Hjem
Lise Bjørkhaug Gundersens bilde

Lise Bjørkhaug Gundersen

Forsker
  • E-postLise.B.Gundersen@uib.no
  • Besøksadresse
    KG Jebsen senter for diabetesforskning
    Universitetet i Bergen
    5020 Bergen
    Rom 
    5A104dB
  • Postadresse
    Postboks 7804
    5020 Bergen

Arbeider med faktorer som årsak til til arvelig diabetes versus type 2 diabetes, og faktorer relatert til utvikling av fedme.

Tidsskriftartikler
  • Johansson, Bente Berg; Fjeld, Karianne; Solheim, Marie Holm; Shirakawa, Jun; Zhang, Enming; Keindl, Magdalena; Hu, Jiang; Lindquist, andreas; Døskeland, Anne Marie Simonne; Mellgren, Gunnar; Flatmark, Torgeir; Njølstad, Pål Rasmus; Kulkarni, Rohit N; Wierup, Nils; Aukrust, Ingvild; Bjørkhaug, Lise. 2017. Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by sumoylation. Molecular and Cellular Endocrinology. doi: 10.1016/j.mce.2017.06.020
  • Najmi, Laeya Abdoli; Aukrust, Ingvild; Flannick, Jason; Molnes, Janne; Burtt, Noël; Molven, Anders; Groop, Leif; Altshuler, David; Johansson, Stefan; Bjørkhaug, Lise; Njølstad, Pål Rasmus. 2017. Functional investigations of HNF1A identify rare variants as risk factors for type 2 diabetes in the general population. Diabetes. 66: 335-346. doi: 10.2337/db16-0460
  • Pakdaman, Yasaman; Sanchez Guixe, Monica; Kleppe, Rune; Erdal, Sigrid; Bustad, Helene J.; Bjørkhaug, Lise; Haugarvoll, Kristoffer; Tzoulis, Charalampos; Heimdal, Ketil Riddervold; Knappskog, Per; Johansson, Stefan; Aukrust, Ingvild. 2017. In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins. Bioscience Reports. 37: 1-12. doi: 10.1042/BSR20170251
  • Lek, M; Aggregation Consortium, Exome; Njølstad, Pål Rasmus; Najmi, Laeya Abdoli; Aukrust, Ingvild; Bjørkhaug, Lise. 2016. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 18: 285-291.
  • Madsen, Andre Greger; Bjune, Jan Inge; Bjørkhaug, Lise; Mellgren, Gunnar; Sagen, Jørn V. 2016. The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. Molecular and Cellular Endocrinology. 419: 92-101. doi: 10.1016/j.mce.2015.10.003
  • Rozenkova, Klara; Malikova, Jana; Nessa, Azizun; Dusatkova, Lenka; Bjørkhaug, Lise; Obermannova, Barbora; Dusatkova, Petra; Kytnarova, Jitka; Aukrust, Ingvild; Najmi, Laeya Abdoli; Rypackova, Blanka; Sumnik, Zdenek; Lebl, Jan; Njølstad, Pål Rasmus; Hussain, Khalid; Pruhova, Stepanka. 2015. High incidence of heterozygous ABCC8 and HNF1A mutations in Czech patients with congenital hyperinsulinism. Journal of Clinical Endocrinology and Metabolism. 100: E1540-E1549. doi: 10.1210/jc.2015-2763
  • Estrada, Karol; Aukrust, Ingvild; Bjørkhaug, Lise; Bjørkhaug, Lise; Burtt, Noël P.; Mercader, Josep P.; García-Ortiz, Humberto; Huerta-Chagoya, Alicia; Moreno-Macías, Hortensia; Walford, Geoffrey; Flannick, Jason; Williams, Amy L.; Gómez-Vázquez, Maria J.; Fernandez-Lopez, Juan C.; Martínez-Hernández, Angélica; Jiménez-Morales, Silvia; Centeno-Cruz, Federico; Mendoza-Caamal, Elvia; Revilla-Monsalve, Cristina; Islas-Andrade, Sergio; Córdova, Emilio J.; Soberón, Xavier; González-Villalpando, María E.; Henderson, Brian E.; Wilkens, Lynne R; Le Marchand, Loic; Arellano-Campos, Olimpia; Ordóñez-Sánchez, Maria L.; Rodríguez-Torres, Maribel; Rodríguez-Guillén, Rosario; Riba, Laura; Najmi, Laeya Abdoli; Jacobs, Susanne B.R.; Fennell, Timothy; Gabriel, Stacey; Fontanillas, Pierre; Hanis, Craig L; Lehman, Donna M.; Jenkinson, Christopher; Abboud, Hanna E.; Bell, Graeme I.; Cortes, Maria L.; Boehnke, Michael; González-Villalpando, Clicerio; Orozco, Lorena; Haiman, Christopher A.; Tusié-Luna, Teresa; Aguilar-Salinas, Carlos A.; Altshuler, David; Njølstad, Pål Rasmus; Florez, Jose C.; MacArthur, Daniel G. 2014. Association of a low-frequency variant in HNF1A with type 2 diabetes in a latino population the SIGMA Type 2 Diabetes Consortium. Journal of the American Medical Association (JAMA). 311: 2305-2314. doi: 10.1001/jama.2014.6511
