Hjem
Jian Wangs bilde

Jian Wang

Forsker
  • E-postJian.Wang@uib.no
  • Besøksadresse
    Jonas Lies vei 91
  • Postadresse
    Postboks 7804
    5020 Bergen
Tidsskriftartikler
  • Han, Ming-Zhi; Bin, Huang; Chen, An-Jing; Xin, Zhang; Xu, Ran; Wang, Jian; Li, Xin-Gang. 2017. High expression of RAB43 predicts poor prognosis and is associated with epithelial-mesenchymal transition in gliomas. Oncology Reports. 37: 903-912. doi: 10.3892/or.2017.5349
  • Leiss, Lina Wik; Mutlu, Ercan; Øyan, Anne Margrete; Yan, Tao; Tsinkalovsky, Oleg; Sleire, Linda; Petersen, Kjell; Rahman, Mohummad Aminur; Johannessen, Mireille; Mitra, Siddharta S.; Jacobsen, Hege; Talasila, Krishna Mukharji; Miletic, Hrvoje; Jonassen, Inge; Li, Xingang; Brons, Nicolas H.C.; Kalland, Karl-Henning; Wang, Jian; Enger, Per Øyvind. 2017. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer. 17:108: 1-13. doi: 10.1186/s12885-017-3109-8
  • Xia, Tongliang; Huang, Bin; Ni, Shilei; Gao, Lei; Wang, Jiangang; Wang, Jian; Chen, Anjing; Zhu, Shaowei; Wang, Benlin; Li, Gang; Zhu, Shugan; Li, Xingang. 2017. The combination of db-cAMP and ChABC with poly(propylene carbonate) microfibers promote axonal regenerative sprouting and functional recovery after spinal cord hemisection injury. Biomedicine and Pharmacotherapy. 86: 354-362. doi: 10.1016/j.biopha.2016.12.045
  • Zhu, Huaiyang; Leiss, Lina Wik; Yang, Ning; Rygh, Cecilie Brekke; Mitra, Siddharta S.; Cheshier, Samuel H.; Weissman, Irving L.; Huang, Bin; Miletic, Hrvoje; Bjerkvig, Rolf; Enger, Per Øyvind; Li, Xingang; Wang, Jian. 2017. Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy. OncoTarget. 8: 12145-12157. doi: 10.18632/oncotarget.14553
  • Chen, Weiliang; Xia, Tongliang; Wang, Donghai; Huang, Bin; Zhao, Peng; Wang, Jian; Qu, Xun; Li, Xingang. 2016. Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14. OncoTarget. 7: 62425-62438. doi: 10.18632/oncotarget.11515
  • Guo, Xiaofan; Xue, Hao; Shao, Qianqian; Wang, Jian; Guo, Xing; Chen, Xi; Zhang, Jinsen; Xu, Shugang; Li, Tong; Zhang, Ping; Gao, Xiao; Qiu, Wei; Liu, Qinglin; Li, Gang. 2016. Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR. OncoTarget. 7: 80521-80542. doi: 10.18632/oncotarget.11825
  • Liu, Ming; Wang, Jian; Huang, Bin; Chen, Anjing; Li, Xingang. 2016. Oleuropein inhibits the proliferation and invasion of glioma cells via suppression of the AKT signaling pathway. Oncology Reports. 36: 2009-2016. doi: 10.3892/or.2016.4978
  • Liu, Ming; Wang, Jiwei; Qi, Qichao; Huang, Bin; Chen, Anjing; Li, Xingang; Wang, Jian. 2016. Nitidine chloride inhibits the malignant behavior of human glioblastoma cells by targeting the PI3K/AKT/mTOR signaling pathway. Oncology Reports. 36: 2160-2168. doi: 10.3892/or.2016.4998
  • Qi, Qichao; Wang, Jiwei; Huang, Bin; Chen, Anjing; Li, Gang; Li, Xingang; Wang, Jian. 2016. Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type. OncoTarget. 7: 38775-38784. doi: 10.18632/oncotarget.9608
  • Wang, Benlin; Li, Haoyuan; Yao, Qingyu; Zhang, Yulin; Zhu, Xiaodong; Xia, Tongliang; Wang, Jian; Li, Gang; Li, Xingang; Ni, Shilei. 2016. Local in vitro delivery of rapamycin from electrospun PEO/PDLLA nanofibers for glioblastoma treatment. Biomedicine and Pharmacotherapy. 83: 1345-1352. doi: 10.1016/j.biopha.2016.08.033
  • Wang, Jiwei; Qi, Qichao; Feng, Zichao; Zhang, Xin; Huang, Bin; Chen, Anjing; Prestegarden, Lars; Li, Xingang; Wang, Jian. 2016. Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway. OncoTarget. 7: 66944-66958. doi: 10.18632/oncotarget.11396
  • Xiong, Yu; Gao, Xusheng; Zhu, Huaiyang; Ding, Caihong; Wang, Jian. 2016. Role of medical thoracoscopy in the treatment of tuberculous pleural effusion. Journal of Thoracic Disease. 8: 52-60. doi: 10.3978/j.issn.2072-1439.2016.01.34
