All publications sorted by year

• Impact of small molecule-mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism. Makris G, Kayhan S, Kreuzer M, Rüfenacht V, Faccin E, Underhaug J, Diez-Fernandez C, Knobel PA, Poms M, Gougeard N, Rubio V, Martinez A, Pruschy M, Häberle J. (2023) Cancer Commun (Lond).  doi: 10.1002/cac2.12402. 

• Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function. Christie MS, Laitaoja M, Aarsand AK, Kallio JP, Bustad HJ. (2022) FEBS Open Bio. 12:2136-2146. doi: 10.1002/2211-5463.13490. 

• Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone. Støve SI, Skjevik ÅA, Teigen K, Martinez A. (2022) Commun Biol. 5:1283. doi: 10.1038/s42003-022-04121-1. 

• HTSDSF Explorer, A Novel Tool to Analyze High-throughput DSF Screenings. Martin-Malpartida P, Hausvik E, Underhaug J, Torner C, Martinez A, Macias MJ. (2022) J Mol Biol. 434:167372. doi: 10.1016/j.jmb.2021.167372. 

• High-affinity anti-Arc nanobodies provide tools for structural and functional studies. Markússon S, Hallin EI, Bustad HJ, Raasakka A, Xu J, Muruganandam G, Loris R, Martinez A, Bramham CR, Kursula P. (2022) PLoS One. 17:e0269281. doi: 10.1371/journal.pone.0269281. 

• Modeling of mutant superoxide dismutase 1 octamers with cross-linked disulfide bonds. Zhang A, Teigen K, Kouznetsova VL, Tsigelny IF. (2022) J Mol Model. 28:89 doi: 10.1007/s00894-022-05072-4. 

• Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Bueno-Carrasco MT, Cuéllar J, Flydal MI, Santiago C, Kråkenes TA, Kleppe R, López-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacón P, Martinez A, Valpuesta JM. (2022) Nat Commun. 13:74. doi: 10.1038/s41467-021-27657-y. 

• The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase. Aubi O, Prestegård KS, Jung-Kc K, Shi TS, Ying M, Grindheim AK, Scherer T, Ulvik A, McCann A, Spriet E, Thöny B, Martinez A. (2021) Nat Commun. 12:2073. doi: 10.1038/s41467-021-22107-1.
• Acute Intermittent Porphyria: An Overview of Therapy Developments and Future Perspectives Focusing on Stabilisation of HMBS and Proteostasis Regulators. Bustad HJ, Kallio JP, Vorland M, Fiorentino V, Sandberg S, Schmitt C, Aarsand AK, Martinez A. (2021) Int J Mol Sci. 22:675. doi: 10.3390/ijms22020675.
• Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles. Bezem MT, Johannessen FG, Kråkenes TA, Sailor MJ, Martinez A. (2021) Mol Pharm. doi: 10.1021/acs.molpharmaceut.0c00960.

• Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. Flydal MI, Kråkenes TA, Tai MDS, Tran MPA, Teigen K, Martinez A. (2020) Biochimie. S0300-9084:30322-30329. doi: 10.1016/j.biochi.2020.12.002.
• Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- In Vitro and In Vivo Investigations. Betari N, Sahlholm K, Morató X, Godoy-Marín H, Jáuregui O, Teigen K, Ciruela F, Haavik J. (2020) Front Pharmacol. 11:593416. doi: 10.3389/fphar.2020.593416.
• Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif. Eriksen MS, Nikolaienko O, Hallin EI, Grødem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuéllar J, Chambers JJ, O'Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A, Bramham CR. (2020) FEBS J. doi: 10.1111/febs.15618.
• Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis. Betari N, Sahlholm K, Ishizuka Y, Teigen K, Haavik J. (2020) Future Med Chem. 12:1461-1474. doi: 10.4155/fmc-2020-0127.
• Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer. Pedersen L, Panahandeh P, Siraji MI, Knappskog S, Lønning PE, Gordillo R, Scherer PE, Molven A, Teigen K, Halberg N. (2020) Cancer Res. 80:2163-2174. doi: 10.1158/0008-5472.CAN-19-3177.
• Pathogenic variants of DNAJC12 and evaluation of the encoded cochaperone as a genetic modifier of hyperphenylalaninemia. Gallego D, Leal F, Gámez A, Castro M, Navarrete R, Sanchez-Lijarcio O, Vitoria I, Bueno-Delgado M, Belanger-Quintana A, Morais A, Pedrón-Giner C, García I, Campistol J, Artuch R, Alcaide C, Cornejo V, Gil D, Yahyaoui R, Desviat LR, Ugarte M, Martinez A, Pérez B. (2020) Hum Mutat. 41:1329-1338. doi: 10.1002/humu.24026.
• The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection. Dobrovolska O, Brilkov M, Madeleine N, Ødegård-Fougner Ø, Strømland Ø, Martin SR, De Marco V, Christodoulou E, Teigen K, Isaksson J, Underhaug J, Reuter N, Aalen RB, Aasland R, Halskau Ø. (2020) FEBS J 287:4458-4480. doi: 10.1111/febs.15256.
• G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury. Lyu C, Lyu GW, Mulder J, Martinez A, Shi TS. (2020) J Pain Res. 13:419-429. doi: 10.2147/JPR.S233744.
• Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins. Støve SI, Flydal MI, Hausvik E, Underhaug J, Martinez A. (2020) Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Chapter 15:329-341. https://doi.org/10.1016/B978-0-12-819132-3.00015-4.
• A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria. Bustad HJ, Toska K, Schmitt C, Vorland M, Skjærven L, Kallio JP, Simonin S, Letteron P, Underhaug J, Sandberg S, Martinez A. (2020) Mol Ther. 28:677-689. doi: https://doi.org/10.1016/j.ymthe.2019.11.010.

