- E-postkarl.brokstad@uib.no
- Telefon+47 55 97 46 22+47 98 84 33 14
- BesøksadresseLaboratoriebygget, 5 etg.Haukeland Universitetssykehus5021 BergenRom5375
- PostadressePostboks 78045020 Bergen
Vitenskapelig artikkel
- (2024). Impact of ageing on homologous and human-coronavirus-reactive antibodies after SARS-CoV-2 vaccination or infection. npj Vaccines. 9 sider.
- (2023). SARS-CoV-2 specific immune responses in overweight and obese COVID-19 patients. Frontiers in Immunology. 11 sider.
- (2023). Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers. Frontiers in Public Health. 13 sider.
- (2023). Herring roe oil in treatment of psoriasis – influence on immune cells and cytokine network. Frontiers in Immunology.
- (2023). Durable immune responses after BNT162b2 vaccination in home-dwelling old adults. Vaccine: X. 1-11.
- (2022). Variability of Primary Sjögren's Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA–DQ Locus. Arthritis & Rheumatology. 1991-2002.
- (2022). Symptom Burden and Immune Dynamics 6 to 18 Months Following Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection (SARS-CoV-2): A Case-control Study. Clinical Infectious Diseases.
- (2022). Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses. npj Vaccines. 10 sider.
- (2022). Persistent Fever and Positive PCR 90 Days Post-SARS-CoV-2 Infection in a Rituximab-Treated Patient: A Case of Late Antiviral Treatment. Viruses.
- (2022). Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients. PLOS ONE. 16 sider.
- (2022). Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases. Arthritis & Rheumatology. 1440-1450.
- (2022). A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern. Communications Medicine. 11 sider.
- (2021). Long COVID in a prospective cohort of home-isolated patients. Nature Medicine. 1607-1613.
- (2021). Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study. The Lancet Regional Health - Europe. 9 sider.
- (2021). 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison’s Disease Are Restricted by HLA-A2 and HLA-C7 Molecules. Frontiers in Immunology. 12 sider.
- (2020). Viral antigens elicit augmented immune responses in primary Sjögren's syndrome. Rheumatology. 1651-1661.
- (2020). SARS-CoV-2-specific neutralizing antibody responses in Norwegian healthcare workers after the first wave of COVID-19 pandemic: a prospective cohort study. Journal of Infectious Diseases.
- (2020). Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction. Journal of Infectious Diseases. 21-32.
- (2020). Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children. Journal of Infectious Diseases. 1528-1537.
- (2020). A randomized, double-blind, placebo-controlled clinical study to investigate the efficacy of herring roe oil for treatment of psoriasis. Acta Dermato-Venereologica. 1-6.
- (2019). Functional immune response to influenza H1N1 in children and adults after live attenuated influenza virus vaccination. Scandinavian Journal of Immunology. 1-12.
- (2019). Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. European Journal of Nutrition. 1-17.
- (2019). Autoantigen-specific B cells and plasma cells are prominent in areas of fatty infiltration in salivary glands of patients with primary Sjogren?s syndrome. Autoimmunity. 242-250.
- (2018). T follicular-like helper cells in the peripheral blood of patients with primary Sjögren's syndrome. Scandinavian Journal of Immunology. 1-15.
- (2018). Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nature Chemical Biology. 94-101.
- (2018). Current concepts on Sjögren's syndrome – classification criteria and biomarkers. European Journal of Oral Sciences. 37-48.
- (2018). Altered levels of cytokines in patients with irritable bowel syndrome are not correlated with fatigue. International Journal of General Medicine. 285-291.
- (2017). Influenza virus hemagglutinin stalk-specific antibodies in human serum are a surrogate marker for in vivo protection in a serum transfer mouse challenge model. mBio. 1-13.
- (2017). Influenza A haemagglutinin specific IgG responses in children and adults after seasonal trivalent live attenuated influenza vaccination. Vaccine. 5666-5673.
- (2017). High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: A randomised trial. British Journal of Nutrition. 1368-1378.
- (2017). H1N1 vaccination in Sjogren's syndrome triggers polyclonal B cell activation and promotes autoantibody production. Annals of the Rheumatic Diseases. 1755-1763.
- (2017). Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. Neurogastroenterology and Motility. 1-9.
- (2017). Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis. Annals of the Rheumatic Diseases. 2031-2037.
