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Adaptive radiation therapy of cancer - molecular imaging and biophysical modelling
Radiation therapy is a critical component in modern management of cancer. Still, approximately 1 out of 5 cancer patients die due to loco-regional failure. Radiation oncology is developing into the paradigm of focused biology, and radiobiological factors may be incorporated into optimization of radiation therapy.
Radiation therapy of tumours aims traditionally at delivering a homogeneous dose to the entire target volume, although intra-tumour variations in cellular and physiological factors of importance for response to therapy have been demonstrated. Biological adaptive radiation therapy (BioART) aims at tailoring the radiation dose distribution on a sub-regional level in the tumour according regional variations in radiobiological factors, like hypoxia.
It has been suggested that non-invasive biological imaging (like MRI, MRSi and PET) may provide the pertinent information to guide the painting or sculpting of the optimal dose distribution to the tumour. Simulations of tumour control probability (TCP) have demonstrated that increasing the dose to hypoxic regions, while keeping the mean dose constant may increase TCP. Moreover, tailored dose distribution is feasible with modern irradiation techniques like intensitymodulated radiation therapy (IMRT) and computer-controlled HDR brachytherapy. The aims of this project are:
- To utilize biological imaging (cedMRI, MRSi and PET) in visualizing cellular and tumour physiological factors of importance for radiation response
- Design models for optimizing dose distribution with respect to tumour control probability, based on biological imaging
- Demonstrate enhanced local control in experimental and clinical studies
- MSc of Biophysics and biomedical technology, Norwegian Institute of Technology, Trondheim, 1986.
- PhD of Medical physics, University of Oslo, Oslo, 1999.
- Management program, Norwegian School of Economics and Business Administration, Bergen, 2006.
- Medical physicist, The Norwegian Radium Hospital, Oslo, 1986-2004.
- Assistant and later associate professor, Oslo University College, Oslo, 1996-2000.
- Professor of Medical Physics, University of Oslo, Oslo, 2000-2010.
- Head of department, Institute of Cancer Research, Oslo University Hospital, Oslo, 2004-2010.
Dean, Faculty of Mathematics and Natural Sciences, University of Bergen, 2010-date
INTERNATIONAL RESEARCH AWARDS:
Klaas Breur Gold Medal 2008
PROFESSIONAL ACTIVITIES (previous and current):
- Editorial board member of Acta Oncologica and Radiotherapy and Oncology, and Physics in Medicine and Biology.
- Referee for several international journals: Radiotherapy and Oncology, Acta Oncological, Medical Physics, Physics in Medicine and Biology, International Journal of Radiation Oncology, Biology and Physics, International Journal of Radiation Biology, Lancet Oncology.
- Reviewer of research programs for Cancer Research Campaign, UK, Medical Research Council, UK, The Danish Medical Research Council and EURATOM, EC.
- Member of evaluation committees for professorship/associated professorship at Karolinska Institute, University of Stockholm, University of Århus, University of Umeå, University of Bergen, Oslo University College, Gjøvik University College, University of Oslo, Trinity College Dublin, University of Madison, Wisconsin, University of Vienna and University of Lund.
- External evaluator and opponent of PhD thesis at Norwegian University for Technology and Science, University of Bergen, University of Lund, University of Århus, University of Oslo, University of Lindköping.
- External examiner at Trinity College, University of Dublin, Norwegian University for Technology and Science and Oslo University College.
- Member of committee for evaluation of higher education, the Swedish National Agency for Higher Education.
- Chairman and member of working groups on heath technology assessment at the Norwegian Knowledge Centre for the Health Services.
- Member of Council for Translational Research, The Norwegian Radium Hospital and member of the management group of Institute of Cancer Research.
- Member of the committee on science and education, and chairman of the education subcommittee in the merger process between The Norwegian Radium Hospital and Rikshospitalet, University of Oslo.
- Member of working group on research strategy for South-Eastern Norway Regional Health Authority
- Delegate to the WHO Global Initiative on Radiation Safety in Health Care Settings and to the IAEA Interregional Technical Cooperation Project in medical physics.
