Hjem
  • E-postArne.Tjolsen@uib.no
  • Telefon+47 55 58 67 86+47 928 04 707
  • Besøksadresse
    Jonas Lies vei 91
  • Postadresse
    Postboks 7804
    5020 Bergen

Mechanisms for regulation of pain sensation. Research on mechanisms in the spinal cord dorsal horn. Emphasis on stimulus-induced potentiation of nociceptive responses in dorsal horn neurones.

Mainly neurophysiology and neuroanatomy, but also general organ physiology. Students of medicine, dentistry and human biology.

Special interest in educational leadership.

Concerned with teaching methods that activate and stimulate students for learning.

Web page with teaching resources:

http://folk.uib.no/mfyat/ressurs/

Tidsskriftartikler
  • Bojovic, Ognjen; Bramham, Clive R.; Tjølsen, Arne. 2016. Stimulation-induced expression of immediate early gene proteins in the dorsal horn is increased in neuropathy. Scandinavian Journal of Pain. 10: 43-51. doi: 10.1016/j.sjpain.2015.09.002
  • Bojovic, Ognjen; Bramham, Clive R.; Tjølsen, Arne. 2015. Chronic morphine treatment enhances sciatic nerve stimulation-induced immediate early gene expression in the rat dorsal horn. Acta Neurobiologiae Experimentalis. 75: 305-313.
  • Bojovic, Ognjen; Panja, Debabrata; Bittins, Margarethe; Bramham, Clive R.; Tjølsen, Arne. 2015. Time course of immediate early gene protein expression in the spinal cord following conditioning stimulation of the sciatic nerve in rats. PLoS ONE. 10:e0123604. doi: 10.1371/journal.pone.0123604
  • You, Hao-Jun; Lei, Jing; Niu, Nan; Yang, Lin; Fan, Xiao-Li; Tjølsen, Arne; Li, Qiang. 2013. Specific thalamic nuclei function as novel ‘nociceptive discriminators’ in the endogenous control of nociception in rats. Neuroscience. 232: 53-63. doi: 10.1016/j.neuroscience.2012.12.021
  • You, Hao-Jun; Lei, Jianhua; Sui, Mei-Yi; Huang, Li; Tan, Yong-Xian; Tjølsen, Arne; Arendt-Nielsen, Lars. 2010. Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception. Journal of Physiology. 588: 4177-4188. doi: 10.1113/jphysiol.2010.196923
  • Haugan, Frøydis; Rygh, Lars Jørgen; Tjølsen, Arne. 2008. Ketamine blocks enhancement of spinal long-term potentiation in chronic opioid treated rats. Acta Anaesthesiologica Scandinavica. 52: 681-687. doi: 10.1111/j.1399-6576.2008.01637.x
  • Haugan, Frøydis; Wibrand, Karin; Fiskå, Atle; Bramham, Clive R. Evjen; Tjølsen, Arne. 2008. Stability of long term facilitation and expression of zif268 and Arc in the spinal cord dorsal horn is modulated by conditioning stimulation within the physiological frequency range of primary afferent fibers. Neuroscience. 154: 1568-1575. doi: 10.1016/j.neuroscience.2008.05.010
  • You, Hao-Jun; Tjølsen, Arne; Arendt-Nielsen, Lars. 2006. High-frequency conditioning electrical stimulation evokes supraspinal independent long-term depression but not long-term potentiation of the spinal withdrawal reflex in rats. Brain Research. 1090: 116-122. doi: 10.1016/j.brainres.2006.03.065
  • Rygh, Lars Jørgen; Hole, Kjell; Tjølsen, Arne. 2005. Molekylære mekanismer ved akutte og kroniske smerter. Tidsskrift for Den norske legeforening. 125: 2374-2377.
  • Rygh, Lars Jørgen; Svendsen, Frode; Fiskå, Atle; Haugan, Frøydis; Hole, Kjell; Tjølsen, Arne. 2005. Long-term potentiation in spinal nociceptive systems - how acute pain may become chronic. Psychoneuroendocrinology. 30: 959-964. doi: 10.1016/j.psyneuen.2005.04.007
  • Sweitzer, SM; Wong, SM; Tjølsen, Arne; Allen, CP; Mochly-Rosen, D; Kendig, JJ. 2004. Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon, and gamma. Pain. 110: 281-289.
