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Nils-Kåre Birkeland

Professor
  • E-mailNils.Birkeland@uib.no
  • Phone+47 55 58 26 57
  • Visitor Address
    Thormøhlensgt. 53 A/B
    Room: 
    3G20
  • Postal Address
    Postboks 7803
    5020 Bergen

My interests include environmental and molecular microbiology, and evolution and adaptations of prokaryotes. Current research activities involve thermophilic bacteria and archaea, metagenomics in extreme environments, extremophilic methane oxidition, and enteropathogenic bacteria in tropical fresh-waters. Present work aims at (1) identifying molecular adaptations to extreme temperatures using extremophilic microorganisms from a variety of environments, (2) enhance our understanding of the enourmous natural microbial diversity in extreme habitats, (3) elucidation of mechanisms and regulation of biological methane oxidation, (4) metagenomics, and (5) to obtain knowledge about the survival and evolution of Shigella-like bacteria. 

Journal articles
  • Islam, Tajul; Torsvik, Vigdis Lid; Larsen, Øivind; Bodrossy, Levente; Øvreås, Lise; Birkeland, Nils-Kåre. 2016. Acid-tolerant moderately thermophilic methanotrophs of the class Gammaproteobacteria isolated from tropical topsoil with methane seeps. Frontiers in Microbiology. 7:851. doi: 10.3389/fmicb.2016.00851
  • Erikstad, Helge Andre; Birkeland, Nils-Kåre. 2015. Draft genome sequence of "Candidatus Methylacidiphilum kamchatkense" strain Kam1, a thermoacidophilic methanotrophic verrucomicrobium. Genome Announcements. 3:e00065-15: 1-2. doi: 10.1128/genomeA.00065-15
  • Islam, Tajul; Larsen, Øivind; Torsvik, Vigdis Lid; Øvreås, Lise; Panosyan, Hovik; Murrell, J Colin; Birkeland, Nils-Kåre; Bodrossy, Levente. 2015. Novel Methanotrophs of the Family Methylococcaceae from Different Geographical Regions and Habitats. Microroganisms.
  • Margaryan, Armine; Panosyan, Hovik; Birkeland, Nils-Kåre; Trchounian, Armen H. 2015. Heavy metal resistance of Bacillus subtilis AG4 isolated from the Sotk Gold Mine in Armenia. The FEBS Journal.
  • Nesbø, Camilla Lothe; Swithers, Kirsten S.; Dahle, Håkon; Haverkamp, Thomas Hendricus Augustus; Birkeland, Nils-Kåre; Sokolova, Tatiana; Kublanov, Ilya; Zhaxybayeva, Olga. 2015. Evidence for extensive gene flow and Thermotoga subpopulations in subsurface and marine environments. The ISME Journal. 9: 1532-1542. doi: 10.1038/ismej.2014.238
  • Saghatelyan, Ani; Poghosyan, Lianna; Panosyan, Hovik; Birkeland, Nils-Kåre. 2015. Draft genome sequence of Thermus scotoductus strain K1, isolated from a geothermal spring in Karvachar, Nagorno Karabakh. Genome Announcements. 3: 1-2. doi: 10.1128/genomeA.01346-15
  • Chowdhury, Fatema Moni; Rahman, Mohammed Ziaur; Khan, Sirajul Islam; Ahsan, Chowdhury Rafiqul; Birkeland, Nils-Kåre. 2014. An Environmental escherichia albertii strain, dm104, induces protective immunity to shigella dysenteriae in guinea pig eye model. Current Microbiology. 68: 642-647. doi: 10.1007/s00284-014-0522-y
  • Knævelsrud, Ingeborg; Kazazic, Sabina; Birkeland, Nils-Kåre; Bjelland, Svein. 2014. The pH optimum of native uracil-DNA glycosylase of Archaeoglobus fulgidus compared to recombinant enzyme indicates adaption to cytosolic pH. Acta Biochimica Polonica. 61: 393-395.
  • Makhalanyane, Thulani P.; Valverde, Angel; Birkeland, Nils-Kåre; Cary, Stephen C.; Marla Tuffin, I.; Cowan, Don A. 2014. Erratum: Evidence for successional development in antarctic hypolithic bacterial communities (ISME Journal (2014) 8 (952) DOI:10.1038/ismej.2013.230). The ISME Journal. 8: 952. doi: 10.1038/ismej.2013.230
  • Makhalanyane, Thulani P.; Valverde, Angel; Birkeland, Nils-Kåre; Cary, Stephen C.; Tuffin, I.M.; Cowan, D.A. 2014. Erratum: Using network analysis to explore co-occurrencepatterns in soil microbial communitie (ISME Journal (2014) 8 (952) DOI:10.1038/ismej.2013.236). The ISME Journal. 8: 952. doi: 10.1038/ismej.2013.236
  • Nitipan, Supachai; Mamimin, Chonticha; Intrasungkha, Nugul; Birkeland, Nils-Kåre; O-Thong, Sompong. 2014. Microbial community analysis of thermophilic mixed culture sludge for biohydrogen production from palm oil mill effluent. International journal of hydrogen energy. 39: 19285-19293. doi: 10.1016/j.ijhydene.2014.05.139
  • Ogino, Hiromi; Ishino, Sonoko; Haugland, Gyri Teien; Birkeland, Nils-Kåre; Kohda, Daisuke; Ishino, Yoshizumi. 2014. Activation of the MCM helicase from the thermophilic archaeon, Thermoplasma acidophilum by interactions with GINS and Cdc6-2. Extremophiles. 18: 915-924. doi: 10.1007/s00792-014-0673-6
  • Panosyan, Hovik; Birkeland, Nils-Kåre. 2014. Microbial diversity in an Armenian geothermal spring assessed by molecular and culture-based methods. Journal of Basic Microbiology. 54: 1240-1250. doi: 10.1002/jobm.201300999
