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Forskerprofil

Øyvind Halskau

førsteamanuensis

Molekylærbiologisk institutt

LIPIDSTRUKT: Funksjon og dysfunksjon i fleksible, membran-bindende proteiner

NUCREG: Molekylære mekanismer for genregulering og biomolekylære interaksjoner

Stilling: førsteamanuensis

Telefon: 55 58 45 63

E-post:

Besøksadresse: HIB - Thormøhlensgt. 55

Proteinkjemi - evolusjon, struktur, folding og dynamikk relatert til funksjon.

NMR og annen spektroskopi (Fluorescence, CD m.m.). Membran- og overflate relaterte teknikker slik som liposomer, Langmuir, Lanmuir-Blodget, samt Atomic Force Microscopi og Quarts Crystal Microbalance (i samarbeid med NTNU). Computerassistert analyse av eksperimentelle data, for eksempel mulit-dimensjonelle NMR-data og Differential Scanning Calorimetri-data.

Publikasjoner i Cristin

<!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0mm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 70.85pt 70.85pt 70.85pt; mso-header-margin:35.4pt; mso-footer-margin:35.4pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> 2. Sælensminde, G., Halskau, Ø., and Jonassen, I. (2009) Amino acid contacts in proteins adapted to different temperatures: hydrophobic interactions and surface charges play a key role. Extremophiles 13, 11-20

3. Halskau, Ø., Muga, A., and Martínez, A. (2009) Linking new paradigms in protein chemistry to reversible membrane-protein interactions Curr. Prot. Pept. Sci. Accepted

4. Halskau, Ø., Underhaug, J., Sanchez-Ruiz, J. M., Ibarra-Molero, B., Muñoz, V., and Martínez, A. (2008) Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics. Proc. Natl. Acad. Science 105, 8625-8630

5. Sælensminde, G., Halskau, Ø., Helland, R., Willassen, N. P., and Jonassen, I. (2007) Structure-dependent relationships between growth temperature of prokaryotes and the amino acid frequency in their proteins. Extremophiles 11, 585-596

6. Glomm, W. R., Halskau, Ø., Hanneseth, A. M., and Volden, S. (2007) Adsorption behavior of acidic and basic proteins onto citrate-coated Au surfaces correlated to their native fold, stability, and pI. J Phys Chem B 111, 14329-14345

7. Rødland, I.*, Halskau, Ø.*, Martínez, A., and Holmsen, H. (2005) alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids. Biochim Biophys Acta 1717, 11-20

8. Halskau, Ø., Underhaug, J., Frøystein, N. A., and Martínez, A. (2005) Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity. J Mol Biol 349, 1072-1086

9. Agasøster, A. V.*, Halskau, Ø.*, Fuglebakk, E., Frøystein, N. A., Muga, A., Holmsen, H., and Martínez, A. (2003) The interaction of peripheral proteins and membranes studied with alpha-lactalbumin and phospholipid bilayers of various compositions. J Biol Chem 278, 21790-21797

10. Halskau, Ø., Frøystein, N. A., Muga, A., and Martínez, A. (2002) The membrane-bound conformation of alpha-lactalbumin studied by NMR-monitored 1H exchange. J Mol Biol 321, 99-110

- Halskau, Ø., Ying, M., Baumann, A., Kleppe, R., Larrea, D. R., Almås, B., Haavik, J., and Martínez, A. (2008) Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase and negatively charged membranes. J Biol Chem Revised submission

- Mossberg, A., Baumann, A., Halskau, Ø., Svanborg, C., and Martínez, A. (2009) Membrane affinity of HAMLET mediates its apoptotic specificity. Manuscript

* First authorship shared

 

 

 

HUB310; Vitenskapsteori for masterstudenter.

2009: Interfaces as folding templates for polypetides (With associate professor Wilhelm Glomm)

2008: From details to drugs – a thorough structural and dynamic analysis of 14-3-3, tyrosine hydroxylase and membranes (Lie and Jensens fund/Norwegian Cancer Society, grant #58240001, with Professor Aurora Martínez)

2007: Dissecting molecular properties of honey bee vitellogenin (Research Council of Norway, grant #185306, with Professor Gro Vang Amdam)

2006: Linking new paradigms in protein chemistry to membrane-protein interaction, apoptosis and signalling (Norwegian Cancer Society, grant #06109/01, with Professor Aurora Martínez)

2002: Structural characterization of protein folding variants that induce apoptosis in tumor cells (Research Council of Norway, grant #149117, with Professor Aurora Martínez)