- (2017). Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. Arthritis Research & Therapy. 1-10.
- (2017). Boosting of cross-reactive and protection-associated T cells in children after live attenuated influenza vaccination. Journal of Infectious Diseases. 1527-1535.
- (2017). 25-hydroxy-vitamin D concentration is not affected by severe or non-severe pneumonia, or inflammation, in young children. Nutrients. 1-11.
- (2016). Serum calprotectin is a biomarker of carotid atherosclerosis in patients with primary Sjögren's syndrome. Clinical and Experimental Rheumatology. 1006-1012.
- (2016). Pulmonary changes in Norwegian fatal cases of pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic study. Influenza and Other Respiratory Viruses. 525-531.
- (2016). Non-proliferating plasma cells detected in the salivary glands and bone marrow of autoimmune NOD.B10.H2b mice, a model for primary Sjögrens syndrome. Autoimmunity. 41-49.
- (2016). Live attenuated influenza vaccine in children induces b-cell responses in tonsils. Journal of Infectious Diseases. 722-731.
- (2016). High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: A randomised trial. British Journal of Nutrition. 648-657.
- (2016). Comparative analysis of influenza A(H3N2) virus hemagglutinin specific IgG subclass and IgA responses in children and adults after influenza vaccination. Vaccine. 191-198.
- (2016). Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer. Proceedings of the National Academy of Sciences of the United States of America. 9339-9344.
- (2015). Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice. mBio. 13 sider.
- (2015). The expression of B & T cell activation markers in children’s tonsils following live attenuated influenza vaccine. Human Vaccines & Immunotherapeutics. 1663-1672.
- (2015). Serum markers in rheumatoid arthritis: A longitudinal study of patients undergoing infliximab treatment. International Journal of Rheumatology. 1-9.
- (2015). Prediction of Sjögren's syndrome years before diagnosis and identification of patients with early onset and severe disease course by autoantibody profiling. Arthritis & Rheumatology. 2427-2436.
- (2015). Persistence and avidity maturation of antibodies to A(H1N1)pdm09 in healthcare workers following repeated annual vaccinations. Vaccine. 4146-4154.
- (2015). Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis Research and Treatment.
- (2015). Longevity of B-cell and T-cell responses after live attenuated influenza vaccination in children. Journal of Infectious Diseases. 1541-1549.
- (2015). Influenza Vaccination Strategies: Comparing Inactivated and Live Attenuated Influenza Vaccines. Vaccines. 373-389.
- (2015). Engraftment of human glioblastoma cells in immunocompetent rats through acquired immunosuppression. PLOS ONE.
- (2015). Cytokine concentrations in plasma from children with severe and non-severe community acquired pneumonia. PLOS ONE. 16 sider.
- (2014). The Influence of Tonsillectomy on Total Serum Antibody Levels. Scandinavian Journal of Immunology. 377-379.
- (2014). Serum IgG titres, but not avidity, correlates with neutralizing antibody response after H5N1 vaccination. Vaccine. 4550-4557.
- (2014). Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjögren's syndrome. Arthritis and Rheumatism. 2545-2557.
- (2014). Ductal epithelial expression of Ro52 correlates with inflammation in salivary glands of patients with primary Sjögren's syndrome. Clinical and Experimental Immunology. 244-252.
- (2014). Comparison of inflammatory markers in induced and spontaneous sputum in a cohort of COPD patients. Respiratory Research.
- (2013). Ro52- and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjögren's syndrome. Clinical and Experimental Immunology. 228-237.
- (2013). Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling. Cancer Research. 7090-7100.
- (2012). The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants. Human Vaccines & Immunotherapeutics. 653-661.
- (2012). Minor changes in serum levels of cytokines after removal of amalgam restorations. Toxicology Letters. 120-125.
- (2012). Low number of memory B cells in the salivary glands of patients with primary Sjögren's syndrome. Autoimmunity. 547-555.
- (2012). Autoantigen-specific memory B cells in primary Sjögren's syndrome. Scandinavian Journal of Immunology. 61-68.
- (2011). Salivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survival. Arthritis Research & Therapy. 18 sider.
- (2011). Phenotypic diversity of peripheral blood plasma cells in primary Sjögren’s Syndrome. Scandinavian Journal of Immunology. 18-28.
- (2011). Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 1363-1368.
- (2011). Implications of long-term medication of oral steroids and antimalarial drugs in primary Sjögren's syndrome. International Immunopharmacology. 2125-2129.