  • Akter, Selina; Islam, Mohammad Sirajul; Afreen, Kazi Sabrina; Azmuda, Nafisa; Khan, Sirajul Islam; Birkeland, Nils-Kåre. 2013. Prevalence and distribution of different diarrhoeagenic Escherichia coli virulotypes in major water bodies in Bangladesh. Epidemiology and Infection. 141: 2516-2525. doi: 10.1017/S0950268813000320
  • Makhalanyane, Thulani P.; Valverde, Angel; Birkeland, Nils-Kåre; Cary, Stephen C.; Tuffin, I. Maria; Cowan, Don A. 2013. Evidence for successional development in Antarctic hypolithic bacterial communities. The ISME Journal. 7: 2080-2090. doi: 10.1038/ismej.2013.94
  • Margaryan, Armine A.; Panosyan, Hovik H.; Birkeland, Nils-Kåre; Trchounian, Armen H. 2013. Heavy metal accumulation and the expression of the copA and nikA genes in Bacillus subtilis AG4 isolated from the Sotk gold mine in Armenia. Biological Journal of Armenia. 3: 51-57.
  • Margaryan, Armine; Birkeland, Nils-Kåre; Panosyan, Hovik; Popov, Y.; Trchounian, Armen H. 2013. The effect of combined heavy metal ions on copA, nikA and czcD genes expression of metal-resistant bacilli. The FEBS Journal. 280: 231-231.
  • Rahman, Mohammed Ziaur; Akter, Selina; Azmuda, Nafisa; Sultana, Munawar; Weill, François-Xavier; Khan, Sirajul islam; Grimont, Patrick A.D.; Birkeland, Nils-Kåre. 2013. Serological cross-reaction between O-antigens of Shigella dysenteriae type 4 and an environmental Escherichia albertii isolate. Current Microbiology. 67: 590-595. doi: 10.1007/s00284-013-0405-7
  • Schouw, Anders; Sinada, Faisal; Birkeland, Nils-Kåre. 2013. Thermoanaerobacter spp. recovered from hot produced water from the Thar Jath oil-field in South Sudan. African Journal of Microbiology Research. 7: 5219-5226. doi: 10.5897/AJMR2013.6172
  • Azmuda, Nafisa; Rahman, Mohammed Ziaur; Madsen, Marit Steine; Khan, Sirajul Islam; Birkeland, Nils-Kåre. 2012. Prevalence of a novel division-level bacterial lineage in Lake Dhanmondi, Dhaka, Bangladesh, as revealed by deep sequencing of 16S rRNA gene amplicons. Current Microbiology. 65: 356-360. doi: 10.1007/s00284-012-0165-9
  • Azmuda, Nafisa; Rahman, Mohammed Ziaur; Sultana, Munawar; Jenssen, Eirin Lunden; Khan, Sirajul islam; Birkeland, Nils-Kåre. 2012. Evidence of interspecies O antigen gene cluster transfer between Shigella boydii 15 and Escherichia fergusonii. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 120: 959-966. doi: 10.1111/j.1600-0463.2012.02926.x
  • Erikstad, Helge Andre; Jensen, Sigmund; Keen, Thomas Jeffrey; Birkeland, Nils-Kåre. 2012. Differential expression of particulate methane monooxygenase genes in the verrucomicrobial methanotroph 'Methylacidiphilum kamchatkense' Kam1. Extremophiles. 16: 405-409. doi: 10.1007/s00792-012-0439-y
  • Moen, Marivi; Knævelsrud, Ingeborg; Haugland, Gyri Teien; Grøsvik, Kristin; Birkeland, Nils-Kåre; Klungland, Arne; Bjelland, Svein. 2011. Uracil-DNA Glycosylase of Thermoplasma acidophilum Directs Long-Patch Base Excision Repair, Which Is Promoted by Deoxynucleoside Triphosphates and ATP/ADP, into Short-Patch Repair. Journal of Bacteriology. 193: 4495-4508. doi: 10.1128/JB.00233-11
  • Ogino, Hiroyasu; Ishino, S; Mayanagi, K; Haugland, Gyri Teien; Birkeland, Nils-Kåre; Yamagishi, A; Ishino, Y. 2011. The GINS complex from the thermophilic archaeon, Thermoplasma acidophilum may function as a homotetramer in DNA replication. Extremophiles. 15: 529-539. doi: 10.1007/s00792-011-0383-2
  • Rahman, Mohammed Ziaur; Azmuda, Nafisa; Hossain, Mohammad Jahangir; Sultana, Munawar; Khan, Sirajul Islam; Birkeland, Nils-Kåre. 2011. Recovery and Characterization of Environmental Variants of Shigella flexneri from Surface Water in Bangladesh. Current Microbiology. 63: 372-376. doi: 10.1007/s00284-011-9992-3
  • Bonny, Tania Sultana; Azmuda, Nafisa; Khan, Sirajul islam; Birkeland, Nils-Kåre; Rahman, Mohammed Ziaur. 2010. Virulence of environmental Stenotrophomonas maltophila serologically cross-reacting with Shigella-specific antisera. Pakistan Journal of Biological Sciences. 13: 937-945.
  • Jahid, Iqbal Kabir; Azad, T.; Rahman, Mohammed Ziaur; Begum, A.; Khan, Sirajul islam; Birkeland, Nils-Kåre; Akhter, Humaira. 2010. Survival study of Eschericia coli O157:H7 in the aquatic system of Bangladesh. Dhaka University Journal of Biological Sciences. 19: 195-201.
  • Jensen, Sigmund; Duperron, Sebastien; Birkeland, Nils-Kåre; Hovland, Martin. 2010. Intracellular Oceanospirillales bacteria inhabit gills of Acesta bivalves. FEMS Microbiology Ecology. 74: 523-533. doi: 10.1111/j.1574-6941.2010.00981.x
  • Karlström, Mikael; Chiaraluce, Roberta; Giangiacomo, Laura; Steen, Ida Helene; Birkeland, Nils-Kåre; Ladenstein, Rudolf; Consalvi, Valerio. 2010. Thermodynamic and kinetic stability of a large multi-domain enzyme from the hyperthermophile Aeropyrum pernix. Extremophiles. 14: 213-223. doi: 10.1007/s00792-009-0300-0
