The focus of CELLNET is to understand interacting networks in normal and diseased cell systems.
Our major interest is the contextual importance of integrated cellular mechanisms regulating phenotypic switches associated with cancer development. We study signaling events and metabolism involved in various phases of tumor development, including tumor growth and metastasis. We use biomedical approaches (pharmacological, nutritional and genetic) to mimic various (patho)physiological contexts and to target specific factors or events, in vitro and in vivo. The research activities of our groups comprise multidisciplinary approaches employing biochemistry, cell based systems, molecular biology, animal models, and clinical/pharmaceutical collaborations to investigate biomedical mechanisms and clinical relevance.
The Cellular Networks Group consist of three laboratories: