Silke Appel
Professor, Leder for forskning Klinisk institutt 2; Leder for kjernefasilitet for flow cytometri
- E-postSilke.Appel@uib.no
- Telefon+47 55 97 46 33
- BesøksadresseHaukeland universitetssykehus, Laboratoriebygget5009 BergenRom5395
- PostadressePostboks 78045020 Bergen
Dendrittiske celler, særlig deres bruk i immunterapi mot kreft og autoimmune sykdommer.
Enkeltcelle analyser for stratifisering av pasienter og for å utvikle nye behandingsstrategier.
Medlem av organisasjonskommitteen for den årlige "Immunologiens dag" (29.4.)
Vitenskapelig artikkel
- (2023). Herring roe oil in treatment of psoriasis – influence on immune cells and cytokine network. Frontiers in Immunology.
- (2022). Variability of Primary Sjögren's Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA–DQ Locus. Arthritis & Rheumatology. 1991-2002.
- (2022). Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome. Arthritis Research & Therapy. 12 sider.
- (2022). Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases. Arthritis & Rheumatology. 1440-1450.
- (2022). Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation. Frontiers in Immunology. 13 sider.
- (2021). Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands. Frontiers in Immunology. 1-16.
- (2021). Evaluation of β-catenin inhibition of axitinib and nitazoxanide in human monocyte-derived dendritic cells. Biomedicines. 1-18.
- (2020). Mass cytometry analysis of blood immune cells from psoriasis patients on biological therapy. European Journal of Immunology. 694-702.
- (2020). Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms. Frontiers in Endocrinology. 1-13.
- (2020). Dual pro- and anti-inflammatory features of monocyte-derived dendritic cells. Frontiers in Immunology. 1-15.
- (2019). The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells. Frontiers in Immunology.
- (2019). Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary sjogren's syndrome. Frontiers in Immunology. 1-18.
- (2018). Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment? Scandinavian Journal of Immunology. 1-7.
- (2018). Phosphorylation of intracellular signaling molecules in peripheral blood cells from psoriasis patients on originator or biosimilar infliximab. British Journal of Dermatology. 371-380.
- (2018). Minimum information about T regulatory cells: A step toward reproducibility and standardization. Frontiers in Immunology. 1-15.
- (2018). Aberrant cell signalling in PBMCs upon IFN-? stimulation in primary Sjogren's syndrome patients associates with type I interferon signature. European Journal of Immunology. 1217-1227.
- (2018). 3-Day monocyte-derived dendritic cells stimulated with a combination of OK432, TLR7/8 ligand, and prostaglandin E2 are a promising alternative for cancer immunotherapy. Cancer Immunology and Immunotherapy. 1-10.
- (2017). Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leucocyte populations. Scandinavian Journal of Immunology. 491-502.
- (2017). Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjogren's Syndrome. Scandinavian Journal of Immunology. 220-226.
- (2016). Minimum information about tolerogenic antigen-presenting cells (MITAP): A first step towards reproducibility and standardisation of cellular therapies. PeerJ.
- (2016). An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells. Journal of Immunological Methods (JIM). 58-63.
- (2015). TLR-7 and -9 Stimulation of Peripheral Blood B Cells Indicate Altered TLR Signalling in Primary Sjögren's Syndrome Patients by Increased Secretion of Cytokines. Scandinavian Journal of Immunology. 523-531.
- (2015). Surface-mediated priming during in vitro generation of monocyte-derived dendritic cells. Scandinavian Journal of Immunology. 56-65.
- (2015). Peritumoral dermis of squamous cell carcinomas in renal transplant recipients contains less CD11c+ myeloid dendritic cells and FoxP3+ T cells compared to immunocompetent controls. Journal of the European Academy of Dermatology and Venereology. 2128-2135.
- (2015). Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome. PLOS ONE. 13 sider.
- (2014). CD11c+ dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. Acta Dermato-Venereologica. 173-178.
- (2014). Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome. Arthritis Research & Therapy.
- (2014). Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells. Scandinavian Journal of Immunology. 20-26.
- (2013). Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. Scandinavian Journal of Immunology. 246-254.
- (2013). No association of primary Sjögren's syndrome with Fcγ receptor gene variants. Genes and Immunity. 234-237.
- (2013). In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome. Arthritis Research & Therapy. 12 sider.
- (2013). Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. Biointerphases. 12 sider.
- (2013). Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas. Scandinavian Journal of Immunology. 291-297.
- (2012). The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner. PLOS ONE. 7 sider.
- (2012). Expression of ESE-3 isoforms in immunogenic and tolerogenic human monocyte-derived dendritic cells. PLOS ONE. 9 sider.
- (2012). Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. Journal of Leukocyte Biology. 729-737.
- (2011). Potential association of muscarinic receptor 3 gene variants with primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 1327-1329.
- (2011). Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunology. 10 sider.
- (2011). Dendritic cell populations in patients with self-reported food hypersensitivity. International Journal of General Medicine. 389-396.
- (2011). Bromelain Treatment Leads to Maturation of Monocyte-derived Dendritic Cells but Cannot Replace PGE(2) in a Cocktail of IL-1 beta, IL-6, TNF-alpha and PGE(2). Scandinavian Journal of Immunology. 135-143.
- (2011). Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome. Genes and Immunity. 100-109.
- (2010). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 1235-1238.
- (2009). Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains. Scandinavian Journal of Immunology. 541-546.
- (2008). New Concepts in the Pathogenesis of Sjogren's Syndrome. Rheumatic Disease Clinics of North America. 833-+.
- (2007). Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. Endocrine, Metabolic & Immune Disorders - Drug Targets. 93-97.
- (2006). Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. Blood. 3265-3270.