- (2011). Distinct phenotypes of plasma cells in spleen and bone marrow of autoimmune NOD.B10.H2b mice. Autoimmunity. 415-426.
- (2009). Cytokine and autoantibody profiling related to histopathological features in primary Sjögren's syndrome. Rheumatology. 1102-1106.
- (2009). Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation. BMC Immunology.
- (2009). Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy. BMC Infectious Diseases. 9 sider.
- (2009). A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice. Influenza and Other Respiratory Viruses. 21-28.
- (2009). A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models. Influenza and Other Respiratory Viruses. 107-117.
- (2007). Sjögren's syndrome - A plethora of clinical and immunological phenotypes with a complex genetic background. Annals of the New York Academy of Sciences. 433-447.
- (2007). A comparison of the humoral and cellular immune responses at different immunological sites after split influenza virus vaccination of mice. Scandinavian Journal of Immunology. 14-21.
- (2006). The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice. Vaccine. 6585-6587.
- (2006). The humoral and cellular responses induced locally and systematically after parenteral influenza vaccination in man. Vaccine. 6577-6580.
- (2006). Interleukin 5, IL6, IL12, IFN-gamma, RANTES and Fractalkine in human nasal polyps, turbinate mucosa and serum. European Archives of Oto-Rhino-Laryngology. 282-289.
- (2006). Impaired salivary gland function in NOD mice - Association with changes in cytokine profile but not with histopathologic changes in the salivary gland. Arthritis and Rheumatism. 2300-2305.
- (2006). Impact of influenza vaccine formulation with a detailed analysis of the cytokine response. Scandinavian Journal of Immunology. 467-475.
- (2006). Human cell lines used in a micro neutralization test for measuring influenza-neutralizing antibodies. Scandinavian Journal of Immunology. 257-264.
- (2005). The serological pattern of autoantibodies to the Ro52, Ro60, and La48 autoantigens in primary Sjögren's syndrome patients and healthy controls. Scandinavian Journal of Rheumatology. 49-55.
- (2005). Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors. European Journal of Neurology. 392-398.
- (2004). Lymphocyte distribution in the tonsils prior to and after influenza vaccination. Vaccine. 57-63.
- (1991). Purification and characterization of a 65-kilodalton diisopropylfluorophosphate-binding protein in the outer membrane of Fusobacterium nucleatum Fev1. Scandinavian Journal of Dental Research. 20-29.
- (1990). Diisopropylfluorophosphate-binding proteins in the outer membrane of Fusobacterium nucleatum: strain variations. FEMS Microbiology Letters. 235-238.
Vitenskapelig foredrag
- (2016). Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial.
- (2016). Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial.
- (2015). Cellular immune responses after live attenuated influenza vaccination in children, a clinical trial.
- (2005). The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man.
- (2000). Distribution of MHC class II in alleles in Norwegian primary Sjøgren's syndrome patients:Implications for development of autoantibodies to the Ro52 autoantigen.
Leder
- (2016). The 2016 Nobel Prize in Physiology or Medicine. Scandinavian Journal of Immunology.
- (2006). Pandernic influenza vaccine development: time is of the essence. Expert Review of Vaccines. 603-606.
- (2006). Pandemic influenza vaccine development: time is of the essence. Expert Review of Vaccines.
Leserinnlegg
- (2013). Autoantibodies Present Before Symptom Onset in Primary Sjogren Syndrome. Journal of the American Medical Association (JAMA). 1854-1855.
- (2009). The Immunogenicity of a Cell-derived H7N1 Split Influenza Virion Vaccine in Mice. Scandinavian Journal of Immunology. 576-578.
- (2005). Influenza specific serum IgE is present in non-allergic subjects. Scandinavian Journal of Immunology. 560-561.
Short communication
- (2020). Seroconversion in household members of COVID-19 outpatients. The Lancet Infectious Diseases.
Vitenskapelig antologi/Konferanseserie
- (2003). Methods in Molecular Medicine focusing on Methods in Viral Immunity. Springer.
Populærvitenskapelig artikkel
- (2020). Vaksinen si historie. . Naturen.
- (2020). Kva skjer med vaksinen i kroppen. . Naturen.
- (2020). COVID-19 og jakta på ein vaksine. Naturen.
