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Xiang Wang

Researcher
  • E-mailXiang.Wang@uib.no
  • Phone+47 55 58 66 95
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen

Cell Biology and Biophysics

(1) Role of tunneling nanotubes in apoptotic signaling of cancer cells.

(2) Collection and phenotyping of circulating tumor cells.

(3) Circulating tumor cell microenvironment.

Journal articles
  • Bittins, Margarethe; Wang, Xiang. 2017. TNT-Induced Phagocytosis: Tunneling Nanotubes Mediate the Transfer of Pro-Phagocytic Signals From Apoptotic to Viable Cells. Journal of Cellular Physiology. doi: 10.1002/jcp.25584
  • Wang, Xiang; Gerdes, Hans-Hermann. 2015. Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells. Cell Death and Differentiation. 22: 1181-1191. doi: 10.1038/cdd.2014.211
  • Austefjord, Magnus Wiger; Gerdes, Hans-Hermann; Wang, Xiang. 2014. Tunneling nanotubes: Diversity in morphology and structure. Communicative & Integrative Biology. 7. doi: 10.4161/cib.27934
  • Andresen, Vibeke; Wang, Xiang; Ghimire, Sakhila; Omsland, Maria; Gjertsen, Bjørn Tore; Gerdes, Hans-Hermann. 2013. Tunneling nanotube (TNT) formation is independent of p53 expression. Cell Death and Differentiation. 20: 1124-1124. doi: 10.1038/cdd.2013.61
  • Gerdes, Hans-Hermann; Rustom, Amin; Wang, Xiang. 2013. Tunneling nanotubes, an emerging intercellular communication route in development. Mechanisms of Development. 130: 381-387. doi: 10.1016/j.mod.2012.11.006
  • Rios Mandragon, Ivan; Wang, Xiang; Gerdes, Hans-Hermann. 2012. Spatio-temporal analysis of tamoxifen-induced bystander effects in breast cancer cells using microfluidics. Biomicrofluidics. 6. 9 pages. doi: 10.1063/1.4726349
  • Wang, Xiang; Bukoreshtliev, Nickolay V; Gerdes, Hans-Hermann. 2012. Developing neurons form transient nanotubes facilitating electrical coupling and calcium signaling with distant astrocytes. PLoS ONE. 7. 9 pages. doi: 10.1371/journal.pone.0047429
  • Wang, Xiang; Gerdes, Hans-Hermann. 2012. Long-distance electrical coupling via tunneling nanotubes. Biochimica et Biophysica Acta - Biomembranes. 1818: 2082-2086. doi: 10.1016/j.bbamem.2011.09.002
  • Wittig, Dierk; Wang, Xiang; Walter, Cindy; Gerdes, Hans-Hermann; Funk, Richard H.W.; Roehlecke, Cora. 2012. Multi-level communication of human retinal pigment epithelial cells via tunneling nanotubes. PLoS ONE. 7. 12 pages. doi: 10.1371/journal.pone.0033195
  • Wang, Xiang; Veruki, Margaret Lin; Bukoreshtliev, Nickolay V; Hartveit, Espen; Gerdes, Hans-Herman. 2010. Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels. Proceedings of the National Academy of Sciences of the United States of America. 107: 17194-17199. doi: 10.1073/pnas.1006785107
  • Bukoreshtliev, Nickolay V; Wang, Xiang; Hodneland, Erlend; Gurke, Steffen; Barroso, Joao Filipe; Gerdes, Hans-Herman. 2009. Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells. FEBS Letters. 583: 1481-1488. doi: 10.1016/j.febslet.2009.03.065
Reports and theses
  • Austefjord, Magnus Wiger; Wang, Xiang. 2015. Probing the Biophysical and Structural Properties of Tunneling Nanotubes Using Laminar Flow in a Microfluidic Device. Universitetet i Bergen. 30 pages.

More information in national current research information system (CRIStin)

Wang X*, Gerdes HH. Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells. Cell Death Diff. Epub ahead of print 2015 (*Corresponding author)

Austefjord MW, Gerdes HH, Wang X*. Tunneling nanotubes: Diversity in morphology and structure. Communicative & Integrative Biology. 7(2014):e27934. (*Corresponding author, review)

Andresen V*, Wang X*, Ghimire S, Omsland M, Gjertsen BT, Gerdes HH. Tunneling nanotube (TNT) formation is independent of p53 expression. Cell Death Diff. 20 (2013):1124. (*Shared first authorship)

Gerdes HH, Rustom A, Wang X. Tunneling nanotubes, an emerging intercellular communication route in development. Mechanisms of Development. 130 (2013): 381-387. (review)

Wang X, Bukoreshtliev NV, Gerdes HH. Developing neurons form transient nanotubes facilitating electrical coupling and calcium signaling with distant astrocytes. PLoS One. 7 (2012): e47429.

Mandragon I, Wang X*, Gerdes HH*. Spatio-temporal analysis of tamoxifen-induced bystander effects in breast cancer cells using microfluidics. Biomicrofluidics. 6 (2012): 024128. (* Shared corresponding authors)

Wittig D, Wang X, Walter C, Gerdes HH, Funk R, Roehlecke C. Multi-level communication of human retinal pigment epithelial cells via tunneling nanotubes. PLoS One. 7 (2012): e33195.

Wang X, Gerdes HH. Long-distance electrical coupling via tunneling nanotubes. Biochim Biophys Acta. 1818 (2012): 2082-2086. (review)

Wang X, Veruki ML, Bukoreshtliev NV, Hartveit E, Gerdes HH. Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels. Proc Natl Acad Sci U S A. 107 (2010):17194-17199. (Highlighted in Nature,published online 20 September 2010, doi:10.1038/news.2010.482.)

Bukoreshtliev NV*, Wang X*, Hodneland E*, Gurke S, Barroso JF, Gerdes HH. Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells. FEBS Lett. 583 (2009):1481-1488. (*Shared first authorship)

Wang X, Zhao HF, Zhang GJ. Mechanism of cytosol phospholipase C and sphingomyelinase induced lysosome destabilization. Biochimie. 88 (2006): 913-922.

Wang X*, Wang LL*,Zhang GJ. Guanosine 5’-[γ-thio]triphosphate-mediated activation of cytosol phospholipase C caused lysosomal destabilization. J. Membr. Biol. 211 (2006): 55-63. (*Shared first authorship)

Yi YP,Wang X, Zhang G, Fu TS, Zhang GJ. Phosphatidic acid osmotically destabilizes lysosomes through increased permeability to K+ and H+. Gen. Physiol. Biophys. 25 (2006): 149-160.

Zhao HF, Wang X, Zhang GJ. Lysosome destabilization by cytosolic extracts, putative involvement of Ca2+/phospholipase C. FEBS Lett. 579 (2005): 1551-1556.

Research groups