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Lars Herfindal's picture
  • E-mailLars.Herfindal@uib.no
  • Phone+47 55 97 46 28+47 974 03 493
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Nygaard, Gyrid; Herfindal, Lars; Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Oveland, Eystein; Berven, Frode; Myhren, Lene Elisabeth; Høivik, Erling Andre; Lunde, Turid Helen Felli; Bakke, Marit; Doskeland, Stein Ove; Selheim, Frode. 2017. Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 7. doi: 10.1038/s41598-017-08975-y
  • Viktorsson, Elvar Örn; Grøthe, Bendik Melling; Aesoy, Reidun; Sabir, Misbah; Snellingen, Simen; Prandina, Anthony; Åstrand, Ove Alexander Høgmoen; Bonge-Hansen, Tore; Doskeland, Stein Ove; Herfindal, Lars; Rongved, Pål. 2017. Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. 25: 2285-2293. doi: 10.1016/j.bmc.2017.02.058
  • Evensen, Lasse; Lie Johansen, Patrick; Koster, Gerbrand; Zhu, Kaizheng; Herfindal, Lars; Speth, Martin; Fenaroli, Federico; Hildahl, Jon Paul; Fam, Shahla Bagheri; Tulotta, Claudia; Prasmickaite, Lina; Mælandsmo, Gunhild; Snaar-Jagalska, Ewa; Griffiths, Gareth Wyn. 2016. Zebrafish as a model system for characterization of nanoparticles against cancer. Nanoscale. 8: 862-877. doi: 10.1039/c5nr07289a
  • Humisto, Anu; Herfindal, Lars; Jokela, Jouni; Karkman, Antti; Bjørnstad, Ronja; Choudhury, Romi Roy; Sivonen, Kaarina. 2016. Cyanobacteria as a source for novel anti-leukemic compounds. Current Pharmaceutical Biotechnology. 17: 78-91. doi: 10.2174/1389201016666150826121124
  • Sauvage, Félix; Barratt, Gillian; Herfindal, Lars; Vergnaud-Gauduchon, Juliette. 2016. The use of nanocarriers in acute myeloid leukaemia therapy: Challenges and current status. Current Pharmaceutical Biotechnology. 17: 30-41. doi: 10.2174/1389201016666150817095045
  • Selheim, Frode; Herfindal, Lars. 2016. Editorial: Toward Personalized Treatment for Acute Myeloid Leukemia. Current Pharmaceutical Biotechnology. 17: 4-5.
  • Selheim, Frode; Herfindal, Lars. 2016. Toward personalized treatment for acute myeloid leukemia. Current Pharmaceutical Biotechnology. 17: 4-5.
  • Vu, Marita Hoang Anh; Herfindal, Lars; Juvik, Ole-Johan; Vedeler, Anni; Haavik, Svein; Fossen, Torgils. 2016. Toxic aromatic compounds from fruits of Narthecium ossifragum L. Phytochemistry. 132: 76-85. doi: 10.1016/j.phytochem.2016.09.010
  • Bouaziz, Zouhair; Issa, Samar; Gentili, Jacques; Gratz, Andreas; Bollacke, Andre; Kassack, Matthias; Jose, Joachim; Herfindal, Lars; Gausdal, Gro; Doskeland, Stein Ove; Mullié, Catherine; Sonnet, Pascal; Desgrouas, Camille; Taudon, Nicolas; Valdameri, Glaucio; Di Pietro, Attilio; Baitiche, Milad; Le Borgne, Marc. 2015. Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of enzyme inhibition and medicinal chemistry (Print). 30: 180-188. doi: 10.3109/14756366.2014.899594
  • Giraud, Francis; Bourhis, Marion; Ebrahimi, Edris; Herfindal, Lars; Roy Choudhury, Romi; Bjørnstad, Ronja; Doskeland, Stein Ove; Anizon, Fabrice; Moreau, Pascale. 2015. Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry. 23: 7313-7323. doi: 10.1016/j.bmc.2015.10.031
  • Kleppe, Rune; Herfindal, Lars; Doskeland, Stein Ove. 2015. Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. Marine Drugs. 13: 6505-6520. doi: 10.3390/md13106505
  • Giraud, Francis; Bourhis, Marion; Nauton, Lionel; Théry, Vincent; Herfindal, Lars; Doskeland, Stein Ove; Anizon, Fabrice; Moreau, Pascale. 2014. New N-1,N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes: synthesis and biological activities. Bioorganic chemistry (Print). 57: 108-115. doi: 10.1016/j.bioorg.2014.09.004
  • Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth; Hagland, Hanne; Kopperud, Reidun Kristin; Teigen, Knut; Schwede, Frank; Kleppe, Rune; Doskeland, Stein Ove. 2014. Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLoS ONE. 9. doi: 10.1371/journal.pone.0094926
  • Liu, Liwei; Herfindal, Lars; Jokela, Jouni; Shishido, Tania Keiko; Wahlsten, Matti; Doskeland, Stein Ove; Sivonen, Kaarina. 2014. Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs. 12: 2036-2053. doi: 10.3390/md12042036