  • Xue, Hao; Zhang, Jinsen; Guo, Xing; Wang, Jian; Li, Jiangbing; Gao, Xiao; Guo, Xiaofan; Li, Tong; Xu, Shugang; Zhang, Ping; Liu, Qinglin; Li, Gang. 2016. CREBRF is a potent tumor suppressor of glioblastoma by blocking hypoxia-induced autophagy via the CREB3/ATG5 pathway. International Journal of Oncology. 49: 519-528. doi: 10.3892/ijo.2016.3576
  • Zhang, Chao; Chen, Wenliang; Zhang, Xin; Huang, Bin; Chen, Aanjing; He, Ying; Wang, Jian; Li, Xingang. 2016. Galunisertib inhibits glioma vasculogenic mimicry formation induced by astrocytes. Scientific Reports. 6:23056. doi: 10.1038/srep23056
  • Sleire, Linda; Skeie, Bente Sandvei; Netland, Inger Anne; Førde, Hilde Elise Sundøy; Dodoo, Ernest; Selheim, Frode; Leiss, Lina Wik; Heggdal, Jan Ingemann; Pedersen, Paal-Henning; Wang, Jian; Enger, Per Øyvind. 2015. Drug repurposing: Sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc<sup>-</sup>, leading to glutathione depletion. Oncogene. 34: 5951-5959. doi: 10.1038/onc.2015.60
  • Brekke, Cecilie; Wang, Jian; Thuen, Marte; Gras Navarro, Andrea; Huuse-Røneid, Else Marie; Thorsen, Frits Alan; Poli, Aurélie; Zimmer, Jacques; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha. 2014. Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLoS ONE. 9. doi: 10.1371/journal.pone.0108414
  • Jarzabek, Monika A.; Amberger-Murphy, Verena; Callanan, John J.; Gao, Cherry; Zagozdzon, Agnieszka M.; Shiels, Liam; Wang, Jian; Ligon, Keith L.; Rich, Benjamin E.; Dicker, Patrick; Gallagher, William M.; Prehn, Jochen H.M.; Byrne, Annette T. 2014. Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models. British Journal of Cancer. 111: 2275-2286. doi: 10.1038/bjc.2014.529
  • Liang, Xiao; Osman, Tarig Al-Hadi; Sapkota, Dipak; Neppelberg, Evelyn; Lybak, Stein; Liavaag, Per Gunnar; Johannessen, Anne Christine; Jacobsen, Hege; Enger, Per Øyvind; Costea, Daniela Elena; Wang, Jian. 2014. Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer. European Journal of Cancer. 50: 3262-3270. doi: 10.1016/j.ejca.2014.09.010
  • Rygh, Cecilie Brekke; Wang, Jian; Thuen, Marte; Navarro, Andrea Gras; Huuse, Else Marie; Thorsen, Frits; Poli, Aurélie; Zimmer, J.; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha. 2014. Dynamic Contrast Enhanced MRI Detects Early Response to Adoptive NK Cellular Immunotherapy Targeting the NG2 Proteoglycan in a Rat Model of Glioblastoma. PLoS ONE. 9. 12 sider. Publisert 2014-09-30. doi: 10.1371
  • Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina Wik; Enger, Per Øyvind; Li, Xingang; Wang, Jian. 2014. A novel GFP nude rat model to investigate tumor-stroma interactions. Cancer Cell International. 14:541. doi: 10.1186/s12935-014-0146-0
  • Yang, Ning; Yan, Tao; Zhu, Huaiyang; Liang, Xiao; Leiss, Lina Wik; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Huang, Bin; Costea, Daniela Elena; Enger, Per Øyvind; Li, Xingang; Wang, Jian. 2014. A co-culture model with brain tumor-specific bioluminescence demonstrates astrocytes-induced drug resistance in glioblastoma. Journal of Translational Medicine. 12:278. doi: 10.1186/s12967-014-0278-y
  • Jacobsen, Hege; Sleire, Linda; Wang, Jian; Netland, Inger Anne; Mutlu, Ercan; Førde, Hilde Elise Sundøy; Pedersen, Paal-Henning; Gullberg, Donald; Enger, Per Øyvind. 2013. Establishment of a novel dsRed NOD/Scid mouse strain to investigate the host and tumor cell compartments. Cancer Investigation. 31: 221-230. doi: 10.3109/07357907.2013.780075
  • Klink, Barbara; Miletic, Hrvoje; Stieber, Daniel; Huszthy, Peter Csaba; Jaime Alberto Campos, Valenzuela; Balss, Jörg; Wang, Jian; Schubert, Manja; Sakariassen, Per Øystein; Sundstrøm, Terje; Torsvik, Anja; Aarhus, Mads; Mahesparan, Rupavathana; von Deimling, Andreas; Kaderali, Lars; Niclou, Simone P; Schröck, Evelin; Bjerkvig, Rolf; Nigro, Janice Marie. 2013. A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1. PLoS ONE. 8: e59773. doi: 10.1371/journal.pone.0059773