  • Knævelsrud, Ingeborg; Moen, Marivi; Grøsvik, Kristin; Haugland, Gyri Teien; Birkeland, Nils-Kåre; Klungland, Arne; Leiros, Ingar; Bjelland, Svein. 2010. The Hyperthermophilic Euryarchaeon Archaeoglobus fulgidus Repairs Uracil by Single-Nucleotide Replacement. Journal of Bacteriology. 192: 5755-5766. doi: 10.1128/JB.00135-10
  • Akhter, Humaira; Fakruddin, M.; Badruddoza, A.H.M.; Jahid, I.K.; Khan, Sirajul islam; Birkeland, Nils-Kåre. 2009. Prevalence of antimicrobial resistant bacteria cultured from cattle feces and surface water. Bangladesh Journal of Zoology. 37: 147-156.
  • Albers, Sonja-Verena; Birkeland, Nils-Kåre; Driessen, Arnold J. M.; Gertig, Susanne; Haferkamp, Patrick; Klenk, Hans-Peter; Kouril, Theresa; Manica, Andrea; Pham, Trong K.; Ruoff, Peter; Schleper, Christa Maria; Schomburg, Dietmar; Sharkey, Kieran J.; Siebers, Bettina; Sierocinski, Pawel; Steuer, Ralf; van der Oost, John; Westerhoff, Hans V.; Wieloch, Patricia; Wright, Philip C.; Zaparty, Melanie. 2009. SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation. Biochemical Society Transactions. 37: 58-64. doi: 10.1042/BST0370058
  • Albers, Sonja-Verena; Birkeland, Nils-Kåre; Driessen, Arnold J.M.; Gertig, Susanne; Haferkamp, Patrick; Klenk, Hans-Peter; Kouril, Theresa; Manica, Andrea; Pham, Trong K.; Ruoff, Peter; Schleper, Christa; Schomburg, Dietmar; Sharkey, Kieran J.; Siebers, Bettina; Sierocinski, Pawel; Steuer, Ralf; van der Oost, John; Westerhoff, H.V.; Wieloch, Patricia; Wright, Phillip C.; Zaparty, Melanie. 2009. SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation. Biochemical Society Transactions. 37: 58-64.
  • DiPippo, Jonathan L.; Nesbø, Camilla L.; Dahle, Håkon; Doolittle, W. Ford; Birkeland, Nils-Kåre; Noll, Kenneth M. 2009. Kosmotoga olearia gen. nov., sp nov., a thermophilic, anaerobic heterotroph isolated from an oil production fluid. International Journal of Systematic and Evolutionary Microbiology. 59: 2991-3000. doi: 10.1099/ijs.0.008045-0
  • Haugland, Gyri Teien; Rollor, Claire R.; Birkeland, Nils-Kåre; Kelman, Zvi. 2009. Biochemical characterization of the minichromosome maintenance protein from the archaeon Thermoplasma acidophilum. Extremophiles. 13: 81-88. doi: 10.1007/s00792-008-0198-y
  • Nesbø, Camilla L.; Bapteste, Eric; Curtis, Bruce; Dahle, Håkon; Lopez, Philippe; Macleod, Dave; Dlutek, Marlena; Bowman, Sharen; Zhaxybayeva, Olga; Birkeland, Nils-Kåre; Doolittle, W. Ford. 2009. The Genome of Thermosipho africanus TCF52B: Lateral Genetic Connections to the Firmicutes and Archaea. Journal of Bacteriology. 191: 1974-1978. doi: 10.1128/JB.01448-08
  • O-Thong, Sompong; Prasertsan, Poonsuk; Birkeland, Nils-Kåre. 2009. Evaluation of methods for preparing hydrogen-producing seed inocula under thermophilic condition by process performance and microbial community analysis. Bioresource Technology. 100: 909-918. doi: 10.1016/j.biortech.2008.07.036
  • Op den Camp, Huub J.M.; Islam, Tajul; Stott, Matthew B.; Harhangi, Harry R.; Hynes, Alexander; Schouten, Stefan; Jetten, Mike S.M.; Birkeland, Nils-Kåre; Pol, Arjan; Dunfield, Peter F. 2009. Environmental, genomic and taxonomic perspectives on methanotrophic Verrucomicrobia. Environmental Microbiology Reports. 1: 293-306. doi: 10.1111/j.1758-2229.2009.00022.x
  • Prasertsan, Poonsuk; O-Thong, Sompong; Birkeland, Nils-Kåre. 2009. Optimization and microbial community analysis for production of biohydrogen from palm oil mill effluent by thermophilic fermentative process. International journal of hydrogen energy. 34: 7448-7459. doi: 10.1016/j.ijhydene.2009.04.075
  • Towhid, S.T.; Akhter, Humaira; Azmuda, N.; Rahman, Mohammed Ziaur; Khan, Sirajul islam; Birkeland, Nils-Kåre. 2009. Comparison of Cultural and Molecular Characteristics of Escherichia coli isolated from Freshwater of Bangladesh. Dhaka University Journal of Biological Sciences. 18: 195-199.
  • Dahle, Håkon; Garshol, Frøydis Kristi; Madsen, Marit Steine; Birkeland, Nils-Kåre. 2008. Microbial community structure analysis of produced water from a high-temperature North Sea oil-field. Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology. 93: 37-49. doi: 10.1007/s10482-007-9177-z
  • Haugland, Gyri Teien; Innselset, M; Madern, Dominique; Birkeland, Nils-Kåre. 2008. Characterization of the Cdc6 Homologues from the Euryarchaeon Thermoplasma acidophilum. Open Biochemistry Journal. 2: 129-134.
  • Haugland, Gyri Teien; Sakakibara, N; Pey, Angel; Rollor, Clair R; Birkeland, Nils-Kåre; Kelman, Zvi. 2008. Thermoplasma acidophilum Cdc6 protein stimulates MCM helicase activity by regulating its ATPase activity. Nucleic Acids Research. 36: 5602-5609. doi: 10.1093/nar/gkn548
  • Islam, Tajul; Jensen, Sigmund; Reigstad, Laila Johanne; Larsen, Øivind; Birkeland, Nils-Kåre. 2008. Methane oxidation at 55 degrees C and pH 2 by a thermoacidophilic bacterium belonging to the Verrucomicrobia phylum. Proceedings of the National Academy of Sciences of the United States of America. 105: 300-304. doi: 10.1073/pnas.0704162105
