Thomas Arnesens bilde
Thomas
Arnesen
Forsker
, Forskergruppe leder
Besøksadresse: 
HIB - Thormøhlensgt. 55
5020 Bergen
Postadresse: 
Postboks 7803
5020 Bergen
Telefon: 
+47 55 58 45 28
Last ned visittkort
Utvalgte publikasjoner
  • Arnesen, Thomas; Starheim, Kristian Kobbenes; Van Damme, Petra; Evjenth, Rune Henrik; Dinh, Huyen Mong Thi; Betts, Matthew James; Ryningen, Anita; Vandekerckhove, Joel; Gevaert, Kris; Anderson, Dave. 2010. The Chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. Molecular and Cellular Biology. 30: 1898-1909. doi: 10.1128/MCB.01199-09
  • Arnesen, Thomas; Van Damme, Petra; Polevoda, Bogdan; Helsens, Kenny; Evjenth, Rune Henrik; Colaert, Niklaas; Varhaug, Jan Erik; Vandekerckhove, Joel; Lillehaug, Johan; Sherman, Fred; Gevaert, Kris. 2009. Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proceedings of the National Academy of Science of the United States of America. 106: 8157-8162. doi: 10.1073/pnas.0901931106
  • Starheim, Kristian Kobbenes; Gromyko, Darina; Evjenth, Rune Henrik; Ryningen, Anita; Varhaug, Jan Erik; Lillehaug, Johan; Arnesen, Thomas. 2009. Knockdown of the human N-alpha-acetyltransferace complex C (hNatC) leads to p53-dependent apoptosis and aberrant hArl8b localization. Molecular and Cellular Biology. 29: 3569-3581. doi: 10.1128/MCB.01909-08
  • Arnesen, Thomas; Gromyko, Darina; Pendino, Fredric G Pascal; Ryningen, Anita; Varhaug, Jan Erik; Lillehaug, Johan. 2006. Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex. Oncogene. 25: 4350-4360. doi: 10.1038/sj.onc.1209469
  • Arnesen, Thomas; Anderson, Dave; Baldersheim, Christian; Lanotte, Michel; Varhaug, Jan Erik; Lillehaug, Johan. 2005. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. Biochemical Journal. 386: 433-443. doi: 10.1042/BJ20041071
  • Arnesen, Thomas. 2011. Towards a Functional Understanding of Protein N-Terminal Acetylation. PLoS biology. 9. 5 sider. doi: 10.1371/journal.pbio.1001074
  • Van Damme, P; Hole, Kristine; Pimenta-Marques, A; Helsens, K; Vandekerckhove, J; Martinho, RG; Gevaert, K; Arnesen, Thomas. 2011. NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation. PLoS Genetics. 7. 19 sider. doi: 10.1371/journal.pgen.1002169
  • Rope, AF; Wang, K; Evjenth, Rune Henrik; Xing, JC; Johnston, JJ; Swensen, JJ; Johnson, WE; Moore, B; Huff, CD; Bird, LM; Carey, JC; Opitz, JM; Stevens, CA; Jiang, T; Schank, C; Fain, HD; Robison, R; Dalley, B; Chin, S; South, ST; Pysher, TJ; Jorde, LB; Hakonarson, H; Lillehaug, Johan R.; Biesecker, LG; Yandell, M; Arnesen, Thomas; Lyon, GJ. 2011. Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency. American Journal of Human Genetics. 89: 28-43. doi: 10.1016/j.ajhg.2011.05.017
  • Starheim, Kristian Kobbenes; Gevaert, Kris; Arnesen, Thomas. 2012. Protein N-terminal acetyltransferases: when the start matters. TIBS -Trends in Biochemical Sciences. Regular ed.. 37: 152-161. doi: 10.1016/j.tibs.2012.02.003
  • Van Damme, Petra; Lasa, Marta; Polevoda, Bogdan; Gazquez, Cristina; Elosegui-Artola, Alberto; Kim, Duk Soo; De Juan-Pardo, Elena; Demeyer, Kimberly; Hole, Kristine; Larrea, Esther; Timmerman, Evy; Prieto, Jesus; Arnesen, Thomas; Sherman, Fred; Gevaert, Kris; Aldabe, Rafael. 2012. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proceedings of the National Academy of Science of the United States of America. 109: 12449-12454. doi: 10.1073/pnas.1210303109