  • Kjørsvik, Anne; Warsame Afrah, Abdul; Gustafsson, Henrik; Tjølsen, Arne; Hole, Kjell; Stiller, Carl-Olav. 2003. Stimulation of spinal 5-HT(2A/2C) receptors potentiates the capsaicin-induced in vivo release of substance P-like immunoreactivity in the rat dorsal horn. Brain Research. 987: 10-16.
  • Wallin, Johan; Fiskå, Atle; Tjølsen, Arne; Linderoth, Bengt; Hole, Kjell. 2003. Spinal cord stimulation inhibits long-term potentiation of spinal wide dynamic range neurons. Brain Research. 43: 153-159.
  • Afrah, Abdullahi; Fiskå, Atle; Gjerstad, Johannes; Gustafsson, Henrik; Tjølsen, Arne; Olgart, Leif; Stiller, Carl-Olav; Hole, Kjell; Brodin, Ernst. 2002. Spinal substance P release during the induction of long-term potentiation in dorsal horn neurons. Pain. 96: 49-55.
  • Rygh, Lars Jørgen; Tjølsen, Arne; Hole, Kjell; Svendsen, Frode. 2002. Cellular memory in spinal nociceptive circuitry. Scandinavian Journal of Psychology. 43: 153-159.
  • Gjerstad, Johannes; Tjølsen, Arne; Hole, Kjell. 2001. Induction of long-term potentiation of single wide dynamic range neurones in the dorsal horn is inhibited by descending pathways. Pain. 91: 263-268.
  • Kjørsvik, Anne; Tjølsen, Arne; Hole, Kjell. 2001. Activation of spinal seritonin 2A/2C receptors augements nociceptive responses in the rat. Brain Research. 910: 179-181.
  • Rosen, Gunnar; Hugdahl, Kenneth; Ersland, Lars; Lundervold, Arvid; Smievoll, Alf Inge; Barndon, Roger; Sundberg, Håkan; Thomsen, Tormod; Roscher, Bjarne; Tjølsen, Arne; Engelsen, Bernt. 2001. Different brain areas activated during imagery of painful and non-painful "finger movements" in a subject with an amputated arm. Neurocase. 7: 255-260.
  • Rygh, Lars Jørgen; Svendsen, Frode; Hole, Kjell; Tjølsen, Arne. 2001. Increased spinal N-methyl-D-aspartate receptor function after 20 h of carrageenan-induced inflammation. Pain. 93: 15-21.
  • Gjerstad, Johannes; Tjølsen, Arne; Svendsen, Frode; Hole, Kjell. 2000. Inhibition of spinal nociceptive responses after intramuscular injection of capsaicin involves activation of noradrenergic and opioid systems. Brain Research. 859: 132-136.
  • Rygh, Lars Jørgen; Green, Mark; Athauda, Nuwan; Tjølsen, Arne; Dickenson, Anthony H. 2000. Effect of spinal morphine after long-term potentiation of wide dynamic range neurones in the rat. Anesthesiology. 92: 140-146.
  • Almeida, Armando; Størkson, Rolf V; Lima, Deolinda; Hole, Kjell Jørgen; Tjølsen, Arne. 1999. The medullary dorsal reticular nucleus facilitates pain behaviour induced by formalin in the rat. European Journal of Neuroscience. 11: 110-122.
  • Gjerstad, Johannes; Tjølsen, Arne; Svendsen, Frode; Hole, Kjell Jørgen. 1999. Inhibition of evoked C-fibre responses in the dorsal horn after contraleteral intramuscular injection of capsaicin involves activation of descending pathways. Pain. 80: 413-418.
  • Rygh, Lars Jørgen; Svendsen, Frode; Hole, Kjell Jørgen; Tjølsen, Arne. 1999. Natural noxious stimulation can induce long-term increase of spinal nociceptive responses. Pain. 82: 305-310.
  • Svendsen, Frode; Hole, Kjell Jørgen; Tjølsen, Arne. 1999. Some problems with wind-up and its calculation. Pain. 83: 109-112.
  • Svendsen, Frode; Rygh, Lars Jørgen; Gjerstad, Johannes; Fiskå, Atle; Hole, Kjell Jørgen; Tjølsen, Arne. 1999. Recording of long-term potentiation in single dorsal horn neurones in vivo in the rat. Brain Research Protocols. 4: 165-172.
  • Svendsen, Frode; Rygh, Lars Jørgen; Hole, Kjell Jørgen; Tjølsen, Arne. 1999. Dorsal horn NMDA receptor function is changed after peripheral inflammation. Pain. 83: 517-523.