• Long Noncoding RNA SChLAP1 Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling. Ji J, Xu R, Ding K, Bao G, Zhang X, Huang B, Wang X, Martinez A, Wang X, Li G, Miletic H, Thorsen F, Bjerkvig R, Xiang L, Han B, Chen A, Li X, Wang J. (2019) Clin Cancer Res 25:6868-6881. doi: 10.1158/1078-0432.CCR-19-0747.
• The Benefit of Large Neutral Amino Acid Supplementation to a Liberalized Phenylalanine-Restricted Diet in Adult Phenylketonuria Patients: Evidence from Adult Pah-Enu2 Mice. van Vliet D, van der Goot E, van Ginkel WG, van Faassen MHJR, de Blaauw P, Kema IP, Martinez A, Heiner-Fokkema MR, van der Zee EA, van Spronsen FJ. (2019) Nutrients 11:E2252. doi: 10.3390/nu11092252.
• Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes. Humisto A, Jokela J, Teigen K, Wahlsten M, Permi P, Sivonen K, Herfindal L. (2019) Biochim Biophys Acta Biomembr 1861:1510-1521. doi: 10.1016/j.bbamem.2019.03.010.
• Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin. Flydal MI, Alcorlo-Pagés M, Johannessen FG, Martínez-Caballero S, Skjærven L, Fernandez-Leiro R, Martinez A, Hermoso JA. (2019) PNAS 116:11229-11234. doi: 10.1073/pnas.1902639116.
• Dominant ARL3-related retinitis pigmentosa. Holtan JP, Teigen K, Aukrust I, Bragadóttir R, Houge G. (2019) Ophthalmic Genet 40:124-128. doi: 10.1080/13816810.2019.1586965.
• A scavenger receptor B (CD36)-like protein is a potential mediator of intestinal heme absorption in the hematophagous ectoparasite Lepeophtheirus salmonis. Heggland EI, Eichner C, Støve SI, Martinez A, Nilsen F, Dondrup M. (2019) Sci Rep 9:4218. doi: 10.1038/s41598-019-40590-x.
• Phenylalanine hydroxylase variants interact with the co-chaperone DNAJC12. Jung-Kc K, Himmelreich N, Prestegård KS, Shi TS, Scherer T, Ying M, Jorge-Finnigan A, Thöny B, Blau N, Martinez A. (2019) Hum Mutat doi: 10.1002/humu.23712.
• EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P. (2019) SLAS Discov doi: 10.1177/2472555218816276.
• Early Stage Discovery and Validation of Pharmacological Chaperones for the Correction of Protein Misfolding Diseases. Aubi O, Knappskog PM, Martinez A. (2019) Methods Mol Biol 1873:279-292. doi: 10.1007/978-1-4939-8820-4_18. 

• Tetrahydrobiopterin treatment reduces brain L-Phe but only partially improves serotonin in hyperphenylalaninemic ENU1/2 mice. Scherer T, Allegri G, Sarkissian CN, Ying M, Grisch-Chan HM, Rassi A, Winn SR, Harding CO, Martinez A, Thöny B. (2018) J Inherit Metab Dis doi: 10.1007/s10545-018-0150-y.
• Blood phenylalanine reduction corrects CNS dopamine and serotonin deficiencies and partially improves behavioral performance in adult phenylketonuric mice. Winn SR, Scherer T, Thöny B, Ying M, Martinez A, Weber S, Raber J, Harding CO. (2018) Mol Genet Metab 123:6-20. doi: 10.1016/j.ymgme.2017.10.009.
• Stabilization of Human Tyrosine Hydroxylase in Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue. Bezem MT, Johannessen FG, Jung-Kc K, Gundersen ET, Jorge-Finnigan A, Ying M, Betbeder D, Herfindal L, Martinez A. (2018) Bioconjug Chem 29:493-502. doi: 10.1021/acs.bioconjchem.7b00807.
• DNAJC12 deficiency: A new strategy in the diagnosis of hyperphenylalaninemias. Blau N, Martinez A, Hoffmann GF, Thöny B. (2018) Mol Genet Metab 123:1-5. doi: 10.1016/j.ymgme.2017.11.005.
• New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type. Brasil S, Briso-Montiano A, Gámez A, Underhaug J, Flydal MI, Desviat L, Merinero B, Ugarte M, Martinez A, Pérez B. (2018) Biochim Biophys Acta 1864:640-648. doi: 10.1016/j.bbadis.2017.11.024.

• Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia. Urbaneja MA, Skjærven L, Aubi O, Underhaug J, López DJ, Arregi I, Alonso-Mariño M, Cuevas A, Rodríguez JA, Martinez A, Bañuelos S. (2017) Sci Rep 7:13959. doi: 10.1038/s41598-017-14497-4.
• Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. Jorge-Finnigan A, Kleppe R, Jung-Kc K, Ying M, Marie M, Rios-Mondragon I, Salvatore MF, Saraste J, Martinez A. (2017) J Biol Chem 292:14092-14107. doi: 10.1074/jbc.M116.762344.
• Substituting Tyr¹³⁸ in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation. Leandro J, Stokka AJ, Teigen K, Andersen OA, Flatmark T. (2017) FEBS Open Bio 7:1026-1036. doi: 10.1002/2211-5463.12243.
• Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability. Anikster Y, Haack TB, Vilboux T, Pode-Shakked B, Thöny B, Shen N, Guarani V, Meissner T, Mayatepek E, Trefz FK, Marek-Yagel D, Martinez A, Huttlin EL, Paulo JA, Berutti R, Benoist JF, Imbard A, Dorboz I, Heimer G, Landau Y, Ziv-Strasser L, Malicdan MCV, Gemperle-Britschgi C, Cremer K, Engels H, Meili D, Keller I, Bruggmann R, Strom TM, Meitinger T, Mullikin JC, Schwartz G, Ben-Zeev B, Gahl WA, Harper JW, Blau N, Hoffmann GF, Prokisch H, Opladen T, Schiff M. (2017) Am J Hum Genet 100:257-266. doi: 10.1016/j.ajhg.2017.01.002.
• Tyrosine hydroxylase binding to phospholipid membranes prompts its amyloid aggregation and compromises bilayer integrity.
  Baumann A, Jorge-Finnigan A, Jung-Kc K, Sauter A, Horvath I, Morozova-Roche LA, Martinez A. (2017) Sci Rep 6:39488. doi: 10.1038/srep39488.
• Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.
  Waløen K, Kleppe R, Martinez A, Haavik J. (2017) Expert Opin Ther Targets 21:167-180. doi: 10.1080/14728222.2017.1272581.
• Pharmacological Chaperoning: A Potential Treatment For PMM2-CDG.
  Yuste-Checa P, Brasil S, Gámez A, Underhaug J, Desviat LR, Ugarte M, Pérez-Cerdá C, Martinez A, Pérez B. (2017) Hum Mutat 38:160-168. doi: 10.1002/humu.23138.

• Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme.
  Bezem MT, Baumann A, Skjærven L, Meyer R, Kursula P, Martinez A, Flydal MI. (2016) Sci Rep 6:30390. doi: 10.1038/srep30390.
• Online interactive analysis of protein structure ensembles with Bio3D-web.
  Skjærven L, Jariwala S , Yao XQ, Grant B. (2016) Bioinformatics 32:3510-3512. doi: 10.1093/bioinformatics/btw482.
• Simulation of lipid bilayer self-assembly using all-atom lipid force fields.
  Skjevik ÅA, Madej BD, Dickson CJ, Lin C, Teigen K, Walker RC, Gould IR. (2016) Phys Chem Chem Phys 18:10573-84. doi: 10.1039/c5cp07379k.
• Pharmacological chaperones that protect tetrahydrobiopterin dependent aromatic amino acid hydroxylases through different mechanisms.
  Hole M, Jorge-Finnigan A, Underhaug J, Teigen K, Martinez A. (2016) Curr Drug Targets 17:1515-26. doi: 10.2174/1389450117666160307143512.
• Rapid Characterization of Allosteric Networks with Ensemble Normal Mode Analysis.
  Yao XQ, Skjærven L, Grant BJ. (2016) J Phys Chem B 120:8276-8288. doi: 10.1021/acs.jpcb.6b01991.
• Dynamic coupling and allosteric networks in the alpha subunit of heterotrimeric G proteins.
  Yao XQ, Malik RU, Griggs NW, Skjærven L, Traynor JR, Sivaramakrishnan S, Grant BJ. (2016) J Biol Chem 291:4742-4753. doi: 10.1074/jbc.M115.702605.

• Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila.
  Aubi O, Flydal MI, Zheng H, Skjærven L, Rekand I, Leiros HK, Haug BE, Cianciotto NP, Martinez A, Underhaug J. (2015) J Med Chem 58:8402-12. doi: 10.1021/acs.jmedchem.5b01589.
• Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.
  Korner G, Noain D, Ying M, Hole M, Flydal MI, Scherer T, Allegri G, Rassi A, Fingerhut R, Becu-Villalobos D, Pillai S, Wueest S, Konrad D, Lauber-Biason A, Baumann CR, Bindoff LA, Martinez A, Thöny B. (2015) Brain 138:2948-63. doi: 10.1093/brain/awv224.
• Dynamics, flexibility, and allostery in molecular chaperonins. Skjærven L, Cuellar J, Martinez A, Valpuesta JM. (2015) FEBS Lett 589:2522-32. doi: 10.1016/j.febslet.2015.06.019.
• Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms.
  Hole M, Underhaug J, Díez H, Ying M, Røhr ÅK, Jorge-Finnigan A, Fernàndez-Castillo N, García-Cazorla A, Andersson KK, Teigen K, Martinez A. (2015) Biochim Biophys Acta 1854:1078-89. doi: 10.1016/j.bbapap.2015.04.030.
• Cuticle Integrity and Biogenic Amine Synthesis in Caenorhabditis elegans Require the Cofactor Tetrahydrobiopterin (BH4).
  Loer CM, Calvo AC, Watschinger K, Werner-Felmayer G, O'Rourke D, Stroud D, Tong A, Gotenstein JR, Chisholm AD, Hodgkin A, Werner ER, Martinez A. (2015) Genetics 200:237-53. doi: 10.1534/genetics.114.174110.
• Arc is a flexible modular protein capable of reversible self-oligomerization.
  Myrum C, Baumann A, Bustad HJ, Flydal MI, Mariaule V, Alvira S, Cuéllar J, Haavik J, Soulé J, Valpuesta JM, Márquez JA, Martinez A, Bramham CR. (2015) Biochem J 468:145-158. doi: 10.1042/BJ20141446.
• All-Atom Lipid Bilayer Self-Assembly with the AMBER and Charmm Lipid Force Fields.
  Skjevik ÅA, Madej BD, Dickson CJ, Teigen K, Walker RC, Gould IR. (2015) Chem Commun 51:4402-4405. doi: 10.1039/c4cc09584g.

• A. Sauter, Y. Mc Duffie, H. Boehm, A. Martinez, J. P. Spatz and S. Appel. Surface-Mediated Priming During In Vitro Generation of Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology 81:56-65, 2014
• Lars Skjærven, Xin-Qiu Yao, Guido Scarabelli, and Barry J Grant. Integrating protein structural dynamics and evolutionary analysis with Bio3D. BMC Bioinformatics 15:399, 2014
• Jozef Hritz, In-Ja L. Byeon, Troy Krzysiak, Aurora Martinez, Vladimir Sklenar, and Angela M. Gronenborn. Dissection of Binding between a Phosphorylated Tyrosine Hydroxylase Peptide and 14-3-3ζ: A Complex Story Elucidated by NMR. Biophys. J. 197:2185-2194, 2014.
• Lars Skjærven, Knut Teigen, and Aurora Martinez. Structure–Function Relationships in the Aromatic Amino Acid Hydroxylases Enzyme Family: Evolutionary Insights. In: eLS. John Wiley & Sons, Ltd: Chichester
• Claudia Szczepanski, Olav Tenstad, Anne Baumann, Aurora Martinez, Reidar Myklebust, Rolf Bjerkvig, and Lars Prestegarden. Identification of a novel lytic peptide for the treatment of solid tumours. Genes Cancer. 2014; 5(5-6): 186–200
• Rune Kleppe, Sara Rosati, Ana Jorge-Finnigan, Sara Alvira, Sadaf Ghorbani, Jan Haavik, Jose Maria Valpuesta, Albert J R. Heck, and Aurora Martinez. Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3gamma. Mol Cell Proteomics, , 2014
• Sarah Wettstein, Jarl Underhaug, Belen Perez, Brian D. Marsden, Wyatt W. Yue, Aurora Martinez, and Nenad Blau. Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuria. Eur J Hum Genet, 13:2017–2030, 2014 (video cast)
• Agnete Fossbakk, Rune Kleppe, Per M. Knappskog, Aurora Martinez, and Jan Haavik. Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia. Hum Mutat, 35:880–890, 2014
• Rune Kleppe, Sadaf Ghorbani, Aurora Martinez, and Jan Haavik. Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins. FEBS Lett, 588:92–98, 2014
• Age Aleksander Skjevik, Mauro Mileni, Anne Baumann, Oyvind Halskau, Knut Teigen, Raymond C. Stevens, and Aurora Martinez. The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. J Mol Biol, 426:150–168, 2014