  • Heimdal, Ketil Riddervold; Sanchez Guixe, Monica; Aukrust, Ingvild; Bollerslev, Jens; Bruland, Ove; Jablonski, Greg; ERICHSEN, ANNE KJERSTI; Gude, Einar; Koht, Jeanette; Erdal, Sigrid; Fiskerstrand, Torunn; Haukanes, Bjørn Ivar; Boman, Helge; Bjørkhaug, Lise; Tallaksen, Chantal; Knappskog, Per; Johansson, Stefan. 2014. STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity. Orphanet Journal of Rare Diseases. 9:146. doi: 10.1186/s13023-014-0146-0
  • Negahdar, Maria; Aukrust, Ingvild; Molnes, Janne; Solheim, Marie Holm; Johansson, Bente Berg; Sagen, Jørn V.; Dahl-Jørgensen, Knut; Kulkarni, Rohit Rajesh; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise. 2014. GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation. Molecular and Cellular Endocrinology. 382: 55-65. doi: 10.1016/j.mce.2013.08.020
  • Aukrust, Ingvild; Bjørkhaug, Lise; Negahdar, Maria; Molnes, Janne; Johansson, Bente Berg; Müller, Yvonne; Haas, Wilhelm; Gygi, Steven P.; Søvik, Oddmund; Flatmark, Torgeir; Kulkarni, Rohit N; Njølstad, Pål Rasmus. 2013. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. Journal of Biological Chemistry. 288: 5951-5962. doi: 10.1074/jbc.M112.393769
  • Søvik, Oddmund; Irgens, Henrik Underthun; Molnes, Janne; Sagen, Jørn V.; Bjørkhaug, Lise; Ræder, Helge; Molven, Anders; Njølstad, Pål Rasmus. 2013. Monogenetic diabetes mellitus in Norway :. Norsk Epidemiologi. 23: 55-60.
  • Negahdar, Maria; Aukrust, Ingvild; Johansson, Bente Berg; Molnes, Janne; Molven, Anders; Matschinsky, Franz M.; Søvik, Oddmund; Kulkarni, Rohit N; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise. 2012. GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822: 1705-1715. doi: 10.1016/j.bbadis.2012.07.005
  • Johansson, Bente Berg; Torsvik, Janniche; Bjørkhaug, Lise; Vesterhus, Mette; Ragvin, Anja; Tjora, Erling; Fjeld, Karianne; Hoem, Dag; Johansson, Stefan; Ræder, Helge; Lindquist, Susanne; Hernell, Olle; Cnop, Miriam; Saraste, Jaakko; Flatmark, Torgeir; Molven, Anders; Njølstad, Pål Rasmus. 2011. Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. Journal of Biological Chemistry. 286: 34593-34605. doi: 10.1074/jbc.M111.222679
  • Molnes, Janne; Teigen, Knut; Aukrust, Ingvild; Bjørkhaug, Lise; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus. 2011. Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity. The FEBS Journal. 278: 2372-2386. doi: 10.1111/j.1742-4658.2011.08160.x
  • Molnes, Janne; Bjørkhaug, Lise; Søvik, Oddmund; Njølstad, Pål Rasmus; Flatmark, Torgeir. 2008. Catalytic activation of human glucokinase by substrate binding - residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions. The FEBS Journal. 275: 2467-2481. doi: 10.1111/j.1742-4658.2008.06391.x
  • Sagen, Jørn V.; Bjørkhaug, Lise; Molnes, Janne; Ræder, Helge; Grevle, Louise; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2008. Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. Pediatric Diabetes. 9: 442-449. doi: 10.1111/j.1399-5448.2008.00399.x
  • Bjørkhaug, Lise; Molnes, Janne; Søvik, Oddmund; Njølstad, Pål Rasmus; Flatmark, Torgeir. 2007. Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation. Journal of Biological Chemistry. 282: 22757-22764. doi: 10.1074/jbc.M700517200
  • Raeder, Helge; Ræder, Helge; Bjorkhaug, Lise; Bjørkhaug, Lise; Johansson, Stefan; Mangseth, Kjersti; Sagen, Jørn V.; Hunting, Anne; Følling, Ivar; Johansen, Odd; Bjørgaas, Marit; Paus, Povel N.; Søvik, Oddmund; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2006. A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry. Diabetes. 55: 1899-1903. doi: 10.2337/db05-1677
