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Olav Martin Kvalheims bilde

Olav Martin Kvalheim

Professor
  • E-postOlav.Kvalheim@uib.no
  • Telefon+47 55 58 33 66
  • Besøksadresse
    Realfagbygget, Allégt. 41
  • Postadresse
    Postboks 7803
    5020 BERGEN

I am mainly working with i) instrumental characterization/profiling of complex multicomponent systems (body fluids and tissue) and development of data-analytical methods and algorithms for resolution, exploration, pattern recognition, discrimination and classification of such systems, and, ii) applications of such methods to solve multifaceted problems of medical and pharmaceutical origin. Typically, spectral or chromatographic fingerprints of whole or fractionated samples are used to select features characterizing and/or discriminating groups of samples or to predict properties such as e.g. bioactivity of natural products or disease states for patients. Feature selection provides a strategy to reveal so-called biomarkers, molecules carrying specific information about biological processes such as pathogenesis. This can be molecules displaying the disease pattern in a way that can be utilized for diagnostic or therapeutic purposes. Collaboration with medical research groups is established in obesity research, and, for neurological diseases (multiple sclerosis). Analytical instrumentation such as NMR, chromatography and mass spectroscopy combined with chemometrics represents key technologies for pattern recognition and biomarker discovery for early diagnosis, risk analysis, and, monitoring of disease development and therapeutic effects.

Master and PhD projects are provided within the areas of new algortihms and methods for profiling and data analysis of complex systems, and, application of such methods to solve medical and pharmaceutical problems.

Examples of recent master theses:

1. Analysis of Brain Lipids Using NMR and Multivariate Methods

2. Multivariate characterization and analysis of brain lipids

Tidsskriftartikler
  • Britton, Emily R.; Kellogg, Joshua J.; Kvalheim, Olav Martin; Cech, Nadja B. 2016. New strategies to identify synergists from Hydrastis canadensis (goldenseal). Planta Medica. 82. 1 sider. doi: 10.1055/s-0036-1596182
  • Kellogg, Joshua J.; Kvalheim, Olav Martin; Cech, Nadja B. 2016. Biochemometric analysis reveals complimentary bacterial inhibitory functionalities of the medicinal lichen Usnea barbata. Planta Medica. 82. 1 sider. doi: 10.1055/s-0036-1596184
  • Kellogg, Joshua J.; Todd, Daniel A.; Egan, Joseph M.; Raja, Huzefa A.; Oberlies, Nicholas H.; Kvalheim, Olav Martin; Cech, Nadja B. 2016. Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds. Journal of natural products. 79: 376-386. doi: 10.1021/acs.jnatprod.5b01014
  • Lin, Chenchen; Andersen, John Roger; Våge, Villy; Rajalahti, Tarja; Mjøs, Svein Are; Kvalheim, Olav Martin. 2016. Intensive lifestyle intervention provides rapid reduction of serum fatty acid levels in women with severe obesity without lowering omega-3 to unhealthy levels. Clinical Obesity. 6. 259-267. doi: 10.1111/cob.12151
  • Lin, Chenchen; Rajalahti, Tarja; Mjøs, Svein Are; Kvalheim, Olav Martin. 2016. Predictive associations between serum fatty acids and lipoproteins in healthy non-obese Norwegians: implications for cardiovascular health. Metabolomics. 12. doi: 10.1007/s11306-015-0886-4
  • Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are; Kvalheim, Olav Martin. 2016. Changes in serum fatty acid and lipoprotein subclass concentrations from prepuberty to adulthood and during aging. Metabolomics. 12:51. 10 sider. doi: 10.1007/s11306-016-0968-y
  • Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are; Kvalheim, Olav Martin. 2016. Serum fatty acid and lipoprotein subclass concentrations and their associations in prepubertal healthy Norwegian children. Metabolomics. 12. doi: 10.1007/s11306-016-1020-y
  • Resaland, Geir Kåre; Aadland, Eivind; Moe, Vegard Fusche; Aadland, Katrine Nyvoll; Skrede, Turid; Stavnsbo, Mette; Suominen, Laura; Steene-Johannessen, Jostein; Glosvik, Øyvind; Andersen, John Roger; Kvalheim, Olav Martin; Engelsrud, Gunn; Andersen, Lars Bo; Holme, Ingar Morten K; Ommundsen, Yngvar; Kriemler, Susi; van Mechelen, Willem; McKay, Heather A.; Ekelund, Ulf; Anderssen, Sigmund Alfred. 2016. Effects of physical activity on schoolchildren's academic performance: The Active Smarter Kids (ASK) cluster-randomized controlled trial. Preventive Medicine. 91: 322-328. doi: 10.1016/j.ypmed.2016.09.005
  • Bleie, Olav; Roberto, Michael F.; Dearing, Thomas I.; Branham, Charles W.; Kvalheim, Olav Martin; Marquardt, Brian J. 2015. Moffat-swern oxidation of alcohols: Translating a batch reaction to a continuous-flow reaction. Journal of Flow Chemistry. 5: 183-189. doi: 10.1556/1846.2015.00025
  • Kvalheim, Olav Martin. 2015. Kan ikkje vere kjøpt og betalt. Firda. Publisert 2015-01-20.
  • Kvalheim, Olav Martin. 2015. Folkeavstemningen om Engebø. Firda. Publisert 2015-09-24.
  • Kvalheim, Olav Martin. 2015. Et miljøvennlig og samfunnsnyttig prosjekt. Firda. Publisert 2015-10-03.
  • Lin, Chenchen; Våge, Villy; Mjøs, Svein Are; Kvalheim, Olav Martin. 2015. Changes in Serum Fatty Acid Levels During the First Year After Bariatric Surgery. Obesity Surgery. Published ahead of print. doi: 10.1007/s11695-015-1980-4
  • Resaland, Geir Kåre; Moe, Vegard Fusche; Aadland, Eivind; Steene-Johannessen, Jostein; Glosvik, Øyvind; Andersen, John Roger; Kvalheim, Olav Martin; McKay, Heather A.; Anderssen, Sigmund Alfred. 2015. Active Smarter Kids (ASK): Rationale and design of a cluster-randomized controlled trial investigating the effects of daily physical activity on children's academic performance and risk factors for non-communicable diseases. BMC Public Health. 15:709. doi: 10.1186/s12889-015-2049-y
  • Kvalheim, Olav Martin; Arneberg, Reidar; Bleie, Olav L.; Rajalahti, Tarja; Smilde, Age K.; Westerhuis, Johan A. 2014. Variable importance in latent variable regression models. Journal of Chemometrics. 28: 615-622. doi: 10.1002/cem.2626
  • Lin, Chenchen; Mjøs, Svein Are; Våge, Villy; Kvalheim, Olav Martin. 2014. Effect of two types of bariatric surgery on the fatty acid profile in serum. The Complexity of obesity proceedings. 1. doi: 10.6084/m9.figshare.1211862
  • Rajalahti, Tarja; Aadland, Eivind; Andersen, John Roger; Våge, Villy; Kvalheim, Olav Martin. 2014. A multivariate approach to reveal biomarker signatures in instrumental profiles of body fluids. The Complexity of obesity proceedings. 1. doi: 10.6084/m9.figshare.1211862
  • Aadland, Eivind; Andersen, John Roger; Anderssen, Sigmund Alfred; Kvalheim, Olav Martin. 2013. Impact of physical activity and diet on lipoprotein particle concentrations in severely obese women participating in a 1-year lifestyle intervention. Clinical Obesity. 3: 202-213. doi: 10.1111/cob.12036
  • Aadland, Eivind; Andersen, John Roger; Anderssen, Sigmund Alfred; Kvalheim, Olav Martin. 2013. Physical activity versus sedentary behavior: associations with lipoprotein particle subclass concentrations in healthy adults. PLoS ONE. 8. 9 sider. Publisert 2013-12-27. doi: 10.1371/journal.pone.0085223
  • Meling, Siv; Kvalheim, Olav Martin; Arneberg, Reidar; Bårdsen, Kjetil; Hjelle, Anne; Ulvund, Martha. 2013. Investigation of serum protein profiles in scrapie infected sheep by means of SELDI-TOF-MS and multivariate data analysis. BMC Research Notes. 6. 14 sider. doi: 10.1186/1756-0500-6-466
  • Kvalheim, Olav Martin. 2012. History, philosophy and mathematical basis of the latent variable approach - from a peculiarity in psychology to a general method for analysis of multivariate data. Journal of Chemometrics. 26: 210-217. doi: 10.1002/cem.2427
  • Ala-Korpela, Mika; Salomaa, Veikko; Kvalheim, Olav Martin. 2011. Clinical and Epidemiological Metabonomics. Journal of Biomedicine and Biotechnology. 2 sider. doi: 10.1155/2011/843150
  • Jepsen, Randi; Andersen, John Roger; Aadland, Eivind; Aasprang, Anny; Kvalheim, Olav Martin; Natvig, Gerd Karin. 2011. Health Related Quality of Life in in-patients undergoing lifestyle treatment for morbid obesity. Obesity Reviews. 12. 87-87.
  • Kvalheim, Olav Martin; Chan, Hoi-Yan; Benzie, Iris; Szeto, Yim-tong; Tzang, Alexander Hing-chung; Mok, Daniel Kim-wah; Chau, Foo-Tim. 2011. Chromatographic profiling and multivariate analysis for screening and quantifying the contributions from individual components to the bioactive signature in natural products. Chemometrics and Intelligent Laboratory Systems. 107: 98-105. doi: 10.1016/j.chemolab.2011.02.002
  • Rajalahti, Tarja; Kvalheim, Olav Martin. 2011. Multivariate data analysis in pharmaceutics: A tutorial review. Internation Journal of Pharmaceutics. 417: 280-290. doi: 10.1016/j.ijpharm.2011.02.019
  • Zhang, Liangxiao; Zhang, Wan; Cao, Dongsheng; Zeng, Maomao; Liang, Yizeng; Kvalheim, Olav Martin. 2011. Resolving co-eluting chromatographic patterns by means of dissimilarity analysis in iterative target transformation factor analysis. Journal of Chromatography A. 1218: 7219-7225. doi: 10.1016/j.chroma.2011.08.010