  • Liu, Liwei; Jokela, Jouni; Herfindal, Lars; Wahlsten, Matti; Sinkkonen, Jari; Permi, Perttu; Fewer, David P.; Doskeland, Stein Ove; Sivonen, Kaarina. 2014. 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology. 9: 2646-2655. doi: 10.1021/cb500436p
  • Myhren, Lene Elisabeth; Nilssen, Ida Mostrøm; Nicolas, Valérie; Doskeland, Stein Ove; Barratt, Gillian; Herfindal, Lars. 2014. Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia. European journal of pharmaceutics and biopharmaceutics. doi: 10.1016/j.ejpb.2014.04.002
  • Nygaard, Gyrid; Herfindal, Lars; Kopperud, Reidun Kristin; Aragay, Anna M.; Holmsen, Holm A; Doskeland, Stein Ove; Kleppe, Rune; Selheim, Frode. 2014. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 449: 357-363. doi: 10.1016/j.bbrc.2014.05.032
  • Prestegard, Siv Kristin; Knutsen, Gjert; Herfindal, Lars. 2014. Adenosine content and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): effect of salinity, light, temperature and nitrate. Diatom Research. 29: 361-369. doi: 10.1080/0269249X.2014.889040
  • Prestegard, Siv Kristin; Knutsen, Gjert; Herfindal, Lars. 2014. Adenosine content and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): effect of salinity, light, temperature and nitrate. Diatom Research. 29: 361-369. doi: 10.1080/0269249X.2014.889040
  • Sletta, Håvard; Degnes, Kristin Fløgstad; Herfindal, Lars; Klinkenberg, Geir; Fjærvik, Espen; Zahlsen, Kolbjørn; Brunsvik, Anders; Nygaard, Gyrid; Aachmann, Finn Lillelund; Ellingsen, Trond Erling; Doskeland, Stein Ove; Zotchev, Sergey. 2014. Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 98: 603-610. doi: 10.1007/s00253-013-5320-0
  • Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frederic; ROUHEE, NAZANIN; McCormack, Emmet; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Doskeland, Stein Ove. 2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease. 4. doi: 10.1038/cddis.2013.39
  • Herfindal, Lars; Myhren, Lene Elisabeth; Gjertsen, Bjørn Tore; Doskeland, Stein Ove; Gausdal, Gro. 2013. Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer. 13. doi: 10.1186/1471-2407-13-341
  • Herfindal, Lars; Nygaard, Gyrid; Kopperud, Reidun Kristin; Krakstad, Camilla; Doskeland, Stein Ove; Selheim, Frode. 2013. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 437: 603-608. doi: 10.1016/j.bbrc.2013.07.007
  • Myhren, Lene Elisabeth; Nilsen, IM; Nicolas, Valerie; Doskeland, Stein Ove; Barratt, Gillian; Herfindal, Lars. 2013. Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect. The FEBS Journal. 280: 322-322.
  • Myhren, Lene Elisabeth; Nygaard, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Doskeland, Stein Ove; Selheim, Frode; Herfindal, Lars. 2013. Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 11: 332-349. Published 2013-01-30. doi: 10.3390/md11020332
  • Herfindal, Lars; Nilssen, Ida Mostrøm; Milankovic, Silje. 2012. Nanokolloidar som verkty for å betra distribusjon av legemiddel. Naturen. 3: 103-110.
  • Jokela, Jouni; Oftedal, Linn Silje Wathne; Herfindal, Lars; Permi, Perttu; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina. 2012. Anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria. PLoS ONE. 7. doi: 10.1371/journal.pone.0041222
  • Oftedal, Linn Silje Wathne; Myhren, Lene Elisabeth; Jokela, Jouni; Gausdal, Gro; Sivonen, Kaarina; Doskeland, Stein Ove; Herfindal, Lars. 2012. The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochimica et Biophysica Acta - Biomembranes. 1818: 3000-3009. doi: 10.1016/j.bbamem.2012.07.015
  • Herfindal, Lars; Myhren, Lene Elisabeth; Kleppe, Rune; Krakstad, Camilla; Selheim, Frode; Jokela, Jouni; Sivonen, Kaarina; Doskeland, Stein Ove. 2011. Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 8: 360-367. doi: 10.1021/mp1002224
  • Oftedal, Linn Silje Wathne; Skjærven, Kaja Helvik; Coyne, Rosie Theresa; Edvardsen, Bente; Rohrlack, Thomas; Skulberg, Olav; Doskeland, Stein Ove; Herfindal, Lars. 2011. The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. Journal of Industrial Microbiology & Biotechnology. 38: 489-501. doi: 10.1007/s10295-010-0791-9