Kronikk
- (2021). Nå har politisk korrekthet nådd WHO og navnsetting på SARS-CoV-2 variantene. . Bergens Tidende.
- (2020). Not just antibodies: B cells and T cells mediate immunity to COVID-19. Nature reviews. Immunology.
- (2020). Det er ikke bare antistoffer som beskytter mot covid-19. Aftenposten (morgenutg. : trykt utg.).
- (2020). CoVid-19; Derfor vil ikke dødeligheten være stor hvis viruset spres i Norge Norsk helsevesen er godt forberedt på at Wuhan-viruset kan spre seg til landet og beredskapen er på plass. Bergens Tidende.
Brev til redaktøren
- (2023). SARS-CoV-2 infection induces long-lived B and T-cell responses up to 15 months post-infection, irrespective of disease severity. Journal of Infection. 346-349.
- (2013). Autoantibodies Present Before Symptom Onset in Primary Sjögren Syndorme. Journal of the American Medical Association (JAMA). 1854-1855.
Doktorgradsavhandling
- (1995). Qualitative, quantitative and kinetic aspects of the humoral immune response induced systemically and locally after influenza vaccination.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
- (2007). Immunologi og andre fagfelt. 7 sider.
- (2004). The kinetics of the systemic and local immune response to parenteral influenza vaccination. 4 sider.
- (2003). Detection of antibodies to influenza virus in human mucosal tissues and fluids.
Sammendrag/abstract
- (2016). Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial. United European Gastroenterology Journal (UEG Journal). A101-A101.
- (2013). Autoantigen-specific memory cell pattern in patients with Primary Sjögren's syndrome. Scandinavian Journal of Immunology. 296-296.
- (2012). Ro52-and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjogren's syndrome. Immunology. 339-339.
- (2012). Hyperreactive B cells upon endosomal TLR triggering underlying primary Sjögren's Syndrome. Scandinavian Journal of Immunology. 199-200.
- (2011). Vaccination of patients with primary Sjögren's syndrome reveals hyperreactive B cell compartment with a skewed maturation pattern. Annals of the Rheumatic Diseases. A67-A67.
- (2011). Vaccination of Patients with Primary Sjogren's Syndrome Reveals Hyperreactive B Cell Compartment. Scandinavian Journal of Immunology. 369-369.
- (2010). The Value of Using Diseased Controls in Studies of Autoimmune Rheumatic Diseases. Scandinavian Journal of Immunology. 491-492.
- (2010). Successful engraftment of glioblastoma biopsy spheroids in immunocompetent rats. European Journal of Cancer. 76-76.
- (2010). Prednisolon Reduce Cytokine but Increase Autoantibody Levels in Patients with Primary Sjogren's Syndrome. Scandinavian Journal of Immunology. 491-491.
- (2008). Salivary gland interstitial fluid cytokines in NOD mice. Arthritis and Rheumatism. S796-S796.
- (2008). Heterogeneity of plasma cell subsets found in the bone marrow of autoimmune NOD.B10.H2b mice. Scandinavian Journal of Immunology. 206-206.
- (2006). Impaired salivary gland function in nod mice - Association with changes in cytokine profile but not with salivary gland histopathology. Arthritis and Rheumatism. S707-S707.
Poster
- (2016). Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial.
- (2009). Cytokine and autoantibody profiling in primary Sjögren's syndrome.
- (2007). Immunisation of mice with whole inactivated avian influenza H7N1 virus vaccine.
- (2005). The cytokine and the antibody responses after vaccination with influenza split or whole virus vaccines in mice.
- (2005). Cytokine profile and lymphocyte pattern influenced by parenteral influenza vaccination.
Vitenskapelig oversiktsartikkel/review
- (2016). Atherosclerosis in Sjögren's syndrome: Evidence, possible mechanisms and knowledge gaps. Clinical and Experimental Rheumatology. 133-142.
- (2007). Role of B cells in Sjögren's syndrome - from benign lymphoproliferation to overt malignancy. Frontiers in Bioscience. 2159-2170.
- (2004). Influenza virus: Immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines. Scandinavian Journal of Immunology. 1-15.
Fagartikkel
- (2021). SARS-CoV-2; livssyklus, mutasjoner, immunreaksjoner og vaksiner. Bioingeniøren.
- (2021). SARS-CoV-2; Mutasjoner og Varianter. . Bioingeniøren.
Kompetansefelt