  • Jensen, Sigmund; Neufeld, Josh D.; Birkeland, Nils-Kåre; Hovland, Martin Torvald; Murrell, John Colin. 2008. Insight into the microbial community structure of a Norwegian deep-water coral reef environment. Deep Sea Research Part I: Oceanographic Research Papers. 55: 1554-1563. doi: 10.1016/j.dsr.2008.06.008
  • Jensen, Sigmund; Neufeld, Josh d; Birkeland, Nils-Kåre; Hovland, Martin Torvald; Murrell, John Colin. 2008. Methane assimilation and trophic interactions with marine Methylomicrobium in deep-water coral reef sediment off the coast of Norway. FEMS Microbiology Ecology. 66: 320-330. doi: 10.1111/j.1574-6941.2008.00575.x
  • Miroshnichenko, Margarita L.; Kublanov, Ilya V.; Kostrikina, Nadezhda A.; Tourova, Tatyana P.; Kolganova, Tatyana V.; Birkeland, Nils-Kåre; Bonch-Osmolovskaya, Elizaveta A. 2008. Caldicellulosiruptor kronotskyensis sp nov and Caldicellulosiruptor hydrothermalis sp nov., two extremely thermophilic, cellulolytic, anaerobic bacteria from Kamchatka thermal springs. International Journal of Systematic and Evolutionary Microbiology. 58: 1492-1496. doi: 10.1099/ijs.0.65236-0
  • O-Thong, Sompong; Prasertsan, Poonsuk; Intrasungkha, Nugul; Dhamwichukorn, Srisuda; Birkeland, Nils-Kåre. 2008. Optimization of simultaneous thermophilic fermentative hydrogen production and COD reduction from palm oil mill effluent by Thermoanaerobacterium-rich sludge. International journal of hydrogen energy. 33: 1221-1231. doi: 10.1016/j.ijhydene.2007.12.017
  • Perevalova, Anna A.; Kolganova, Tatyana V.; Birkeland, Nils-Kåre; Schleper, Christa; Bonch-Osmolovskaya, Elizaveta A.; Lebedinsky, Alexander V. 2008. Distribution of Crenarchaeota Representatives in Terrestrial Hot Springs of Russia and Iceland. Applied and Environmental Microbiology. 74: 7620-7628. doi: 10.1128/AEM.00972-08
  • Leiros, Ingar; Nabong, Marivi P.; Grøsvik, Kristin; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Reite, Karen; Olsbu, Inger K.; Knævelsrud, I.; Moe, Elin; Andersen, Ole A.; Birkeland, Nils-Kåre; Ruoff, Peter; Klungland, Arne; Bjelland, Svein. 2007. Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal. 26.
  • Leiros, Ingar; Nabong, Marivi; Nabong, MP; Grosvik, K; Grøsvik, Kristin; Ringvoll, J; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Uldal, L; Reite, K; Olsbu, IK; Knævelsrud, Ingeborg; Knaevelsrud, I; Moe, Elin; Andersen, Ole Andreas; Birkeland, NK; Ruoff, P; Klungland, A; Bjelland, S. 2007. Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal. 26. doi: 10.1038/sj.emboj.7601662
  • O-Thong, Sompong; Prasertsan, Poonsuk; Intrasungkha, Nugul; Dhamwichukom, Srisuda; Birkeland, Nils-Kåre. 2007. Improvement of biohydrogen production and treatment etticiency on palm oil mill effluent with nutrient supplementation at thermophilic condition using an anaerobic sequencing batch reactor. Enzyme and microbial technology. 41: 583-590. doi: 10.1016/j.enzmictec.2007.05.002
  • Rahman, Mohammed Ziaur; Sultana, Munawar; Khan, Sirajul Islam; Birkeland, Nils-Kåre. 2007. Serological cross-reactivity of environmental isolates of Enterobacter, Escherichia, Stenotrophomonas, and Aerococcus with Shigella spp.-specific antisera. Current Microbiology. 54: 63-67. doi: 10.1007/s00284-006-0387-9
  • Stokke, R; Leiros, Ingar; Karlström, Mikael; Karlstrom, M; Yang, Nannan; Ladenstein, R; Birkeland, NK; Steen, IH. 2007. Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers. Extremophiles. 11. doi: 10.1007/s00792-006-0060-z
  • Stokke, Runar; Birkeland, Nils-Kåre; Steen, Ida Helene. 2007. Thermal stability and biochemical properties of isocitrate dehydrogenase from the thermoacidophilic archaeon Thermoplasma acidophilum. Extremophiles. 11: 397-402. doi: 10.1007/s00792-006-0045-y
  • Stokke, Runar; Madern, Dominique; Fedøy, Anita-Elin; Fedøy, Anita-Elin; Karlsen, Solveig; Birkeland, Nils-Kåre; Steen, Ida Helene. 2007. Biochemical characterization of isocitrate dehydrogenase from Methylococcus capsulatus reveals a unique NAD(+)-dependent homotetrameric enzyme. Archives of Microbiology. 187. doi: 10.1007/s00203-006-0200-y
  • Dahle, Håkon; Birkeland, Nils-Kåre. 2006. Thermovirga lienii gen. nov., sp. nov., a novel moderately thermophilic, anaerobic, amino-acid-degrading bacterium isolated from a North Sea oil well. International Journal of Systematic and Evolutionary Microbiology. 56: 1539-1545. doi: 10.1099/ijs.0.63894-0
  • Haugland, Gyri Teien; Shin, J.H.; Birkeland, Nils-Kåre; Kelman, Z. 2006. Stimulation of MCM helicase activity by a Cdc6 protein in the archaeon Thermoplasma acidophilum. Nucleic Acids Research. 34: 6337-6344.
  • Karlström, Mikael; Steen, Ida Helene; Madern, Dominique; Fedøy, Anita-Elin; Birkeland, Nils-Kåre; Ladenstein, Rudolf. 2006. The crystal structure of a hyperthermostable subfamily II isocitrate dehydrogenase from Thermotoga maritima. The FEBS Journal. 273: 2851-2868. doi: 10.1111/j.1742-4658.2006.05298.x
