Tehmina Mustafa

Professor, Centre for International Health

Department of Global Public Health and Primary Care

E-mailTehmina.Mustafa@uib.no
Phone+47 55 58 67 22
Visitor Address
Overlege Danielssens hus, 5 floor, Årstadveien 21

Room
525
Postal Address
Postboks 7804

5020 Bergen

Tehmina Mustafa has research experience on various aspects of tuberculosis, including epidemiological, clinical and basic laboratory research on immunology, pathology, and development of new diagnostic tests for disease. She is the leader of the Tuberculosis Research Group at the Centre for International Health.

Medical specialist and consultant

Mustafa is a specialist in both pulmonary and internal medicine, and works as a consultant in respiratory diseases at the Department of Thoracic Medicine, Haukeland University Hospital.

Research

Mustafa studies immunepathogenesis of tuberculosis (TB), development of new diagnostic methods for paucibacillary TB cases, discovery of biomarkers for monitoring response to treatment, interaction between undernutrition and TB. Her main impact is in the development of better TB diagnostic methods. She has established research and academic partnerships with multiple institutions in Tanzania, Zanzibar, India and Pakistan, using funding from the Research Council of Norway and the Western Region Health Authorities of Norway. She has led and completed (2020) a multicenter international project in four countries on the implementation of a better diagnostic test for TB in routine clinical settings. She is currently working on increasing understanding the immunopathogenesis of TB based on studies using the human archival material from the Biobank at the Department of Pathology.

Project leader and collaborator

Mustafa leads multi-centre projects on improved TB diagnosis and immunopathogenesis. See her project descriptions for more information

Coordinator and Teacher- Global Tuberculosis Epidemiology and Intervention (INTH328, INTH928, ELMED311)
Coordinator and Teacher-Research Proposal Development (INTH330), UiB
Teacher- Global health - challenges and responses- SDG303, UiB
Teacher- Methods in global health research- INTH315, UiB
Teacher- Medical students-respiratory medicine, UiB
Teacher- Global Health Course for nursing students at the Western Norway University of Applied Sciences

Research Supervision

PhD students: 14 (completed 7, current 7)

Master students: 15 (completed 13, current 2)

Medical students: completed 3

Show author(s) (2023). Significance of non-granulomatous cytomorphology on fine needle aspirate in lymphadenitis cases classified as tuberculous by using a composite reference standard. Diagnostic Cytopathology. 575-583.
Show author(s) (2023). Proteomic analysis of peripheral blood mononuclear cells isolated from patients with pulmonary tuberculosis: A pilot study from Zanzibar, Tanzania. PLOS ONE. 15 pages.
Show author(s) (2023). Previous tuberculosis infection associated with increased frequency of asthma and respiratory symptoms in a Nordic–Baltic multicentre population study. European Respiratory Journal Open Research (ERJ Open Research). 8 pages.
Show author(s) (2023). Novel Insights into the Pathogenesis of Human Post-Primary Tuberculosis from Archival Material of the Pre-Antibiotic Era, 1931–1947. Pathogens.
Show author(s) (2023). Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe. Frontiers in Allergy.
Show author(s) (2023). Identification of host biomarkers from dried blood spots for monitoring treatment response in extrapulmonary tuberculosis. Scientific Reports. 12 pages.
Show author(s) (2023). Care-seeking pathways and diagnostic delays in extrapulmonary TB patients. Public Health Action. 148-154.

Show author(s) (2022). The value of histological examination in the diagnosis of tuberculous lymphadenitis in the era of rapid molecular diagnosis. Scientific Reports. 1-11.
Show author(s) (2022). Parental TB associated with offspring asthma and rhinitis. The International Journal of Tuberculosis and Lung Disease. 544-549.
Show author(s) (2022). Improving diagnosis of tuberculous lymphadenitis by combination of cytomorphology and MPT64 immunostaining on cell blocks from the fine needle aspirates. PLOS ONE. 1-14.
Show author(s) (2022). Improved diagnosis of extrapulmonary tuberculosis in adults with and without HIV in Mbeya, Tanzania using the MPT64 antigen detection test. PLOS Global Public Health.