  • Kvalheim, Olav Martin. 2010. Interpretation of partial least squares regression models by means of target projection and selectivity ratio plots. Journal of Chemometrics. 24. 9 sider. doi: 10.1002/cem.1289
  • Kvalheim, Olav Martin; Grung, Bjørn; Nodland, Egil; Kvalheim, Tarja Anniki Rajalahti. 2010. The 11th Scandinavian Symposium on Chemometrics, Loen, Norway, 8-11 June 2009. Journal of Chemometrics. 24: 343-345. doi: 10.1002/cem.1318
  • Kvalheim, Tarja Anniki Rajalahti; Kroksveen, Ann Cathrine; Arneberg, Reidar; Berven, Frode; Vedeler, Christian A.; Myhr, Kjell-Morten; Kvalheim, Olav Martin. 2010. A multivariate approach to reveal biomarker signatures for disease classification: application to mass spectral profiles of cerebrospinal fluid from patients with multiple sclerosis. Journal of Proteome Research. 9: 3608-3620. doi: 10.1021/pr100142m
  • Zhang, Liangxiao; Dai, Hui; Liang, Yizeng; Kvalheim, Olav Martin. 2010. Detection and use of selective ions for providing initial estimates of the concentration vectors in iterative target transformation factor analysis. Journal of Chromatography A. 1217: 3128-3135. doi: 10.1016/j.chroma.2010.02.036
  • Zhang, Liangxiao; Mjøs, Svein Are; Meier, Sonnich; Kvalheim, Olav Martin; Liang, Yizeng. 2010. The vector of calibration ratios: A simple transfer method for mass spectra. Journal of Chromatography A. 1217: 5986-5994. doi: 10.1016/j.chroma.2010.07.039
  • Chau, Foo-Tim; Chan, Hoi-Yan; Cheung, Chui-Yee; Liang, Yizeng; Liang, Y; Kvalheim, Olav Martin. 2009. Recipe for Uncovering the Bioactive Components in Herbal Medicine. Analytical Chemistry. 81: 7217-7225. doi: 10.1021/ac900731z
  • Kvalheim, Olav Martin; Rajalahti, Tarja; Arneberg, Reidar. 2009. X-tended target projection (XTP) - comparison with orthogonal partial least squares (OPLS) and PLS post-processing by similarity transformation (PLS + ST). Journal of Chemometrics. 23: 49-55. doi: 10.1002/cem.1193
  • Rajalahti, Tarja; Arneberg, Reidar; Berven, Frode; Myhr, Kjell-Morten; Ulvik, Rune Johan; Kvalheim, Olav Martin. 2009. Biomarker discovery in mass spectral profiles by means of selectivity ratio plot. Chemometrics and Intelligent Laboratory Systems. 95: 35-48. doi: 10.1016/j.chemolab.2008.08.004
  • Rajalahti, Tarja; Arneberg, Reidar; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Myhr, Kjell-Morten; Kvalheim, Olav Martin. 2009. Discriminating Variable Test and Selectivity Ratio Plot: Quantitative Tools for Interpretation and Variable (Biomarker) Selection in Complex Spectral or Chromatographic Profiles. Analytical Chemistry. 81: 2581-2590. doi: 10.1021/ac802514y
  • Kvalheim, Olav Martin; Arneberg, Reidar; Marquardt, Brian. 2008. PAT - Optimal prediction of properties by means of tailormade modelling of spectroscopic/chromatographic profiles. European Journal of Pharmaceutical Sciences. 34: S16-S16. doi: 10.1016/j.ejps.2008.02.038
  • Liang, Yizeng; Yuan, Dalin; Xu, Qingsong; Kvalheim, Olav Martin. 2008. Modeling based on subspace orthogonal projections for QSAR and QSPR research. Journal of Chemometrics. 22: 23-36. doi: 10.1002/cem.1094
  • Rajalahti, Tarja; Arneberg, Reidar; Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Myhr, Kjell-Morten; Vedeler, Christian A.; Ulvik, Rune Johan; Kvalheim, Olav Martin. 2008. Early diagnosis and biomarker discovery from mass spectral profiles: application to multiple sclerosis. Multiple Sclerosis. 14: S285-S285. doi: 10.1177/1352458508096399
  • Rajalahti, Tarja; Arneberg, Reidar; Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Myhr, Kjell-Morten; Vedeler, Christian A.; Ulvik, Rune Johan; Kvalheim, Olav Martin. 2008. Biomarker discovery from mass spectral profiles: A combined proteomics and multivariate analysis. European Journal of Pharmaceutical Sciences. 34: S27-S27. doi: 10.1016/j.ejps.2008.02.068
  • Yuan, Dalin; Liang, Yizeng; Yi, Lunzhao; Xu, Qingsong; Kvalheim, Olav Martin. 2008. Uncorrelated linear discriminant analysis (ULDA): A powerful tool for exploration of metabolomics data. Chemometrics and Intelligent Laboratory Systems. 93: 70-79. doi: 10.1016/j.chemolab.2008.04.005
  • Arneberg, Reidar; Rajalahti, Tarja; Flikka, Kristian; Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Myhr, Kjell-Morten; Vedeler, Christian A.; Ulvik, Rune Johan; Kvalheim, Olav Martin. 2007. Pretreatment of mass spectral profiles: Application to proteomic data. Analytical Chemistry. 79: 7014-7026. doi: 10.1021/ac070946s
  • Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Rajalahti, Tarja; Flikka, Kristian; Arneberg, Reidar; Myhr, Kjell-Morten; Vedeler, Christian A.; Kvalheim, Olav Martin; Ulvik, Rune Johan. 2007. Pre-analytical influence on the low molecular weight cerebrospinal fluid proteome. PROTEOMICS - Clinical Applications. 1: 699-711. doi: 10.1002/prca.200700126
  • Flåten, Geir Rune; Botnen, Helge; Grung, Bjørn; Kvalheim, Olav Martin. 2007. Quantifying disturbances in benthic communities - comparison of the community disturbance index (CDI) to other multivariate methods. Ecological Indicators. 7: 254-276. doi: 10.1016/j.ecolind.2006.02.001
  • Flåten, Geir Rune; Grung, Bjørn; Kvalheim, Olav Martin. 2007. A comparison of different pre-treatment procedures for reducing heteroscedasticity and other irrelevant features in data prior to modelling of benthic count profiles. Journal of Chemometrics. 21: 386-396. doi: 10.1002/cem.1087
  • Kvalheim, Olav Martin. 2007. CO2-lobbyen styrer forskningen. Bergens Tidende. 1 sider. Publisert 2007-12-27.
  • Kvalheim, Olav Martin. 2007. Media med dommedagsprofetier om klimaet. Ingeniør-nytt : ukeavis for teknologi og nyskapning. 7. 12-12. Publisert 2007-08-22.
  • Kvalheim, Olav Martin. 2007. Proppfull av CO2 ? Firda. 1 sider. Publisert 2007-12-27.
  • Eide, Ingvar; Neverdal, Gunhild; Thorvaldsen, Bodil; Arneberg, Reidar; Grung, Bjørn; Kvalheim, Olav Martin. 2004. Toxicological evaluation of complex mixtures: fingerprinting and multivariate analysis. Environmental Toxicology and Pharmacology. 18: 127-133.
  • Flaten, GR; Grung, Bjørn; Kvalheim, Olav Martin. 2004. A method for validation of reference sets in SIMCA modelling. Chemometrics and Intelligent Laboratory Systems. 72: 101-109.
  • Flaten, GR; Grung, Bjørn; Kvalheim, Olav Martin. 2004. Quantification of pollution levels by multiway modelling. Journal of Chemometrics. 18: 173-182.
  • Flåten, Geir Rune; Botnen, Helge; Grung, Bjørn; Kvalheim, Olav Martin. 2004. Assigning environmental variables to observed biological changes. Analytical and Bioanalytical Chemistry. 380: 453-466.
  • Flåten, Geir Rune; Grung, Bjørn; Kvalheim, Olav Martin. 2004. A method for validation of reference sets in SIMCA modelling. Chemometrics and Intelligent Laboratory Systems. 72: 101-109.
  • Flåten, Geir Rune; Grung, Bjørn; Kvalheim, Olav Martin. 2004. Quantification of pollution levels by multiway modelling. Journal of Chemometrics. 18: 173-182.
  • Idborg-Björkman, H.; Edlund, P.-O.; Kvalheim, Olav Martin; Scuppe-Koistinen, I.; Jacobsen, S.P. 2003. Screening of biomakers in rat urine using LC/MC electrospray ionization-MS and two-way data analysis. Analytical Chemistry. 75: 4784-4792.