Vitenskapelig foredrag
- (2023). Planter vs. dødelig virus.
Leserinnlegg
- (2013). Reply to 'Comment on No association of primary Sjogren's syndrome with Fc gamma receptor gene variants'. Genes and Immunity. 532-532.
- (2012). Quantification of Plasmacytoid Dendritic Cells and Type 1 Myeloid Dendritic Cells in Peripheral Blood of Renal Transplant Recipients With and Without Squamous Cell Carcinoma. Acta Dermato-Venereologica. 623-624.
- (2012). Anti-Ro and anti-La autoantibody profiling in Norwegian patients with primary Sjogren's syndrome using luciferase immunoprecipitation systems (LIPS). Scandinavian Journal of Rheumatology. 314-315.
- (2010). The First Dendritic Cell-Based Therapeutic Cancer Vaccine is Approved by the FDA. Scandinavian Journal of Immunology. 554-554.
Brev til redaktøren
- (2023). Biological treatment in severe psoriasis: Influence on peripheral blood dendritic cells. Scandinavian Journal of Immunology.
Doktorgradsavhandling
- (2019). Systemic inflammation in psoriasis: Circulating immune cells and cytokines.
- (2017). Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome.
- (2015). Toll-like receptors in primary Sjögren’s syndrome. Special emphasis on B cells.
- (2011). Epidemiological, clinical, and immunogenetic aspects of primary Sjögren's syndrome.
Intervju
- (2023). Dreper kreftceller med hageplanter.
Sammendrag/abstract
- (2013). Type 1 Regulatory T cells and Regulatory B Cells Induced by Dexamethasone and 1,25-Dihydroxyvitamin D3 Treated Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology. 299-300.
- (2012). No association of primary Sjögren's Syndrome with Fc gamma? Receptor gene variants. Scandinavian Journal of Immunology. 198-198.
- (2012). Expression of Toll-like receptors 7 and 9 in B cell populations of patients with Sjogren's syndrome. Immunology. 331-331.
- (2012). Comparison of different protocols for the generation of monocytes-derived tolerogenic dendritic cells for immunotherapy. Immunology. 679-679.
- (2011). The Epithelial Specific Transcription Factor ESE-3 is Expressed in Immature Dendritic Cells and Occurs Primarily as the ESE-3b Isoform. Scandinavian Journal of Immunology. 366-366.
- (2011). Maturation of Dendritic Cells with the Bacterial Compound OK432 Induces High Secretion of IL-12p70 in a TLR3 Dependent Manner. Scandinavian Journal of Immunology. 387-388.
- (2011). Generation of Tolerogenic Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology. 378-379.
- (2011). Can Levels of Blood Plasmacytoid Dendritic Cells be used as a Prognostic Factor for Development of Squamous Cell Carcinomas in Organ Transplant Recipients? Scandinavian Journal of Immunology. 394-394.
- (2010). Patients with Primary Sjogren's Syndrome have Significantly Reduced Amounts of Plasmacytoid and Type 2 Myeloid Dendritic Cells in Peripheral Blood. Scandinavian Journal of Immunology. 479-479.
- (2010). Maturation of Monocyte Derived Dendritic Cells With OK432 Leads to Altered Expression of Surface Markers. Scandinavian Journal of Immunology. 504-504.
- (2010). Gene Variants in Fam167A-Blk and Tnfsf4 are associated with Primary Sjogren's Syndrome. Scandinavian Journal of Rheumatology. 32-32.
- (2010). Fc gamma receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc gamma receptor IIIB copy number variation: No association with primary Sjögren's syndrome. Scandinavian Journal of Rheumatology. 36-36.
- (2010). Dendritic cell populations in patients with self-reported food hypersensitivity. Gut. A394.
- (2010). Bromelain Treatment Leads to Maturation of Monocyte Derived Dendritic Cells. Scandinavian Journal of Immunology. 506-507.
- (2008). Maturation of monocyte derived dendritic cells with OK432 leads to altered expression of surface markers. Scandinavian Journal of Immunology. 217-217.
- (2008). Characterization of Gene p306 Expressed in Monocyte Derived Dendritic Cells. Blood. 891-891.
- (2008). Age-related distribution of cDC and pDC in salivary glands of NOD mice. Scandinavian Journal of Immunology. 206-207.
Poster
- (2023). Diagnostic gut biomarkers with imaging mass cytometry in irritable bowel syndrome.
- (2023). Bergen BrainGut study: diagnostic gut biomarkers in irritable bowel syndrome with imaging mass cytometry.
- (2009). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome.
- (2009). Fc receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc receptor IIIB copy number variation: No association with primary Sjögren’s syndrome.
- (2009). Dendritic cells from patients with primary Sjögren's syndrome have slightly enhanced endocytic capacity.
- (2009). Association of C8orf13-BLK and TNFSF4 Gene Variants with Primary Sjögren's Syndrome.
Vitenskapelig oversiktsartikkel/review
- (2020). The TNF/IL-23/IL-17 axis-Head-to-head trials comparing different biologics in psoriasis treatment. Scandinavian Journal of Immunology.
- (2020). Current knowledge on autoantigens and autoantibodies in psoriasis. Scandinavian Journal of Immunology.
- (2013). Current status and future perspectives of dendritic cell-based cancer immunotherapy. Scandinavian Journal of Immunology. 167-171.
- (2012). The 2011 Nobel Prize in physiology or medicine. Scandinavian Journal of Immunology. 1-4.
- (2011). The complexity of Sjögren's syndrome: Novel aspects on pathogenesis. Immunology Letters. 1-9.
- (2006). Role of dendritic cells in Sjögren´s syndrome. Scandinavian Journal of Immunology. 219-226.