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Rune Kleppe

Senior Adviser
  • E-mailRune.Kleppe@uib.no
  • Phone+47 55 58 40 68
  • Visitor Address
    HIB - Thormøhlensgt. 55
  • Postal Address
    Postboks 7803
    5020 Bergen
Journal articles
  • Pakdaman, Yasaman; Sanchez Guixe, Monica; Kleppe, Rune; Erdal, Sigrid; Bustad, Helene J.; Bjørkhaug, Lise; Haugarvoll, Kristoffer; Tzoulis, Charalampos; Heimdal, Ketil Riddervold; Knappskog, Per; Johansson, Stefan; Aukrust, Ingvild. 2017. In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins. Bioscience Reports. 37: 1-12. doi: 10.1042/BSR20170251
  • Waløen, Kai; Kleppe, Rune; Martinez, Aurora; Haavik, Jan. 2017. Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease. Expert opinion on therapeutic targets. 21: 167-180. doi: 10.1080/14728222.2017.1272581
  • Ghorbani, Sadaf; Fossbakk, Agnete; Jorge Finnigan, Ana; Flydal, Marte Innselset; Haavik, Jan; Kleppe, Rune. 2016. Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins. Amino Acids. 48: 1221-1229. doi: 10.1007/s00726-015-2157-0
  • Kopperud, Reidun Kristin; Rygh, Cecilie Brekke; Karlsen, Tine Veronica; Krakstad, Camilla; Kleppe, Rune; Høivik, Erling Andre; Bakke, Marit; Tenstad, Olav; Selheim, Frode; Liden, Åsa; Madsen, Lise; Pavlin, Tina; Taxt, Torfinn; kristiansen, k; Curry, FE; Reed, Rolf K.; Doskeland, Stein Ove. 2016. Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiologica. 219: 441-452. doi: 10.1111/apha.12697
  • Zayats, Tetyana; Jacobsen, Kaya Kvarme; Kleppe, Rune; Jacob, CP; Kittel-Schneider, Sarah; Ribases, Marta; Ramos-Quiroga, JA; Richarte, Vanesa; Casas, M; Mota, NR; Grevet, EH; Klein, M; Corominas, J; Bralten, Janita; Galesloot, T; Vasquez, AA; Herms, S; Forstner, AJ; Larsson, H; Breen, G; Asherson, P; Gross-Lesch, Silke; Lesch, KP; Cichon, Sven; Gabrielsen, Maiken Elvestad; Holmen, Oddgeir Lingaas; Bau, CH; Buitelaar, Jan; Kiemeney, L; Faraone, Stephen V.; Cormand, B; Franke, Barbara; Reif, Andreas; Haavik, Jan; Johansson, Stefan. 2016. Exome chip analyses in adult attention deficit hyperactivity disorder. Translational psychiatry. 6. 7 pages. doi: 10.1038/tp.2016.196
  • Jacobsen, Kaya Kvarme; Kleppe, Rune; Johansson, Stefan; Zayats, Tetyana; Haavik, Jan. 2015. Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 168: 423-432. doi: 10.1002/ajmg.b.32339
  • Kleppe, Rune; Herfindal, Lars; Doskeland, Stein Ove. 2015. Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. Marine Drugs. 13: 6505-6520. doi: 10.3390/md13106505
  • Winge, Ingeborg; Teigen, Knut; Fossbakk, Agnete; Mahootchi, Elaheh; Kleppe, Rune; Sköldberg, Filip; Kämpe, Olle; Haavik, Jan. 2015. Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression. Neurochemistry International. 90: 173-184. doi: 10.1016/j.neuint.2015.08.013
  • Fossbakk, Agnete; Kleppe, Rune; Knappskog, Per; Martinez, Aurora; Haavik, Jan. 2014. Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia. Human Mutation. 35: 880-890. doi: 10.1002/humu.22565
  • Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth; Hagland, Hanne; Kopperud, Reidun Kristin; Teigen, Knut; Schwede, Frank; Kleppe, Rune; Doskeland, Stein Ove. 2014. Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLoS ONE. 9. doi: 10.1371/journal.pone.0094926
  • Kleppe, Rune; Ghorbani, Sadaf; Martinez, Aurora; Haavik, Jan. 2014. Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins. FEBS Letters. 588: 92-98. doi: 10.1016/j.febslet.2013.11.012
  • Kleppe, Rune; Rosati, Sara; Jorge Finnigan, Ana; Alvira, Sara; Ghorbani, Sadaf; Haavik, Jan; Valpuesta, José María; Heck, Albert J.R.; Martinez, Aurora. 2014. Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ. Molecular & Cellular Proteomics. 13: 2017-2030. doi: 10.1074/mcp.M113.035709
  • Nygaard, Gyrid; Herfindal, Lars; Kopperud, Reidun Kristin; Aragay, Anna M.; Holmsen, Holm A; Doskeland, Stein Ove; Kleppe, Rune; Selheim, Frode. 2014. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 449: 357-363. doi: 10.1016/j.bbrc.2014.05.032
  • Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frederic; ROUHEE, NAZANIN; McCormack, Emmet; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Doskeland, Stein Ove. 2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease. 4. doi: 10.1038/cddis.2013.39
  • Herfindal, Lars; Myhren, Lene Elisabeth; Kleppe, Rune; Krakstad, Camilla; Selheim, Frode; Jokela, Jouni; Sivonen, Kaarina; Doskeland, Stein Ove. 2011. Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 8: 360-367. doi: 10.1021/mp1002224
  • Huseby, Sjur; Gausdal, Gro; Keen, Thomas Jeffrey; Kjærland, Endre; Krakstad, Camilla; Myhren, Lene Elisabeth; Brønstad, Kirsten Marie; Kunick, Conrad; Schwede, Frank; Genieser, Hans-Gottfried; Kleppe, Rune; Doskeland, Stein Ove. 2011. Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death and Differentiation. 2. 11 pages. doi: 10.1038/cddis.2011.124
  • Jensen, Baard Olav; Kleppe, Rune; Kopperud, Reidun Kristin; Nygård, Gyrid; Doskeland, Stein Ove; Holmsen, Holm A; Selheim, Frode. 2011. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 22: 8-19. doi: 10.3109/09537104.2010.517581
  • Kleppe, Rune; Krakstad, Camilla; Selheim, Frode; Kopperud, Reidun Kristin; Doskeland, Stein Ove. 2011. The cAMP-dependent protein kinase pathway as therapeutic target - possibilities and pitfalls. Current Topics in Medicinal Chemistry. 11: 1393-1405.