  • Singh, P.; Birkeland, Nils-Kåre; Iyengar, L.; Gurunath, R. 2006. Mineralization of 4-aminobenzenesulfonate (4-ABS) by Agrobacterium sp. strain PNS-1. Biodegradation. 17: 495-502.
  • Slobodkin, Alexander I.; Tourova, Tatyana P.; Kostrikina, Nadezhda A.; Lysenko, Anatoly M.; German, KE; Bonch-Osmolovskaya, Elizaveta A.; Birkeland, Nils-Kåre. 2006. Tepidimicrobium ferriphilum gen nov, sp nov, a novel moderately thermophilic, Fe(III)-reducing bacterium of the order Clostridiales. International Journal of Systematic and Evolutionary Microbiology. 56: 369-372. doi: 10.1099/ijs.0.63694-0
  • Karlström, Mikael; Stokke, Runar; Steen, Ida Helene; Birkeland, Nils-Kåre; Ladenstein, Rudolf. 2005. Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability. Journal of Molecular Biology. 345: 559-577.
  • Khijniak, T.V.; Slobodkin, A.I.; Coker, V.; Renshaw, J.C.; Livens, F.R.; Bonch-osmolovskaya, E.A.; Birkeland, Nils-Kåre; Medvedeva-lyalikova, N.N.; Lloyd, J.R. 2005. Reduction of uranium(VI) phosphate during growth of the thermophilic bacterium Thermoterrabacterium ferrireducens. Applied and Environmental Microbiology. 71: 6423-6426.
  • Yadav, K.K.; Iyengar, L.; Birkeland, Nils-Kåre; Ramanathan, G. 2005. Transient accumulation of metabolic intermediates of p-cresol in the culture medium by a Pseudomonas sp strain A isolated from a sewage treatment plant. World Journal of Microbiology & Biotechnology. 21: 1529-1534.
  • Birkeland, Nils-Kåre. 2004. The microbial diversity of deep subsurface oil reservoirs. Studies in Surface Science and Catalysis. 151: 385-403.
  • Irimia, Adriana; Vellieux, Frederic M.D.; Madern, Dominique; Zaccai, Giuseppe; Karshikoff, Andrey; Tibbelin, Gudrun; Ladenstein, Rudolf; Lien, Torleiv; Birkeland, Nils-Kåre. 2004. The 2.9 Ångström resolution crystal structure of malate dehydrogenase from Archaeoglobus fulgidus: mechanisms of oligomerisation and thermal stabilisation. Journal of Molecular Biology. 335: 343-356.
  • Ward, Naomi; Larsen, Øivind; Bruseth, Live J.; Jensen, Harald B; Birkeland, Nils-Kåre; Grindhaug, Svenn Helge; Eidhammer, Ingvar; Jonassen, Inge; Lillehaug, Johan; Eisen, Jonathan. 2004. Genomic insights into methanotrophy: The complete genome sequence of Methylococcus capsulatus (Bath). PLoS biology. 2: 1616-1628.
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Knævelsrud, Ingeborg; Kristoffersen, Wenche; Bjørås, M.; Robb, F.T.; Klungland, Arne; Bjelland, Svein. 2002. Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus. Biochemistry. 41: 12697-12705.
  • Birkeland, Nils-Kåre; Ånensen, Hilde; Knævelsrud, Ingeborg; Kristoffersen, Wenche; Bjørås, M.; Robb, F.T.; Klungland, Arne; Bjelland, Svein. 2002. Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus. Biochemistry. 41: 12697-12705.
  • Karlstrøm, Michael; Steen, Ida Helene; Tibbelin, Gudrun; Lien, Torleiv; Birkeland, Nils-Kåre; Ladenstein, Rudolf. 2002. Crystallization and preliminary X-ray structure analysis of isocitrate dehydrogenase from two hyperthermophiles, Aeropyrum pernix and Thermotoga maritima. Acta Crystallographica Section D: Biological Crystallography. 58: 2162-2164.
  • Maisnier-Patin, Sophie; Malandrin, Laurence; Birkeland, Nils-Kåre; Bernander, Rolf. 2002. Chromosome replication patterns in the hyperthermophilic euryarchaea Archaeoglobus fulgidus and Methanocaldococcus (Methanococcus) jannaschii. Molecular Microbiology. 45: 1443-1450.
  • Steen, Ida Helene; Lien, Torleiv; Madsen, Marit; Birkeland, Nils-Kåre. 2002. Identification of cofactor discrimination sites in NAD-isocitrate dehydrogenase from Pyrococcus furiosus. Archives of Microbiology. 178: 297-300.
  • Steen, Ida Helene; Madsen, Marit Steine; Birkeland, Nils-Kåre; Lien, Torleiv. 2002. Identification of cofactor discrimination siten in NAD-isocitrate dehydrogenase from Pyrococcus furious. Archives of Microbiology. 178: 297-300.
  • Knævelsrud, Ingeborg; Ruoff, Peter; Ånensen, Hilde; Klungeland, Arne; Bjelland, Svein; Birkeland, Nils-Kåre. 2001. Excision of uracil from DNA by the hyperthermophilic Afung protein is dependent on the opposite base and stimulated by heat-induced transition to a more open structure. Mutation Research (DNA Repair). 487: 175-192.
  • Larsen, Øyvind; Lien, Torleiv; Birkeland, Nils-Kåre. 2001. A novel organization of the dissimilatory sulfite reductase operon of Thermodesulforhabdus norvegica verified by RT-PCR. FEMS Microbiology Letters. 203: 81-85.
  • Madern, Dominique; Ebel, C.; Dale, Hege Avsnes; Lien, Torleiv; Steen, Ida Helen; Birkeland, Nils-Kåre; Zaccai, G. 2001. Differences in Oligomeric States of the (LDH-like)L-MalDH from the Hyperthermophilic Archaea Methanococcus jannaschii and Archaeoglobus fulgidus. Biochemistry. 40: 10310-10316.
  • Madern, Dominique; Ebel, C.; Dale, Hege Avsnes; Lien, Torleiv; Steen, Ida Helene; Birkeland, Nils-Kåre; Zaccai, G. 2001. Differences in the oligomeric state of the LDH-like L-MalDH from the hyperthermophilic archaea Methanococcus jannaschii and Archaeoglobus fulgidus. Biochemistry. 40: 10310-10316.