  • Svendsen, Frode; Tjølsen, Arne; Gjerstad, Johannes; Hole, Kjell Jørgen. 1999. Long term potentiation of single WDR neurons in spinalized rats. Brain Research. 816: 487-492.
  • Svendsen, Frode; Tjølsen, Arne; Rygh, Lars Jørgen; Hole, Kjell Jørgen. 1999. Expression of long-term potentiation in single wide dynamic range neurons in the rat is sensitive to blockade of glutamate receptors. Neuroscience Letters. 259: 25-28.
  • Svendsen, Frode; Tjølsen, Arne; Rykkja, Frøydis; Hole, Kjell Jørgen. 1999. Behavioural effects of LTP-inducing sciatic nerve stimulation in rat. European Journal of Pain. 3: 355-363.
  • Bach-Gansmo, E.; Holen, A.; Tjølsen, Arne; Wilhelmsen, Lars Skjold; Stalsberg, H. 1998. (Group learning in medical education). Tidsskrift for Den norske legeforening. 118: 916-920.
  • Rønneberg, M.; Tjølsen, Arne. 1998. Smerter hos nyfødte. Tidsskrift for Den norske legeforening. 118: 3610-3613.
  • Svendsen, Frode; Tjølsen, Arne; Hole, Kjell Jørgen. 1998. AMPA and NMDA receptor-dependent spinal LTP after nociceptive tetanic stimulation. NeuroReport. 9: 1185-1190.
  • Gjerstad, Johannes; Tjølsen, Arne; Hole, Kjell Jørgen. 1997. The dual effect of 5-HT1B receptor stimulation on nociceptive dorsal horn neurones in rats. European Journal of Pharmacology. 335: 127-132.
  • Kjørsvik, Anne; Størkson, Rolf V; Tjølsen, Arne; Hole, Kjell Jørgen. 1997. Differential effects of activation of lumbar and thoracic 5-HT2A/2C receptors on nociception in rats. Pharmacology, Biochemistry and Behavior. 56: 523-527.
  • Svendsen, Frode; Tjølsen, Arne; Hole, Kjell Jørgen. 1997. LTP of spinal A-beta and C-fibre evoked responses after electrical sciatic nerve stimulation. NeuroReport. 8: 3427-3430.
  • Berge, Odd-Geir; Tjølsen, Arne. 1994. Tail-flicks, temperatures and latencies. Reply. Letter to the editor. Pain. 57: 256-257.
  • Chapman, V.; Dickenson, A.H; Tjølsen, Arne. 1994. Bi-directional effects of intrathecal NMDA and substance P on rat dorsal horn neuronal responses. Neuroscience Letters. 178: 90-94.
  • Tjølsen, Arne. 1994. Evaluering av undervisning. Universitetspedagogisk utviklingsarbeid i Bergen, UPED-skri ft no.4 Program for læringsforskning, Universitetet i Berge n. 4: 170-176.
  • Kanui, T. I.; Tjølsen, Arne; Lund, Anders; Mjellem-Joly, N.; Hole, Kjell Jørgen. 1993. Antinociceptive effects of intrathecal administration of alpha-adrenoceptor antagonists and clonidine in the formalin test in the mouse. Neuropharmacology. 32: 367-371.
  • Tjølsen, Arne; Hole, Kjell Jørgen. 1993. The tail-flick latency is influenced by skin temperature. APS Journal. 2: 107-111.
  • Tjølsen, Arne; Hole, Kjell Jørgen. 1993. Tail skin temperature should always be measured in the standard tail-flick test. APS Journal. 2: 115-116.
  • Tjølsen, Arne; Hole, Kjell Jørgen. 1993. The formalin test. Letter to the Editor. Pain. 53: 237-237.
  • Tjølsen, Arne; Hole, Kjell Jørgen. 1993. Smerteregulering og plastisitet. Tidsskrift for Den norske legeforening. 2921-2924.
  • Mjellem, N.; Lund, Anders; Eide, P. K.; Størkson, R.; Tjølsen, Arne. 1992. The role of 5HT%bA and 5HT%bB receptors in spinal nociceptive transmission and in the modulation of N-methyl-Daspartate induced behaviour. NeuroReport. 3: 1061-1064.
  • Tjølsen, Arne; Berge, Odd-Geir; Hunskår, Steinar; Rosland, Jan Henrik; Hole, Kjell Jørgen. 1992. The formalin test: an evaluation of the method. Pain. 51: 5-17.