Protein modifications with an emphasis on protein N-terminal acetylation

Cellular signaling

Development of anticancer drugs

Tidsskriftartikler
  • Van Damme, Petra; Støve, Svein Isungset; Glomnes, Nina; Gevaert, Kris; Arnesen, Thomas. 2014. A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant. Molecular & Cellular Proteomics. 13: 2031-2041. doi: 10.1074/mcp.M113.035402
  • Aksnes, Henriette; Osberg, Camilla; Arnesen, Thomas. 2013. N-Terminal Acetylation by NatC Is Not a General Determinant for Substrate Subcellular Localization in Saccharomyces cerevisiae. PLoS ONE. 8. 7 sider. doi: 10.1371/journal.pone.0061012
  • Arnesen, Thomas; Glomnes, Nina; Strømsøy, Siri S.; Knappskog, Stian; Heie, Anette; Akslen, Lars A.; Grytaas, Marianne Aardal; Varhaug, Jan Erik; Gimm, Oliver; Brauckhoff, Michael. 2013. Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway. Langenbeck's archives of surgery (Print). 398: 869-874. doi: 10.1007/s00423-013-1093-2
  • Evjenth, Rune Henrik; Van Damme, Petra; Gevaert, Kris; Arnesen, Thomas. 2013. HPLC-based Quantification of in vitro N-terminal Acetylation. Methods in Molecular Biology. 981. doi: 10.1007/978-1-62703-305-3_7
  • Foyn, Håvard; Jones, Justin E.; Lewallen, Dan; Narawane, Rashmi Shahapure; Varhaug, Jan Erik; Thompson, Paul R.; Arnesen, Thomas. 2013. Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors. ACS Chemical Biology. 8: 1121-1127. doi: 10.1021/cb400136s
  • Foyn, Håvard; Van Damme, Petra; Støve, Svein Isungset; Glomnes, Nina; Evjenth, Rune Henrik; Gevaert, Kris; Arnesen, Thomas. 2013. Protein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo. Molecular & Cellular Proteomics. 12: 42-54. doi: 10.1074/mcp.M112.019299
  • Kalvik, Thomas Vikestad; Arnesen, Thomas. 2013. Protein N-terminal acetyltransferases in cancer. Oncogene. 32: 269-276. Publisert 2013-01-17. doi: 10.1038/onc.2012.82
  • Liszczak, Glen; Goldberg, Jacob M.; Foyn, Håvard; Petersson, E. James; Arnesen, Thomas; Marmorstein, Ronen. 2013. Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nature Structural & Molecular Biology. 20: 1098-+. doi: 10.1038/nsmb.2636
  • Van Damme, Petra; Arnesen, Thomas; Ruttens, Bart; Gevaert, Kris. 2013. In-gel N-acetylation for the quantification of the degree of protein in vivo N-terminal acetylation. Methods in Molecular Biology. doi: 10.1007/978-1-62703-305-3_9
  • Evjenth, Rune Henrik; Brenner, Annette; Thompson, Paul R.; Arnesen, Thomas; Frøystein, Nils Åge; Lillehaug, Johan R. 2012. Human Protein N-terminal Acetyltransferase hNaa50p (hNAT5/hSAN) Follows Ordered Sequential Catalytic Mechanism (combined kinetic and NMR study). Journal of Biological Chemistry. 287: 10081-10088. doi: 10.1074/jbc.M111.326587
  • Grauffel, Cédric; Abboud, Angele; Liszczak, Glen; Marmorstein, Ronen; Arnesen, Thomas; Reuter, Nathalie. 2012. Specificity and Versatility of Substrate Binding Sites in Four Catalytic Domains of Human N-Terminal Acetyltransferases. PLoS ONE. 7. doi: 10.1371/journal.pone.0052642
  • Starheim, Kristian Kobbenes; Gevaert, Kris; Arnesen, Thomas. 2012. Protein N-terminal acetyltransferases: when the start matters. TIBS -Trends in Biochemical Sciences. Regular ed.. 37: 152-161. doi: 10.1016/j.tibs.2012.02.003