  • Steen, Ida Helen; Madern, Dominique; Karlstrøm, Mikael; Lien, Torleiv; Ladenstein, Rudolf; Birkeland, Nils-Kåre. 2001. Comparison of Isocitrate Dehydrogenase from Three Hyperthermophiles Reveals Differences in Thermostability,Cofactor Specificity,Oligomeric State, and Phylogenetic Affiliation. Journal of Biological Chemistry. 276: 43924-43931.
  • Steen, Ida Helene; Hvoslef, Hilde; Birkeland, Nils-Kåre; Lien, Torleiv. 2001. Archaeoglobus fulgidus isocitrate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase. Methods in Enzymology. 331: 13-26.
  • Steen, Ida Helene; Madern, Dominique; Karlstrøm, Mikael; Lien, Torleiv; Ladenstein, R; Birkeland, Nils-Kåre. 2001. Comparison of isocitrate dehydrogenase from three different hyperthermophiles reveals differences in thermostability, cofactor specificity, oligomeric state and phylogenetic affiliation. Journal of Biological Chemistry. 47: 43924-43931.
  • Larsen, Øyvind; Lien, Torleiv; Birkeland, Nils-Kåre. 2000. Characterization of the desulforubidin operons from Desulfobacter vibrioformis and Desulfobulbus rhabdoformis. FEMS Microbiology Letters. 186: 41-46.
  • Larsen, Øivind; Lien, Torleiv; Birkeland, Nils-Kåre. 1999. Dissimilatory sulfite reductase from <I>Archaeoglobus profundus</I> and <I>Desulfotomaculum thermocisternum</I>: phylogenetic and structural implications from gene sequences. Extremophiles. 3: 63-70.
  • Emmerhoff, Oddmund Johan; Klenk, Hans-Petter; Birkeland, Nils-Kåre. 1998. Characterization and sequence comparison of temperature-regulated chaperonins from the hyperthermophilic archaeon <I>Archaeoglobus fulgidus</I>. Gene. 215: 431-438. Published 1998-07-30.
  • Lien, Torleiv; Madsen, Marit Steine; Birkeland, Nils-Kåre; Rainey, Fred. 1998. Petrotoga mobilis sp. nov., from a North Sea oil-production well. International Journal of Systematic Bacteriology. 48: 1007-1014.
  • Lien, Torleiv; Madsen, Marit Steine; Rainey, Fred A.; Birkeland, Nils-Kåre. 1998. Petrotoga mobilis sp. nov., from a North Sea oil-production well. International Journal of Systematic Bacteriology. 48: 1007-1013.
  • Steen, Ida Helene; Madsen, Marit Steine; Birkeland, Nils-Kåre; Lien, Torleiv. 1998. Purification and characterization of a monomeric isocitrate dehydrogenase from the sulfate-reducing bacterium Desulfobacter vibrioformis and demonstration of the presence of a monomeric enzyme in other bacteria. FEMS Microbiology Letters. 160: 469-474.
  • Aalen, Nina; Steen, Ida Helene; Birkeland, Nils-Kåre; Lien, Torleiv. 1997. Purification and properties of an extremely thermostable NADP-specific glutamate dehydrogenase from Archaeoglobus fulgidus. Archives of Microbiology. 168: 536-539.
  • Langelandsvik, Anne Siri; Steen, Ida Helene; Birkeland, Nils-Kåre; Lien, Torleiv. 1997. Properties and primary structure of a thermostable L-malate dehydrogenase from Archaeoglobus fulgidus. Archives of Microbiology. 168: 59-67.
  • Steen, Ida Helene; Lien, Torleiv; Birkeland, Nils-Kåre. 1997. Biochemical and phylogenetic characterization of isocitrate dehydrogenase from a hyperthermophilic archaeon, Archaeoglobus fulgidus. Archives of Microbiology. 168: 412-420.
  • Birkeland, Nils-Kåre. 1994. Cloning, molecular characterization, and expression of the genes encoding the lytic functions of lactococcal bacteriophage phi-LC3: a dual lysis system og modular design. Canadian journal of microbiology (Print). 40: 658-665.
Book sections
  • Sharma, Rohit; Thakur, Vishal; Sharma, Monika; Birkeland, Nils-Kåre. 2013. Biocatalysis through thermostable lipases: adding flavor to chemistry. Chapter 34, pages 905-927. In:
    • Satyanarayana, Tulasi; Littlechild, Jennifer; Kawarabayasi, Yutaka. 2013. Thermophilic Microbes in Environmental and Industrial Biotechnology. Springer. 954 pages. ISBN: 978-94-007-5898-8.
  • Birkeland, Nils-Kåre. 2005. Sulphate-reducing Bacteria and Archaea. Kapittel 3, pages 35-54. In:
    • Ollivier, Bernard; Magot, Michel. 2005. Petroleum Microbiology. ASM International. 300 pages. ISBN: 1555813275.
  • Birkeland, Nils-Kåre. 2004. The Microbial Diversity of Deep Subsurface Oil Reservoirs. Chapter 14, pages 385-403. In:
    • Vazquez-Duhalt, R.; Quintero-Ramirez, R. 2004. Petroleum Biotechnology, developments and perspectives. 554 pages. ISBN: 0444516999.
  • Steen, Ida Helen; Hvoslef, Hilde; Lien, Torleiv; Birkeland, Nils-Kåre. 2001. Isocitrate Dehydrogenase, Malate Dehydrogenase, and Glutamate Dehydrogenase from Archaeoglobus fulgidus. Hyperthermophilic Enzymes, Part B. Michael W.W.Adams and Robert M. Kelly (eds.). 13-26. In:
    • Abelson, John N.; Simon, Melvin I.; Colowick, Sidney P.; Kaplan, Nathan O.; Adams, Michael W.W.; Kelly, Robert M. 2001. Hyperthermophilic enzymes. Part B. 494 pages. ISBN: 0-12-182232-X.