Show author(s) (2021). Successful Outpatient Management of Children at a Secondary Care Hospital in Pakistan in a Dengue Fever Epidemic and Their Clinical Outcomes. Journal of Tropical Medicine. 1-10.
Show author(s) (2021). Role of a Digital Clinical Decision-Support System in General Practitioners' Management of COPD in Norway. The International Journal of Chronic Obstructive Pulmonary Disease.
Show author(s) (2021). Predictors of slow clinical response and extended treatment in patients with extrapulmonary tuberculosis in Pakistan, A hospital-based prospective study. PLOS ONE. 14 pages.
Show author(s) (2021). Paediatric Contacts of Adult COVID-19 Patients: Clinical Parameters, Risk Factors, and Outcome. International Journal of Pediatrics. 8 pages.
Show author(s) (2021). MPT64 antigen detection test improves diagnosis of pediatric extrapulmonary tuberculosis in Mbeya, Tanzania. Scientific Reports. 1-11.
Show author(s) (2021). Isolation of non-tuberculous mycobacteria among tuberculosis patients, a study from a tertiary care hospital in Lahore, Pakistan. BMC Infectious Diseases. 9 pages.
Show author(s) (2021). Improving diagnosis of extrapulmonary tuberculosis by implementation of a sensitive and specific MPT64 antigen detection test in routine diagnostics.
Show author(s) (2021). Immunochemistry-based diagnosis of extrapulmonary tuberculosis: A strategy for large-scale production of mpt64-antibodies for use in the mpt64 antigen detection test. Antibodies. 1-14.
Show author(s) (2021). Host biomarkers for monitoring therapeutic response in extrapulmonary tuberculosis. Cytokine. 1-11.
Show author(s) (2021). A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients. Nature Communications.

Show author(s) (2020). Xpert MTB/RIF Ultra for rapid diagnosis of extrapulmonary tuberculosis in a high-income low-tuberculosis prevalence setting. Scientific Reports.
Show author(s) (2020). Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients. BMC Infectious Diseases. 1-13.
Show author(s) (2020). Mycobacterial antigens accumulation in foamy macrophages in murine pulmonary tuberculosis lesions: Association with necrosis and making of cavities. Scandinavian Journal of Immunology. 1-13.
Show author(s) (2020). Isoniazid resistance profile and associated levofloxacin and pyrazinamide resistance in rifampicin resistant and sensitive isolates/ from pulmonary and extrapulmonary tuberculosis patients in Pakistan: A laboratory based surveillance study 2015-19. PLOS ONE. 1-20.
Show author(s) (2020). Extrapulmonary tuberculosis in Pakistan- A nation-wide multicenter retrospective study. PLOS ONE.
Show author(s) (2020). Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting. BMC Infectious Diseases. 1-11.

Show author(s) (2019). Viable Mycobacterium tuberculosis in sputum after pulmonary tuberculosis cure. BMC Infectious Diseases. 1-8.
Show author(s) (2019). Utility of MPT64 Antigen Detection Test for Diagnosis of HIV Coinfected Extrapulmonary Tuberculosis in Tanzania .
Show author(s) (2019). Primary drug resistance in extra-pulmonary tuberculosis: a hospital-based prospective study from Pakistan. The International Journal of Tuberculosis and Lung Disease. 900-906.
Show author(s) (2019). Pre-diagnostic cost of extrapulmonary tuberculosis from patient perspective in Zanzibar, Tanzania.
Show author(s) (2019). Patient Health Seeking and Diagnostic Delay in Extrapulmonary Tuberculosis: A Hospital Based Study from Central India. Tuberculosis Research and Treatment. 8 pages.
Show author(s) (2019). MPT 64 Antigen Detection Test Performs Better Than Xpert MTB/RIF Assay for Extrapulmonary Tuberculosis in Adults in Tanzania.
Show author(s) (2019). IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting. Scientific Reports. 1-9.
Show author(s) (2019). Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting. BMC Infectious Diseases. 1-9.
Show author(s) (2019). Developing a new diagnostic test for extrapulmonary TB.
Show author(s) (2019). DEMOGRAPHIC CHARACTERISTICS OF PATIENTS WITH EXTRAPULMONARY TUBERCULOSIS IN PAKISTAN:RETROSPECTIVE COHORT ANALYSIS.
Show author(s) (2019). Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice. Communications Biology. 1-10.