  • Ræder, Helge; Johansson, Stefan; Holm, Pål I.; Haldorsen, Ingfrid S.; Mas, Eric; Sbarra, Véronique; Nermoen, Ingrid; Eide, Stig Åge; Grevle, Louise; Bjørkhaug, Lise; Sagen, Jørn V.; Aksnes, Lage; Søvik, Oddmund; Lombardo, Dominique; Molven, Anders; Njølstad, Pål Rasmus. 2006. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics. 38: 54-62. doi: 10.1038/ng1708
  • Ræder, Helge; Nermoen, Ingrid; Johansson, Stefan; Søvik, Oddmund; Molven, Anders; Sagen, Jørn V.; Aksnes, Lage; Haldorsen, Ingfrid S.; Bjørkhaug, Lise; Holm, Pål Ivar; Eide, Stig Åge; Grevle, Louise; Mas, Eric; Sbarra, Véronique; Lombardo, Dominique; Njølstad, Pål Rasmus. 2006. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics. 38: 54-62.
  • Sagen, Jørn; Odili, Stella; Bjørkhaug, Lise; Zelent, Dorothy; Buettger, Carol; Kwagh, Jae; Stanley, Charles; Dahl-Jørgensen, Knut; de Beaufort, Carine; Bell, Graeme I.; Han, Yi; Grimsby, Joseph; Taub, Rebecca; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus; Matschinsky, Franz M. 2006. From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Diabetes. 55: 1713-1722. doi: 10.2337/db05-1513
  • Bjørkhaug, Lise; Johansson, Stefan; Ræder, Helge; Thorsby, PM; Undlien, DE; Søvik, Oddmund; Molven, Anders; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2005. Molekylærgenetisk diagnostikk ved diabetes mellitus. Tidsskrift for Den norske legeforening. 125: 2968-2972.
  • Gundersen, Lise Bj.; Bratland, Andre; Njølstad, Pål Rasmus; Molven, Anders. 2005. Functional dissection of the HNF-1alpha transcription factor: A study on nuclear localization and transcriptional activation. DNA and Cell Biology. 24: 661-669.
  • Gundersen, Lise Bj.; Johansson, Stefan; Ræder, Helge; Undlien, Dag E.; Molven, Anders; Søvik, Oddmund; Thorsby, Per; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2005. Molekylærgenetisk diagnostikk ved diabetes mellitus. Tidsskrift for Den norske legeforening. 125: 2968-2972.
  • Gundersen, Lise Bj.; Sagen, Jørn V.; Thorsby, P; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2003. Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway. Journal of Clinical Endocrinology and Metabolism. 88: 920-931.
  • Njølstad, Pål Rasmus; Sagen, Jørn V.; Bjørkhaug, Lise; Odili, Stella; Shehadeh, Naim; Bakry, Doua; Sarici, U; Alpay, Faruk; Molnes, Janne; Molven, Anders; Søvik, Oddmund; Matschinsky, Franz M. 2003. Permanent neonatal diabetes caused by glucokinase deficiency; inborn error of the glucose-insulin signaling pathway. Diabetes. 52: 2854-2860.
  • Bjørkhaug, Lise; Horikawa, Y; Ye, Hong; Bell, Graeme I.; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus. 2000. MODY associated with two novel hepatocyte nuclear factor 1 alpha loss of function mutations. Biochemical and Biophysical Research Communications - BBRC. 279: 792-798.
  • Bjørkhaug, Lise; Søvik, Oddmund; Bell, Graeme I.; Njølstad, Pål Rasmus; Molven, Anders. 2000. A simple test for the hot spot mutation P291fsinsC in MODY3. Diabetologia. 43: 818-819.
  • Bolino, Alessandra; Yin, L; Seri, M; Cusano, R; Cinti, R; Coffey, A; Brooksbank, R; Howell, G; Bentley, D; Davis, JR; Lanyi, A; Huang, D; Stark, M; Creaven, Martina; Bjørkhaug, Lise; Heitzmann, F; Lamartine, J; Gaudi, Simona; Sylla, BS; Lenior, G; Castagnola, E; Giacchino, R; Porta, G; Franco, B; Zollo, M.; Sumegi, J; Romeo, Giovanni. 1998. A new candidate region for the positional cloning of the XLP gene. European Journal of Human Genetics. 6: 509-517.
  • Harrison, Patrick; Bjørkhaug, Lise; Hutchinsom, MJ; Allen, JM. 1995. The interaction between human FcgammaRI and the gamma-chain is mediated solely by the 21 amino acid transmembrane domain of FcgammaRI. Molecular membrane biology. 12: 309-312.