  • Poli, Aurélie; Wang, Jian; Domingues, Olivia; Planaguma, Jesus; Yan, Tao; Brekke, Cecilie; Skaftnesmo, Kai Ove; Thorsen, Frits Alan; McCormack, Emmet; Hentges, François; Pedersen, Paal-Henning; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha. 2013. Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. OncoTarget. 4: 1527-1546.
  • Skeie, Bente Sandvei; Wang, Jian; Dodoo, Ernest; Heggdal, Jan Ingemann; Grønli, Janne; Sleire, Linda; Bragstad, Sidsel Marit; Ganz, Jeremy Christopher; Chekenya, Martha; Mørk, Sverre; Pedersen, Paal-Henning; Enger, Per Øyvind. 2013. Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model. Biomedical research. 2013. 9 sider. doi: 10.1155/2013/139674
  • Talasila, Krishna Mukharji; Soentgerath, Anke; Euskirchen, Philipp; Rosland, Gunnar Alm; Wang, Jian; Huszthy, Peter; Prestegarden, Lars; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Eskilsson, Eskil; Stieber, Daniel; Keunen, Olivier; Nigro, Janice; Vintermyr, Olav Karsten; Lund-Johansen, Morten; Niclou, Simone P; Mork, Stian; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2013. EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Neuro-Oncology. 15: 6-6. doi: 10.1007/s00401-013-1101-1
  • Talasila, Krishna Mukharji; Soentgerath, Anke; Euskirchen, Philipp; Røsland, Gro Vatne; Wang, Jian; Huszthy, Peter Csaba; Prestegarden, Lars; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Eskilsson, Eskil; Stieber, Daniel; Keunen, Olivier; Brekkå, Narve; Moen, Ingrid; Nigro, Janice Marie; Vintermyr, Olav Karsten; Lund-Johansen, Morten; Niclou, Simone P; Mørk, Sverre; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2013. EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathologica. 125: 683-698. doi: 10.1007/s00401-013-1101-1
  • Brekke, Cecilie; Thuen, Marte; Poli, Aurélie; Wang, Jian; Lokka, Guro; Huuse, Else Marie; Thorsen, Frits Alan; Enger, Per Øyvind; Chekenya, Martha. 2012. Early MRI findings of targeting the NG2 proteoglycan in GBM. The FASEB Journal. 26. 1 sider.
  • Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug. 2012. Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation. BMC Cancer. 12. 10 sider. doi: 10.1186/1471-2407-12-21
  • Viel, Thomas; Talasila, Krishna Mukharji; Monfared, Parisa; Wang, Jian; Jikeli, Jan F.; Waerzeggers, Yannic; Neumaier, Bernd; Backes, Heiko; Brekkå, Narve; Thorsen, Frits Alan; Stieber, Daniel; Niclou, Simone P; Winkeler, Alexandra; Tavitian, Bertrand; Hoehn, Mathias; Bjerkvig, Rolf; Miletic, Hrvoje; Jacobs, Andreas Hans. 2012. Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI. Journal of Nuclear Medicine. 53: 1135-1145. doi: 10.2967/jnumed.111.101659
  • Willingham, Stephen B.; Volkmer, Jens-Peter; Gentles, Andrew J.; Sahoo, Debashis; Dalerba, Piero; Mitra, Siddharta S.; Wang, Jian; Contreras-Trujillo, Humberto; Martin, Robin; Cohen, Justin D.; Lovelace, Patricia; Scheeren, Ferenc A.; Chao, Mark P.; Weiskopf, Kipp; Tang, Chad; Volkmer, Anne Kathrin; Naik, Tejaswitha J.; Storm, Theresa A.; Mosley, Adriane R.; Edris, Badreddin; Schmid, Sersina M.; Sun, Chris K.; Chua, Mei-Sze; Murillo, Oihana; Rajendran, Pradeep; Cha, Adriel C.; Chin, Robert K.; Kim, Dongkyoon; Adorno, Maddalena; Raveh, Tal; Tseng, Diane; Jaiswal, Siddhartha; Enger, Per Øyvind; Steinberg, Gary K.; Li, Gordon; So, Samuel K.; Majeti, Ravindra; Harsh, Griffith R.; van de Rijn, Matt; Teng, Nelson N.H.; Sunwoo, John B.; Alizadeh, Ash A.; Clarke, Michael F; Weissman, Irving L. 2012. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proceedings of the National Academy of Sciences of the United States of America. 109: 6662-6667. doi: 10.1073/pnas.1121623109