  • Ingvar, Eide; Neverdal, Gunhild; Thorvaldsen, Bodil; Grung, Bjørn; Kvalheim, Olav Martin. 2002. Toxicological evaluation of complex mixtures by pattern recognition: Correlating chemical fingerprints to mutagenicity. Environmental Health Perspectives. 110: 985-988.
  • Stordrange, Laila; Christy, Alfred Anthony; Kvalheim, Olav Martin; Shen, Hailin; Liang, Yi-zeng. 2002. Study of the Self-Association of Alcohols by Near-Infrared Spectroscopy and Multivariate 2D Techniques. Journal of Physical Chemistry A. 106: 8543-8553.
  • Stordrange, Laila; Libnau, Fred Olav; Malthe-Sørensen, Dick; Kvalheim, Olav Martin. 2002. Feasibility study of NIR for surveillance of a pharmaceutical process, including a study of different preprocessing techniques. Journal of Chemometrics. 16: 529-541.
  • Eide, Ingvar; Neverdal, Gunhild; Thorvaldsen, Bodil; Shen, Hailin; Grung, Bjørn; Kvalheim, Olav Martin. 2001. Resolution of GC-MS Data of Complex PAC Mixtures and Regression Modeling of Mutagenicity by PLS. Environmental Science and Technology. 35: 2314-2318.
  • Midttun, Øyvind; Kvalheim, Olav Martin. 2001. Interactions in chromatographic separation of resins from deasphaltened crude oils studied by means of infrared spectroscopy and principal component analysis. Fuel. 80: 717-730.
  • Shen, Hailin; Grung, Bjørn; Kvalheim, Olav Martin; Eide, Ingvar. 2001. Automated curve resolution applied to data from multi-detection instruments. Analytica Chimica Acta. 446: 313-328.
  • Kallevik, H.; Hansen, S. B.; Sæther, O.; Kvalheim, Olav Martin; Sjøblom, J. 2000. Crude oil model emulsion characterised by means of near infrared spectroscopy and multivariate techniques. Journal of Dispersion Science and Technology. 21: 245-262.
  • Kallevik, Harald; Kvalheim, Olav Martin; Sjöblom, Johan. 2000. Quantitative determination of asphaltenes and resins in solution by means of near-infrared spectroscopy. Correlations to emulsion stability. Journal of Colloid and Interface Science. 225: 494-504.
  • Midttun, Øyvind; Kallevik, H.; Sjøblom, J.; Kvalheim, Olav Martin. 2000. Multivarite screening analysis of water-in-oil emulsions in high external electric fields as studied by means of dielectric time domain spectroscopy - III emulsions containing asphaltenes and resins. Journal of Colloid and Interface Science. 227: 262-271.
  • Shen, Hailin; Liang, Y.; Kvalheim, Olav Martin; Manne, Rolf. 2000. Determination of chemical rank of two-way data from subspace comparisons. Chemometrics and Intelligent Laboratory Systems. 51: 49-59.
  • Shen, Hailin; Storedrange, Laila; Manne, Rolf; Kvalheim, Olav Martin; Liang, Y. 2000. Morphological score and its application to chemical rank determination. Chemometrics and Intelligent Laboratory Systems. 51: 37-47.
  • Christry, Alfred A.; Nyhus, Anne K.; Grung, Bjørn; Kvalheim, Olav Martin; Hagen, Steinar; Schanche, Jon S. 1998. Friedel-Crafts Acylation on Porous Divinyl Benzene Polymer Particles: A Reaction Kinetic Process Studied by Mid-and Near-Infrared spectroscopy. Applied Spectroscopy. 52: 1230-1239.
  • Førland, Geir Martin; Liang, Yi-Zeng; Kvalheim, Olav Martin; Høiland, Harald; Chazy, Annick. 1997. Associative Behavior of Benzyl Alcohol in Carbon Tetrachloride Solutions. Journal of Physical Chemistry. 101: 6960-6969.
  • Førland, Geir Martin; Liang, Yi-zeng; Kvalheim, Olav Martin; Høiland, Harald; Chazy, A. 1997. Associative bahaviour of benzyl alcohol in carbon tetrachloride solutions. Journal of Physical Chemistry A. 101: 6960-6969.
  • Kvalheim, Olav Martin. 1997. Chemometrics at the University of Bergen. NAMICS Newsletter. 14: 10-11.
  • Kvalheim, Olav Martin. 1997. Ny prosessutvikling. Teknisk Ukeblad. 38: 50-51.
  • Sæten, B.G.; Sjöblom, Johan; Toft, J.; Kvalheim, Olav Martin. 1997. Complexation between benzoic acid and fatty amines. An adsorption and chemometric study. Colloids and Surfaces. A123-124: 135-144.
  • Fluge, Øystein; Gilje, K.; Sletten, Einar; Kvalheim, Olav Martin; Skaarland, E.; Halvorsen, Jan F.; Farstad, Mikael; Søreide, Odd. 1996. Proton nuclear magnetic resonance spectroscopy of serum from patients with colorectal neoplasia. European Journal of Surgical Oncology. 22: 78-83.
  • Fluge, Øystein; Gilje, K.; Sletten, Einar; Kvalheim, Olav Martin; Skaarland, E.; Halvorsen, Jan F.; Farstad, Mikael; Søreide, Odd. 1996. Proton nuclear magnetic resonance spectroscopy of serum from patients with colorectal neoplasia. European Journal of Surgical Oncology. 22: 78-83.
  • Fluge, Øystein; Gilje, K.; Sletten, Einar; Kvalheim, Olav Martin; Skaarland, E.; Halvorsen, Jan F.; Farstad, Mikael; Søreide, Odd. 1996. Proton nuclear magnetic resonance spectroscopy of serum from patients with colorectal neoplasia. European Journal of Surgical Oncology. 22: 78-83.
  • Fluge, Øystein; Gilje, K.; Sletten, Einar; Kvalheim, Olav Martin; Skaarland, E.; Halvorsen, Jan F.; Farstad, Mikael; Søreide, Odd. 1996. Proton nuclear magnetic resonance spectroscopy of serum from patients with colorectal neoplasia. European Journal of Surgical Oncology. 22: 78-83.
  • Førdedal, Harald; Midttun, Bjørn Øivind; Sjøblom, Johan; Kvalheim, Olav Martin; Schildberg, Yannick; Volle, J.L. 1996. A multivariate analysis of w/o emulsions in high external electric fields, as studied by means of dielectric time domain spectroscopy. Part II. Model emulsions stabilised by interfacially active fractions from crude oils. Journal of Colloid and Interface Science. 173: 396-405.
  • Førdedal, Harald; Midttun, Bjørn Øivind; Sjøblom, Johan; Kvalheim, Olav Martin; Schildberg, Yannick; Volle, J.L. 1996. A multivariate analysis of w/o emulsions in high external electric fields, as studied by means of dielectric time domain spectroscopy. Journal of Colloid and Interface Science. 182: 117-125.
  • Førland, Geir Martin; Libnau, Fred Olav; Kvalheim, Olav Martin; Høiland, Harald. 1996. Self-Association of Medium-Chain Alcohols in n-Decane Solutions. Applied Spectroscopy. 50: 1264-1272.
  • Kvalheim, Olav Martin. 1996. Kjemometri - en metodikk for generering og analyse av data. Kjemi. 8. 33-35.
  • Kvalheim, Olav Martin. 1996. Kan kjemometrien hjelpe Norge til å bli "Europas Japan"? Kjemi. spesial. 15-18.
  • Kvalheim, Olav Martin. 1996. Chemometrics, quality, information and "The Third Wawe". Chemometrics and Intelligent Laboratory Systems. 33: 1-2.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1996. Methods for multivariate analysis. Chemometrics and Intelligent Laboratory Systems. 32: 1-10.
  • Massart, B.; Libnau, Fred Olav; Kvalheim, Olav Martin; Ugland, K.I.; Tjessem, K.; Bryne, K. 1996. Projective modelling by SIMCA - a new dynamic strategy for cost-efficient environmental monitoring around offshore installations. Aquatic Sciences. 58: 120-138.
  • Nodland, Egil; Libnau, Fred Olav; Kvalheim, Olav Martin. 1996. Resolution of infrared profiles from variable temperature experiments on mixtures and conformers in rapid equilibrum by compensating for thermal and solvent effects. Vibrational Spectroscopy. 12: 163-176.