  • Van Damme, Petra; Lasa, Marta; Polevoda, Bogdan; Gazquez, Cristina; Elosegui-Artola, Alberto; Kim, Duk Soo; De Juan-Pardo, Elena; Demeyer, Kimberly; Hole, Kristine; Larrea, Esther; Timmerman, Evy; Prieto, Jesus; Arnesen, Thomas; Sherman, Fred; Gevaert, Kris; Aldabe, Rafael. 2012. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proceedings of the National Academy of Science of the United States of America. 109: 12449-12454. doi: 10.1073/pnas.1210303109
  • Arnesen, Thomas. 2011. Towards a Functional Understanding of Protein N-Terminal Acetylation. PLoS biology. 9. 5 sider. doi: 10.1371/journal.pbio.1001074
  • Helsens, K; Van Damme, P; Degroeve, S; Martens, L; Arnesen, Thomas; Vandekerckhove, J; Gevaert, K. 2011. Bioinformatics Analysis of a Saccharomyces cerevisiae N-Terminal Proteome Provides Evidence of Alternative Translation Initiation and Post-Translational N-Terminal Acetylation. Journal of Proteome Research. 10: 3578-3589. doi: 10.1021/pr2007325
  • Hole, Kristine; Van Damme, Petra; Dalva, Monica; Aksnes, Henriette; Glomnes, Nina; Varhaug, Jan Erik; Lillehaug, Johan R.; Gevaert, Kris; Arnesen, Thomas. 2011. The human N-Alpha-Acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. PLoS ONE. 6. 11 sider. doi: 10.1371/journal.pone.0024713
  • Liszczak, Glen; Arnesen, Thomas; Marmorstein, Ronen. 2011. Structure of a ternary Naa50p (NAT5/SAN) N-terminal acetyltransferase complex reveals the molecular basis for substrate-specific acetylation. Journal of Biological Chemistry. 286: 37002-37010. doi: 10.1074/jbc.M111.282863
  • Rope, AF; Wang, K; Evjenth, R; Xing, JC; Johnston, JJ; Swensen, JJ; Johnson, WE; Moore, B; Huff, CD; Bird, LM; Carey, JC; Opitz, JM; Stevens, CA; Schank, C; Fain, HD; Robison, R; Dalley, B; Chin, S; South, ST; Pysher, TJ; Jorde, LB; Hakonarson, H; Lillehaug, Johan R.; Biesecker, LG; Yandell, M; Arnesen, Thomas; Lyon, GJ. 2011. Massively parallel sequencing identifies a previously unrecognized X-linked disorder resulting in lethality in male infants owing to amino-terminal acetyltransferase deficiency. Genome Biology. 12: 11-11.
  • Rope, AF; Wang, K; Evjenth, Rune Henrik; Xing, JC; Johnston, JJ; Swensen, JJ; Johnson, WE; Moore, B; Huff, CD; Bird, LM; Carey, JC; Opitz, JM; Stevens, CA; Jiang, T; Schank, C; Fain, HD; Robison, R; Dalley, B; Chin, S; South, ST; Pysher, TJ; Jorde, LB; Hakonarson, H; Lillehaug, Johan R.; Biesecker, LG; Yandell, M; Arnesen, Thomas; Lyon, GJ. 2011. Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency. American Journal of Human Genetics. 89: 28-43. doi: 10.1016/j.ajhg.2011.05.017
  • Van Damme, P; Evjenth, Rune Henrik; Foyn, Håvard; Demeyer, K; De Bock, PJ; Lillehaug, Johan R.; Vandekerckhove, J; Arnesen, Thomas; Gevaert, K. 2011. Proteome-derived Peptide Libraries Allow Detailed Analysis of the Substrate Specificities of N-alpha-acetyltransferases and Point to hNaa10p as the Post-translational Actin N-alpha-acetyltransferase. Molecular & Cellular Proteomics. 10. 12 sider. doi: 10.1074/mcp.M110.004580
  • Van Damme, P; Hole, Kristine; Pimenta-Marques, A; Helsens, K; Vandekerckhove, J; Martinho, RG; Gevaert, K; Arnesen, Thomas. 2011. NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation. PLoS Genetics. 7. 19 sider. doi: 10.1371/journal.pgen.1002169
  • Van Damme, Petra; Arnesen, Thomas; Gevaert, Kris. 2011. Protein alpha-N-acetylation studied by N-terminomics. The FEBS Journal. 278: 3822-3834. doi: 10.1111/j.1742-4658.2011.08230.x
  • Arnesen, Thomas; Gromyko, Darina; Varhaug, Jan Erik; Lillehaug, Johan R. 2010. The protein N-terminal acetyltransferase NatA: A novel target for cancer chemotherapy? The FEBS Journal. 277: 175-175.
