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Charalampos (Haris) Tzouliss bilde

Charalampos (Haris) Tzoulis

Forsker, Principal Investigator / Group Leader (Forsker I)
  • E-postCharalampos.Tzoulis@uib.no
  • Besøksadresse
    Nevologisk avdeling, Haukeland Universitetssykehus
    Rom: 
    Telefon: 55 97 50 45
  • Postadresse
    Postboks 7804
    5020 Bergen

Charalampos Tzoulis received his medical degree from Albert Szent-Györgyi Medical University of Szeged, Hungary in 2003. He subsequently trained in neurology at Haukeland University Hospital in Bergen, Norway and received his PhD degree with title “Clinical and molecular studies of disease caused by mutations of the mitochondrial DNA-polymerase gamma” from the University of Bergen in 2010.

Currently, he holds a position as a Consultant Neurologist and Research Group Leader at the Department of Neurology, Haukeland University Hospital and the University of Bergen. He specializes in neurodegenerative and neurogenetic diseases, in particular Parkinson's disease, movement disorders such as ataxia, dystonia and parkinsonism, and mitochondrial disorders.

He leads the Translational Science in Neurodegeneration & Aging research group (TSNA), which is devoted to the study of neurodegeneration and aging with a main focus on elucidating the etiology of Parkinson's disease and developing novel therapies. For more details please visit the groups website here: http://www.uib.no/en/rg/neurodegeneration  

  1. Tzoulis C, Bindoff LA. Molecular genetics of DNA polymerase gamma-associated neurodegeneration. Encyclopedia of Life Sciences (eLS). In press, Sep 2016.
  2. Tzoulis C, Sztromwasser P, Johansson S, Gjerde IO, Knappskog P, Bindoff LA. PNKP Mutations Identified by Whole-Exome Sequencing in a Norwegian Patient with Sporadic Ataxia and Edema. Cerebellum. 2016 May 10.
  3. Talasila KM, Rosland G, Hagland H, Eskilsson E, Tran GT, Fritah S, Azuaje F, Atai N, Harter P, Mittelbronn M, Anderson M, van Noorden R, Niclou SP, Thorsen F, Tronstad KJ, Tzoulis C, Bjerkvig R, and Miletic H. The angiogenic switch leads to a metabolic switch in human glioblastoma. Neuro Oncol. 2016 Sep 3.
  4. Hikmat O, Tzoulis C, Knappskog PM, Johansson S, Boman H, Sztromwasser P, Lien E, Brodkorb E, Ghezzi D, Bindoff LA. ADCK3 mutations with epilepsy, stroke-like episodes and ataxia: a POLG mimic? Eur J Neurol. 2016 Apr 23.
  5. Tzoulis C*, Schwarzlmüller T, Biermann M, Haugarvoll K, Bindoff LA. Mitochondrial DNA homeostasis is essential for nigrostriatal integrity. Mitochondrion. 2016 May;28:33-7.
  6. Valadas A, Contarino MF, Albanese A, Bhatia KP, Falup-Pecurariu C, Forsgren L, Friedman A, Giladi N, Hutchinson M, Kostic VS, Krauss JK, Lokkegaard A, Marti MJ, Milanov I, Pirtosek Z, Relja M, Skorvanek M, Stamelou M, Stepens A, Tamás G, Taravari A, Tzoulis C, Vandenberghe W, Vidailhet M, Ferreira JJ, Tijssen MA. Management of dystonia in Europe: a survey of the European network for the study of the dystonia syndromes. Eur J Neurol. 2016 Jan 29.
  7. Flønes I, Sztromwasser P, Haugarvoll K, Dölle C, Lykouri M, Schwarzlmüller T, Jonassen I, Miletic H, Johansson S, Knappskog PM, Bindoff LA, Tzoulis C*. Novel SLC19A3 promoter deletion and allelic silencing in biotin-thiamine-responsive basal ganglia encephalopathy. PLoS One. 2016 Feb 10.