More information in national current research information system (CRIStin)

CV

Education

Cand.real. (M.Sc.) in microbiology 1981, University of Bergen, Norway.

Dr.philos. 1992, University of Oslo, Norway (bacteriophage molecular biology).

 

Career/Employment

· Dept. of Physical Chemistry, Norwegian Institute of Technology, Trondheim, Norway: Research assistant, 1981-1982.  Membrane transport in halobacteria.

. Dept. of Medical Biology, University of Tromsø, Tromsø, Norway: Research assistant, 1982-1985. Gene regulation in the Escherichia coli P2:P4 system.

. Dept. of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA: Research scientist, 1986-1987.  Regulation of gene expression in the P2:P4  bacteriophage system.

·  Laboratory of Microbial Gene Technology, The Norwegian Research Council/The Norwegian   Agricultural University, Ås, Norway: Research scientist, 1988-1993.  Molecular biology and  biotechnology of lactic acid bacteria and phages.

·  Dept. of Biology (previous Dept. of Microbiology), University of Bergen, Bergen, Norway: Associate professor, 1993-1996; full Professor in microbiology from 1996 - present. From 2007 also affiliated with the Centre for Geobiology (a CoE) at Univ. of Bergen. Molecular biology and biochemistry of extremophiles; anaerobic microbiology; methane-oxidising bacteria; environmental microbiology.

 

International experience

·  Research scientist at Dept. of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA 1986-1987. Gene regulation.

·  Visiting Professor at the Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA, 1998-1999 (one year). Molecular biology of hyperthermophiles.

· Coordinator for the NorFA-network Biology of Thermophiles, 1998 – 2003.

· Coordinator of the INTAS program Reduction of toxic metals and radionuclides by thermophilic prokaryotes. 2002 – 2005.

·  Coordinator of the NUFU program Assessment of microbial pollution, diversity and community structure in freshwater resources in Bangladesh using molecular techniques, 2003 – 2012.

· Convenor for the 9th International Thermophiles conference in Bergen in September 2007.