Se fullstendig oversikt over publikasjoner i CRIStin.

Original Papers

1.      Estrada K, Aukrust I, Bjørkhaug L, Burtt N, Mercader JM, et al. (2014) Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.Journal of the American Medical Association June issue. Impact factor 30.

2.      Negahdar M, Molnes J, Johansson BB, Aukrust I, Dahl-Jørgensen K., Søvik O, Kulkarni RN, Flatmark T, Njølstad PR and Bjørkhaug L. The GCK-MODY mutation R275C promotes protein misfolding, aggregation and cellular degradation of glucokinase. Mol Cell Endocrinol 2013 Aug 31. doi:pii: S0303-7207(13)00357-2. 10.1016/j.mce.2013.08.020. [Epub ahead of print].

3.      Aukrust I* and Bjørkhaug L*, Molnes J, Haas W, Gygi SP, Søvik O, Flatmark T, Kulkarni RN and Njølstad PR. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. (2013) J Biol Chem, 288:5951-62. *Both 1st authors.       Impact factor 4.7.

4.      Negahdar M, Aukrust I, Johansson BB, Molnes J, Molven A., Matschinsky FM., Søvik O, Kulkarni RN, Flatmark T, Njølstad PR and Bjørkhaug L. (2012) GCK-MODY Associated with Protein Misfolding, Aggregation and Cellular Degradation of Glucokinase. Biochim Biophys Acta, 20:1705-1715.

5.      Johansson BB., Torsvik J., Bjørkhaug L., Vesterhus M., Ragvin A., Tjora E., Fjeld K., Hoem D., Johansson S., Rader H., Lindquist S., Hernell O., Cnop M., Saraste J., Flatmark T., Molven A., Njølstad PR. (2011) Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl-ester lipase gene (CEL-MODY): a protein misfolding disease. J Biol Chem, 286(40):34593-605. Impact factor 4.7.

6.      Molnes J., Teigen K., Aukrust I., Bjørkhaug L., Søvik O., Flatmark T., Njølstad PR. (2011). Binding of ATP at the active site of human pancreatic glucokinase; nucleotide- induced conformational changes with possible implications for its kinetic cooperativity. FEBS J, 278:2372-86.

7.      Molnes, J., Bjørkhaug, L. Søvik, O., Njølstad, P.R. and Flatmark, T. (2008) Catalytic activation of human glucokinase by substrate binding - residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions. FEBS J, 275: 2467-81. 6.

8.      Sagen, J.V., Bjørkhaug, L., Odili, S., Zelent, D., Grevle, L., Molven, A., Matschinsky, F.M., Søvik, O., Njølstad, P.R. (2008). Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. Pediatr Diabetes, 9: 442-9.

9.   Bjørkhaug, L., Molnes, J., Njølstad, P., and Flatmark, T. (2007). Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation. J Biol Chem, 282: 22757-64. Impact factor 4.7.

10.   Ræder, H., Bjørkhaug, L., Johansson, S., Mangseth, K., Sagen, J.V., Hunting, A., Følling, I., Johansen, O., Bjørgaas, M., Paus, P.N., Søvik, O., Molven, A., Njølstad, P.R. (2006) Hepatocyte nuclear factor-4α mutations in the Norwegian MODY registry: A novel P2 promoter variant co-segregating with late-onset diabetes. Diabetes 55: 1899-1903. Impact factor 7.9.

11. Sagen, J.V., Odili, S., Bjørkhaug, L., Zelent, D., Buettger, C., Kwagh, J., Stanley, C., Dahl-Jørgensen, K., de Beaufort, C., Bell, G.I., Han, Y. Grimsby, J., Taub, R., Molven, A., Søvik, O., Njølstad, P.R., Matschinsky, F.M. (2006) From clinicogenetic studies of Maturity-Onset Diabetes of the Young to unravelling complex mechanisms of glucokinase regulation. Diabetes55: 1713-1722. Impact factor 7.9.