  8. Haugarvoll K, Bindoff LA, Tzoulis C*. Nigrostriatal degeneration sine parkinsonism. Brain. 2016 Jan 25.
  9. Flønes IH, Haugarvoll K, Sundal C, Tzoulis C*. A woman in her 70s with chronic walking difficulties. Tidsskr Nor Laegeforen. 2015 Oct 20;135(19):1753-5.
  10. Bjørk MH, Gjerde IO, Tzoulis C, Ulvik RJ, Bindoff LA. A man in his 50s with high ferritin levels and increasing cognitive impairment. Tidsskr Nor Laegeforen. 2015 Aug 25;135(15):1369-72. 
  11. Tzoulis C*, Schwarzlmüller T, Gjerde IO, Søfteland E, Neckelmann G, Biermann M, Haroche J, Straume O, Vintermyr OK. Excellent response of intramedullary Erdheim-Chester disease to vemurafenib: a case report. BMC Res Notes. 2015 Apr 30;8(1):171.
  12. Albanese A, Abbruzzese G, Dressler D, Duzynski W, Khatkova S, Marti MJ, Mir P, Montecucco C, Moro E, Pinter M, Relja M, Roze E, Skogseid IM, Timerbaeva S, Tzoulis C. Practical guidance for CD management involving treatment of botulinum toxin: a consensus statement. J Neurol. 2015 Apr .1
  13. Tzoulis C, Zayats T, Knappskog PM, Müller B, Larsen JP, Tysnes OB, Bindoff LA, Johansson S, Haugarvoll K. HTRA2 p.G399S in Parkinson disease, essential tremor, and tremulous cervical dystonia. Proc Natl Acad Sci U S A. 2015 Mar 30.
  14. Tzoulis C, Kent, R. M, Robertson, A, et al.TRUDOSE pilot study: An evaluation of the dose of incobotulinumtoxinA and onabotulinumtoxinA for the clinical management of cervical dystonia and blepharospasm. Movement disorders. Vol 29, suppl-1. Pages: S531-S531.
  15. Tzoulis C, Tran GT, Coxhead J, Bertelsen B, Lilleng P, Balafkan N, Payne B, Miletic H, Chinnery PF, Miletic H, Bindoff LA. The molecular pathogenesis of POLG-related neurodegeneration. Ann Neurol. 2014 Jul;76(1):66-81.
  16. Tzoulis C, Kent R,  Robertson A, MAltman J, Purdy C, Magar R. The Retrospective Evaluation of the Dose of IncobotulinumtoxinA and OnabotulinumtoxinA for the Clinical Management of Cervical Dystonia and Blepharospasm: TRUDOSE Pilot Study. Neurology April 8, 2014 vol. 82 no. 10 Supplement P7.065
  17. Sofou K, De Coo IF, Isohanni P, Ostergaard E, Naess K, De Meirleir L, Tzoulis C, Uusimaa J, De Angst IB, Lönnqvist T, Pihko H, Mankinen K, Bindoff LA, Tulinius M, Darin N. A multicenter study on Leigh syndrome: disease course and predictors of survival. Orphanet J Rare Dis. 2014 Apr 15;9(1):52
  18. Wedding IM, Koht J, Tran GT, Misceo D, Selmer K, Holmgren A, Frengen E, Bindoff LA, Tallaksen CME, Tzoulis C. Spastic Paraplegia type 7 is associated with multiple mitochondrial DNA deletions. PLoS One. 2014 Jan 22;9(1):e86340
  19. Haugarvoll K, Tzoulis C, Tran GT, Karlsen B, Engelsen BA, Knappskog PM, Bindoff LA. Myoclonus-dystonia and epilepsy in a family with a novel epsilon-sarcoglycan mutation. J Neurol. 2014 Feb;261(2):358-62.