• Rune I Lindstad, Knut Teigen, and Lars Skjeldal. Inhibition of sorbitol dehydrogenase by nucleosides and nucleotides. Biochem Biophys Res Commun, 435:202–208, 2013
• Hanna-Kirsti S. Leiros, Marte Innselset Flydal, and Aurora Martinez. Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila. FEBS Open Bio, 3:370–378, 2013
• Ianire Martin, Jarl Underhaug, Garbiñe Celaya, Fernando Moro, Knut Teigen, Aurora Martinez, and Arturo Muga. Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. J Med Chem, 56:7177--7189, 2013
• Helene J Bustad, Marta Vorland, Eva Ronneseth, Sverre Sandberg, Aurora Martinez, and Karen Toska. Conformational stability and activity analysis of two hydroxymethylbilane synthase mutants, K132N and V215E, with different phenotypic association with acute intermittent porphyria. Biosci Rep, 33:617–626, 2013
• Heli Havukainen, Daniel Munch, Anne Baumann, Shi Zhong, Øyvind Halskau, Michelle Krogsgaard, and Gro V Amdam. Vitellogenin recognizes cell damage through membrane binding and shields living cells from reactive oxygen species. J Biol Chem, , 2013
• Alexander Sauter, Gunther Richter, Alexandre Micoulet, Aurora Martinez, Joachim P Spatz, and Silke Appel. Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. Biointerphases, 8:14, 2013
• Cecilie Totland, Ming Ying, Mette Haugen, Kibret Mazengia, Anette Storstein, Jan Aarseth, Aurora Martinez, and Christian Vedeler. Avidity of onconeural antibodies is of clinical relevance. Cancer Immunol Immunother, 62:1393–1396, 2013
• Ana Jorge-Finnigan, Sandra Brasil, Jarl Underhaug, Pedro Ruíz-Sala, Begoña Merinero, Ruma Banerjee, Lourdes R. Desviat, Magdalena Ugarte, Aurora Martinez, and Belén Pérez. Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type. Hum Mol Genet, 22:3680–3689, 2013
• Marte I. Flydal and Aurora Martinez. Phenylalanine hydroxylase: function, structure, and regulation. IUBMB Life, 65:341–349, 2013

• Jarl Underhaug, Oscar Aubi, and Aurora Martinez. Phenylalanine hydroxylase misfolding and pharmacological chaperones. Curr Top Med Chem, 12:2534–2545, 2012
• Åge A. Skjevik, Benjamin D. Madej, Ross C. Walker, and Knut Teigen. LIPID11: a modular framework for lipid simulations using amber. J Phys Chem B, 116:11124–11136, 2012
• Anne Baumann, Anja Underhaug Gjerde, Ming Ying, Catharina Svanborg, Holm Holmsen, Wilhelm R. Glomm, Aurora Martinez, and Øyvind Halskau. HAMLET forms annular oligomers when deposited with phospholipid monolayers. J Mol Biol, 418:90–102, 2012
• Marte Innselset Flydal, Christa H. Chatfield, Huaiixing Zheng, Felizza F. Gunderson, Oscar Aubi, Nicholas P. Cianciotto, and Aurora Martinez. Phenylalanine hydroxylase from legionella pneumophila is a thermostable enzyme with a major functional role in pyomelanin synthesis. PLoS ONE, 7:e46209, 2012
• Helene Johannessen Bustad, Lars Skjaerven, Ming Ying, Øyvind Halskau jr, Anne Baumann, David Rodriguez-Larrea, Miguel Costas, Jarl Underhaug, Jose Manuel Sanchez-Ruiz, and Aurora Martinez. The Peripheral Binding of 14-3-3g to Membranes Involves Isoform-Specific Histidine Residues. PLoS ONE, 7:e49671, 2012
• Caroline Heintz, Heinz Troxler, Aurora Martinez, Beat Thöny, and Nenad Blau. Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry. Mol Genet Metab, 105:559–565, 2012
• Christineh N. Sarkissian, Ming Ying, Tanja Scherer, Beat Thöny, and Aurora Martinez. The mechanism of BH4-responsive hyperphenylalaninemia-as it Occurs in the ENU1/2 genetic mouse model. Hum Mutat, 33:1464–1473, 2012
• Karin U. Schallreuter, Mohamed A.E.L. Salem, Nick C.J. Gibbons, Aurora Martinez, Radomir Slominski, Jürgen Lüdemann, and Hartmut Rokos. Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: epidermal H2O2/ONOO–mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels. FASEB J, 26:2457–2470, 2012
• Lars Skjaerven, Arturo Muga, Nathalie Reuter, and Aurora Martinez. A dynamic model of long-range conformational adaptations triggered by nucleotide binding in GroEL-GroES. Proteins: Struct Funct Genet, 80:2333–2346, 2012
• Heli Havukainen, Jarl Underhaug, Florian Wolschin, Gro Amdam, and Øyvind Halskau. A vitellogenin polyserine cleavage site: highly disordered conformation protected from proteolysis by phosphorylation. J Exp Biol, 215:1837–1846, 2012