  • Jacobsen, Hege; Dicko, Aly; Wang, Jian; Storli, Kristian Eeg; Leh, Sabine; Thorsen, Frits Alan; Pavlin, Tina; Sondenaa, Karl; Gullberg, Donald; Bjerkvig, Rolf; Enger, Per Øyvind. 2011. Separate analysis of the cancer and stroma cell populations from orthotopically implanted tumor biopsies in eGFP scid mice. Clinical and Experimental Metastasis. 28: 203-203.
  • Keunen, Olivier; Johansson, Mikael; Oudin, Anaîs; Sanzey, Morgane; Rahim, Siti A. Abdul; Fack, Fred; Thorsen, Frits Alan; Taxt, Torfinn; Bartos, Michael; Jirík, Radovan; Miletic, Hrvoje; Wang, Jian; Stieber, Daniel; Stuhr, Linda Elin Birkhaug; Moen, Ingrid; Brekke, Cecilie; Bjerkvig, Rolf; Niclou, Simone P. 2011. Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. 108: 3749-3754. doi: 10.1073/pnas.1014480108
  • Wang, Jian; Daphu, Inderjit Kaur; Pedersen, Paal-Henning; Miletic, Hrvoje; Hovland, Randi; Mørk, Sverre; Bjerkvig, Rolf; Tiron, Crina Elena; McCormack, Emmet Martin; Micklem, David Robert; Lorens, James; Immervoll, Heike; Thorsen, Frits Alan. 2011. A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. Neuropathology and Applied Neurobiology. 37: 189-205. doi: 10.1111/j.1365-2990.2010.01119.x
  • Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna; Immervoll, Heike; Skaftnesmo, Kai Ove; Planaguma, Jesus; Reed, Rolf K.; Bjerkvig, Rolf; Miletic, Hrvoje; Enger, Per Øyvind; Brekke, Cecilie; Chekenya, Martha. 2011. Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. PLoS ONE. 6. 14 sider. doi: 10.1371/journal.pone.0023062
  • Yan, Tao; Skaftnesmo, Kai Ove; Leiss, Lina Wik; Sleire, Linda; Wang, Jian; Li, XinGang; Enger, Per Øyvind. 2011. Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide. BMC Cancer. 20. doi: 10.1186/1471-2407-11-524
  • Chekenya, Martha; Wang, Jian; Poli, A; Thuen, Marte; Brekke, Cecilie; Thorsen, Frits Alan; Zimmer, J; Enger, Per Øyvind. 2010. THERAPEUTIC TARGETING OF THE NG2 PROTEOGLYCAN WITH MAB 9.2.27 AND ADOPTIVELY TRANSFERRED NK CELLS LYSES HUMAN GLIOBLASTOMA MULTIFORME IN VIVO. Neuro-Oncology. 12: 9-9.
  • Goplen, Dorota; Bougnaud, Sébastien; Rajcevic, Uros; Bøe, Stig Ove; Skaftnesmo, Kai Ove; Voges, Jurgen; Enger, Per Øyvind; Wang, Jian; Tysnes, Berit Bølge; Lærum, Ole Didrik; Niclou, Simone P; Bjerkvig, Rolf. 2010. alpha B-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells. American Journal of Pathology. 177: 1618-1628. doi: 10.2353/ajpath.2010.090063
  • Huszthy, Peter Csaba; Immervoll, Heike; Wang, Jian; Goplen, Dorota; Miletic, Hrvoje; Eide, Geir Egil; Bjerkvig, Rolf. 2010. Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment. Gene Therapy. 17: 202-216. doi: 10.1038/gt.2009.130
  • Keunen, Oliver; Johansson, M; Oudin, A; Sanzey, M; Rahim, SABA; Fack, F; Thorsen, F; Taxt, Torfinn; Wang, Jian; Bjerkvig, Rolf; Niclou, SP. 2010. ANTI-ANGIOGENIC TREATMENT IN A CLINICALLY RELEVANT GLIOBLASTOMA MODEL REDUCES BLOOD FLOW AND INCREASES TUMOR CELL INVASION. Neuro-Oncology. 12: 20-20.
  • Liang, Xiao; Labeed, FH; Abdallat, R; Johannessen, Anne Chr.; Tsinkalovsky, Oleg; Wang, Jian; Costea, Daniela Elena. 2010. Rapid adherence to collagen IV enriches for tumour initiating cells. European Journal of Cancer. 8: 124-124.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Sleire, Linda; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Yan, Tao; Askland, Lasse Haugen; Persson, Andreas; Sakariassen, Per Øystein; Enger, Per Øyvind. 2010. Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Research. 70: 4274-4279. doi: 10.1158/0008-5472.CAN-09-3904
  • Sleire, Linda; Wang, Jian; Heggdal, Jan; Pedersen, Paal-Henning; Enger, Per Øyvind. 2010. SULFASALAZINE SENSITIZES GLIOBLASTOMA CELLS TO RADIATION TREATMENT. Neuro-Oncology. 12: 109-109.
  • Johannessen, Tor-Christian Aase; Wang, Jian; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Enger, Per Øyvind; Petersen, Kjell; Øyan, Anne Margrete; Kalland, Karl-Henning; Bjerkvig, Rolf; Tysnes, Berit Bølge. 2009. Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype. Neuropathology and Applied Neurobiology. 35: 380-393. doi: 10.1111/j.1365-2990.2009.01008.x