  20. Tzoulis C, Johansson S, Boman H, Knappskog PM, Haukanes BI, Bindoff LA. Novel SACS mutations in a Norwegian family with autosomal recessive spastic ataxia of Charlevoix-Chaguenay identified by next generation sequencing. PLoS One. 2013 Jun 13;8(6):e66145
  21. Tzoulis C, Vedeler C, Haugen M, Storstein A, Tran GT, Gjerde IO, Biermann M, Schwarzlmüller T, Bindoff LA. Progressive striatal necrosis associated with anti-NMDA receptor antibodies. BMC Neurol. 2013 May 31;13:55.
  22. Tzoulis C, Tran GT, Schwarzlmüller T, Specht K, Haugarvoll K, Balafkan N, Lilleng PK, Miletic H, Biermann M, , Bindoff LA. Severe nigrostriatal degeneration without clinical parkinsonism in patients with POLG mutations. Brain. 2013 Aug;136(Pt 8):2393-404. doi: 10.1093/brain/awt103. 
  23. Haugarvoll K, Johansson S, Tzoulis C, Haukanes BI, Bredrup C, Neckelmann G Boman H, Knappskog PM, Bindoff LA. MRI characterisation of adult onset α-methylacyl-coA racemase deficiency diagnosed by exome sequencing. Orphanet Journal of Rare Diseases.2013, 8:1.
  24. Balafkan N, Tzoulis C, Müller B, Haugarvoll K, Tysnes OB, Larsen JP, Bindoff LA. Number of CAG repeats in POLG1 associated with Parkinson disease in the Norwegian population. Mitochondrion 2012 2012 Nov;12(6):640-3. doi: 10.1016/j.mito.2012.08.004.
  25. Tzoulis C, Bindoff LA. Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects. Brain. 2012 Dec;135(Pt 12):3627-34.
  26. Tzoulis C, Gjerde IO, Søfteland E, Neckelmann G, Strøm E, Vintermyr OK, Sviland L, Biermann M. Erdheim-Chester disease presenting with an intramedullary spinal cord lesion. J Neurol. 2012 Jun.
  27. Tzoulis C, Tran GT, Gjerde IO, Aasly J, Neckelmann G, Rydland J, Varga V, Wadel-Andersen P, Bindoff LA. Leukoencephalopathy with brainstem and spinal cord involvement caused by a novel mutation in the DARS2 gene. J Neurol. 2012 Feb;259(2):292-6. doi: 10.1007/s00415-011-6176-9.
  28. Tzoulis C, Bindoff LA. Defining the mitochondrial POLG-related spinocerebellar ataxia and epilepsy in Norway. ACNR. 2011 Nov.
  29. Tzoulis C, Neckelmann G, Mørk SJ , Viscomi C, Moen G, Ersland L, Zeviani M, Bindoff LA. Localized cerebral energy failure in DNA polymerase gamma-associated encephalopathy syndromes. Brain. 2010 May;133(Pt 5):1428-37.
  30. Sanaker PS, Toompuu M, Hogan VE, He L, Tzoulis C, Chrzanowska-Lightowlers ZM, Taylor RW, Bindoff LA. Differences in RNA processing underlie the tissue specific phenotype of ISCU myopathy. Biochim Biophys Acta. 2010 Mar 4
  31. Tzoulis C, Bindoff LA. The syndrome of mitochondrial spinocerebellar ataxia and epilepsy (MSCAE) caused by POLG1 mutations. ACNR. 2009 Feb.
  32. Gramstad A, Bindoff LA, Lillebø A, Tzoulis C, Engelsen BA. Neuropsychological performance in patients with POLG1 mutations and the syndrome of mitochondrial spinocerebellar ataxia and epilepsy. Epilepsy Behav. 2009 Jan 27.
  33. Tzoulis C, Bindoff LA. Serial diffusion imaging in a case of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). Stroke. 2009 Feb;40(2):e15-7.
  34. Tzoulis C, Denora PS, Santorelli FM, Bindoff LA. Hereditary spastic paraplegia caused by the novel mutation 1047insC in the SPG7 gene.  J Neurol. 2008 Aug;255(8):1142-4. doi: 10.1007/s00415-008-0858-y.