  • Arnesen, Thomas; Starheim, Kristian Kobbenes; Van Damme, Petra; Evjenth, Rune Henrik; Dinh, Huyen Mong Thi; Betts, Matthew James; Ryningen, Anita; Vandekerckhove, Joel; Gevaert, Kris; Anderson, Dave. 2010. The Chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. Molecular and Cellular Biology. 30: 1898-1909. doi: 10.1128/MCB.01199-09
  • Evjenth, Rune Henrik; Hole, Kristine; Karlsen, Odd Andre; Ziegler, Mathias; Arnesen, Thomas; Lillehaug, Johan R. 2010. Human Naa50p (Nat5/San) displays both protein N-alpha- and N-epsilon-Acetyltransferase activity. The FEBS Journal. 277: 182-182.
  • Gromyko, Darina; Arnesen, Thomas; Ryningen, Anita; Varhaug, Jan Erik; Lillehaug, Johan R. 2010. Depletion of the human N-alpha-terminal acetyltransferase A induces p53-dependent apoptosis and p53-independent growth inhibition. International Journal of Cancer. 127: 2777-2789. doi: 10.1002/ijc.25275
  • Hole, Kristine; Karlsen, Odd Andre; Ziegler, Mathias; Arnesen, Thomas; Lillehaug, Johan R.; Ryningen, Anita; Vandekerckhove, Joel; Gevaert, Kris; Anderson, D. 2010. The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. The FEBS Journal. 277: 185-185.
  • Arnesen, Thomas. 2009. Protein N-terminal acetylation: NAT 2007–2008 Symposia. BMC Proceedings. 3. doi: 10.1186/1753-6561-3-S6-S1
  • Arnesen, Thomas; Gromyko, Darina; Kagabo, Diane; Betts, Matthew James; Starheim, Kristian Kobbenes; Varhaug, Jan Erik; Anderson, Dave; Lillehaug, Johan. 2009. A novel human NatA N-alpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). BMC Biochemistry. 10. 17 sider. doi: 10.1186/1471-2091-10-15
  • Arnesen, Thomas; Van Damme, Petra; Polevoda, Bogdan; Helsens, Kenny; Evjenth, Rune Henrik; Colaert, Niklaas; Varhaug, Jan Erik; Vandekerckhove, Joel; Lillehaug, Johan; Sherman, Fred; Gevaert, Kris. 2009. Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proceedings of the National Academy of Science of the United States of America. 106: 8157-8162. doi: 10.1073/pnas.0901931106
  • Evjenth, Rune Henrik; Hole, Kristine; Karlsen, Odd Andre; Ziegler, Mathias; Arnesen, Thomas; Lillehaug, Johan R. 2009. Human Naa50p (Nat5/San) Displays Both Protein N-alpha- and N-epsilon-Acetyltransferase Activity. Journal of Biological Chemistry. 284: 31122-31129. doi: 10.1074/jbc.M109.001347
  • Målen, Hiwa; Lillehaug, Johan R.; Arnesen, Thomas. 2009. The protein Nα-terminal acetyltransferase hNaa10p (hArd1) is phosphorylated in HEK293 cells. BMC Research Notes. 2. doi: 10.1186/1756-0500-2-32
  • Polevoda, Bogdan; Arnesen, Thomas; Sherman, Fred. 2009. A synopsis of eukaryotic N-alpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proceedings. 3. doi: 10.1186/1753-6561-3-S6-S2
  • Starheim, Kristian Kobbenes; Gromyko, Darina; Evjenth, Rune Henrik; Ryningen, Anita; Varhaug, Jan Erik; Lillehaug, Johan; Arnesen, Thomas. 2009. Knockdown of the human N-alpha-acetyltransferace complex C (hNatC) leads to p53-dependent apoptosis and aberrant hArl8b localization. Molecular and Cellular Biology. 29: 3569-3581. doi: 10.1128/MCB.01909-08
  • Starheim, Kristian Kobbenes; Gromyko, Darina; Velde, Rolf Sturla; Varhaug, Jan Erik; Arnesen, Thomas. 2009. Composition and biological significance of the human N-alpha-terminal acetyltransferases. BMC Proceedings. 3. doi: 10.1186/1753-6561-3-S6-S3
  • Takubo, Kazuko; Tsuchiya, Hiroyuki; Kurimasa, Akihiro; Arnesen, Thomas; Ryoke, Kazuo; Shiota, Goshi. 2009. Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil. Anti-Cancer Drugs. 20: 668-675. doi: 10.1097/CAD.0b013e32832d5159