  • Niclou, SP; Johansson, Mikael; Keunen, O; Wang, Jian; Thorsen, Frits Alan; Bjerkvig, Rolf. 2009. PHENOTYPIC AND PHYSIOLOGIC EFFECTS OF BEVACIZUMAB IN A HIGHLY INFILTRATIVE AND ANGIOGENIC HUMAN GLIOBLASTOMA MODEL. Neuro-Oncology. 11: 906-906.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Askland, L; Persson, A; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Hovland, Randi; Enger, Per Øyvind. 2009. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. Neuro-Oncology. 11: 917-917.
  • Rajcevic, U; Peterson, K; Knol, Jaco C; Loos, Maarten; Bougnaud, Sébastien; Miletic, Hrvoje; Wang, Jian; Bjerkvig, Rolf; Jimenez, Connie R; Niclou, SP. 2009. MOLECULAR VARIATIONS IN TUMOR-HOST INTERACTIONS BETWEEN INVASIVE AND ANGIOGENIC PHENOTYPE IN HIGH-GRADE GLIOMAS. Neuro-Oncology. 11: 961-961.
  • Rajcevic, Uros; Petersen, Kjell; Knol, Jaco C; Loos, Maarten; Bougnaud, Sébastien; Klychnikov, Oleg; Li, Kan Wa; Pham, Thang V; Wang, Jian; Miletic, Hrvoje; Peng, Zhao; Bjerkvig, Rolf; Jimenez, Connie R; Niclou, Simone P. 2009. iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype. Molecular & Cellular Proteomics. 8: 2595-2612. doi: 10.1074/mcp.M900124-MCP200
  • Thulin, Asa; Ringvall, Maria; Dimberg, Anna; Kårehed, Karin; Väisänen, Timo; Väisänen, Marja-Riitta; Hamad, Osama; Wang, Jian; Bjerkvig, Rolf; Nilsson, Bo; Pihlajaniemi, Taina; Akerud, Helena; Pietras, Kristian; Jahnen-Dechent, Wilhelm; Siegbahn, Agneta; Olsson, Anna Karin. 2009. Activated Platelets Provide a Functional Microenvironment for the Antiangiogenic Fragment of Histidine-Rich Glycoprotein. Molecular Cancer Research. 7: 1792-1802. doi: 10.1158/1541-7786.MCR-09-0094
  • Wang, Jian; Miletic, Hrvoje; Sakariassen, Per Øystein; Huszthy, Peter Csaba; Jacobsen, Hege; Brekka, N; Li, X; Mork, S; Chekenya, Martha; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. PHENOTYPIC MODULATION OF EXPERIMENTAL GLIOMAS: PROGRESSION FROM GLIOMATOSIS CEREBRI-LIKE LESIONS TO GLIOBLASTOMA. Neuro-Oncology. 11: 897-897.
  • Wang, Jian; Miletic, Hrvoje; Sakariassen, Per Øystein; Huszthy, Peter Csaba; Jacobsen, Hege; Brekkå, Narve; Li, X; Zhao, P; Mørk, Sverre; Chekenya, Martha; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer. 9. doi: 10.1186/1471-2407-9-465
  • Wang, Jian; Tsinkalovsky, Oleg; Svendsen, Agnete; Prestegarden, Lars; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. Neuro-Oncology. 11: 221-222.
  • Wang, Jian; Tsinkalovsky, Oleg; Zhao, P; Prestegarden, L; Li, X; Cormark, E; Gjertsen, Bjørn Tore; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. TARGETING THE TUMOR STROMA: A NOVEL THERAPEUTIC STRATEGY BASED ON SEPARATE ANALYSIS OF THE MALIGNANT AND STROMAL CELL COMPARTMENTS IN BRAIN TUMORS. Neuro-Oncology. 11: 965-965.
  • Chekenya, Martha; Krakstad, Camilla; Svendsen, Agnete; Netland, Inger Anne; Staalesen, Vidar; Tysnes, Berit Bølge; Selheim, Frode; Wang, Jian; Sakariassen, Per Øystein; Sandal, Tone; Lønning, Per Eystein; Flatmark, Torgeir; Enger, Per Øyvind; Bjerkvig, Rolf; Sioud, M; Stallcup, William B. 2008. The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. Oncogene. 27: 5182-5194. doi: 10.1038/onc.2008.157
  • Huszthy, Peter Csaba; Goplen, Dorota; Thorsen, Frits Alan; Immervoll, Heike; Wang, Jian; Gutermann, Anja; Miletic, Hrvoje; Bjerkvig, Rolf. 2008. Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma. Clinical Cancer Research. 14: 1571-1580. doi: 10.1158/1078-0432.CCR-07-2000
  • Huszthy, Peter Csaba; Wang, Jian; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2008. Human glioblastoma tissue engraftment in immunocompetent rodent hosts. Neuro-Oncology. 10: 815-815. doi: 10.1215/15228517-2008-051