  35. Engelsen BA, Tzoulis C, Karlsen B, Lillebø A, Laegreid LM, Aasly J, Zeviani M, Bindoff LA. POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection. Brain. 2008 Mar;131(Pt 3):818-28.
  36. Tzoulis C, Bindoff LA. Correspondence on “MELAS associated with mutations in the POLG1 gene” by Deschauer et al. Neurology. 2007; 68: 1741-1742
  37. Sanaker PS, Aarhus M, Tzoulis C, Smievoll AI, Skeie GO. A 90-year-old woman with acute hemiparesis. 2006 Aug 10; Tidsskr Nor Laegeforen126(15):1933.
  38. Tzoulis C, Engelsen BA, Telstad W, Aasly J, Zeviani M, Winterthun S, Ferrari G, Bindoff LA. The spectrum of clinical disease caused by the A467T and W748S POLG mutations: a study of 26 cases. Brain. 2006 Jul;129(Pt 7):1685-92.
  39. Tzoulis C, Naess H, Thomassen L. Migrainous cerebral infarction in a previously healthy 93 year old female patient with no risk factors for stroke. Cephalalgia. 2006 Jul;26(7):894-5.
  • Varhaug, Kristin; Vedeler, Christian A.; Tzoulis, Charalampos; Bindoff, Laurence. 2017. Multippel sklerose - en mitokondriemediert sykdom? Tidsskrift for Den norske legeforening. 137: 274-287. doi: 10.4045/tidsskr.16.0210
  • Abdullah, Rashed; Patil, Ketan S.; Rosen, Benjamin; Pal, Ramavati; Prabhudesai, Shubhangi; Lee, Sungsu; Basak, Indranil; Hoedt, Esthelle; Yang, Peter; Panick, Keith; Ho, Hsin-Pin; Chang, Emmanuel; Tzoulis, Charalampos; Larsen, Jan Petter; Neubert, Thomas A.; Alves, Guido; Møller, Simon Geir. 2016. Subcellular Parkinson’s disease-specific alpha-synuclein species show altered behavior in neurodegeneration. Molecular Neurobiology. Published ahead of print: 1-17. doi: 10.1007/s12035-016-0266-8
  • Dölle, Christian; Flønes, Irene Hana; Sanchez Nido, Gonzalo; Miletic, Hrvoje; Osuagwu, Nelson; Kristoffersen, Stine; Lilleng, Peer Kåre; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos. 2016. Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Nature Communications. 7:13548. 11 sider. doi: 10.1038/ncomms13548
  • Flønes, Irene Hana; Sztromwasser, Pawel Szymon; Haugarvoll, Kristoffer; Dölle, Christian; Lykouri, Maria; Schwarzlmüller, Thomas; Jonassen, Inge; Miletic, Hrvoje; Johansson, Stefan; Knappskog, Per; Bindoff, Laurence; Tzoulis, Charalampos. 2016. Novel SLC19A3 promoter deletion and allelic silencing in biotin-thiamine-responsive basal ganglia encephalopathy. PLoS ONE. 11. doi: 10.1371/journal.pone.0149055
  • Gaare, Johannes Jernqvist; Skeie, Geir Olve; Tzoulis, Charalampos; Larsen, Jan Petter; Tysnes, Ole-Bjørn. 2016. Familial aggregation of Parkinson's disease may affect progression of motor symptoms and dementia. Movement Disorders. 32: 241-245. doi: 10.1002/mds.26856
  • Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos. 2016. Nigrostriatal denervation sine parkinsonism. Brain. 139. doi: 10.1093/brain/awv410
  • Hikmat, Omar; Tzoulis, Charalampos; Knappskog, Per; Johansson, Stefan; Boman, Helge; Sztromwasser, Pawel Szymon; Lien, Espen; Brodtkorb, Eylert; Ghezzi, Daniele; Bindoff, Laurence. 2016. ADCK3 mutations with epilepsy, stroke-like episodes and ataxia: a POLG mimic? European Journal of Neurology. 23: 1188-1194. doi: 10.1111/ene.13003