- Member of the international advisory board for the National Radiation Oncology Plan, Ireland
- Member of review committee of clinical research, University of Gothenburg.
Professional society memberships:
- European Society of Radiotherapy and Oncology, acting past chair of physics committee and member of the education and training committee.
- European Institute of Radiotherapy, past board member
- Norwegian Association of Medical Physics, board member and chair.
- board member European Society of Radiotherapy and Oncology
Artikler i internationale 'peer-review' tidsskrift 2005-dd
Kathrine Røe, Lars TG Mikalsen, Albert J van der Kogel, Johan Bussink, Heidi Lyng, Anne H Ree, Laure Marignol and Dag R Olsen. (2012) Vascular responses to radiotherapy and androgendeprivation therapy in experimental prostate cancer. Radiation Oncology 2012, 7:75
Eriksen JG, Beavis AW, Coffey MA, Leer JW, Magrini SM, Benstead K, Boelling T, Hjälm-Eriksson M, Kantor G, Maciejewski B, Mezeckis M, Oliveira A, Thirion P, Vitek P, Olsen DR, Eudaldo T, Enghardt W, François P, Garibaldi C, Heijmen B, Josipovic M, Major T, Nikoletopoulos S, Rijnders A, Waligorski M, Wasilewska-Radwanska M, Mullaney L, Boejen A, Vaandering A, Vandevelde G, Verfaillie C, Pötter R. (2012) The updated ESTRO core curricula 2011 for clinicians, medical physicists and RTTs in radiotherapy/radiation oncology. Radiother Oncol. 103(1):103-8
Edin NJ, Olsen DR, Sandvik JA, Malinen E, Pettersen EO. (2011) Low dose
hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but
returns after reoxygenation. Int J Radiat Biol. 88(4):311-9.
Mikalsen LT, Dhakal HP, Bruland OS, Nesland JM, Olsen DR. (2011 Quantification of angiogenesis in breast cancer by automated vessel identification in CD34 immunohistochemical sections. Anticancer Res. 31(12):4053-60.
Hagtvet E, Roe K, Olsen DR. (2011) Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts. Radiat Oncol. 6(1):135.
Johansen S, Reinertsen K, Knutstad K, Olsen D, Fossa S. (2011) Dose distribution in the thyroid gland following radiation therapy of breast cancer-a retrospective study. Radiat Oncol. 6:68.
Roe K, Kakar M, Seierstad T, Ree AH, Olsen DR. (2011) Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study. Radiation Oncology 6:65.
Martinsen AC, Sæther HK, Hol PK, Olsen DR, Skaane (2011). Iterative reconstruction reduces abdominal CT dose. Eur J Radiol. [Epub ahead of print]
Hagtvet E, Evjen TJ, Olsen DR, Fossheim SL, Nilssen EA (2011). Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice. J Drug Target. 19(8):701-8
Johansen S, Vikström J, Hjelstuen MH, Mjaaland I, Dybvik KI, Olsen DR (2011). Dose evaluation and risk estimation for secondary cancer in contralateral breast and a study of correlation between thorax shape and dose to organs at risk following tangentially breast irradiation during deep inspiration breath-hold and free breathing. Acta Oncol. 50(4):563-8.
Fangberget A, Nilsen LB, Hole KH, Holmen MM, Engebraaten O, Naume B, Smith HJ, Olsen DR, Seierstad T (2011). Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion weighted MR imaging. Eur Radiol. 21(6):1188-99.
Weber DC, Johanson S, Peguret N, Cozzi L, Olsen DR (2011). Predicted Risk of Radiation-Induced Cancers after Involved Field and Involved Node Radiotherapy with or without Intensity Modulation for Early-Stage Hodgkin Lymphoma in Female Patients. Int J Radiat Oncol Biol Phys. 81(2):490-7
Røe K, Seierstad T, Kristian A, Mikalsen LTG, Mælamdsmo GM, van der Kogel AJ, Ree AH, Olsen DR (2010). Longitudinal MRI-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions. Neoplasia 12(10):818-25.