• Helene J. Bustad, Jarl Underhaug, Oyvind Halskau, Jr, and Aurora Martinez. The binding of 14-3-3g to membranes studied by intrinsic fluorescence spectroscopy. FEBS Lett, 585:1163–1168, 2011
• Ana C. Calvo, Angel L. Pey, Antonio Miranda-Vizuete, Anne P. Døskeland, and Aurora Martinez. Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine. Biochem J, 434:133–141, 2011
• Khanh K. Dao, Angel L. Pey, Anja Underhaug Gjerde, Knut Teigen, In-Ja L. Byeon, Stein O. Døskeland, Angela M. Gronenborn, and Aurora Martinez. The regulatory subunit of PKA-I remains partially structured and undergoes b-aggregation upon thermal denaturation. PLoS One, 6:e17602, 2011
• Rune Kleppe, Aurora Martinez, Stein Ove Døskeland, and Jan Haavik. The 14-3-3 proteins in regulation of cellular metabolism. Semin Cell Dev Biol, 22:713–719, 2011
• Elaine Olsson, Aurora Martinez, Knut Teigen, and Vidar R. Jensen. Formation of the iron-oxo hydroxylating species in the catalytic cycle of aromatic amino acid hydroxylases. Chemistry, 17:3746–3758, 2011
• Elaine Olsson, Aurora Martinez, Knut Teigen, and Vidar R Jensen. Substrate Hydroxylation by the Oxido–Iron Intermediate in Aromatic Amino Acid Hydroxylases: A DFT Mechanistic Study. Eur J Inorg Chem, 2011:2720–2732, 2011
• Lars Skjaerven, Nathalie Reuter, and Aurora Martinez. Dynamics, flexibility and ligand-induced conformational changes in biological macromolecules: a computational approach. Future Med Chem, 3:2079–2100, 2011
• Lars Skjaerven, Aurora Martinez, and Nathalie Reuter. Principal component and normal mode analysis of proteins; a quantitative comparison using the GroEL subunit. Proteins: Struct, Funct, Bioinf, 79:232–243, 2011
• Lars Skjaerven, Barry Grant, Arturo Muga, Knut Teigen, J Andrew McCammon, Nathalie Reuter, and Aurora Martinez. Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations. PLoS Comput Biol, 7:e1002004, 2011
• Åge Aleksander Skjevik, Bengt Erik Haug, Henning Lygre, and Knut Teigen. Intramolecular hydrogen bonding in articaine can be related to superior bone tissue penetration: a molecular dynamics study. Biophys Chem, 154:18–25, 2011