  • Talasila, Krishna Mukharji; Røsland, Gro Vatne; Hagland, Hanne Røland; Eskilsson, Eskil; Flønes, Irene Hana; Fritah, Sabrina; Azuaje, Francisco; Atai, Nadia A; Harter, Patrick N.; Mittelbronn, Michel; Vareecal Joseph, Justin; Hossain, Jubayer; Vallar, Laurent; van Noorden, Cornelis J.F.; Niclou, Simone Pierrette; Thorsen, Frits; Tronstad, Karl Johan; Tzoulis, Charalampos; Bjerkvig, Rolf; Miletic, Hrvoje; Andersen, Michael Borenste. 2016. The angiogenic switch leads to a metabolic shift in human glioblastoma. Neuro-Oncology. 19: 383-393. doi: 10.1093/neuonc/now175
  • Tzoulis, Charalampos; Schwarzlmüller, Thomas; Biermann, Martin; Haugarvoll, Kristoffer; Bindoff, Laurence. 2016. Mitochondrial DNA homeostasis is essential for nigrostriatal integrity. Mitochondrion (Amsterdam. Print). 28: 33-37. doi: 10.1016/j.mito.2016.03.003
  • Tzoulis, Charalampos; Sztromwasser, Pawel Szymon; Johansson, Stefan; Gjerde, Ivar Otto; Knappskog, Per; Bindoff, Laurence. 2016. PNKP Mutations Identified by Whole-Exome Sequencing in a Norwegian Patient with Sporadic Ataxia and Edema. Cerebellum. 16: 272-275. doi: 10.1007/s12311-016-0784-y
  • Valadas, Anabela; Contarino, Maria Fiorella; Albanese, Alberto; Bhatia, Kailash P.; Falup-Pecurariu, Cristian; Forsgren, Lars; Friedman, Andrzej; Giladi, Nir; Hutchinson, Michael; Kostic, Vladimir S.; Krauss, Joachim K.; Løkkegaard, Annemette; Marti, Maria Jose; Milanov, Ivan G.; Pirtošek, Zvezdan; Relja, Maja; Skorvanek, Matej; Stamelou, Maria; Stepens, Ainars; Tamás, Gertrúd; Taravari, Arben; Tzoulis, Charalampos; Vandenberghe, Wim; Vidailhet, Marie; Ferreira, Joaquim J.; Tijssen, Marina A. 2016. Management of dystonia in Europe: A survey of the European network for the study of the dystonia syndromes. European Journal of Neurology. 23: 772-779. doi: 10.1111/ene.12940
  • Varhaug, Kristin; Vedeler, Christian A.; Myhr, Kjell-Morten; Aarseth, Jan Harald; Tzoulis, Charalampos; Bindoff, Laurence. 2016. Increased levels of cell-free mitochondrial DNA in the cerebrospinal fluid of patients with multiple sclerosis. Mitochondrion (Amsterdam. Print). doi: 10.1016/j.mito.2016.12.003
  • Albanese, Alberto; Abbruzzese, Giovanni; Dressler, Dirk; Duzynski, Wojciech; Khatkova, Svetlana; Marti, Maria Jose; Mir, Pablo; Montecucco, Cesare; Moro, Elena; Pinter, Michaela; Relja, Maja; Roze, Emmanuel; Skogseid, Inger Marie; Timerbaeva, Sofiya; Tzoulis, Charalampos. 2015. Practical guidance for CD management involving treatment of botulinum toxin: a consensus statement. Journal of Neurology. 262: 2201-2213. doi: 10.1007/s00415-015-7703-x
  • Bjørk, Marte Helene; Gjerde, Ivar Otto; Tzoulis, Charalampos; Ulvik, Rune Johan; Bindoff, Laurence. 2015. En mann i 50-årene med høyt ferritinnivå og økende kognitiv svikt. Tidsskrift for Den norske legeforening. 135: 1369-1372.