  • Wei, W; Yi, X; Arnesen, Thomas; Gao, Y; Yu, XD. 2009. Carboxyl terminus of Hsc70-interacting protein is required for ubiquitination and acetylation-mediated degradation of HIF-1 alpha in prolonged hypoxia. Clinical and Experimental Metastasis. 26: 905-905.
  • Arnesen, Thomas; Thompson, Paul R.; Varhaug, Jan Erik; Lillehaug, Johan. 2008. The Protein Acetyltransferase ARD1: A Novel Cancer Drug Target? Current Cancer Drug Targets. 8: 545-553. doi: 10.2174/156800908786241113
  • Starheim, Kristian Kobbenes; Arnesen, Thomas; Gromyko, Darina; Ryningen, Anita; Varhaug, Jan Erik; Lillehaug, Johan. 2008. Identification of the human N-alpha-acetyltransferase complex B (hnatB): a complex important for cell-cycle progression. Biochemical Journal. 415: 325-331. doi: 10.1042/BJ20080658
  • Arnesen, Thomas. 2006. HIF-1alpha and ARD1: enemies, friends or neither? Nature Reviews. Cancer. 6. doi: 10.1038/nrc1779-c1
  • Arnesen, Thomas; Anderson, Dave; Torsvik, Janniche; Halseth, Helene Brekke; Varhaug, Jan Erik; Lillehaug, Johan. 2006. Cloning and characterization of hNAT5/hSAN: An evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex. Gene. 371. doi: 10.1016/j.gene.2005.12.008
  • Arnesen, Thomas; Betts, Matthew James; Pendino, Frederic; Liberles, David A; Anderson, Dave; Caro, Jaime; Kong, Xianguo; Varhaug, Jan Erik; Lillehaug, Johan. 2006. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-a-acetyltransferase. BMC Biochemistry. 7. 12 sider. doi: 10.1186/1471-2091-7-13
  • Arnesen, Thomas; Gromyko, Darina; Pendino, Fredric G Pascal; Ryningen, Anita; Varhaug, Jan Erik; Lillehaug, Johan. 2006. Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex. Oncogene. 25: 4350-4360. doi: 10.1038/sj.onc.1209469
  • Knappskog, Stian; Geisler, Jürgen; Arnesen, Thomas; Lillehaug, Johan; Lønning, Per Eystein. 2006. A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family. Genes, Chromosomes and Cancer. 45: 1155-1163. Publisert 2006-09-25. doi: 10.1002
  • Arnesen, Thomas; Anderson, Dave; Baldersheim, Christian; Lanotte, Michel; Varhaug, Jan Erik; Lillehaug, Johan. 2005. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. Biochemical Journal. 386: 433-443. doi: 10.1042/BJ20041071
  • Arnesen, Thomas; Gromyko, Darina; Horvli, Ole; Fluge, Øystein; Lillehaug, Johan; Varhaug, Jan Erik. 2005. Expression of N-Acetyl Transferase Human and Human Arrest Defective 1 Proteins in Thyroid Neoplasms. Thyroid. 15: 1131-1136.
  • Arnesen, Thomas; Kong, Xianguo; Evjenth, Rune Henrik; Gromyko, Darina; Varhaug, Jan Erik; Lin, Zhao; Sang, Nianli; Caro, Jaime; Lillehaug, Johan. 2005. Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha. FEBS Letters. 579: 6428-6432. doi: 10.1016/j.febslet.2005.10.036
  • Furnes, Clemens; Arnesen, Thomas; Askjaer, Peter; Kjems, Jørgen; Szilvay, Anne Marie. 2005. HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain. Retrovirology. 2. 8 sider.
Rapporter/avhandlinger
  • Reyes, Javier Sanchez; Arnesen, Thomas. 2012. The study of potential hNaa30p substrates EHD1 and eIF2D in hNaa30p depleted cells. Universitetet i Bergen, Bergen. 74 sider.
  • Arnesen, Thomas. 2006. NATH and hARD1, components of the human NatA protein Nα-acetyltransferase complex: Characterization of cellular function.
  • Arnesen, Thomas. 2002. HIV-1 Rev oligomerization and the cellular protein p32: Implications for Rev function. V, 90 bl.