Show author(s) (2018). Performance of MPT 64 antigen detection test compared to Xpert MTB/RIF assay and Culture for diagnosis of Extrapulmonary Tuberculosis in children in Tanzania.
Show author(s) (2018). Nye diagnostiske metoder for tuberkulose.
Show author(s) (2018). Mycobacterial antigen accumulation in foamy macrophages in pulmonary tuberculosis lesions is associated with tissue destruction and disease severity.
Show author(s) (2018). MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar. PLOS ONE. 1-15.
Show author(s) (2018). Forbedring av tuberkulosediagnostikk ved bruk av immunokjemi-baserte metoder.
Show author(s) (2018). First and second line drug resistance pattern in new Extra Pulmonary TB cases, Prospective study in a tertiary care hospital in Pakistan.
Show author(s) (2018). Diagnostic delay in extrapulmonary tuberculosis and impact on patient morbidity: A study from Zanzibar. PLOS ONE. 1-17.
Show author(s) (2018). Bacteriological examination for the diagnosis of tuberculous lymphadenitis -Is it sufficient?
Show author(s) (2018). A survey of knowledge, attitude, and practices of private retail pharmacies staff in tuberculosis care: Study from Dera Ismail Khan City, Pakistan. Journal of Pharmaceutical Policy and Practice. 1-7.

Show author(s) (2017). Rapid and specific diagnosis of extrapulmonary tuberculosis by immunostaining of tissues and aspirates with anti-MPT64. Applied immunohistochemistry & molecular morphology (Print). 282-288.
Show author(s) (2017). Improved diagnosis of tuberculous lymphadenitis by mycobacterial antigen detection in fine-needle aspirates by a novel immunochemistry-based test.
Show author(s) (2017). Implementation of a new immunohistochemistry-based test for diagnosing extrapulmonary tuberculosis by detection of mycobacterial antigen MPT64.
Show author(s) (2017). IP-10 point-of-care test for monitoring treatment efficacy in tuberculosis in a low-resource setting.

Show author(s) (2015). Tuberkulosediagnostikk.
Show author(s) (2015). Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis Research and Treatment.
Show author(s) (2015). Laboratory Diagnosis of Extra-pulmonary Tuberculosis (EPTB) in Resource-constrained Setting: State of the Art, Challenges and the Need. Journal of Clinical and Diagnostic Research.
Show author(s) (2015). Improved diagnosis of extrapulmonary tuberculosis by antigen detection in extrapulmonary samples by immunochemistry-based assay.
Show author(s) (2015). Improved diagnosis of extra pulmonary tuberculosis by antigen detection in extra pulmonary samples by immunochemistry-based assay.
Show author(s) (2015). Forbedring av diagnostikk ved ekstrapulmonal tuberkulose.

Show author(s) (2014). Mycobacterial antigens disappear from host tissue during latent Mycobacterium tuberculosis infection.
Show author(s) (2014). Immunocytochemical detection of Mycobacterium Tuberculosis complex specific antigen, MPT64, improves diagnosis of tuberculous lymphadenitis and tuberculous pleuritis. BMC Infectious Diseases.
Show author(s) (2014). Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosis infected lungs and lymph node tissues. BMC Infectious Diseases.

Show author(s) (2012). Rapid diagnosis of tuberculosis in aspirate, effusions, and cerebrospinal fluid by immunocytochemical detection of Mycobacterium tuberculosis complex specific antigen MPT64. Diagnostic Cytopathology. 782-791.
Show author(s) (2012). Long-term persistence of BCG Pasteur in lungs of C57BL/6 mice following intranasal infection. Scandinavian Journal of Immunology. 489-499.

Show author(s) (2010). Evidence for waning of latency in a cohort study of tuberculosis. BMC Infectious Diseases.
Show author(s) (2010). Comparison of Immune Response in Mice Infected with M-Bovis BCG Russia and M-Bovis BCG Pasteur. Scandinavian Journal of Immunology. 536-536.

Show author(s) (2009). Gender differences in the clinical diagnosis of tuberculous lymphadenitis-a hospital-based study from Central India. International Journal of Infectious Diseases. 600-605.
Show author(s) (2009). Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis.