  • Nodland, Egil; Libnau, Fred Olav; Kvalheim, Olav Martin; Luinge, H.J.; Klæboe, Peter. 1996. Influence and correction of peak shift and band broadening observed by rank analysis on vibrational bands from variable-temperature measurement. Vibrational Spectroscopy. 10: 105-123.
  • Barth, Tanja; Seim, M.; Christy, A. A.; Kvalheim, Olav Martin. 1995. Maturity trends in asphaltenes from pyrolysed source rocks and natural coals-Multivariate modelling of diffuse reflectance Fourier transform infrared spectra. Organic Geochemistry. 23: 139-158.
  • Christy, A. A.; Kvalheim, Olav Martin. 1995. Particle size effect on diffuse reflectance spectra: Modification of Kubelka-Munk equation. Vibrational Spectroscopy. 9: 19-27.
  • Libnau, F. O.; Christy, A. A.; Kvalheim, Olav Martin. 1995. Determination of the equilibrium constant and resolution of the HOD spectrum by alternating least squares. Applied Spectroscopy. 48: 561-568.
  • Alsberg, B. K.; Kvalheim, Olav Martin. 1994. Speed improvement of multivariate algorithms by the method of postponed basis matrix multiplication method. Part II. Three-mode principal component analysis. Chemometrics and Intelligent Laboratory Systems. 24: 43-54.
  • Alsberg, B. K.; Kvalheim, Olav Martin. 1994. Compression of three-mode data arrays by B-splines prior to three-mode principal component analysis (PCA). Chemometrics and Intelligent Laboratory Systems. 23: 29-38.
  • Alsberg, B. K.; Kvalheim, Olav Martin. 1994. Speed improvement of multivariate algorithms by the method of postponed basis matrix multiplication method. Part 1. Principal component analysis. Chemometrics and Intelligent Laboratory Systems. 24: 31-42.
  • Alsberg, B. K.; Nodland, Egil; Kvalheim, Olav Martin. 1994. Compression of an order data arrays by B-splines. Part 2. Application to second- order FT-IR data. Journal of Chemometrics. 8: 127-145.
  • Brakstad, F.; Kvalheim, Olav Martin; Ugland, K. I.; Tjessem, K.; Bryne, K. 1994. Prediction of the Shannon Wiener index from trace element profiles in sediments around the Statfjord platforms. Chemosphere. 29: 1441-1465.
  • Brereton, R. G.; Rahmani, A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1994. Investigation of the allomerization reaction of chlorophyll a: use of diode array HPLC, mass spectrometry and chemometric factor analysis for the detection of early products. Photochemistry and Photobiology. 59: 99-110.
  • Christy, A. A.; Kvalheim, Olav Martin; Høiland, Harald. 1994. Bulk compositional variations of coal asphaltenes studied by latent variable analysis of infrared microspectroscopic data. Chemometrics and Intelligent Laboratory Systems. 23: 197-204.
  • Christy, A. A.; Nodland, Egil; Kvalheim, Olav Martin. 1994. Determination of kinetic parameters for the dehydration of calcium oxalate monohydrate by diffuse reflectance infrared FT-IR spectroscopy. Applied Spectroscopy. 48: 561-568.
  • Grung, Bjørn; Kvalheim, Olav Martin. 1994. Rank determination of spectroscopi data by means of cross validation - The effect of replicated measurements on the degrees of fredom. Chemometrics and Intelligent Laboratory Systems. 22: 115-125.
  • Kvalheim, Olav Martin. 1994. Kjemometri - En strategi for total optimalisering av produktkvalitet og industrielle prosesser. Automatisering. 2: 9-12.
  • Kvalheim, Olav Martin; Brakstad, F.; Liang, Yi-zeng. 1994. Preprocessing of analytical profiles in the presence of homoscedastic or heteroscedastic noise. Analytical Chemistry. 1: 43-51.
  • Liang, Yi-zeng; Hämäläinen, M. D.; Kvalheim, Olav Martin; Andersson, R. 1994. Assessment of peak origin and purity by orthogonal design and Heuristic evolving latent projections. Journal of Chromatography A. 662: 113-122.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1994. Diagnosis and resolution of multiwavelength chromatograms by rank map, orthogonal projections and sequential rank analysis. Analytica Chimica Acta. 292: 5-15.
  • Liang, Yi-zeng; Manne, Rolf; Kvalheim, Olav Martin. 1994. Resolution of embedded chromatographic peaks by sequential rank analysis of the firs-order differentiated elution profile in the domiain. Chemometrics and Intelligent Laboratory Systems. 22: 229-240.
  • Libnau, F. O.; Christy, A. A.; Kvalheim, Olav Martin. 1994. Resolution of infrared spectra and kinetic analysis of mutarotation of D-Glucose in water by sequential rank analysis. Vibrational Spectroscopy. 7: 139-148.
  • Libnau, F. O.; Kvalheim, Olav Martin; Christy, A. A. 1994. Spectra of water in the near- and mid-infrared region. Vibrational Spectroscopy. 7: 243-254.
  • Libnau, F. O.; Toft, J.; Christy, A. A.; Kvalheim, Olav Martin. 1994. Structure of liquid water determined from infrared temperature profiling and evolutionary curve resolution. Journal of the American Chemical Society. 116: 8311-8316.
  • Toft, J.; Kvalheim, Olav Martin. 1994. Multi-array resolution parameter for multidetection chromatography. Performance of alternating regression, iterative target transformation factor analysis and heuristic evolving latent projections. Chemometrics and Intelligent Laboratory Systems. 25: 61-75.
  • Toft, J.; Kvalheim, Olav Martin. 1994. Nonlinear curve fitting of bilinear data by ortogonal projections for rank analysis. Applications to GC-IR and temperature IR studies. Vibrational Spectroscopy. 7: 125-137.
  • Toft, Jostein; Kvalheim, Olav Martin; Libnau, Fred Olav; Nodland, Egil. 1994. Non-linear curvefitting of bilinear data using orthogonal projections for rank analysis. Applications to gas chromatography/ infrared spectrometry and variable temperature infrared studies. Vibrational Spectroscopy. 7: 125-137.
  • Toft, Jostein; Kvalheim, Olav Martin; Libnau, Fred Olav; Nodland, Egil. 1994. Non-linear curvefitting of bilinear data using orthogonal projections for rank analysis. Applications to gas chromatography/ infrared spectrometry and variable temperature infrared studies. Vibrational Spectroscopy. 7: 125-137.
  • Alsberg, B. K.; Kvalheim, Olav Martin. 1993. Compression of n-order data arrays by B-splines. Part 1. Theory. KJ. Chemometrics. 7: 61-73.
  • Christy, A. A.; Kvalheim, Olav Martin; Libnau, F. O.; Aksnes, G.; Toft, J. 1993. Interpretation of chemical structural changes by target-projection analysis of infrared profiles. Vibrational Spectroscopy. 6: 1-14.
  • Christy, A. A.; Liang, Yi-zeng; Hui, C.; Kvalheim, Olav Martin; Velapoldi, R. A. 1993. Effect of particle size on diffuse reflectance Fourier-transform infrared spectra of polystyrene spheres. Vibrational Spectroscopy. 5: 233-244.
  • Christy, A. A.; Nodland, Egil; Kvalheim, Olav Martin. 1993. A gas cell for on-line transmission Fourier-transform infrared spectrometry. Vibrational Spectroscopy. 4: 365-371.
  • Hämäläinen, M. D.; Liang, Yi-zeng; Kvalheim, Olav Martin; Andersson, R. 1993. Deconvolution in one-dimensional chromomatography by heuristic evolving latent projections of whole profiles retention time shifted b y Simplex optimization of cross correlation between target peaks. Analytica Chimica Acta. 271: 101-114.
  • Kvalheim, Olav Martin. 1993. Chemometrics: academic and industrial perspectives. (Editorial). Chemometrics and Intelligent Laboratory Systems. 19: iii-iv.