  • Tjølsen, Arne; Hole, Kjell Jørgen. 1992. The effect of morphine on core and skin temperature. NeuroReport. 3: 512-514.
  • Hole, Kjell Jørgen; Berge, Odd-Geir; Tjølsen, Arne; Eide, P. K.; Garcia-Cabrera, I.; Lund, Anders; Rosland, Jan Henrik. 1991. The tail-flick test needs to be improved. Pain. 43: 391-392.
  • Tjølsen, Arne; Berge, Odd-Geir; Hole, Kjell Jørgen. 1991. Lesions of bulbo-spinal serotonergic or noradrenergic pathways reduce nociception as measured by the formalin test. Acta Physiologica Scandinavica. 236: 229-236.
  • Tjølsen, Arne; Lund, Anders; Hole, Kjell Jørgen. 1991. Antinociceptive effect on paracetamol in rats is partly dependent on the spinal serotonergic systems. European Journal of Pharmacology. 193: 193-201.
  • Tjølsen, Arne; Rosland, Jan Henrik; Berge, Odd-Geir; Hole, Kjell Jørgen. 1991. The increasing temperature hot plate test: An improved test of nociception in mice and rats. J Pharmacol Meth. 25: 241-250.
  • Eide, Per Kristian; Tjølsen, Arne. 1988. Effects of serotonin receptor antagonists and agonists on the tail-flick response in mice involve altered tail-skin temperature. Neuropharmacology. 27: 889-893.
  • Tjølsen, Arne; Berge, Odd-Geir; Eide, Per Kristian; Broch, Ole Jacob; Hole, Kjell. 1988. Apparent hyperalgesia after lesions of the descending serotonergic pathways is due to increased tail skin temperature. Pain. 33: 225-231.
Rapporter/avhandlinger
  • Tjølsen, Arne. 1991. The role of descending serotonergic and noradrenergic pathways in the regulation of nociception - with special emphasis on the development of appropriate tests of nociception in rats. (dr.med.). [Mangler utgivernavn], Bergen Universitetet i Bergen.
Bokkapitler
  • Rosland, Jan Henrik; Tjølsen, Arne. 2016. Grunnleggende smertefysiologi. kapittel 25, sider 328-340. I:
    • Kaasa, Stein; Loge, Jon Håvard. 2016. Palliasjon. Nordisk lærebok. 3. utgave. Gyldendal Akademisk. 832 sider. ISBN: 9788205488403.
  • Rosland, Jan Henrik; Tjølsen, Arne. 2008. Patofysiologiske mekanismer ved kreftrelaterte smerter. 17, sider . I:
    • Kaasa, Stein. 2008. Palliasjon - Nordisk lærebok 2. utgave. Gyldendal Akademisk. 690 sider. ISBN: 978-82-05-35181-3.
  • Tjølsen, Arne. 2002. Nociceptiive modulation as studied in Bergen. 38-47. I:
    • Tjølsen, Arne; Berge, Odd-Geir. 2002. Pain and Brain; Festschrift Kjell Hole 70 year. Universitetet i Bergen. ISBN: 82-90952-45-7.
  • Svendsen, Frode; Tjølsen, Arne. 2000. Long-term potentiation in single wide dynamic range neurons induced by noxious stimulation in intact and spinalized rats. 153-161. I:
    • Sandkühler, J; Bromm, B; Gebhart, GF. 2000. Nervous system plasticity and chronic pain.
  • Tjølsen, Arne; Hole, Kjell Jørgen. 1997. Animal models of analgesia. 1-20. I:
    • Dickenson, A; Besson, J-M. 1997. The pharmacology of pain.
  • Tjølsen, Arne. 1995. Smertefysiologi. 129-139. I:
    • Abusdal, U.G.; Natvig, B. 1995. Fibromyalgi? En bok om muskelsmerter. ISBN: 82-518-3351-5.
  • Tjølsen, Arne; Hole, Kjell Jørgen; Hunskår, Steinar. 1994. Animal models in pain research. 137-144. I:
    • Hau, J.; Svendsen, P. 1994. Animal selection and handling in biomedical research.
  • Hole, Kjell Jørgen; Berge, Odd-Geir; Eide, P. K.; Fasmer, Ole Bernt; Hunskår, Steinar; Lund, Anders; Rosland, Jan Henrik; Tjølsen, Arne. 1992. Modifications in nociceptive reactivity following various serotonergic treatments. Methodological difficulties. 137-152. I:
    • [Mangler etternavn], [Mangler fornavn]. 1992. Serotonin and Pain. (Red.: Besson, J. M.).

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