  • Flønes, Irene Hana; Haugarvoll, Kristoffer; Sundal, Christina Heidemann; Tzoulis, Charalampos. 2015. En kvinne i 70-årene med langvarige gangvansker. Tidsskrift for Den norske legeforening. doi: 10.4045/tidsskr.15.0111
  • Tzoulis, Charalampos; Schwarzlmüller, Thomas; Gjerde, Ivar Otto; Søfteland, Eirik; Neckelmann, Gesche F; Biermann, Martin; Haroche, Julien; Straume, Oddbjørn; Vintermyr, Olav Karsten. 2015. Excellent response of intramedullary Erdheim-Chester disease to vemurafenib: a case report. BMC Research Notes. 8:171: 1-5. doi: 10.1186/s13104-015-1135-7
  • Tzoulis, Charalompos; Zayats, Tetyana; Knappskog, Per; Müller, Bernd; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Bindoff, Laurence; Johansson, Stefan; Haugarvoll, Kristoffer. 2015. HTRA2 p.G399S in Parkinson disease, essential tremor, and tremulous cervical dystonia. Proceedings of the National Academy of Sciences of the United States of America. 18:E2268. doi: 10.1073/pnas.1503105112
  • Haugarvoll, Kristoffer; Tzoulis, Charalampos; Tran, Gia Tuong Thi; Karlsen, Bjørn; Engelsen, Bernt; Knappskog, Per; Bindoff, Laurence. 2014. Myoclonus-dystonia and epilepsy in a family with a novel epsilon-sarcoglycan mutation. Journal of Neurology. 261: 358-362. doi: 10.1007/s00415-013-7203-9
  • Sofou, Kalliopi; De Coo, Irenaeus F.M.; Isohanni, Pirjo; Ostergaard, Elsebet; Naess, Karin; De Meirleir, Linda; Tzoulis, Charalampos; Uusimaa, Johanna; De Angst, Isabell B.; Lönnqvist, Tuula; Pihko, Helena; Mankinen, Katariina; Bindoff, Laurence; Tulinius, Már; Darin, Niklas. 2014. A multicenter study on Leigh syndrome: Disease course and predictors of survival. Orphanet Journal of Rare Diseases. 9. doi: 10.1186/1750-1172-9-52
  • Tzoulis, Charalampos; Tran, Gia Tuong Thi; Coxhead, Jonathan; Bertelsen, Bjørn; Lilleng, Peer Kåre; Balafkan, Novin; Payne, Brendan; Miletic, Hrvoje; Chinnery, Patrick F.; Bindoff, Laurence. 2014. Molecular pathogenesis of polymerase gamma-related neurodegeneration. Annals of Neurology. 76: 66-81. doi: 10.1002/ana.24185
  • Wedding, Iselin Marie; Koht, Jeanette; Tran, Gia Tuong Thi; Misceo, Doriana; Selmer, Kaja Kristine; Holmgren, Asbjørn; Frengen, Eirik; Bindoff, Laurence; Tallaksen, Chantal; Tzoulis, Charalampos. 2014. Spastic paraplegia type 7 is associated with multiple mitochondrial DNA deletions. PLoS ONE. 9. doi: 10.1371/journal.pone.0086340
  • Haugarvoll, Kristoffer; Johansson, Stefan; Tzoulis, Charalampos; Haukanes, Bjørn Ivar; Bredrup, Cecilie; Neckelmann, Gesche F; Boman, Helge; Knappskog, Per; Bindoff, Laurence. 2013. MRI characterisation of adult onset alpha-methylacyl-coA racemase deficiency diagnosed by exome sequencing. Orphanet Journal of Rare Diseases. 8. 10 sider. doi: 10.1186/1750-1172-8-1
  • Tzoulis, Charalampos; Johansson, Stefan; Haukanes, Bjørn Ivar; Boman, Helge; Knappskog, Per; Bindoff, Laurence. 2013. Novel SACS mutations identified by whole exome sequencing in a Norwegian family with autosomal recessive spastic ataxia of Charlevoix-Saguenay. PLoS ONE. 8. 5 sider. doi: 10.1371/journal.pone.0066145