Røe K, Aleksandersen TB, Kristian A, Nilsen LB, Seierstad T, Qu H, Ree AH,
Olsen DR, Malinen E. (2010) Preclinical dynamic (18)F-FDG PET - tumor characterization and radiotherapy response assessment by kinetic compartment analysis. Acta Oncol. 49(7):914-21.
Grau C, Olsen DR, Overgaard J, Høyer M, Lindegaard JC, Muren LP (2010).
Biology-guided adaptive radiation therapy - presence or future? Acta Oncol. 49(7):884-7.
Martinsen AC, Saether HK, Olsen DR, Wolff PA, Skaane P. Improved image quality of low-dose thoracic CT examinations with a new postprocessing software. J Appl Clin Med Phys. 2010 May 25;11(3):3242.
Nilsen L, Fangberget A, Geier O, Olsen DR and Seierstad T. Diffusion-weighted magnetic resonance imaging for pretreatment prediction and monitoring of treatment response of patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. Acta Oncol. (2010) Apr;49(3):354-60.
Gudjónsdóttir J, Ween B, Olsen DR (2010). Optimal use of AEC in CT: a literature review. Radiol Technol. 81(4):309-17.
Søvik A, Malinen E, Olsen DR (2010). Adapting biological feedback in radiotherapy. Semin Radiat Oncol. 20(2):138-46.
Olsen DR, Overgaard J (2010). Leveraging clinical performance by technological excellence - The case of particle therapy. Radiother Oncol. 95(1):1-2. (editorial)
Dale,E, Harsaker,V, Kristoffersen,DT, Bruland,O, and Olsen,DR (2010). CT Density in Lung Cancer Patients After Radiotherapy Sensitized by Metoclopramide A Subgroup Analysis of a Randomized Trial. Strahlentherapie und Onkologie 186(3):163-168.
Hellebust,TP, Kristensen,GB, and Olsen,DR (2010). Late Effects After Radiotherapy for Locally Advanced Cervical Cancer: Comparison of Two Brachytherapy Schedules and Effect of Dose Delivered Weekly. International Journal of Radiation Oncology Biology Physics 76(3):713-718.
Edin,NJ, Olsen,DR, Stokke,T, Sandvik,JA, Ebbesen,P, and Pettersen,EO (2009). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming. International Journal of Radiation Biology 85(12):1157-1165.
Sovik,A, Skogmo,HK, Andersen,EKF, Bruland,OS, Olsen,DR, and Malinen,E (2009). DCEMRI of spontaneous canine tumors during fractionated radiotherapy: A pharmacokinetic analysis. Radiotherapy and Oncology 93(3):618-624.
Kakar,M, Seierstad,T, Roe,K, and Olsen,DR (2009). Artificial Neural Networks for Prediction of Response to Chemoradiation in Ht29 Xenografts. International Journal of Radiation Oncology Biology Physics 75(2):506-511.
Johansen,S, Cozzi,L, and Olsen,DR (2009). A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and Volumetric modulated arc treatment techniques. Acta Oncologica 48(4):495-503.
Sovik,A, Malinen,E, and Olsen,DR (2009). Strategies for Biologic Image-Guided Dose Escalation: A Review. International Journal of Radiation Oncology Biology Physics 73(3):650-658.
Vagane,R, Danielsen,T, Fossa,SD, Lokkevik,E, and Olsen,DR (2009). Late regional density changes of the lung after radiotherapy for breast cancer. Radiotherapy and Oncology 90(1):148-152.
Kakar,M and Olsen,DR (2009). Automatic segmentation and recognition of lungs and lesion from CT scans of thorax. Computerized Medical Imaging and Graphics 33(1):72-82.
Edin,NJ, Sandvik,JA, Olsen,DR, and Pettersen,EO (2009). The Elimination of Low-Dose Hyper-radiosensitivity by Transfer of Irradiated-Cell Conditioned Medium Depends on Dose Rate. Radiation Research 171(1):22-32.