  • Liang, Yi-zeng; Brereton, R. G.; Kvalheim, Olav Martin; Rahmani, A. 1993. Use of chemometrics factor analysis for chromatographic integration: Application to diode-array high-performance liquid chroma tography of mixtures of chlorophyll a degradation products. The Analyst. 118: 779-790.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1993. Unique resolution of hidden peaks in multidetection chromatography by first-order differentiation and orthogonal projectio ns. Analytica Chimica Acta. 276: 425-440.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1993. Heuristic evolving latent projections: Resolving hyphenated chromatographic profiles by component stripping. Chemometrics and Intelligent Laboratory Systems. 20: 115-125.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1993. A two-way procedure for background correction of chromatographic/spectroscopic data by means of congruence analysis and least-squares fit of the zero-component regions, comparison with double-centering. Chemometrics and Intelligent Laboratory Systems. 18: 265-279.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Höskuldsson, A. 1993. Determination of detection limit and local chemical rank by designing a nonparametric test from the zero-component regions. Journal of Chemometrics. 7: 277-289.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Manne, Rolf. 1993. White, grey and black - A classification of methods for quantitative analysis of multicomponent analytical systems. Chemometrics and Intelligent Laboratory Systems. 18: 235-250.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Ramani, A.; Brereton, R. G. 1993. Resolution of strongly overlapping two-way multicomponent data by means of Heuristic Evolving Latent Projections. Journal of Chemometrics. 7: 15-43.
  • Toft, J.; Kvalheim, Olav Martin. 1993. Resolution parameter for multidetection chromatography. Analytical Chemistry. 65: 2270-2275.
  • Toft, J.; Kvalheim, Olav Martin. 1993. Eigenstructure tracking analysis for demonstration of heteroscedastic noise in instrumental profiles - application to transm ittance and aborbance IR. Chemometrics and Intelligent Laboratory Systems. 19: 65-73.
  • Alsberg, Bjørn K.; Kvalheim, Olav Martin. 1992. Compression of n-order data arrays by B-plines. Part. theory. Journal of Chemometrics.
  • Brereton, R. G.; Rahmani, A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1992. Investigation of the allomerization reaction of chlorophylla: use of diode array HPLC, mass spectrometry and chemometrics factor analysis for the detection of early products. Photobiol.
  • Brereton, R. G.; Rahmani, A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1992. Investigation of the allomerization reaction of chlorophylla: use of diode array HPLC, mass spectrometry and chemometrics factor analysis for the detection of early products. Photochem.
  • Christy, A. A.; Kvalheim, Olav Martin. 1992. Applications of diffuse reflectance Fourier-transform infrared spectroscopy in petroleum geochemistry. Scan Time, Spectra-Tech.
  • Christy, Alfred A.; Kvalheim, Olav Martin. 1992. Applications of diffuse reflectance Fourier transform infrared spectroscopy in petroleum geochemistry. Spectra-Tech.
  • Christy, Alfred A.; Kvalheim, Olav Martin. 1992. Applications of diffuse reflectance Fourier-transform infrared spectroscopy in petroleum geochemistry. Scan Time.
  • Christy, Alfred A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1992. On-line pyrolysis of asphaltenes studied by Diffuse reflectance Fourier transform infrared spectroscopy. Fuel. 71: 125-127.
  • Christy, Alfred A.; Liang, Yi-zeng; Velapoldi, R.; Kvalheim, Olav Martin. 1992. Effect of particle size on diffuse reflectance infrared spectra of polysterene spheres. Vibrational Spectroscopy.
  • Hämäläinen, M. D.; Liang, Yi-zeng; Kvalheim, Olav Martin; Andersson, R. 1992. Deconvolution in one-dimensional chromotography by heuristic evolving latent projections of whole profiles retention time shifted by Simplex optimization of cross correlation between target peaks. Analytica Chimica Acta.
  • Karstang, Terje V.; Toft, Jostein; Kvalheim, Olav Martin. 1992. Estimation of prediction error for samples within the calibration range. Journal of Chemometrics. 6: 177-188.
  • Keller, H. R.; Liang, Yi-zeng; Kvalheim, Olav Martin; Massart, D. L. 1992. Evolving factor analysis in the presence of heteroscedastic noise. Analytica Chimica Acta. 263: 29-36.
  • Keller, H. R.; Liang, Yi-zeng; Kvalheim, Olav Martin; Massart, D. L. 1992. A comparison of the Heuristic envolving latent projection and evolving factor analysis methods for peak purity control in HPLCDAD. Analytica Chimica Acta. 267: 63-71.
  • Kvalheim, Olav Martin. 1992. The latent variable. Chemometrics and Intelligent Laboratory Systems. 14: 1-3.
  • Kvalheim, Olav Martin. 1992. Laboratory Profile. Journal of Chemometrics. 6: 113-116.
  • Kvalheim, Olav Martin. 1992. Universitets-industri samarbeid - går det an? Universitetsnytt.
  • Kvalheim, Olav Martin. 1992. Kjemometri og kvalimetri - Pilotprosjekt i COMETT-regi. Teknisk Ukeblad. 2: 18-19.
  • Kvalheim, Olav Martin; Liang, Yi-zeng. 1992. Heuristic Evolving Latent Projection - resolving two-way multicomponent data. Part 1. Selectivity, latent-projective graph, datascope, local rank analysis and unique resolution. Analytical Chemistry. 64: 936-946.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1992. A two-way procedure for background correction of chromatographic/ spectroscopic data by means of congruence analysis and least-squares fit of the zerocomponent regions, comparison with double-centering. Chemometrics and Intelligent Laboratory Systems.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Keller, H. R.; Massart, D. L.; Kiechle, [Mangler fornavn]; Ernie, F. 1992. Heuristic Evolving Latent Projection - resolving two-way multicomponent data. Part 2. Detection and resolution of minor component. Analytical Chemistry. 14: 946-953.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Manne, Rolf. 1992. White, grey and black - A classification of methods for quantitative and qualitative analysis of multicomponent analytical systems. Chemometrics and Intelligent Laboratory Systems.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Ramani, A.; Brereton, R. G. 1992. Resolution of strongly overlapping two-way multicomponent data by means of Heuristic Evolving Latent Projections. Journal of Chemometrics.
  • Liang, Yi-zeng; Manne, Rolf; Kvalheim, Olav Martin. 1992. Constrained background bilinearization. Chemometrics and Intelligent Laboratory Systems. 14: 175-184.
  • Toft, J.; Kvalheim, Olav Martin; Christy, A. A.; Kleveland, Karl Torbjørn; Henriksen, A.; Karstang, T. V. 1992. Analysis of non transparent polymers: Mixture design, 2nd derivate attenuated total internal reflectance FT-IR and multivariate calibration. Applied Spectroscopy. 46: 1002-1008.
  • Toft, Jostein; Kvalheim, Olav Martin. 1992. Eigenstructure tracking analysis for demonstration of heteroscedastic noise in instrumental profiles - application to transmittance and oborbance IR. Chemometrics and Intelligent Laboratory Systems.