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Lasse, A; Andreas, P; Oystein, SP; Skaftnesmo, KO; Randi, H; Enger, Per Øyvind. 2008. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. Neuro-Oncology. 10: 778-778.
  • Thorsen, Frits Alan; Daphu, Inderjit Kaur; Pedersen, Paal-Henning; Wang, Jian; Miletic, Hrvoje; Bjerkvig, Rolf. 2008. DEVELOPMENT OF A NEW BRAIN METASTASES MODEL IN IMMUNODEFICIENT ANIMALS. Neuro-Oncology. 10: 854-854.
  • Thorsen, Frits Alan; Jirak, Daniel; Wang, Jian; Sykova, Eva; Bjerkvig, Rolf; Enger, Per Øyvind; van der Kogel, Albert; Hajek, Milan. 2008. Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. NMR in Biomedicine. 21: 830-838. Publisert 2008-10-21. doi: 10.1002/nbm.1263
  • Wang, Jian; Sakariassen, Per Øystein; Tsinkalovsky, Oleg; Immervoll, Heike; Bøe, Stig Ove; Svendsen, Agnete; Prestegarden, Lars; Røsland, Gro Vatne; Thorsen, Frits Alan; Stuhr, Linda Elin Birkhaug; Molven, Anders; Bjerkvig, Rolf; Enger, Per Øyvind. 2008. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. International Journal of Cancer. 122: 761-768. doi: 10.1002/ijc.23130
  • Thorsen, Frits Alan; Enger, Per Øyvind; Wang, Jian; Bjerkvig, Rolf; Pedersen, PH. 2007. Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery. Journal of Neuro-Oncology. 82: 1-10. doi: 10.1007/s11060-006-9240-z
  • Goplen, Dorota; Wang, Jian; Enger, Per Øyvind; Tysnes, Berit Bølge; Terzis, A. Jorge A.; Lærum, Ole Didrik; Bjerkvig, Rolf. 2006. Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Research. 66: 9895-9902. doi: 10.1158/0008-5472.CAN-05-4589
  • Piepoli, Tiziana; Jakupoglu, Cemile; Gu, Wenli; Lualdi, Elena; Suarez-Merino, Blanca; Poliani, Pietro L.; Cattaneo, Maria Grazia; Ortino, Barbara; Goplen, Dorota; Wang, Jian; Mola, Rosa; Inverardi, Francesca; Frassoni, Carolina; Bjerkvig, Rolf; Steinlein, Ortrud; Vicentini, Lucia M.; Brüstle, Oliver; Finocchiaro, Gaetano. 2006. Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1. Neuro-Oncology. 8: 96-108. doi: 10.1215/15228517-2005-006
  • Sakariassen, Per Øystein; Prestegarden, Lars; Wang, Jian; Skaftnesmo, Kai Ove; Mahesparan, Rupavathana; Molthoff, Carla; Sminia, Peter; Sundlisæter, Eirik; Misra, Anjan; Tysnes, Berit Bølge; Chekenya, Martha; Peters, Hans; Lende, Gabriel; Kalland, Karl-Henning; Øyan, Anne Margrete; Petersen, Kjell; Jonassen, Inge; van der Kogel, Albert; Feuerstein, Burt G.; Terzis, A. Jorge A.; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 16466-16471. doi: 10.1073/pnas.0607668103
  • Sundlisæter, Eirik; Wang, Jian; Sakariassen, Per Øystein; Marie, Michael Bruno Eric; Mathisen, Juan Robbie; Karlsen, Bård-Ove; Prestegarden, Lars; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Primary glioma spheroids maintain tumourogenicity and essential phenotypic traits after cryopreservation. Neuropathology and Applied Neurobiology. 32: 419-427. doi: 10.1111/j.1365-2990.2006.00744.x
  • Goplen, Dorota; Wang, Jian; Tysnes, Berit Bølge; Terzis, A. Jorge A.; Lærum, Ole Didrik; Bjerkvig, Rolf. 2005. Bacitracin inhibits glioma cell migration and invasion in vitro. Neuro-Oncology. 7: 357-357.
  • Enger, Per Øyvind; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Wang, Jian; Sundlisæter, Eirik; Prestegarden, Lars; Misra, Anjan; Tysnes, Berit Bølge; Chekenya, Martha; Feuerstein, Burt G.; Terzis, A. Jorge A.; Bjerkvig, Rolf. 2004. Angiogenesis-independent growth by brain tumor cells exhibiting cancer stem cell properties. Neuro-Oncology. 6: 309-309.
  • Sakariassen, Per Øystein; Prestegarden, Lars; Wang, Jian; Terzis, A. Jorge A.; Bjerkvig, Rolf; Enger, Per Øyvind. 2004. Forced differentiation suppresses the proliferative rate of cancer cells in brain tumours. Neuro-Oncology. 6.
Rapporter/avhandlinger
  • Wang, Jian. 2008. Xenografted brain tumors for modelling glioma biology – a study of brain tumor initiating cells and phenotypic modulation in gliomas.