Se fullstendig oversikt over publikasjoner i CRIStin.

Scientific publications (peer reviewed)

 

Arnesen T, Anderson D, Baldersheim C, Lanotte M, Varhaug JE, Lillehaug JR. (2005) Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. Biochemical J 386(Pt 3):433-43.

 

Furnes C, Arnesen T, Askjaer P, Kjems J, Szilvay AM. (2005) HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain. Retrovirology 2(1):39.

 

Arnesen T, Gromyko D, Horvli O, Fluge Ø, Lillehaug JR, Varhaug JE (2005) Expression of NATH and hARD1 proteins in thyroid neoplasms. Thyroid 15(10):1131-6.

 

Arnesen T, Kong X, Evjenth R, Gromyko D, Varhaug JE, Lin Z, Sang N, Caro J, Lillehaug JR. (2005) Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α. FEBS Lett 579(28):6428-32.

 

Arnesen T, Anderson D, Torsvik J, Varhaug JE, Lillehaug JR. (2006) Cloning and characterization of hNAT5/hSAN: An evolutionary conserved component of the NatA protein N-α-acetyltransferase complex. Gene 371:291-295.

 

Arnesen T, Gromyko D, Pendino F, Ryningen A, Varhaug JE, Lillehaug JR. (2006) Induction of apoptosis in human cells by RNAi mediated knock-down of hARD1 and NATH, components of the protein N-α-acetyltransferase complex. Oncogene 25:4350-4360.

 

Arnesen T. (2006) HIF-1α and ARD1: enemies, friends or neither? Nat Rev Cancer. 6 (3): doi:10.1038/nrc1779-c1.

 

Arnesen T, Betts M, Pendino F, Liberles D, Anderson D, Caro J, Kong X, Varhaug JE, Lillehaug JR. (2006) Characterization of hARD2, a processed hARD1 gene duplicate encoding a human protein N-α-acetyltransferase. BMC Biochem 7:13.

 

Knappskog S, Geisler J, Arnesen T, Lillehaug JR, Lønning PE. (2006) A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family. Genes Chr. Cancer.45(12):1155-63.

 

Starheim K, Arnesen T, Gromyko D, Ryningen A, Varhaug JE, Lillehaug JR. (2008) Identification of the human Na-acetyltransferase complex B (hNatB) – a complex important for cell cycle progression. Biochemical J 415:325-331.

 

Arnesen T, Thompson PR, Varhaug JE, Lillehaug JR. (2008) The protein acetyltransferase ARD1 – a novel cancer drug target? Curr Cancer Drug Targets. 8:545-553.

 

Målen H, Lillehaug JR, Arnesen T. (2009) The protein Nα-terminal acetyltransferase hNaa10p (hArd1) is phosphorylated in HEK293 cells. BMC Res Notes2:32.

 

Arnesen T, Van Damme P, Polevoda B, Helsens K, Evjenth R, Colaert N, Varhaug JE, Vandekerckhove J, Lillehaug JR, Sherman F, Gevaert K. (2009)Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci USA. 106:8157-8162.

 

Starheim K, Gromyko D, Ryningen A, Varhaug JE, Lillehaug JR, Arnesen T. (2009) Knockdown of the human NatC protein Nα-terminal acetyltransferase complex induces p53-mediated apoptosis and aberrant hArl8b localization. Mol Cell Biol 29(13):3569-81.

 

Arnesen T, Gromyko D, Kagabo D, Betts MJ, Varhaug JE, Anderson D, Lillehaug JR. (2009) A novel human NatA Nα-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). BMC Biochem. 10:15.

 

Takubo K, Tsuchiya H, Kurimasa A, Arnesen T, Ryoke K, Shiota G. (2009) Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil. Anti-Cancer Drugs. 20:668-75.

 

Arnesen T. (2009) Protein N-terminal acetylation: NAT 2007–2008 Symposia. BMC Proc. 3 (Suppl 6):S1.