  • Toft, Jostein; Kvalheim, Olav Martin; Christy, Alfred A.; Kleveland, Karl Torbjørn; Henriksen, A.; Karstang, Terje V. 1992. Analysis of nontransparent polymers-mixture design, 2nd derivative attenuated total internal reflectance FT-IR and multivariate calibration. Applied Spectroscopy. 46: 1002-1008.
  • Christy, A. A.; Kvalheim, Olav Martin; Øygard, K.; Dahl, Birger; Karstang, T. V. 1991. Maturity of Kerogen and asphaltenes determined by Partial-Least -Squares (PLS) calibration and target projection of diffuse reflectance Fourier-transformed infrared spectra. Organic Geochemistry. 17: 63-74.
  • Christy, A. A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1991. On-Line pyrolysis of asphaltenes studied by Diffuse reflectance Fourier-transform infrared spectroscopy. Fuel. 71: 125-127.
  • Karstang, T. V.; Christy, A. A.; Kvalheim, Olav Martin. 1991. Diffuse reflectance Fourier-transformed infrared spectroscopy in petroleum exploration: A multivariate approach to maturity determination. Journal of Geochemical Exploration. 41: 213-226.
  • Sletten, Einar; Kvalheim, Olav Martin; Kruse, S.; Farstad, Marit; Søreide, Odd. 1990. Detection of malignant tumors by multivariate analysis of proton magnetic resonance spectra of serum. European Journal of Cancer. 26: 615-618.
  • Christy, A. A.; Dahl, Birger; Kvalheim, Olav Martin. 1989. Structural features of resins, asphaltenes and kerogen studied by diffuse reflectance Fourier-transform infrared spectroscopy. Fuel. 68: 429-435.
  • Christy, A. A.; Hopland, A. L.; Barth, Tanja; Kvalheim, Olav Martin. 1989. Quantitative determination of thermal maturity in sedimentary organic matter by diffuse reflectance infrared spectroscopy of asphaltenes. Organic Geochemistry. 14: 77-81.
  • Christy, A. A.; Velapoldi, R. A.; Kvalheim, Olav Martin; Telnæs, N.; Karstang, T. V.; Sletten, Einar. 1987. Multivariate calibration of diffuse reflectance Fourier-transform infrared spectra of coals as an alternative to rank determination by vitrinite reflectance. Chemometrics and Intelligent Laboratory Systems. 2: 199-207.
  • Kvalheim, Olav Martin; Christy, A. A.; Bjørseth, A.; Telnæs, N. 1987. Maturity determination of organic matter in coals using the methyl phenanthrene distribution. Geochimica et Cosmochimica Acta. 51: 1883-1888.
  • Telnæs, N.; Bjørseth, A.; Christy, A. A.; Kvalheim, Olav Martin. 1987. Interpretation of multivariate data: Relationship between phenanthrenes in crude oils. Chemometrics and Intelligent Laboratory Systems. 2: 149-153.
Rapporter/avhandlinger
  • Kvalheim, Olav Martin; Ugland, K.I. 1997. Virkninger av kjemikalieutslipp fra petroleumsvirksomhet i Skagerak. Konsekvensutredning for OED. [Mangler utgivernavn].
  • Libnau, F. O.; Christy, A. A.; Kvalheim, Olav Martin. 1995. Grunn-hydrofilisering av QX-6, Prins-reaksjon. Project report. Kjemisk institutt, UiB-MatNat.
  • Christy, A. A.; Kvalheim, Olav Martin. 1994. Determination of kinetic parameters of kerogen samples by on-line diffuse reflectance FT-IR spectroscopy. Project report. Kjemisk institutt, UiB-MatNat.
  • Christy, A. A.; Kvalheim, Olav Martin. 1990. Comparison of infrared spectra of petroleum fractions oil fractions. Project report. Kjemisk institutt, UiB-MatNat.
  • Christy, A. A.; Kvalheim, Olav Martin. 1989. Characterization of crude oils by multivariate data analysis of diffuse reflectance infrared spectra of asphaltenes. Project report. Kjemisk institutt, UiB-MatNat.
  • Christy, A. A.; Kvalheim, Olav Martin. 1987. Multivariate calibration of diffuse reflectance spectra of coke samples against volatile organic matter. Project report. Kjemisk institutt, UiB-MatNat.
  • Kvalheim, Olav Martin. 1987. Methods for the interpretation of multivariate data : examples from petroleum geochemistry.
Bokkapitler
  • Kvalheim, Olav Martin. 2002. Introduction to factor-based approaches. 2079-2085. I:
    • Chalmers, John M.; Griffiths, Peter R. 2002. Handbook of Vibrational Spectroscopy Sample caracterization and spectral data processing. ISBN: 0-471-98847-2.
  • Brekke, Trond; Kvalheim, Olav Martin. 1996. Analysis of nuclear magnetic resonance spectra of mixtures using multivariate techniques. 422-451. I:
    • Ruthless, D.N.; Fried, Bernhard. 1996. Signal treatment and signal analyasis in NMR.
  • Kvalheim, Olav Martin. 1996. Fra data til informasjon. 53-65. I:
    • Nordtvedt, Ragnar; et al., [Mangler fornavn]. 1996. Anvendelse av kjemometri innen forskning og industri. (Nors k Kjemisk Selskaps Faggruppe for Kjemometri, Svenska Kemist samfundet). ISBN: 82-91294-01-1.
  • Kvalheim, Olav Martin. 1996. Kvalitet, organisasjon og psykososialt arbeidsmiljø. 535-551. I:
    • Nordtvedt, Ragnar; et al., [Mangler fornavn]. 1996. Anvendelse av kjemometri innen forskning og industri. (Nors k Kjemisk Selskaps Faggruppe for Kjemometri, Svenska Kemist samfundet). ISBN: 82-91294-01-1.
  • Kvalheim, Olav Martin. 1996. Taksonomi og kvantifisering av blandinger. 481-498. I:
    • Nordtvedt, Ragnar; et al., [Mangler fornavn]. 1996. Anvendelse av kjemometri innen forskning og industri. (Nors k Kjemisk Selskaps Faggruppe for Kjemometri, Svenska Kemist samfundet). ISBN: 82-91294-01-1.
  • Kvalheim, Olav Martin; Brakstad, F. 1996. Kartlegging av komplekse industriprosesser for total prosesskvalitet. 481-498. I:
    • Nordtvedt, Ragnar; et al., [Mangler fornavn]. 1996. Anvendelse av kjemometri innen forskning og industri. (Nors k Kjemisk Selskaps Faggruppe for Kjemometri, Svenska Kemist samfundet). ISBN: 82-91294-01-1.
  • Libnau, Fred Olav; Christy, A.A.; Kvalheim, Olav Martin. 1996. Surface layer and multilayer laminate analysis by chemometrics and and infrared spectroscopy. I:
    • [Mangler etternavn], [Mangler fornavn]. 1996. Surface characterization. A practical approach.
  • Libnau, Fred Olav; Christy, Alfred Antony; Kvalheim, Olav Martin. 1996. Infrarød spektroskopi og kjemisk analyse. 265-282. I:
    • Nordtvedt, Ragnar; et al., [Mangler fornavn]. 1996. Anvendelse av kjemometri innen forskning og industri. (Nors k Kjemisk Selskaps Faggruppe for Kjemometri, Svenska Kemist samfundet). ISBN: 82-91294-01-1.
  • Christy, A. A.; Kvalheim, Olav Martin. 1995. Analytical profiles and Multivariate modelling in Geochemistry. 87-133. I:
    • [Mangler etternavn], [Mangler fornavn]. 1995. Handbook on environmental chemistry.
  • Christy, A. A.; Kvalheim, Olav Martin. 1993. Analytical profiles and Multivariate modelling in Geochemistry. I:
    • [Mangler etternavn], [Mangler fornavn]. 1993. Handbook on environmental chemistry.
  • Kruse, S.; Kvalheim, Olav Martin; Farstad, Marit; Søreide, Odd; Sletten, Einar. 1992. Effect of sample storage on spectra of serum - multivariate data analysis of protein NMR spectra. I:
    • [Mangler etternavn], [Mangler fornavn]. 1992. Detection of malignant tumors. Multivariate analysis of protein nuclear magnetic resonance spectra of blood serum. (Red.: Kruse S.) Dissertation.
  • Kvalheim, Olav Martin; Karstang, Terje V. 1992. SIMCA - classification by means of cross validated disjoint principal component models. I:
    • [Mangler etternavn], [Mangler fornavn]. 1992. Data Handling in Science and Technology, Chemometrics Course Books (R. G. Brereton, ed.).