Se fullstendig oversikt over publikasjoner i CRIStin.

1.         Poli A, Wang J, Domingues O, Yan T, Thuen M, Thorsen F, Rygh CB, McCormack E, Fischer W, Planaguma J, Hentges F, Pedersen PH, Zimmer J, Enger PØ, and Chekenya M. Targeting NG2 with mAb9.2.27 activated NK-cells promotes microglial cytotoxicity against GBM, prolonging survival in rats (Co-first author, Oncotarget. 2013 Sep;4(9):1527-46)

2.         Skeie BS, Wang J, Dodoo E, Heggdal JI, Grønli J, Sleire L, Bragstad S, Chekenya M, Mørk S, Pedersen PH, Enger PØ, and Ganz JC. Gamma Knife Surgery as monotherapy with clinically relevant doses Prolongs Survival in a Human GBM Xenograft Model. (Biomed Res Int. 2013;2013:139674. doi: 10.1155/2013/139674. Epub 2013 Nov 10).

3.         Talasila KM, Soentgerath A, Euskirchen P, Rosland GV, Wang J, Huszthy PC, Prestegarden L, Skaftnesmo KO, Brekka N, Nigro J, Lund-Johansen M, Mørk S, Enger PØ, Bjerkvig R and MiletiC H. EGFR activation promotes invasion and tumor development independent of angiogenesis. (Acta Neuropathologica, Epub 2013 Feb 22)

4.         Klink B, Miletic H, Stieber D, Huszthy P, Valenzuela JAC, Balss J, Wang J, Schubert M, Sakariassen PØ, Sundstrøm T, Torsvik A, Aarhus M, Mahesparan R, Deimling AV, Kaderali L, Niclou S, Schröck E, Bjerkvig R, Nigro J. A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1. (Plos one, Epub 2013 Mar 19)

5.         Jacobsen HK, Sleire L, Wang J, Netland IA, Mutlu E, Førde H, Pedersen PH, Gullberg Dand Enger PØ. Establishment of a novel dsRed NOD/Scid mouse strain to investigate the host and tumor cell compartments. (Cancer investigation, 2013 May;31(4):221-30)

6.         Kim DK, Wang J, Willingham SB, Martin R, Wernig G, and Weissman IL. Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells. Leukemia. 2012 May 30. doi: 10.1038/leu.2012.140. [Epub ahead of print]

7.         Viel T, Talasila T, Talasila KM, Monfared P, Wang J, Jikeli JfF, Waerzeggers Y, Neumaier B, Backes H, Brekka N, Thorsen F, Stieber D, Niclou SP, Winkeler A, Tavitian B, Hoehn M, Bjerkvig R, Miletic H, and Jacobs A. Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multi-modal µPET and µMRI. J Nucl Med. 2012 Jul;53(7):1135-45. Epub 2012 Jun 11.

8.         Willingham SB, Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD, Lovelace P, Scheeren FA, Chao MP, Weiskopf K, Tang C, Volkmer AK, Naik TJ, Storm TA, Mosley AR, Edris B, Schmid SM, Sun CK, Chua MS, Murillo O, Rajendran P, Cha AC, Chin RK, Kim D, Adorno M, Raveh T, Tseng D, Jaiswal S, Enger PO, Steinberg GK, Li G, So SK, Majeti R, Harsh GR, van de Rijn M, Teng NN, Sunwoo JB, Alizadeh AA, Clarke MF, Weissman IL. CD47 Is A Therapeutic Target On Human Solid Tumor Cells. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7. Epub 2012 Mar 26.

9.         Moen I, Jevne C, Wang J, Kalland KH, Chekenya M, Akslen LA, Sleire L, Enger PØ, Reed RK, Øyan AM and Stuhr L. Tumor-stroma interactions in red 4T1 mammary tumors in green mice with and without enhanced oxygenation. BMC Cancer. 2012 Jan 17;12:21.

10.       Yan T, Skaftnesmo KO, Leiss L, Sleire L, Wang J, Li XG, Enger PO. Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide. BMC Cancer. 2011 Dec 20;11:524.

11.       Wang J, Svendsen A, Kmiecik J, Miletic H, Immervoll H, Planaguma J, Bjerkvig R, Enger PØ, Rygh CB,  Chekenya M. Targeting the NG2 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma. (PLoS One. 2011;6(7):e23062. Epub 2011 Jul 29).

12.       Keunen O, Johansson M, Oudin A, Sanzey M, Rahim SAA, Fack F, Thorsen F, Taxt T, Bartos M, Jirik R, Miletic H, Wang J, Stuhr L, Moen I, Brekke C, Bjerkvig B and Niclou1 SP. Bevacizumab reduces blood flow and increases tumor cell invasion in glioblastomas. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3749-54.

13.       Wang J, Daphu I, Pedersen PH, Miletic H, Hovland R, Mørk S, Bjerkvig R, Tiron C, McCormack E, Micklem D, Lorens JB, Immervoll H, Thorsen F. A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. Neuropathol Appl Neurobiol. 2011 Feb;37(2):189-205.

14.       Goplen D, Bougnaud S, Rajcevic U, Bøe SO, Skaftnesmo KO, Voges J, Enger PO, Wang J, Tysnes BB, Laerum OD, Niclou S, Bjerkvig R. {alpha}B-Crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells. Am J Pathol. 2010 Oct;177(4):1618-28. Epub 2010 Sep 2.

15.       Prestegarden L, Svendsen A, Wang J, Sleire L, Skaftnesmo KO, Bjerkvig R, Yan T, Askland L, Persson A, Sakariassen PØ, Enger PØ. Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Res. 2010 Jun 1; 70(11): 4274-9.