 

Polevoda B, Arnesen T, Sherman F. (2009) A synopsis of eukaryotic Nα-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc. 3 (Suppl 6):S2.

 

Starheim KK, Gromyko D, Velde R, Varhaug JE, Arnesen T. (2009) Composition and biological significance of the human Nα-terminal acetyltransferases. BMC Proc. 3 (Suppl 6):S3

 

Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T, Lillehaug JR (2009) Human Naa50 (Nat5/San) displays both protein N-alpha and N-epsilon acetyltransferase activity. J Biol Chem. 284(45):31122-9.

 

Arnesen T, Starheim KK, Van Damme P, Evjenth R, Dinh H, Betts M, Ryningen A, Vandekerckhove J, Gevaert K, Anderson D. (2010) The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. Mol Cell Biol 30(8):1898-909.

 

Gromyko D, Arnesen T, Ryningen A, Varhaug JE, Lillehaug JR (2010) Depletion of the human N-terminal acetyltransferase A (hNatA) induces p53-dependent apoptosis and p53-independent growth inhibition. Int J Cancer 127(12):2777-89.

 

Van Damme P, Evjenth R, Foyn H, Demeyer K, De Bock P-J, Lillehaug JR, Vandekerckhove J, Arnesen T, Gevaert K. (2011) Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of Nα-acetyltransferases and point to hNaa10p as the posttranslational actin Nα-acetyltransferase. Mol Cell Proteomics 10: M110.004580.

 

Helsens K, Van Damme P, Degroeve S, Martens L, Arnesen T, Vandekerckhove J, Gevaert K. (2011) Bioinformatics analysis of a Saccharomyces cerevisiae N-terminal proteome provides evidence of alternative translation initiation and post-translational N-terminal acetylation. J Proteome Res 10(8):3578-3589.

 

Arnesen T. (2011) Towards a functional understanding of protein N-terminal acetylation. PLoS Biology 9(5): e1001074.

 

Rope A, Wang K, Evjenth R, Xing J, Johnston JJ, Swensen JJ, Johnson WE, Moore B, Huff CD, Bird LM, Carey JC, Opitz JM, Stevens CA, Jiang T, Schank C, Fain HD, Robison R, Dalley B, Chin S, South ST, Pysher TJ, Jorde LB, Hakonarson H, Lillehaug JR, Biesecker LB, Yandell M, Arnesen T, Lyon GJ (2011) Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency. Am J Hum Genet 89(1):28-43. Comment in Nature News: doi:10.1038/news.2011.382

 

Van Damme P, Arnesen T, Gevaert K (2011) Protein alpha-N-acetylation studied by N-terminomics. FEBS J 278(20):3822-34.

 

Van Damme P, Hole K, Pimenta-Marques A, Helsens K, Vandekerckhove J, Martinho RG, Gevaert K, Arnesen T (2011) NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation. PLoS Genet 7(7): e1002169.

 

Hole K, Van Damme P, Dalva M, Aksnes H, Glomnes N, Varhaug J, Lillehaug JR, Gevaert K, Arnesen T (2011) The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. PLoS ONE 6(9): e24713.

 

Liszczak G, Arnesen T, Marmorstein R (2011) Structure of a ternary Naa50p (NAT5/San) Nα-terminal Acetyltransferase complex reveals the molecular basis for substrate specific acetylation. J Biol Chem 286(42):37002-10.

 

Evjenth R, Brenner A, Thompson PR, Arnesen T, Frøystein NÅ, Lillehaug JR (2012) The human protein N-terminal acetyltransferase hNaa50p (hNat5/hSan) follows an ordered sequential catalytic mechanism: A combined kinetic and NMR study. J Biol Chem 287(13):10081-8.

 

Starheim KK, Gevaert K, Arnesen T (2012) Protein N-terminal acetyltransferases: when the start matters. Trends Biochem Sci 37(4):152-61.

 

Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R (2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci USA 109(31):12449-54.

 

Grauffel C, Abboud A, Liszczak G, Marmorstein R, Arnesen T, Reuter N (2012) Specificity and Versatility of Substrate Binding Sites in Four Catalytic Domains of Human N-Terminal Acetyltransferases. PLoS ONE 7(12): e52642

 

Kalvik TV and Arnesen T (2013) Protein N-terminal acetyltransferases in cancer. Oncogene 32(3):269-76.