Sovik,A, Skogmo,HK, Bruland,OS, Olsen,DR, and Malinen,E (2008). DCEMRI monitoring of canine tumors during fractionated radiotherapy. Acta Oncologica 47(7):1249-1256.
Roe,K, Muren,LP, Rorvik,J, Olsen,DR, Dahl,O, Bakke,A et al. (2008). Dynamic contrast enhanced magnetic resonance imaging of bladder cancer and implications for biological image-adapted radiotherapy. Acta Oncologica 47(7):1257-1264.
Seierstad,T, Roe,K, Sitter,B, Halgunset,J, Flatmark,K, Ree,AH et al. (2008). Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning H-1 magnetic resonance spectroscopy. Molecular Cancer 7.
Martinsen,ACT, Saether,HK, Olsen,DR, Skaane,P, and Olerud,HM (2008). Reduction in dose from CT examinations of liver lesions with a new postprocessing filter: A ROC phantom study. Acta Radiologica 49(3):303-309.
Vagane,R, Bruland,OS, Fossa,SD, and Olsen,DR (2008). Radiological and functional assessment of radiation-induced pulmonary damage following breast irradiation. Acta Oncologica 47(2):248-254.
Johansen,S, Danielsen,T, and Olsen,DR (2008). Estimated risk for secondary cancer in the contra-lateral breast following radiation therapy of breast cancer. Acta Oncologica 47(3):391-396.
Pettersen,MN, Aird,E, and Olsen,DR (2008). Quality assurance of dosimetry and the impact on sample size in randomized clinical trials. Radiotherapy and Oncology 86(2):195-199.
Sovik,A, Ovrum,J, Olsen,DR, and Malinen,E (2007). On the parameter describing the generalised equivalent uniform dose (gEUD) for tumours. Physica Medica 23(3-4):100-106.
Olsen,DR and Thwaites,DI (2007). Now you see it... Imaging in radiotherapy treatment planning and delivery. Radiotherapy and Oncology 85(2):173-175.
Seierstad,T, Roe,K, and Olsen,DR (2007). Noninvasive monitoring of radiation-induced treatment response using proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging in a colorectal tumor model. Radiotherapy and Oncology 85(2):187-194.
Sovik,A, Malinen,E, Skogmo,HK, Bentzen,SM, Bruland,OS, and Olsen,DR (2007). Radiotherapy adapted to spatial and temporal variability in tumor hypoxia. International Journal of Radiation Oncology Biology Physics 68(5):1496-1504.
Hellebust,TP, Tanderup,K, Bergstrand,ES, Knutsen,BH, Roislien,J, and Olsen,DR (2007). Reconstruction of a ring applicator using CT imaging: impact of the reconstruction method and applicator orientation. Physics in Medicine and Biology 52(16):4893-4904.
Hanisch,PH, Furre,T, Olsen,DR, and Pettersen,EO (2007). Radiobiological responses for two cell lines following continuous low dose-rate (CLDR) and pulsed dose rate (PDR) brachytherapy. Acta Oncologica 46(5):602-611.
Olsen,DR, Bruland,OS, Frykholm,G, and Norderhaug,IN (2007). Proton therapy - A systematic review of clinical effectiveness. Radiotherapy and Oncology 83(2):123-132.
Seierstad,T, Folkvord,S, Roe,K, Flatmark,K, Skretting,A, and Olsen,DR (2007). Early changes in apparent diffusion coefficient predict the quantitative antitumoral activity of capecitabine, oxaliplatin, and irradiation in HT29 xenografts in athymic nude mice. Neoplasia 9(5):392-400.
Johansen,S, Olsen,DR, Danielsen,T, and Malinen,E (2007). Contralateral breast doses following radiotherapy of the breast and regional lymph nodes: Measurements and treatment planning calculations. Radiotherapy and Oncology 82(3):332-336.
Sastre-Padro,M, Welleweerd,J, Malinen,E, Eilertsen,K, Olsen,DR, and van der Heide,UA (2007). Consequences of leaf calibration errors on IMRT delivery. Physics in Medicine and Biology 52(4):1147-1156.