 

Some of my active collaborators

· Prof. Arne Smalås, the Norwegian Structural Biology Center (NORSTRUCT), University of Tromsø, Norway (Protein structure)

· Prof. Svein Bjelland, University of Stavanger, Norway (DNA repair in hyperthermophiles)

· Dr. Elizaveta Bonch-Osmolovskaya, Institute of Microbiology, the Russian Academy of Sciences, Moscow (Thermophilic bacteria from hot springs)

· Dr. Rudolf Ladenstein, Center for Structural Biochemistry, Karolinska Institutet, NOVUM, Stockholm, Sweden (Protein structure and stability)

· Dr. Zvi Kelman, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute (Regulation of archaeal cell-cycle)

· Dr. Poonsuk Prasertsan, Department of Industrial Biotechnology, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Thailand (Biohydrogen)

· Professor Don Cowan, University of the Western Cape, South Africa (Antarctic metagenomics)

· Professor Sirajul Islam Khan, Department of Microbiology, University of Dhaka, Bangladesh (enteropathogens in tropical freshwaters)

 

Patent applications

· Lillehaug D and Birkeland NK (1994): Bacteriophage ΦLC-3-based vector system for transformation of bacteria. WO 9419460.

· Jonassen I et al. (2002): Systems for expression of heterologous proteins in Methylococcus capsulatus. WO 02055549.

· Eisen JA et al. (2002): Metylococcus capsulatus genes and DNA array for the determination of gene expression in Metylococcus capsulatus. WO 02055655. 

· Birkeland NK and Islam T: Novel methanotroph (biological conversion of methane to methanol). Pending.

 

Current and previous projects, networks and funding for advanced equipment:

2017 - 2021: Methane oxidation by extremophilic Verrucomicrobia adapted to geothermal
environments. Research Council of Norway. FRIMEDBIO.

2017 - 2020: Thermostable isomerase processes for biotechnology (TIPs). ERA-IB/BIOTEK2021.

2017 - 2019: (Eurasian - Norwegian) Network for improving research based higher education in basic and applied microbiology.

2015 - 2016: Extremophilic Archaea in Bulgarian geothermal environments. BG09 Programme. EEA Scholarships Fund.

2013 - 2016: THERMOGENE - Novel thermostable enzymes for industrial biotechnology. NFR/ERA-NET Industrial Biotechnology project

2014 - 2015: Integrative analysis of extremophiles in search for new biotechnological solutions. NILS Science and Sustainability (ES07). EEA Grant.

2013 - 2015: Eurasian-Norwegian network for higher education and research in environmental microbiology and biotechnology

2011 - 2015: Cooperation in environmental microbiology between Armenia and Norway. SIU

 2012: Geomicrobiology for bioenergy. The Agricultural Research Development Agency, Thailand.

2011 - 2014: Cooperation with Armenia in microbiology of extreme environments. SIU/UD. 1.8 mill NOK.

2011-2014: Biological methane oxidation by methanotrophic Verrucomicrobia under  hot and acidic conditions; evolution of an ancient metabolic trait. NFR, 3.5 mill NOK.

 2009-2012: Subsurface metagenomics, functional microbial diversity analysis and gene discovery in deep and hot petroleum reservoirs. VISTA. 2.5 mill NOK.

2010: Is methane oxidation an ancient metabolic trait? Centre for Geobiology, UiB. 180.000 NOK.

2007-2010: Metagenomics and gene discovery in Antarctic terrestrial habitats. The Research Council of Norway/The South-Africa programme. 898.000 NOK.

2009-2012: The Nordic Archaea Network. NordForsk.

2008: Comparative genomics of Archaeoglobus fulgidus strain 7324, a subsurface hyperthermophilic sulfate-reducing archaeon isolated from a hot North-Sea oil-well. University of Bergen/ Friforsk. 300.000 NOK.

2003-2011: Assessment of microbial pollution and diversity of Escherichia coli and Shigella in freshwater resources in Bangladesh. NUFU. 6.5 mill NOK.

2007-2010: Silicon Cell Model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation. SysMo.

2004-2007: Metanspisende bakterier i havbunnsmiljø. VISTA. 1.5 millNOK.

2006-2007: Archaeoglobus fulgidus strain 7324: a unique archaeal sulfate reducer. The Research Council of Norway/ DAAD. 50.000 NOK.

2003-2007: Natural gas and biotechnology (NABI): bioprospecting of methane-oxidizing bacteria. The Norwegian Research Council/ Bioprospecting programme. 6.7 mill NOK.

2003-2007: Biological adaptations to extreme temperatures. The Norwegian Research Council/ Strategic university programme. 5.9 mill NOK.

2003-2007: Archaeal cell-cycle regulation. The Research Council of Norway. 1.7 mill NOK.

2006: Robot for automated picking of bacterial colonies (GenePix2xt). The Research Council of Norway. 1.7 mill NOK.

2002-2006: Biotechnology of intraterrestrial microorganisms. The Research Council of Norway/ Bioprospecting. 1.6 mill NOK.

2003-2005: Reduction of toxic metals and radionuclides by thermophilic prokaryotes. INTAS. 450.000 NOK.

2002-2004: Reduction of metals by thermophilic prokaryotes. NATO. 100.000 NOK.

1999-2003: Biology of Thermophiles. Nordic network. NorFA. 1.5 mill NOK.

1997-2001: VIRTUE: Bioaktive substanser. Wallenbergfondet. 475.000 NOK.

1997-1999: Termoresistens hos Archaeoglobus. The Research Council of Norway. 288.000 NOK.

1996-1999: Dissimilatorisk sulfitt reduktase fra oljebakterier. The Research Council of Norway. 1.2 mill NOK.

1995: Iso-sitronsyre dehydrogenase i Desulfobacter. The Research Council of Norway. 412.000 NOK.

1994: Generell drifts- og utstyrsbevilgning. The Research Council of Norway. 150.000 NOK.

 

 

 

 

 

 

 

Research groups