Luiza Mihaela Ghila

Forsker

Vitenskapelig artikkel

Vis forfatter(e) (2024). Targeted Gene Silencing by Using GapmeRs in Differentiating Human-Induced Pluripotent Stem Cells (hiPSC) Toward Pancreatic Progenitors. Methods in molecular biology. 23-38.
Vis forfatter(e) (2024). Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells. Transplant International.

Vis forfatter(e) (2023). Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A. International Journal of Molecular Sciences.
Vis forfatter(e) (2023). Global proteomics reveals insulin abundance as a marker of human islet homeostasis alterations. Acta Physiologica. 15 sider.

Vis forfatter(e) (2022). Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. Diabetes. 862-869.
Vis forfatter(e) (2022). Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes. Scientific Reports.

Vis forfatter(e) (2021). Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human ipsc-derived pancreatic progenitors. International Journal of Molecular Sciences.
Vis forfatter(e) (2021). A Method for Encapsulation and Transplantation into Diabetic Mice of Human Induced Pluripotent Stem Cells (hiPSC)-Derived Pancreatic Progenitors. Methods in molecular biology.

Vis forfatter(e) (2020). In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. Frontiers in Cell and Developmental Biology. 1-14.
Vis forfatter(e) (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling . Scientific Reports. 1-16.
Vis forfatter(e) (2020). Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. Biomedicines. 1-20.

Vis forfatter(e) (2019). The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. Frontiers in Endocrinology. 1-13.
Vis forfatter(e) (2019). Reprogrammed cells display distinct proteomic signaturesAssociated with colony morphology variability. Stem Cells International. 1-16.
Vis forfatter(e) (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica. 1-16.
Vis forfatter(e) (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. bioRxiv.
Vis forfatter(e) (2019). Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 43-48.

Vis forfatter(e) (2018). Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Nature Cell Biology. 1267-1277.
Vis forfatter(e) (2018). Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. PLOS ONE. 1-15.

Vis forfatter(e) (2017). Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. Scientific Reports. 1-14.

Faglig foredrag

Vis forfatter(e) (2023). Hnf1a Is An Important Regulator in Ageing And Maturation Of Pancreatic Islets.
Vis forfatter(e) (2023). Exploring the role of transcription factors HNF1A, HNF1B, and HNF4A in human pancreatic islet cell differentiation.
Vis forfatter(e) (2023). Exploring the role of transcription factors HNF1A, HNF1B, and HNF4A in human induced pluripotent stem cell-derived pancreatic islet cell differentiation.

Vis forfatter(e) (2022). Mapping tumour heterogeneity and predictive cancer signatures in vivo.
Vis forfatter(e) (2022). Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors.

Vitenskapelig foredrag

Vis forfatter(e) (2023). Islet maturation and ageing is governed by the Hnf1a transcription factor.

Leder

Vis forfatter(e) (2022). Editorial: Beta-Cell Fate: From Gene Circuits to Disease Mechanisms. Frontiers in Genetics.

Populærvitenskapelig artikkel

Vis forfatter(e) (2021). Islet transplantation tolerance in animals with defined histocompatibility and diabetes. bioRxiv.

Sammendrag/abstract

Vis forfatter(e) (2021). 402.2: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells. Transplantation. S27-S27.

Poster

Vis forfatter(e) (2023). Mapping predictive bladder cancer signatures in a mouse model.
Vis forfatter(e) (2023). Mapping islet architecture changes upon high fat diet challenge in a HNF1A-MODY mouse model.
Vis forfatter(e) (2023). Investigating the developmental role of HNF1A, HNF1B and HNF4A in human pancreatic islet cell differentiation.
Vis forfatter(e) (2023). Human induced pluripotent stem cells as a model for environmental impact on diabetes.

Vis forfatter(e) (2022). Molecular mechanisms affecting islet like cell fate acquisition in differentiating iPSC derived β-like cells”.
Vis forfatter(e) (2022). Mind your background!
Vis forfatter(e) (2022). Know your background, know your data.
Vis forfatter(e) (2022). Investigating the developmental role of HNF1A, HNF1B and HNF4A in human pancreatic islet cell differentiation.
Vis forfatter(e) (2022). Investigating the developmental role of HNF1A in human pancreatic islet cell differentiation.
Vis forfatter(e) (2022). Hnf1a is a key regulator of β-cell identity and function.

Vis forfatter(e) (2021). Glucose during in vitro pancreatic beta cells regeneration: friends or for?

Vitenskapelig oversiktsartikkel/review

Vis forfatter(e) (2019). Tissue repair brakes: A common paradigm in the biology of regeneration: Concise review. Stem Cells. 330-339.

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