12. Ræder, H., Johansson, S., Holm, P.I., Haldorsen, I.S., Mas, E., Sbarra, V., Nermoen, I., Eide, S.Å., Grevle, L., Bjørkhaug, L., Sagen, J.V., Aksnes, L., Søvik, O., Lombardo, D., Molven, A., Njølstad, P.R. (2006) Mutations within a VNTR in CEL cause a novel syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics 38(1): 54-62. Impact factor 35.

13. Bjørkhaug, L., Bratland, A., Njølstad, P.R., Molven, A. (2005). Functional dissection of the HNF-1alpha transcription factor: a study on nuclear localization and transcriptional activation. DNA and Cell Biology. 24(11): 661-669.

14. Njølstad PR, Sagen JV, Bjørkhaug L, Odili S, Shehadeh N, Bakry D, Sarici U, Alpay F, Molnes J, Molven A, Søvik O, Matschinsky FM (2003). Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway. Diabetes52: 2854-2860. Impact factor 7.9.

15. Bjørkhaug, L., Sagen J.V., Thorsby, P., Søvik, O., Molven A. and Njølstad, P.R (2003). Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway. J Clin Endocrinol Metab 88(2): 920-931. Impact factor 6.4.

16. Njølstad, P.R., Søvik, O., Cuesta-Munoz, A., Bjørkhaug, L., Massa, O., Barbetti, F., Undlien, D., Shiota, C., Magnusson, M.A., Molven, A., Matschinsky, P. and Bell, G.I. (2001): Permanent neonatal diabetes mellitus due to complete glucokinase deficiency. N Engl J Med 344(21): 1588-1592. Impact factor 51

17. Bjørkhaug, L., Ye, Y., Horikawa, Y., Bell, G.I., Molven, A., Søvik, O. and Njølstad, P.R. (2000): MODY associated with two Novel hepatocyte nuclear factor-1α loss-of-function mutations (P112L and Q466X). Biochem and Biophys Res Commun 279(3): 792-798.

18. Bjørkhaug, L., Søvik, O., Bell G.I., Njølstad, P.R. and Molven, A. (2000): A simple test for the hot spot mutation P291fsinsC in MODY3. Diabetologia. 43:818-9.

19. Bolino, A., Yin, L., Seri, M., Cusano, R., Cinti, R., Coffey, A., Brooksbank, R., Howell, G., Bentley, D., Davis, J.R., Lanyi, A., Huang, D., Stark, M., Creaven, M., Bjørkhaug, L. et al.(1998): A new candidate region for the positional cloning of the XLP gene. European J Human Genetics 6: 509-517.

20. Harrison, P., Bjørkhaug, L., Hutchinson, J. and Allen, J.M. (1995): The interaction between human FcgRI and the g-chain is mediated solely by the 21 amino acid transmembrane domain of FcgRI. Mol Memb Biol 12: 309-312.

 

Review Papers/Popular Science:

1.  Bjørkhaug, L., Aukrust, I. (2014). Strukturelle og funksjonelle studier av enzyme glukokinase – en sentral regulator av insulinsekresjonen. BestPractise Diabetes 10:14-17.

2.   Søvik, O., Irgens, H.U., Molnes, J., Sagen, J.V., Bjørkhaug, L., Ræder, H., Molven, A.,

     Njølstad, P.R. (2013). Monogenic diabetes mellitus in Norway. Norsk Epidemiologi,

     23:55-60.

3.   Bjørkhaug, L., Johansson, S., Ræder, H., Thorsby, P.M., Undlien, D.E., Søvik, O., Molven, A., Sagen, J.V., Njølstad, P.M. (2005). Molekylærgenetisk diagnostikk ved diabetes mellitus. Tidsskrift for den norske Lægeforening 125: 2968-72.[Review]

4.  Njølstad PR, Bjørkhaug, L (2003). Klinisk molekylærmedisin (5): Eksempler på funksjonelle analyser. Pediatrisk endokrinologi 16: 64-69.

 

 

 

 

Hepatocytt nukleær faktor 1-alfa; sjeldne varianter som risiko/årsak til type 2 diabetes

Funksjonell karakterisering av homeobox faktorer i fedme og metabolsk sykdom

Rollen til Pi3kr1 i utvikling av lipodystrofi

Subcellulær regulering av glukosesensoren glukokinase