  • Kleppe, Rune; Martinez, Aurora; Doskeland, Stein Ove; Haavik, Jan. 2011. The 14-3-3 proteins in regulation of cellular metabolism. Seminars in Cell and Developmental Biology. 22: 713-719. doi: 10.1016/j.semcdb.2011.08.008
  • Jensen, Baard Olav; Kleppe, Rune; Kopperud, Reidun Kristin; Nygård, Gyrid; Doskeland, Stein Ove; Holmsen, Holm A; Selheim, Frode. 2010. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 22: 7-18. doi: 10.3109/09537104.2010.517581
  • Halskau jr, Øyvind; Ying, Ming; Baumann, Anne; Kleppe, Rune; Rodriguez-Larrea, David; Almås, Bjørg; Haavik, Jan; Martinez, Aurora. 2009. Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase and negatively charged membranes. Journal of Biological Chemistry. 284: 32758-32769. doi: 10.1074/jbc.M109.027706
  • Rostrup, Morten; Fossbakk, Agnete; Hauge, Anton; Kleppe, Rune; Gnaiger, Erich; Haavik, Jan. 2008. Oxygen dependence of tyrosine hydroxylase. Amino Acids. 34: 455-464. doi: 10.1007/s00726-007-0547-7
  • Winge, Ingeborg; Mckinney, Jeffrey; Ying, Ming; D Santos, Clive; Kleppe, Rune; Knappskog, Per; Haavik, Jan. 2008. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. Biochemical Journal. 410: 195-204. doi: 10.1042/BJ20071033
  • Kjærland, Endre; D Santos, Clive; Døskeland, Stein Ove; Kleppe, Rune. 2006. 14-3-3 proteins as substrates for cAMP-dependent protein kinase. European Journal of Pharmaceutical Sciences. 28: S27-S27.
  • Kjærland, Endre; Keen, Thomas Jeffrey; Kleppe, Rune. 2006. Does isoform diversity explain functional differences in the 14-3-3 protein family? Current Pharmaceutical Biotechnology. 7: 217-223. doi: 10.2174/138920106777549777
  • Kjærland, Endre; Viste, Kristin; Kleppe, Rune; Døskeland, Stein Ove. 2006. Camp-dependent protein kinase. European Journal of Pharmaceutical Sciences. 28: S4-S5.
  • Kleppe, Rune; Kjærland, Endre; Selheim, Frode. 2006. Proteomic and computational methods in systems modeling of cellular signaling. Current Pharmaceutical Biotechnology. 7: 135-145. doi: 10.2174/138920106777549722
  • Kleppe, Rune; Haavik, Jan. 2004. Different stabilities and denaturation pathways for structurally related aromatic amino acid hydroxylases. FEBS Letters. 565: 155-159.
  • Kleppe, Rune; Uhlemann, K; Knappskog, Per; Haavik, Jan. 1999. Urea-induced denaturation of human phenylalanine hydroxylase. Journal of Biological Chemistry. 274: 33251-33258.
  • Kleppe, Rune; Uhlemann, K; Knappskog, Per; Haavik, Jan. 1999. Urea-induced denaturation of human phenylalanine hydroxylase. Journal of Biological Chemistry. 274: 33251-33258.
  • Aakvaag, Asbjørn; Kleppe, Rune. 1995. Studies on the synthetic DNAs, repair replication, transcription and gene synthesis. Naturen. 1. 3-24.
Reports and theses
  • Kleppe, Rune. 1998. A study on the thermodynamic stability of human phenylalanine hydroxylase. cand.scient.-oppgave. [Mangler utgivernavn]. 84 pages.
  • Kleppe, Rune. 1998. A study on the thermodynamic stability of human phenylalanine hydroxylase. Hovedfagsoppgaver. Institutt for biokjemi og molekylærbiologi.

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