  • Tzoulis, Charalampos; Tran, Gia Tuong Thi; Schwarzlmüller, Thomas; Specht, Karsten; Haugarvoll, Kristoffer; Balafkan, Novin; Lilleng, Peer Kåre; Miletic, Hrvoje; Biermann, Martin; Bindoff, Laurence. 2013. Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations. Brain. 136: 2393-2404. doi: 10.1093/brain/awt103
  • Tzoulis, Charalampos; Vedeler, Christian A.; Haugen, Mette; Storstein, Anette; Tran, Gia Tuong Thi; Gjerde, Ivar Otto; Biermann, Martin; Schwarzlmüller, Thomas; Bindoff, Laurence. 2013. Progressive striatal necrosis associated with anti-NMDA receptor antibodies. BMC Neurology. 13. 4 sider. doi: 10.1186/1471-2377-13-55
  • Balafkan, Novin; Tzoulis, Charalampos; Muller, Bernd; Haugarvoll, Kristoffer; Tysnes, Ole-Bjørn; Larsen, Jan Petter; Bindoff, Laurence. 2012. Number of CAG repeats in POLG1 and its association with Parkinson disease in the Norwegian population. Mitochondrion (Amsterdam. Print). 12: 640-643. doi: 10.1016/j.mito.2012.08.004
  • Tzoulis, Charalampos; Bindoff, Laurence. 2012. Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects. Brain. 135: 3627-3634. doi: 10.1093/brain/aws223
  • Tzoulis, Charalampos; Gjerde, Ivar Otto; Søfteland, Eirik; Neckelmann, Gesche F; Strøm, Eivind; Vintermyr, Olav Karsten; Sviland, Lisbeth; Biermann, Martin. 2012. Erdheim-Chester disease presenting with an intramedullary spinal cord lesion. Journal of Neurology. 259: 2240-2242. doi: 10.1007/s00415-012-6544-0
  • Tzoulis, Charalampos; Tran, Gia Tuong Thi; Gjerde, Ivar Otto; Aasly, Jan; Neckelmann, Gesche F; Rydland, Jana; Varga, Viktoria; Wadel-Andersen, Pia; Bindoff, Laurence. 2012. Leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate (LBSL) caused by a novel mutation in DARS2. European Journal of Neurology. 19: 728-728. doi: 10.1111/j.1468-1331.2012.03889.x
  • Tzoulis, Charalampos; Tran, Gia Tuong Thi; Gjerde, Ivar Otto; Aasly, Jan; Neckelmann, Gesche F; Rydland, Jana; Varga, Viktoria; Wadel-Andersen, Pia; Bindoff, Laurence. 2012. Leukoencephalopathy with brainstem and spinal cord involvement caused by a novel mutation in the DARS2 gene. Journal of Neurology. 259: 292-296. doi: 10.1007/s00415-011-6176-9
  • Tzoulis, Charalampos; Tran, Gia Tuong Thi; Miletic, Hrvoje; Bindoff, Laurence. 2012. Polymerase gamma (POLG) associated encephalopathy is characterised by neuronal mtDNA depletion and respiratory complex-I deficiency. European Journal of Neurology. 19: 63-63.
  • Bindoff, Laurence; Tzoulis, Charalampos. 2011. Defining the mitochondrial POLG-related spinocerebellar ataxia and epilepsy in Norway. Advances in Clinical Neurosciences. 11: 20-21.
  • Sanaker, Petter Schandl; Toompuu, Marina; Hogan, Vanessa E.; He, Langping; Tzoulis, Charalampos; Chrzanowska-Lightowlers, Zofia MA; Taylor, Robert W.; Bindoff, Laurence. 2010. Differences in RNA processing underlie the tissue specific phenotype of ISCU myopathy. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1802: 539-544. doi: 10.1016/j.bbadis.2010.02.010
  • Tzoulis, Charalampos. 2010. Clinical and molecular studies of disease caused by mutations of the mitochondrial DNA polymerase gamma (POLG).