Show author(s) (2008). Real-time quantitative PCR in the diagnosis of tuberculosis in formalin-fixed paraffin-embedded pleural tissue in patients from a high HIV endemic area. Diagnostic molecular pathology (Print). 112-117.
Show author(s) (2008). Rapid, sensitive and specific test for diagnosis of tuberculosis by using immunochemistry for detection of M. tuberculosis complex specific antigen MPT64.
Show author(s) (2008). Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium tuberculosis Complex Specific Antigen MPT64 in Patients From a HIV Endemic Area. Applied immunohistochemistry & molecular morphology (Print). 554-561.
Show author(s) (2008). Patient and health systems delays: Health-care seeking behaviour among pulmonary tuberculosis patients in Pakistan. JOURNAL OF PAKISTAN MEDICAL ASSOCIATION. 318-321.
Show author(s) (2008). Estimating the half-life of latent Mycobacterium tuberculosis infection based on the decline of tuberculosis in Norway.
Show author(s) (2008). Does leptin have a role in immunity to tuberculosis? . Indian Journal of Medical Research (IJMR).
Show author(s) (2008). Does leptin have a role in immunity to tuberculosis? Indian Journal of Medical Research (IJMR). 691-693.
Show author(s) (2008). Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. Virchows Archiv. 449-456.
Show author(s) (2008). Detection of Mycobacterium tuberculosis by polymerase chain reaction with DNA eluted from aspirate smears of tuberculous lymphadenitis. Diagnostic molecular pathology (Print). 174-178.

Show author(s) (2007). Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response. Clinical and Experimental Immunology. 105-113.
Show author(s) (2007). Immunohistochemistry for the detection of Mycobacterium tuberculosis complex specific antigen (MPT64) improves the diagnosis of extrapulmonary tuberculosis caused by pathogenic mycobacteria. APMIS - Journal of Pathologiy, Microbiology and Immunology. 1316-1316.
Show author(s) (2007). Immunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64. Diagnostic Pathology.
Show author(s) (2007). How does clinical diagnosis of mycobacterial adenitis correlate with histological findings? . East African Journal of Public Health.
Show author(s) (2007). How does clinical diagnosis of mycobacterial adenitis correlate with histological findings? East African Journal of Public Health. 47-50.
Show author(s) (2007). Detection of mycobacterium tuberculosis specific antigens by immunohistochemical technique: application for improved diagnosis of abdominal tuberculosis.
Show author(s) (2007). Correlation of Mycobacterium tuberculosis antigen MPT64 expression and apoptosis in human tuberculosis lesions.

Show author(s) (2006). Vaccine approaches to prevent tuberculosis. Scandinavian Journal of Immunology.
Show author(s) (2006). Vaccine approaches to prevent tuberculosis. Scandinavian Journal of Immunology. 243-250.
Show author(s) (2006). Immunohistochemistry using a Mycobacterium tuberculosis complex specific antibody for improved diagnosis of tuberculous lymphadenitis. Modern Pathology. 1606-1614.
Show author(s) (2006). Immunohistochemical analysis of cytokines and apoptosis in tuberculous lymphadenitis. Immunology. 454-462.

Show author(s) (2005). Significance of Fas and Fas ligand in tuberculous lymphadenitis. Immunology. 255-262.
Show author(s) (2005). Significance of Fas and Fas Ligand in tuberculous lymphadenitis.
Show author(s) (2005). Mycobacterial Lymphadenitis: Host immune response and new diagnostic tools.
Show author(s) (2005). Is Mycobacterium paratuberculosis a cause of Crohn`s disease?
Show author(s) (2005). Immunohistochemistry and polymerase chain reaction based detection of Mycobacterium tuberculosis in histologic specimens.
Show author(s) (2005). Cytokine profile during latent and slowly progressive primary tuberculosis: a possible role for interleukin-15 in mediating clinical disease. Clinical and Experimental Immunology. 180-192.

Show author(s) (2004). Role of Fasligand/Fas system and apoptosis in the pathogenesis of tuberculosis. 10 pages.

Show author(s) (2003). Title: Role of apoptosis in the pathogenesis of murine and human tuberculosis lesions; immune evasion strategies of mycobacteria.
Show author(s) (2003). In situ expression of CD40, CD40L (CD154), IL-12, TNF-alpha, IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 327-334.

Show author(s) (2002). Increased Bcl-2 and reduced Bax expression in infected macrophages in slowly progressive primary murine mycobacterium tuberculosis infection. Scandinavian Journal of Immunology. 383-391.

Show author(s) (2001). Increased expression of fas ligand in human tuberculosis and leprosy lesions: a potential novel mechanism of immune evasion in mycobacterial infection. Scandinavian Journal of Immunology. 630-639.

Show author(s) (2000). Murine models of chronic tuberculosis: significance of granuloma morphology, apoptosis and immune evasion.
Show author(s) (2000). In Situ Expression of cytokines and cellular phenotypes in the lungs of mice with slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 548-556.
Show author(s) (2000). Diversity of lung and spleen immune responses in mice with slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 147-154.