  • Jokela, Jouni; Herfindal, Lars; Wahlsten, Matti; Permi, Perttu; Selheim, Frode; Vasconçelos, Vitor M.; Doskeland, Stein Ove; Sivonen, Kaarina. 2010. A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. ChemBioChem (Print). 11: 1594-1599. doi: 10.1002/cbic.201000179
  • Oftedal, Linn Silje Wathne; Selheim, Frode; Wahlsten, Matti; Sivonen, Kaarina; Doskeland, Stein Ove; Herfindal, Lars. 2010. Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 8: 2659-2672. doi: 10.3390/md8102659
  • Herfindal, Lars; Kasprzykowski, Franciszek; Schwede, Frank; Lankiewicz, Leszek; Fladmark, Kari Espolin; Lukomska, Joanna; Wahlsten, Matti; Sivonen, Kaarina; Grzonka, Zbigniew; Jastorff, Bernd; Doskeland, Stein Ove. 2009. Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 52: 5758-5762. doi: 10.1021/jm900502e
  • Jørgensen, Hanne; Degnes, Kristin; Sletta, Håvard; Fjærvik, Espen; Dikiy, Alexander; Dikiy, Alexander; Herfindal, Lars; Bruheim, Per; Klinkenberg, Geir; Bredholt, Harald; Nygård, Gyrid; Doskeland, Stein Ove; Ellingsen, Trond E.; Zotchev, Sergey B. 2009. Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 16: 1109-1121. doi: 10.1016/j.chembiol.2009.09.014
  • Prestegard, Siv Kristin; Oftedal, Linn Silje Wathne; Coyne, Rosie Theresa; Nygård, Gyrid; Skjærven, Kaja Helvik; Knutsen, Gjert; Doskeland, Stein Ove; Herfindal, Lars. 2009. Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 7: 605-623. doi: 10.3390/md7040605
  • Jokela, J; Matti, W; Herfindal, Lars; Fewer, D; Rouhiainen, L; Oksanen, I; Halinen, K; Sivonen, K. 2008. Bioactive peptides from cyanobacteria. Journal of Peptide Science. 14: 93-93.
  • Martins, Rosário F.; Ramos, Miguel F.; Herfindal, Lars; Sousa, José A.; Skjærven, Kaja Helvik; Vasconcelos, Vitor M. 2008. Antimicrobial and cytotoxic assessment of marine cyanobacteria - Synechocystis and synechococcus. Marine Drugs. 6: 1-11.
  • Herfindal, Lars; Selheim, Frode. 2006. Microcystin produces disparate effects on liver cells in a dose dependent manner. Mini-Reviews in medical chemistry. 6: 279-285. doi: 10.2174/138955706776073475
  • Krakstad, Camilla; Herfindal, Lars; Gjertsen, Bjørn Tore; Bøe, Roald; Vintermyr, Olav Karsten; Fladmark, Kari Espolin; Doskeland, Stein Ove. 2006. CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 13: 1191-1202. doi: 10.1038/sj.cdd.4401798
  • Herfindal, Lars; Selheim, Frode; Oftedal, Linn Silje Wathne; Wahlsten, Matti; Sivonen, Kaarina; Doskeland, Stein Ove. 2005. A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon. 46: 252-260. doi: 10.1016/j.toxicon.2005.04.005
  • Selheim, Frode; Herfindal, Lars; Martins, Rosario; Vasconcelos, Vitor; Doskeland, Stein Ove. 2005. Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicology. 74: 294-306. doi: 10.1016/j.aquatox.2005.06.005
  • Prestegard, Siv Kristin; Herfindal, Lars. 2004. Havet som apotek. Naturen. 1. 15-24.
  • Bruserud, Øystein; Glenjen, Nils; Gjertsen, Bjørn Tore; Herfindal, Lars; Døskeland, Stein Ove. 2002. Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Expert Opinion on Biological Therapy. 2: 197-210.
  • Selheim, Frode; Herfindal, Lars; Knutsen, Gjert; Holmsen, Holm; Døskeland, Stein Ove. 2001. Alterations in platelet phospholipid metabolism by substances from a marine microalgae. Chemistry and Physics of Lipids. 110: 139-140.
  • Tonheim, Sigurd; Herfindal, Lars; Rønnestad, I. 2000. Anrikning av vannløselige komponenter i Artemia. Norsk Fiskeoppdrett. 7: 26-27.
Reports and theses
  • Herfindal, Lars. 2006. Apoptosis modulating and anti-thrombotic activities from marine micro-organisms.
  • Hagland, Hanne; Selheim, Frode; Keen, TJ; Skjærven, Kaja H; Christensen, Anne Elisabeth; Herfindal, Lars; Doskeland, Stein Ove. 2005. The cAMP Receptors Epac and PKA synergize to induce PC12 cell neuritogenesis and to protect against apoptosis. Medimond. 6 pages.
Book sections
  • Gausdal, Gro; Krakstad, Camilla; Herfindal, Lars; Doskeland, Stein Ove. 2007. Serine/Threonine Protein Phosphatases in Apoptosis. 7, pages 151-166. In:
    • Srivastava, Rakesh. 2007. Apoptosis, Cell Signaling, and Human Diseases Molecular Mechanisms, Volume 2. 402 pages. ISBN: 978-1-58829-882-9.

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