  • Tzoulis, Charalampos; Neckelmann, Gesche F; Mørk, Sverre; Engelsen, Bernt; Viscomi, Carlo; Moen, Gunnar; Ersland, Lars; Zeviani, Massimo; Bindoff, Laurence. 2010. Localized cerebral energy failure in mitochondrial polymerase gamma-associated encephalopathy. European Journal of Neurology. 17: 71-71.
  • Tzoulis, Charalampos; Neckelmann, Gesche F; Mørk, Sverre; Engelsen, Bernt; Viscomi, Carlo; Moen, Gunnar; Ersland, Lars; Zeviani, Massimo; Bindoff, Laurence. 2010. Localized cerebral energy failure in DNA polymerase gamma-associated encephalopathy syndromes. Brain. 133: 1428-1437. doi: 10.1093/brain/awq067
  • Gramstad, Arne; Bindoff, Laurence; Lillebø, Atle; Tzoulis, Charalampos; Engelsen, Bernt. 2009. Neuropsychological performance of patients with polg1 mutation and epilepsy: evidence of more pronounced right than left hemisphere dysfunction? Epilepsia. 50: 119-119. doi: 10.1111/j.1528-1167.2009.02063.x
  • Gramstad, Arne; Bindoff, Laurence; Lillebø, Atle; Tzoulis, Charalampos; Engelsen, Bernt. 2009. Neuropsychological performance in patients with POLG1 mutations and the syndrome of mitochondrial spinocerebellar ataxia and epilepsy. Epilepsy & Behavior. 16: 172-174. doi: 10.1016/j.yebeh.2009.01.014
  • Sanaker, Petter Schandl; Toompuu, M; Chrzanowska-Lightowlers, Z; He, L; Hogan, V; Taylor, RW; Tzoulis, Charalampos; Bindoff, LA. 2009. RNA processing differences explain tissue specificity in exercise intolerance myopathy due to ISCU intronic mutation. Neuromuscular Disorders. 19: 623-623. doi: 10.1016/j.nmd.2009.06.248
  • Tzoulis, Charalampos; Bindoff, Laurence. 2009. Serial Diffusion Imaging in a Case of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes. Stroke. 40: E15-E17. doi: 10.1161/STROKEAHA.108.523118
  • Tzoulis, Charalampos; Papingji, Migena; Fiskestrand, Torunn; Røste, Line Sveberg; Bindoff, Laurence. 2009. Mitochondrial DNA depletion in progressive external ophthalmoplegia caused by POLG1 mutations. Acta Neurologica Scandinavica. 120: 38-41. doi: 10.1111/j.1600-0404.2009.01212.x
  • Tzoulis, Charalampos; Sætran, Hege; Mørk, Sverre; Bindoff, Laurence. 2009. MRI and neuropathology findings in three patients with the syndrome of mitochondrial spinocerebellar ataxia and epilepsy (MSCAE). Neuropathology and Applied Neurobiology. 35: 20-20.
  • Engelsen, Bernt; Tzoulis, Charalampos; Karlsen, Bjørn; Lillebø, Atle; Lægreid, Liv Marie; Aasly, Jan; Zeviani, Massimo; Bindoff, Laurence. 2008. POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection. Brain. 131: 818-828. doi: 10.1093/brain/awn007
  • Tzoulis, Charalampos; Denora, Paola S.; Santorelli, Filippo M; Bindoff, Laurence. 2008. Hereditary spastic paraplegia caused by the novel mutation 1047insC in the SPG7 gene. Journal of Neurology. 255: 1142-1144. doi: 10.1007/s00415-008-0858-y
  • Tzoulis, Charalampos; Denora, Paola S.; Bindoff, Laurence. 2007. Hereditary spastic paraplegia caused by the novel mutation 1047INSC in the SPG7 gene. European Journal of Neurology. 14: 240-240.
  • Tzoulis, Charalampos; Moen, Gunnar; Bindoff, Laurence. 2007. Cerebral imaging in mitochondrial spinocerebellar ataxia caused by POLG mutations shows diagnostic specificity and provides insight into disease evolution. European Journal of Neurology. 14: 14-15.

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