Show author(s) (1999). Increased expresson of Fas ligand on Mycobacterium tuberculosis infected macrophages: a potential novel mechanism of immune evation by Mycobacterium tuberculosis? Inflammation. 507-521.
Show author(s) (1999). Increased expression of FAS ligand on Mycobacterium tuberculosis infected macrophages: A potential novel mechansim of immune evasion by Mycobacterium tuberculosis? Inflammation. 507-521.
Show author(s) (1999). Changes in T-Lymphocyte Subsets in Lungs and Spleens of Mice with Slowly Progressive Primary Mycobacterium tuberculosis Infection: Involvement of Unconventional T-Cell Subsets. Scandinavian Journal of Immunology. 137-144.
Show author(s) (1999). A mouse model for slowly proressing tuberculosis. Scandinavian Journal of Immunology. 127-136.
Show author(s) (1999). A mouse model for slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 127-136.
Show author(s) (1999). A mouse model for slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 127-136.

Show author(s) (1998). TGF in primary progressive, latent and reactivated murine tuberculosis. Abstract 86.
Show author(s) (1998). Study of cytokines involved in progressive primary disease and latent tuberculosis in mice. Abstract 244 (Host response: pathogenesis, latency, immunogencicity, vaccine).
Show author(s) (1998). Compartmentalized immune responses in the spleens and lungs of chronically Mycobacterium tuberculosis infected mice.
Show author(s) (1998). Compartmentalized immune responses in the spleens and lungs of chronically Mycobacterium tuberculosis infected mice.
Show author(s) (1998). Compartmentalized immune responses in the spleens and lungs of chronically <I>mycobacterium tuberculosis</I> infected mice.
Show author(s) (1998). A novel mechanism of immune evasion by Mycobacterium tuberculosis.
Show author(s) (1998). A novel mechanism of immune evasion by <I>Mycobacterium tuberculosis</I>.
Show author(s) (1998). A Mouse Model for Latent Tuberculosis.
Show author(s) (1998). A Mouse Model for Latent Tuberculosis. Scandinavian Journal of Infectious Diseases. 59-68.

Show author(s) (1997). T cell Phenotypes in Lungs of Normal and TB Infected Mice, Compared to Spleen and Peripheral Blood.
Show author(s) (1997). Pattern of Cell Death in Mtb infected Mouse organs.
Show author(s) (1997). Lungs in Murine Latent Tuberculosis. International conference on immunopathology of mucous membranes and exocrine glands.
Show author(s) (1997). Lungs in Murine Latent Tuberculosis.
Show author(s) (1997). Histopathology of the Mouse Model for Latent TB Infection and Slowly Progressive Disease.
Show author(s) (1997). Cytokine Production and Bacillary Growth In Lungs of Mtb infected Mice Compared to Liver and Spleen.

More information in national current research information system (CRIStin)

An integrated multidisciplinary approach to improve diagnosis and management of tuberculosis in children (Funded by HelseVest/UiB).
Better health through partnership in higher education and bilateral student mobility: Collaboration between Pakistan and Norway (NORPART)
Pathogenesis of human Post-Primary Tuberculosis: Novel insights from Norwegian archival tissue material of the pre-antibiotic era
Risk of infection with Mycobacterium tuberculosis in a low tuberculosis prevalence setting
Association between tuberculosis and obstructive lung diseases and allergies
Biomarkers in tuberculosis: implications for improved diagnosis, monitoring treatment response, and host-directed therapies
Proteomic and bioinformatic studies of the host therapeutic response to tuberculosis treatment
Improving diagnosis of extrapulmonary tuberculosis by implementation of a sensitive and specific assay in routine tuberculosis diagnostics (Funding- Research Council of Norway, GLOVBVAC program)

Fields of competence

Atypical mybacteria

Biomarkers

Bronchiectasis

Chronic obstructive lung disease

Diagnostics

Immune system in disease

Respiratory infections

Tuberculosis

Tuberculosis Research Group

Tuberculosis (TB), one of the oldest known human diseases, is still one of the major causes of morbidity and mortality globally. Over 90% of TB cases occur in low- and middle-income countries that have fragile healthcare infrastructures and constrained resources.

New TB test

CIH researcher, Tehmina Mustafa, has developed a new robust, rapid, sensitive, and specific test for TB, implementable in low-resource settings!