• In-Ja L. Byeon, Khanh K. Dao, Jinwon Jung, Jeffrey Keen, Ingar Leiros, Stein O. Døskeland, Aurora Martinez, and Angela M. Gronenborn. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. J. Biol. Chem., 285:14062–14070, 2010
• Ana C. Calvo, Tanja Scherer, Angel L. Pey, Ming Ying, Ingeborg Winge, Jeffrey McKinney, Jan Haavik, Beat Thöny, and Aurora Martinez. Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2. J. Neurochem., 114:853–863, 2010
• Marte I. Flydal, Tonje C. Mohn, Angel L. Pey, Jessica Siltberg-Liberles, Knut Teigen, and Aurora Martinez. Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications. Amino Acids, 39:1463–1475, 2010
• Oyvind Halskau, Sondre Volden, Ana C. Calvo, Aurora Martínez, and Wilhelm R. Glomm. Adsorption and bioactivity of tyrosine hydroxylase on gold surfaces and nanoparticles. Protein Pept. Lett., 17:1376–1382, 2010
• Ann-Kristin Mossberg, Maja Puchades, Øyvind Halskau, Anne Baumann, Ingela Lanekoff, Yinxia Chao, Aurora Martinez, Catharina Svanborg, and Roger Karlsson. HAMLET interacts with lipid membranes and perturbs their structure and integrity. PLoS One, 5:e9384, 2010
• Raymond C. Stevens, Javier Sancho, and Aurora Martinez. Rescue of misfolded proteins and stabilization by small molecules. Methods Mol. Biol., 648:313–324, 2010
• Ming Ying, Angel L. Pey, Niels Aarsaether, and Aurora Martinez. Phenylalanine hydroxylase expression in primary rat hepatocytes is modulated by oxygen concentration. Mol. Genet. Metab., 101:279–281, 2010
• Øyvind Halskau, Jr, Ming Ying, Anne Baumann, Rune Kleppe, David Rodriguez-Larrea, Bjørg Almås, Jan Haavik, and Aurora Martinez. Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes. J Biol Chem, 284:32758–32769, 2009
• Øyvind Halskau, Arturo Muga, and Aurora Martínez. Linking new paradigms in protein chemistry to reversible membrane-protein interactions. Curr Protein Pept Sci, 10:339–359, 2009
• Angel Luis Pey and Aurora Martinez. Iron binding effects on the kinetic stability and unfolding energetics of a thermophilic phenylalanine hydroxylase from Chloroflexus aurantiacus. J Biol Inorg Chem, 14:521–531, 2009
• Jessica Siltberg-Liberles and Aurora Martinez. Searching distant homologs of the regulatory ACT domain in phenylalanine hydroxylase. Amino Acids, 36:235–249, 2009
• Age Aleksander Skjevik, Knut Teigen, and Aurora Martinez. Overview of computational methods employed in early-stage drug discovery. Future Med Chem, 1:49–63, 2009
• Ana C. Calvo, Angel L. Pey, Ming Ying, Curtis M. Loer, and Aurora Martinez. Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans. FASEB J, 22:3046–3058, 2008
• Oyvind Halskau, Jr, Raul Perez-Jimenez, Beatriz Ibarra-Molero, Jarl Underhaug, Victor Muñoz, Aurora Martinez, and Jose M. Sanchez-Ruiz. Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics. Proc Natl Acad Sci U S A, 105:8625–8630, 2008
• Aurora Martinez, Ana C. Calvo, Knut Teigen, and Angel L. Pey. Rescuing proteins of low kinetic stability by chaperones and natural ligands phenylketonuria, a case study. Prog Mol Biol Transl Sci, 83:89–134, 2008
• Angel L. Pey, Ming Ying, Nunilo Cremades, Adrian Velazquez-Campoy, Tanja Scherer, Beat Thöny, Javier Sancho, and Aurora Martinez. Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria. J Clin Invest, 118:2858–2867, 2008
• Jessica Siltberg-Liberles, Ida Helene Steen, Randi M. Svebak, and Aurora Martinez. The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene, 427:86–92, 2008
• Beat Thöny, Ana C. Calvo, Tanja Scherer, Randi M. Svebak, Jan Haavik, Nenad Blau, and Aurora Martinez. Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase. J Neurochem, 106:672–681, 2008
• Anita-Elin Fedøy, Nannan Yang, Aurora Martinez, Hanna-Kirsti S. Leiros, and Ida Helene Steen. Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability. J Mol Biol, 372:130–149, 2007
• Hanna-Kirsti S Leiros, Angel L Pey, Marte Innselset, Elin Moe, Ingar Leiros, Ida Helene Steen, and Aurora Martinez. Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability. J. Biol. Chem., 282:21973–21986, 2007
• Angel L. Pey and Aurora Martinez. Tetrahydrobiopterin for patients with phenylketonuria. Lancet, 370:462–463, 2007
• Angel L. Pey, Francois Stricher, Luis Serrano, and Aurora Martinez. Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases. Am J Hum Genet, 81:1006–1024, 2007
• Knut Teigen, Jeffrey Alan McKinney, Jan Haavik, and Aurora Martínez. Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem, 14:455–467, 2007
• Khanh Kim Dao, Knut Teigen, Reidun Kopperud, Erlend Hodneland, Frank Schwede, Anne E. Christensen, Aurora Martinez, and Stein Ove Døskeland. Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. J Biol Chem, 281:21500–21511, 2006
• Angel L. Pey, Aurora Martinez, Ramamurthy Charubala, Derek J. Maitland, Knut Teigen, Ana Calvo, Wolfgang Pfleiderer, John M. Wood, and Karin U. Schallreuter. Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. FASEB J, 20:2130–2132, 2006
• Laila J. Reigstad, Aurora Martinez, Jan Erik Varhaug, and Johan R. Lillehaug. Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines. Exp Cell Res, 312:782–795, 2006
• Oyvind Halskau, Jarl Underhaug, Nils Age Frøystein, and Aurora Martínez. Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity. J Mol Biol, 349:1072–1086, 2005
• Frederico F. Miranda, Matthias Kolberg, K Kristoffer Andersson, Carlos F G C. Geraldes, and Aurora Martínez. The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase. J Inorg Biochem, 99:1320–1328, 2005
• Belén Pérez, Lourdes R. Desviat, Paulino Gómez-Puertas, Aurora Martínez, Rymond C. Stevens, and Magdalena Ugarte. Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients. Mol Genet Metab, 86 Suppl 1:S11–S16, 2005
• Angel L. Pey and Aurora Martinez. The activity of wild-type and mutant phenylalanine hydroxylase and its regulation by phenylalanine and tetrahydrobiopterin at physiological and pathological concentrations: an isothermal titration calorimetry study. Mol Genet Metab, 86 Suppl 1:S43–S53, 2005
• Ingunn Rødland, Øyvind Halskau, Aurora Martínez, and Holm Holmsen. alpha-Lactalbumin binding and membrane integrity–effect of charge and degree of unsaturation of glycerophospholipids. Biochim Biophys Acta, 1717:11–20, 2005
• Rossana Scavelli, Zhaobing Ding, Nenad Blau, Jan Haavik, Aurora Martínez, and Beat Thöny. Stimulation of hepatic phenylalanine hydroxylase activity but not Pah-mRNA expression upon oral loading of tetrahydrobiopterin in normal mice. Mol Genet Metab, 86 Suppl 1:S153–S155, 2005

