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ProtMetD: Protein Modifications, Metabolism and Disease

The ProtMetD programme is a collaboration of 3 research groups lead by:

 Mathias Ziegler:

Thomas Arnesen:

Nathalie Reuter:

Signalling and Metabolism

This programme investigates the structural, molecular and (patho-)physiological aspects of protein modifications. Many proteins undergo chemical modifications which lead to modulation of their biological activity. These modifications are highly regulated and mediated by important metabolites, for example, acetylation by acetyl-coenzyme A, phosphorylation by ATP, and ADP-ribosylation by NAD. We strive to unravel the molecular mechanisms by which these protein modifications are brought about, what the target proteins and the functional consequences are. This knowledge will not only extend our understanding of fundamental biological principles, but also contribute to the identification of disease mechanisms and potential treatments.

Based on a long-standing expertise, this programme currently focusses on protein acetylation, its subcellular distribution, regulation, functional consequences and its role in cancer biology. In addition to experimental laboratory work, we use structural bioinformatics and molecular modelling to gain understanding of the functional implications of protein modifications and for the identification of novel target proteins.

Research

New NAA10 mutations identified in 11 girls and boys with development delays.

In recent years, several sporadic cases of NAA10 mutations have been identified in patients with varying degrees of developmental delays. In the curremt issue of Human Mutation, Svein Isungset Støve, Marina Blenski and Thomas Arnesen from the NAT-group at the Department of Molecular Biology in...

News

New hope for creating drought-resistant plants

Drought is an increasing problem all over the world and the main reason for crop failure, thus there is a need to develop plants that are highly resistant to drought. We have found targeting of the NatA enzyme to be a way to develop highly drought resistant plants since NatA controls the stress...

News

Cellular GPS-system reveals new territory for an influential enzyme family

UiB researchers have developed a “GPS system” to find protein-positions in cells. The method was used to reveal a special localization the newest member of an enzyme family with important tasks in the human body. This new enzyme knowledge may be useful in medicine and the cellular "GPS system...

News

Researchers at MBI discover why vitamin B3 is essential

This week, researchers Nick Love, Nadine Pollak, Christian Dölle and Marc Niere from the Ziegler group report their discovery that the final step in the conversion of vitamin B3 to a molecule called NADP is critical for the embryonic development of animals.