HUIMM903 – Human Immunobiology

COURSE:

Human Immunobiology (PhD / Research School)

COURSE CODE:

HUIMM903

FKU_ANBKRV - Recommended Qualifications/Knowledge

- No special requirements, but basic cell biology and immunological knowledge is advantageous.

FKU_DELTA - Target group/student

PhD-students

FKU_FAGANS - Scientific Responsible

Karl Albert Brokstad

Bergen Research School in Inflammation (BRSI)

http://www.uib.no/Broegelmann/brsi/index.html

Broegelmanns Forskningslaboratorium, Gades Institutt

FKU_FORKRV - Prerequisites

- The student should be at post-graduate level (have a MSc or equivalent)

- No knowledge immunology is needed, but advantageous

- Basic knowledge of human biology

FKU_INNGAR - Part of training program

- Part of the formal training of the PhD program

FKU_INNHLD - Content

The course covers the main areas of immunology, with special focus on the role in health and disease.

FKU_INNLED - Teachers/Lecturers

Karl Albert Brokstad

Roland Jonsson

Torbjørn Hansen

Silke Appel

Rebecca Jane Cox

Elling Ulvestad

Einar Kristoffersen

FKU_KONTKT - Contact

Karl Albert Brokstad

Bergen Research School in Inflammation (BRSI)

http://www.uib.no/Broegelmann/brsi/index.html

Broegelmanns Forskningslaboratorium, Gades Institutt

FKU_KSTNAD - Expenses

Not Applicable

FKU_LITT - Syllabus

The syllabus will be covered by lectures and the text book:

Abbas, Lichtman and Pillai. Cellular and Molecular Immunology. 7^th Edition, 2011, Saunders Elsevier, ISBN 978-1-4377-1528-6.

Alternative text book (Norwegian): Bogen and Munthe. Immunologi 2. Utg, 2007, Universitetsforlaget, Olso, ISBN 978-8-2150-1093-9.

FKU_OVRLPP - Course Overlap

The course is overlapping with HUIMM303 and MOL212

FKU_PAMLD  - Registration deadline

The registration deadline for Spring semester is usually 1st February.

FKU_PRGRAM - Program

- 20 x 2 hour lectures

- project work

- exam

A detailed program is prepared prior to start of course, please contact the course coordinator for more information. http://www.uib.no/Broegelmann/brsi/index.html

FKU_STPNG - Credits

10 (ECTS)

FKU_UNDPER - Shedule

In general, from February to May, every Tuesdays and Thursdays from 13:15-15:00, with exam in May/June. A detailed program is prepared prior to start of course, please contact the course coordinator for more information.

FKU_USPRAK - Language

English (Norwegian on request)

FKU_USTED - Location

Seminar rooms 5.1 and 5.2, 5th floor, The Laboratory Building, The Gade institute

FKU_UTBYTE - Learning Outcome

* Knowledge

After completing the course the student should be able to:

- Recognize the main types of cells, tissues, signal molecules and bioactive factors (components), which the immune system is comprised of.

- Outline the development and maturation process of immune competent cells.

- Understand the basic mechanisms for how the immune system becomes activated and responds to stimuli e.g. infections or tissue damage.

- Have knowledge about the basic principles for defence and fight against infections. Present methods/treatment that can strengthen the immunity against infectious agents (e.g. vaccination).

- Account for main groups of diseases related to a failing immune system (auto immunity, allergy and immune deficiency) and describe in general the disease processes.

- Outline methods for treatment of immune related diseases and symptoms..

* Skills

- Describe how immunological methods can be used in biological and medical research.

- Apply the immunological knowledge to own research project.

* General Competence

- Obtain a general knowledge of how the immune system work in health and disease.

- To be able to distinguish the immunological component in a variety of complex health issues.

- Understand the importance of using immunological knowledge in both prevention and combating diseases.

FKU_UTFYLL - Supplementary information

More information is avaialable at http://www.uib.no/Broegelmann/brsi/index.html

FKU_VURD - Form of Assessment

Oral Examination

Grading: Pass/Fail

 

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Content

Part I - Introduction to the immune system

=   Elling Ulvestad, tel. 55974616 – elling.ulvestad@helse-bergen.no

•   Properties and overview of immune responses

•   Innate immunity

•   Cells and tissues of the adaptive immune system

Part II - Recognition of antigens

=   Torbjørn Hansen, tel. 55974637 – torbjorn.hansen@gades.uib.no

•   Antibodies and antigens

•   The major histocompatibility complex

•   Antigen processing and presentation to T lymphocytes (AO Hovden)

•   Antigen receptors and accessory molecules of T lymphocytes

Part III - Maturation, activation and regulation of lymphocytes

=   Karl A. Brokstad, tel. 55974622 – karl.brokstad@gades.uib.no

•   Lymphocyte development and the rearrangement and expression of antigen receptor genes

•   Activation of T lymphocytes

•   B cell activation and antibody production

•   Immunological tolerance (R Jonsson)

Part IV - Effector mechanisms of immune responses

=  Roland Jonsson, tel. 55974649 – roland.jonsson@gades.uib.no

•   Cytokines (KA Brokstad)

•   Effector mechanisms of cell-mediated immunity

•   Effector mechanisms of humoral immunity

Part V -  The immune system in defense and disease

=  Einar Kristoffersen, tel. 55974683 – einar.kristoffersen@gades.uib.no

•   Immunity to microbes

•   Transplantation immunology

•   Immunity to tumors

•   Diseases caused by immune responses: hypersensitivity and autoimmunity

•   Immediate hypersensitivity

•   Congenital and acquired immunodeficiencies

Part VI – Additional information

=   Karl A. Brokstad, tel. 55974622 – karl.brokstad@gades.uib.no

•   Laboratory techniques commonly used in immunology (RJ Cox)