2004

• Heidi Erlandsen, Angel L. Pey, Alejandra Gámez, Belén Pérez, Lourdes R. Desviat, Cristina Aguado, Richard Koch, Sankar Surendran, Stephen Tyring, Reuben Matalon, Charles R. Scriver, Magdalena Ugarte, Aurora Martínez, and Raymond C. Stevens. Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc Natl Acad Sci U S A, 101:16903–16908, 2004
• Jeffrey McKinney, Per M. Knappskog, Jacinto Pereira, Trude Ekern, Karen Toska, Baukje B. Kuitert, David Levine, Angela M. Gronenborn, Aurora Martinez, and Jan Haavik. Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastoris. Protein Expr Purif, 33:185–194, 2004
• Frederico Faria Miranda, Matthías Thórólfsson, Knut Teigen, Jose M. Sanchez-Ruiz, and Aurora Martínez. Structural and stability effects of phosphorylation: Localized structural changes in phenylalanine hydroxylase. Protein Sci, 13:1219–1226, 2004
• Angel L. Pey, Belén Pérez, Lourdes R. Desviat, Maria Angeles Martínez, Cristina Aguado, Heidi Erlandsen, Alejandra Gámez, Raymond C. Stevens, Matthías Thórólfsson, Magdalena Ugarte, and Aurora Martínez. Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations. Hum Mutat, 24:388–399, 2004
• Angel Luis Pey, Matthías Thórólfsson, Knut Teigen, Magdalena Ugarte, and Aurora Martínez. Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase. J Am Chem Soc, 126:13670–13678, 2004
• Knut Teigen, Khanh K. Dao, Jeffrey A. McKinney, Antonius C F. Gorren, Bernd Mayer, Nils Age Frøystein, Jan Haavik, and Aurora Martínez. Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity. J Med Chem, 47:5962–5971, 2004
• Beat Thöny, Zhaobing Ding, and Aurora Martínez. Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: implications for tetrahydrobiopterin-responsive hyperphenylalaninemia. FEBS Lett, 577:507–511, 2004

2003

• Armelle Varnier Agasøster, Øyvind Halskau, Edvin Fuglebakk, Nils Age Frøystein, Arturo Muga, Holm Holmsen, and Aurora Martínez. The interaction of peripheral proteins and membranes studied with alpha-lactalbumin and phospholipid bilayers of various compositions. J Biol Chem, 278:21790–21797, 2003
• Anne E. Christensen, Frode Selheim, Johan de Rooij, Sarah Dremier, Frank Schwede, Khanh K. Dao, Aurora Martinez, Carine Maenhaut, Johannes L. Bos, H-G. Genieser, and Stein O. Døskeland. cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. J Biol Chem, 278:35394–35402, 2003
• Laila J. Reigstad, Hege M. Sande, Øystein Fluge, Ove Bruland, Arturo Muga, Jan Erik Varhaug, Aurora Martinez, and Johan R. Lillehaug. Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure. J Biol Chem, 278:17114–17120, 2003
• Knut Teigen and Aurora Martinez. Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations. J Biomol Struct Dyn, 20:733–740, 2003
• Matthías Thórólfsson, Knut Teigen, and Aurora Martínez. Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237. Biochemistry, 42:3419–3428, 2003

2002

• Øyvind Halskau, Nils Age Frøystein, Arturo Muga, and Aurora Martínez. The membrane-bound conformation of alpha-lactalbumin studied by NMR-monitored 1H exchange. J Mol Biol, 321:99–110, 2002
• Frederico Faria Miranda, Knut Teigen, Matthías Thórólfsson, Randi M. Svebak, Per M. Knappskog, Torgeir Flatmark, and Aurora Martínez. Phosphorylation and mutations of Ser(16) in human phenylalanine hydroxylase. Kinetic and structural effects. J Biol Chem, 277:40937–40943, 2002
• Matthías Thórólfsson, Anne P. Døskeland, Arturo Muga, and Aurora Martínez. The binding of tyrosine hydroxylase to negatively charged lipid bilayers involves the N-terminal region of the enzyme. FEBS Lett, 519:221–226, 2002
• Matthías Thórólfsson, Beatriz Ibarra-Molero, Peter Fojan, Steffen B. Petersen, Jose M. Sanchez-Ruiz, and Aurora Martínez. L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study. Biochemistry, 41:7573–7585, 2002

Publications by professor emeritus Holm Holmsen can be found here