Se fullstendig oversikt over publikasjoner i CRIStin.

Arneberg R., Rajalahti T., Flikka K., Berven F.S., Kroksveen A.C., Berle M., Myhr K.-M., Vedeler C., Ulvik  R.J., Kvalheim O.M. (2007) Pretreatment of mass spectral profiles: Applications to proteomic data, Anal. Chem., 79, 7014-7026.

Kvalheim O.M., Rajalahti T., Arneberg R. (2009) X-tended Target Projection (XTP) – comparison with ortogonal partial least squares (OPLS) and PLS post-processing by similarity transformation (PLS+ST), J. Chemometrics, 23, 49-55.

Rajalahti T., Arneberg R., Berven F.S., Myhr K.-M., Ulvik R.J., Kvalheim O.M. (2009) Biomarker discovery in mass spectral profiles by means of selectivity ratio plot, Chemometrics & Intell. Lab. Syst., 95, 35-48.

Rajalahti T., Arneberg R, Kroksveen A.C., Berle M., Myhr K.-M., Kvalheim O.M. (2009) Discriminating variables test and selectivity ratio plot – Quantitative tools for interpretation and variable (biomarker) selection in complex spectral or chromatographic profiles, Analytical Chemistry, 81, 2581-90.

Chau F.-T., Chan H.-Y., Cheung C.-Y., Xu C.-J., Liang Y., Kvalheim O.M. (2009) Recipe for Uncovering the Bioactive Components in Herbal Medicine, Analytical Chemistry, 81, 7217-7225.

Rajalahti T., Kroksveen A.C., Arneberg R., Berven F.S., Vedeler C., Myhr K.-M., Kvalheim O.M. (2010) A multivariate approach to reveal biomarker signatures for disease classification: Application to mass spectral profiles of cerebrospinal fluid from patients with multiple sclerosis, J. Proteome Res., 9, 3608-3620.

Kvalheim O.M. (2010) Interpretation of partial least squares regression models by means of target projection and selectivity ratio plots, J. Chemometrics, 24, 496-504.

Kvalheim O.M., Chan H.-Y., Lau T.-Y., Benzie I.F.F, Szeto Y.-T., Tzang A.H.-C., Chau F.-T. (2011) Chromatographic Profiling and Multivariate analysis for revealing and quantifying the contributions from individual components to the Bioactive Signature in Natural Products, Chemom. & Intell. Lab. Syst., in press.

Rajalahti T., Kvalheim O.M. (2011), Multivariate data analysis in pharmaceutics: a tutorial review, Intern. J. Pharmaceutics, in press.