Sovik,A, Malinen,E, Bruland,OS, Bentzen,SM, and Olsen,DR (2007). Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study. Physics in Medicine and Biology 52(2):499-513.
Osteras,BH, Hole,EO, Olsen,DR, and Malinen,E (2006). EPR dosimetry of radiotherapy photon beams in inhomogeneous media using alanine films. Physics in Medicine and Biology 51(24):6315-6328.
Tanderup,K, Hellebust,TP, Honore,HB, Nielsen,SK, Olsen,DR, Grau,C et al. (2006). Dose optimisation in single plane interstitial brachytherapy. Radiotherapy and Oncology 81(1):105-111.
Malinen,E, Sovik,A, Hristov,D, Bruland,OS, and Olsen,DR (2006). Adapting radiotherapy to hypoxic tumours. Physics in Medicine and Biology 51(19):4903-4921.
Tanderup,K, Olsen,DR, and Grau,C (2006). Dose painting: Art or science? Radiotherapy and Oncology 79(3):245-248.
Vagane,R and Olsen,DR (2006). Analysis of normal tissue complication probability of the lung using a reliability model. Acta Oncologica 45(5):610-617.
Dahle,J, Borrebaek,J, Melhus,KB, Bruland,OS, Salberg,G, Olsen,DR et al. (2006). Initial evaluation of Th-227-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy. Nuclear Medicine and Biology 33(2):271-279.
Brurberg,KG, Skogmo,HK, Graff,BA, Olsen,DR, and Rofstad,EK (2005). Fluctuations in pO(2) in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy. Radiotherapy and Oncology 77(2):220-226.
Kakar,M, Nystrom,H, Aarup,LR, Nottrup,TJ, and Olsen,DR (2005). Respiratory motion prediction by using the adaptive neuro fuzzy inference system (ANFIS). Physics in Medicine and Biology 50(19):4721-4728.
Norum,J, Bruland,OS, Spanne,O, Bergmo,T, Green,T, Olsen,DR et al. (2005). Telemedicine in radiotherapy: a study exploring remote treatment planning., supervision and economics. Journal of Telemedicine and Telecare 11(5):245-250.
Dale,E, Hellebust,TP, Bruland,OS, and Olsen,DR (2005). Comparative analyses of the dynamic properties of the bladder wall studied by repetitive pelvic CT scans of patients and cryo-sections of cadavers. British Journal of Radiology 78(930):528-532.
Eilertsen K, Olsen DR. Data format, Networking, Archiving and Telemedicine. In: New Technologies in Radiation Therapy. Schlegel W, Bortfeld T and Grosu AL. (eds.). Springer Verlag, ISBN 3-540-00321-5, pp. 53-65 (2006).
Bruland, Ø.S., Dahle, J., Olsen, D.R., and Larsen, R.H.: Targeted high-LET therapy of bone metastases. In: Tageted radionuclide tumor therapy - Biological aspects. Stigbrand, Adams & Carlsson (eds.). Springer Verlag. ISBN 978 1 4020 8695 3, pp. 181-194 (2008).
Bokkapitler på norsk:
Moan JE, Olsen DR. Fysikk og medisin, In: Naturens kode, Einevoll GT & Newth E (eds.). Gyldendal Akademisk ISBN/EAN: 9788205345393 (2005).
'Still de store spørsmålene', Bergens Tidende, 28 nov 2011
'Kunnskapsbasert politikk', Dagens Næringsliv, april 2011.
'Kunnskap – nøkkelen til fremtidens verdiskapning', Bergens Tidende/På Høyden 2011
'Styrk finansieringen!', Aftenposten, 2011
'For dårlig kreftbehandling?', Schrödingers katt 2010
'Kvantemedisin': Schrödingers katt 2009
'Kreft, en global utfordring', Dagsavisen, 17.08. 2009.
'Protonterapi - men hva så?' Dagsavisen, 03.02.2008.
'Fusk og forskningskultur', Morgenbladet 06.06, 2006
'Angrep på vitenskapelig utprøvd medisin skyter over målet', Aftenposten 02.09.2004.
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