambek, Marte; Tronstad, Karl Johan; Breilid, Harald; Løvlie, Roger; Berge, Rolf Kristian; Stansberg, Christine; Steen, Vidar Martin. 2005. Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 5: 298-304.
  • Tronstad, Karl Johan; Berge, Rolf Kristian. 2004. Book review: Lipid Biochemistry - An Introduction, 5th edn., edited by Michael I. Gurr, John L Harwood and Keith N. Frayn. Blackwell Science Ltd., Oxford (UK) 2002. European Journal of Lipid Science and Technology. 106: 452-452.
  • Tronstad, Karl Johan; Berge, Kjetil; Dyrøy, Endre; Madsen, Lise; Berge, Rolf Kristian. 2001. Growth reduction in glioma cells after treatment with tetradecylthioacetic acid: changes in fatty acid metabolism and oxidative status. Biochemical Pharmacology. 61: 639-649.
  • Berge, Rolf Kristian; Madsen, Lise; Vaagenes, Hege; Tronstad, Karl Johan; Göttlicher, Martin; Rustan, Arild C. 1999. In contrast with docosahexaenoic acid, eicosapentaenoic acid and hypolipidaemic derivatives decrease hepatic synthesis and secretion of triacyllycerol by decreased diacylglycerol acyltransferase activity and stimulation of fatty acid oxidation. Biochemical Journal. 343: 191-197.
Reports and theses
  • Tronstad, Karl Johan. 1997. Proliferation of malignant rat glioma cells in reduced by the sulphur substituted fatty acid analogue tetradecylthioacetic acid; a stud on oxidative status (Cand. scient). [Mangler utgivernavn].

More information in national current research information system (CRIStin)