16.       Huszthy PC, Immervoll H, Wang J, Goplen D, Miletic H, Eide GE, Bjerkvig R. Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment. Gene Ther. 2010 Feb; 17(2): 202-16.

17.       Wang J, Miletic H, Per Ø Sakariassen, Peter C Huszthy, Hege Jacobsen, Narve Brekka, Xingang Li, Peng Zhao, Sverre Mørk, Martha Chekenya, Rolf Bjerkvig and Per Ø Enger. A standardised brain tumor model established from the human glioblastoma multiforme biopsies. BMC Cancer. 2009 Dec 29; 9:465.

18.       Thulin Å, Ringvall M, Dimberg A, Kårehed K, Väisänen T, Väisänen MR, Hamad O, Wang J, Bjerkvig R, Nilsson B, Pihlajaniemi T, Åkerud H, Pietras K, Jahnen-Dechent W, Siegbahn A, Olsson AK. Activated platelets provide a functional microenvironment for the anti-angiogenic fragment of histidine-rich glycoprotein. Mol Cancer Res. 2009 Nov; 7(11): 1792-802. Epub 2009 Nov 10.

19.       Rajcevic U, Petersen K, Knol JC, Loos M, Bougnaud S, Klychnikov O, Li KW, Pham TV, Wang J, Miletic H, Peng Z, Bjerkvig R, Jimenez CR, Niclou SP. iTRAQ based proteomic profiling reveals increased metabolic activity and cellular crosstalk in angiogenic compared to invasive Glioblastoma phenotype. Mol Cell Proteomics. 2009 Nov;8(11): 2595-612. Epub 2009 Aug 12.

20.      Johannessen TC, Wang J, Skaftnesmo KO, Sakariassen PØ, Enger PØ, Petersen K, Øyan AM, Kalland KH, Bjerkvig R, Tysnes BB. Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype. Neuropathol Appl Neurobiol. 2009 Aug; 35(4): 380-93.

21.       Thorsen F, Jirak D, Wang J, Sykova E, Bjerkvig R, Enger PØ, van der Kogel A, Hajek M. Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. NMR Biomed. 2008 Oct; 21(8): 830-8.

22.       Chekenya M, Krakstad C, Svendsen A, Netland IA, Staalesen V, Tysnes BB, Selheim F, Wang J, Sakariassen PØ, Sandal T, Lønning PE, Flatmark T, Enger PØ, Bjerkvig R, Sioud M, Stallcup WB. The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. Oncogene. 2008 Sep 4; 27(39): 5182-94. Epub 2008 May 12.

23.       Huszthy PC, Goplen D, Thorsen F, Immervoll H, Wang J, Gutermann A, Miletic H, Bjerkvig R. Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma. Clin Cancer Res. 2008 Mar 1; 14 (5): 1571-80.

24.       Wang J, Sakariassen PØ, Tsinkalovsky O, Immervoll H, Bøe SO, Svendsen A, Prestegarden L, Røsland G, Thorsen F, Stuhr L, Molven A, Bjerkvig R, Enger PØ. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer. 2008 Feb 15; 122 (4):761-8.

25.       Sakariassen PØ, Prestegarden L, Wang J, Skaftnesmo KO, Mahesparan R, Molthoff C, Sminia P, Sundlisaeter E, Misra A, Tysnes BB, Chekenya M, Peters H, Lende G, Kalland KH, Øyan AM, Petersen K, Jonassen I, van der Kogel A, Feuerstein BG, Terzis AJ, Bjerkvig R, Enger PØ. Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proc Natl Acad Sci U S A. 2006 Oct 31;103 (44):16466-71. Epub 2006 Oct 20.

26.       Goplen D, Wang J, Enger PØ, Tysnes BB, Terzis AJ, Laerum OD, Bjerkvig R. Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Res. 2006 Oct 15; 66 (20): 9895-902.

27.       Thorsen F, Enger PØ, Wang J, Bjerkvig R, Pedersen PH. Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery. J Neurooncol. 2007 Mar; 82 (1): 1-10. Epub 2006 Sep 6.

28.       Sundlisaeter E, Wang J, Sakariassen PØ, Marie M, Mathisen JR, Karlsen BO, Prestegarden L, Skaftnesmo KO, Bjerkvig R, Enger PØ. Primary glioma spheroids maintain tumourogenicity and essential phenotypic traits after cryopreservation. Neuropathol Appl Neurobiol. 2006 Aug; 32 (4): 419-27.

29.       Piepoli T, Jakupoglu C, Gu W, Lualdi E, Suarez-Merino B, Poliani PL, Cattaneo MG, Ortino B, Goplen D, Wang J, Mola R, Inverardi F, Frassoni C, Bjerkvig R, Steinlein O, Vicentini LM, Brüstle O, Finocchiaro G. Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1. Neuro Oncol. 2006 Apr; 8(2): 96-108. Epub 2006 Mar 2.

Book chapter: Wang, J. Terzis. A.J.A, Aboody, K. Enger, PO and Bjerkvig, R. Transplants for Glioblastoma In Cell Transplantation from Laboratory to Clinic, Elsevier Publishers, C. Halberstadt and D. Emerich eds. (2007)