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Klinisk institutt 1

Midtveisevaluering - Aslaug Drotningsvik

Midtveisevaluering for ph.d.-graden ved Universitetet i Bergen for kandidat Aslaug Drotningsvik

Hovedinnhold

Abstract:

Health effects of fish proteins

Fish consumption is associated with reduced risk of common life-style diseases, and this is often explained by the high content of long chain PUFAs in fatty fish. I addition to marine n-3 PUFAS, fish is an excellent protein source. Recent research show effects on lipid metabolism, glucose regulation and inflammation after dietary fish protein supplementation, both in animal studies and in clinical intervention trials. Health effects of fish proteins has mainly been investigated in relation to obesity-related diseases such as cardiovascular disease and diabetes and little is known about how fish protein can affect other conditions.

 

The aim of this PhD-project is to investigate potential health effects of a dietary supplement of fish proteins. The project consists of an animal study and a clinical study. In the animal study health effects of fish proteins was investigated in obese Zucker fa/fa rats. The focus of this study is on lipid metabolism, blood pressure, inflammation and organ damage. In the clinical study, elderly nursing home residents were given a dietary supplement of fish proteins for six weeks. The aim of the clinical trial is to investigate effects on catabolic factors such as insulin resistance and inflammation.