 

Foyn H, Van Damme P, Støve S, Glomnes N, Evjenth R, Gevaert K, Arnesen T (2013) Protein N-Terminal acetyltransferases act as N-Terminal propionyltransferases in vitro and in vivo. Mol Cell Proteomics 12:42-54. Covered by ASBMB news.

 

Van Damme P, Arnesen T, Ruttens B, Gevaert K (2013) In-gel N-acetylation for the Quantification of the Degree of Protein in vivo N-terminal Acetylation. Methods Mol Biol 981:115-26.

 

Evjenth R, Van Damme P, Gevaert K, Arnesen T (2013) HPLC-based Quantification of in vitro N-terminal Acetylation. Methods Mol Biol 981:95-102.

 

Foyn H, Jones JE, Lewallen D, Narawane R, Varhaug JE, Thompson PR, Arnesen T (2013) Design, Synthesis, and Kinetic Characterization of Protein N-Terminal Acetyltransferase Inhibitors. ACS Chem Biol 8:1121–1127.

 

Aksnes H, Osberg C, Arnesen T (2013) N-Terminal Acetylation by NatC Is Not a General Determinant for Substrate Subcellular Localization in Saccharomyces cerevisiae. PLOS ONE 8(4): e61012.

 

Arnesen T, Glomnes N, Strømsøy S, Knappskog S, Heie A, Akslen LA, Grytaas M, Varhaug JE, Gimm O, Brauckhoff M (2013) Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population based study from Western Norway. Langenbecks Arch Surg 398(6):869-74.

 

Liszczak G, Goldberg JM, Foyn H, Petersson EJ, Arnesen T, Marmorstein R (2013) Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nature Struct Mol Biol 20(9):1098-105.

 

Dutta RK, Welander J, Brauckhoff M, Arnesen T, Alesina P, Walz M, Söderkvist P, Gimm O (2014) Complementary somatic mutations in sporadic aldosterone producing adrenal adenomas Endocr Relat Cancer ERC 21(1):L1-4.

 

Van Damme P, Støve SI, Glomnes N, Gevaert K, Arnesen T (2014) A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase Naa10S37P mutant. Mol Cell Proteomics 13(8):2031-41.

 

Popp B, Støve SI, Endele S, Myklebust LM, Hoyer J, Sticht H, Azzarello-Burri S, Rauch A, Arnesen T, Reis A (2014) De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females. Eur J Hum Genet in press

 

Myklebust LM, Van Damme P, Støve SI, Dörfel MJ, Abboud A, Kalvik TV, Grauffel C, Jonckheere V, Wu Y, Swensen J, Kaasa H, Liszczak G, Marmorstein R, Reuter N, Lyon GJ, Gevaert K, Arnesen T (2014) Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Hum Mol Genet in press

2012-> Researcher/Group leader (Bergen Research Foundation BFS)

Department of Molecular Biology, University of Bergen.

 

2010-> Researcher

Department of Surgery, Haukeland University Hospital

 

2010-2013 Researcher/Principal Investigator (Research Council of Norway)                                                                                                                                                                                                                                                  University of Bergen, Norway

 

2009-2009 Associate Professor                                                                                                                                                                                                                                                                                                                                                    University of Bergen, Norway

 

2006-2009 Post Doc (Norwegian Health Authorities West)                                                                                                                                                                                                                                                                   University of Bergen, Norway (Prof. JE Varhaug and Prof. JR Lillehaug) and                                                                                                                                                                                                                                                             University of Rochester, USA (Prof. Fred Sherman)

 

2006 Ph.D. Molecular Biology (Norwegian Cancer Society)                                                                                                                                                                                                                                                                     University of Bergen, Norway (Prof. JE Varhaug and Prof. JR Lillehaug)

 

2002 Cand. scient. (M.Sc.) Molecular Biology                                                                                                                                                                                                                                                                                       University of Bergen, Norway  (Prof. AM Szilvay)

 

1999 Biomedical Laboratory Scientist (B.Sc.)                                                                                                                                                                                                                                                                                         Bergen University College, Norway

Prosjekter

-Human protein N-terminal acetyltransferases (NATs):

identification, substrate specificities, biological importance, molecular mechanisms.

-Development of NAT inhibitors