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Employee profile

Rein Aasland

Head of Department

Chromatin-based gene regulation and cellular memory

Department of Molecular Biology

NUCREG: Mechanisms of gene regulation and molecular interactions

ETECvac: Vaccines for childhood diarrhea in low- and middle-income countries

Homepage: https://www.uib.no/fg/genreg

Title: Head of Department

Phone: +47 55 58 45 31

Cellphone: +47 924 25 456 SMS

E-mail:

Visiting address: HIB - Thormøhlensgt. 55

Brief CV:

  • Cand. scient. (UiB, 1983) - Thesis: "Proteins Associated with the Chromatin of E. coli."
  • Dr. scient. (UiB, 1991) - Thesis: "Oncogenes and Growth Factors in Thyroid Carcinogenesis"
  • Post-doc (EMBL, Heidelberg, 1992-1995) - Chromatin-based gene regulation
  • Assoc.prof (Fellslaboratorium for bioteknologi, UiB, 1995-1996)
  • Assoc.prof (Department of Molecular Biology, UiB, 1997-2001
  • Professor (Department of Molecular Biology, UiB, 2002-)
  • Senior scientist (Computational Biology Unit, BCCS, 2002-)
  • Visiting scientist, NIMR/MRC (May 2010 - Jan 2011)

Competence:

  • Molecular biology: gene regulation, proteins, protein domains
  • Applied bioinformatics: sequence and structure analysis of proteins

 

 

Utvalgte publikasjoner:

    Hoppmann V, Thorstensen T, Kristiansen PE, Veiseth SV, Rahman MA, Finne K, Aalen RB, Aasland R. (2011) The CW domain, a new histone recognition module in chromatin proteins. EMBO J.  Epub ahead of print, Apr. 26th.
    Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, Gamblin SJ. (2011) Structure of mammalian AMPK and its regulation by ADP. Nature 472:230-233.
    Denoeud F, Henriet S, Mungpakdee S, Aury JM, Da Silva C, Brinkmann H, Mikhaleva J, Olsen LC, Jubin C, Cañestro C, Bouquet JM, Danks G, Poulain J, Campsteijn C, Adamski M, Cross I, Yadetie F, Muffato M, Louis A, Butcher S, Tsagkogeorga G, Konrad A, Singh S, Jensen MF, Cong EH, Eikeseth-Otteraa H, Noel B, Anthouard V, Porcel BM, Kachouri-Lafond R, Nishino A, Ugolini M, Chourrout P, Nishida H, Aasland R, Huzurbazar S, Westhof E, Delsuc F, Lehrach H, Reinhardt R, Weissenbach J, Roy SW, Artiguenave F, Postlethwait JH, Manak JR, Thompson EM, Jaillon O, Du Pasquier L, Boudinot P, Liberles DA, Volff JN, Philippe H, Lenhard B, Roest Crollius H, Wincker P, Chourrout D. (2010) Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate.Science. 330:1381-5.
    Justin N, De Marco V, Aasland R, Gamblin SJ. (2010) Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies. Curr Opin Struct Biol. 20:730-8.
    Taxt A, Aasland R, Sommerfelt H, Nataro J, Puntervoll P. (2010) Heat-stable enterotoxin of enterotoxigenic Escherichia coli as a vaccine target.Infect Immun. 78:1824-31.
    Gould CM, Diella F, Via A, Puntervoll P, Gemünd C, Chabanis-Davidson S, Michael S, Sayadi A, Bryne JC, Chica C, Seiler M, Davey NE, Haslam N, Weatheritt RJ, Budd A, Hughes T, Pas J, Rychlewski L, Travé G, Aasland R, Helmer-Citterich M, Linding R, Gibson TJ. ELM: the status of the 2010 eukaryotic linear motif resource. Nucleic Acids Res. 2010 Jan;38(Database issue):D167-80
    Buchanan L, Durand-Dubief M, Roguev A, Sakalar C, Wilhelm B, Strålfors A, Shevchenko A, Aasland R, Shevchenko A, Ekwall K, Francis Stewart A. (2009) The Schizosaccharomyces pombe JmjC-protein, Msc1, prevents H2A.Z localization in centromeric and subtelomeric chromatin domains.PLoS Genet. 5:e1000726
    Thorstensen T, Grini PE, Mercy IS, Alm V, Erdal S, Aasland R, Aalen RB. (2008) The Arabidopsis SET-domain protein ASHR3 is involved in stamen development and interacts with the bHLH transcription factor ABORTED MICROSPORES (AMS). Plant Mol Biol. 66:47-59
    Glaser S, Schaft J, Lubitz S, Vintersten K, van der Hoeven F, Tufteland KR,Aasland R., Anastassiadis, K, Ang, SL., Stewart, AF. (2006) Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development.133:1423-1432.
    Slagsvold T, Aasland R, Hirano S, Bache KG, Raiborg C, Trambaiolo D, Wakatsuki S, Stenmark H. (2005) Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J Biol Chem. 2005 280:19600-6

    Ragvin A, Valvatne H, Erdal S, Årskog V, Tufteland KR, Breen K, Øyan AM, Eberharter A, Gibson TJ, Becker PB, Aasland R. (2004) Nucleosome binding by the bromodomain and PHD finger of the transcriptional cofactor p300. J Mol Biol. 337:773-88.

    Korenjak M, Taylor-Harding B, Binne UK, Satterlee JS, Stevaux O, Aasland R, White-Cooper H, Dyson N, Brehm A. (2004) Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell. 119:181-93

    Puntervoll P, Linding R, Gemund C, Chabanis-Davidson S, Mattingsdal M, Cameron S, Martin DM, Ausiello G, Brannetti B, Costantini A, Ferre F, Maselli V, Via A, Cesareni G, Diella F, Superti-Furga G, Wyrwicz L, Ramu C, McGuigan C, Gudavalli R, Letunic I, Bork P, Rychlewski L, Kuster B, Helmer-Citterich M, Hunter WN, Aasland R, Gibson TJ. (2003) ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins. Nucleic Acids Res. 31:3625-3630.

    Roguev A, Schaft D, Shevchenko A, Aasland R, Shevchenko A, Stewart AF. (2003) High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts. J Biol Chem. 278:8487-8493.

    Conklin D, Jonassen I, Aasland R, Taylor WR. (2002) Association of nucleotide patterns with gene function classes: application to human 3' untranslated sequences. Bioinformatics. 18:182-189.

    Pijnappel, W.W., Schaft D., Roguev, A., Schevchenko, A., Tekotte, H., Wilm, M., Rigaut, G., Seraphin B., Aasland, R., Stewart, A.F. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev. 15, 2991-3004

    Roguev, A., Schaft, D., Schevchenko, A., Pijnappel, W.W., Wilm, M.,Aasland, R., and Stewart, A.F. (2001) The Saccharomyces cerevisiae Set1 complex includes and Ash2 homologue and methylates histone 3 lysine 4. EMBO J. 20, 137-148
    Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R.(1998) FYVE fingers bind PtdIns(3)P. Nature 394:432-3

    Gibson, T.J., Ramu, C. Christine Gemund, C., and Aasland, R. (1998). The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor. Trends Biochem. Sci. 23(7):242-244

    Aasland, R., Stewart, A. F., and Gibson, T. J. (1996). The SANT domain:A putative DNA binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB. Trends Biochem. Sci. 21, 87-88.

    Aasland, R., and Stewart, A. F. (1995). The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1. Nucl. Acids. Res. 23, 3168-3173.

    Aasland, R., Gibson, T. J., and Stewart, A. F. (1995). The PHD-finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem. Sci. 20, 56-59.