Skip to content
Norsk A A A
Scientist profile

Jérôme Ruzzin


Department of Biology

Environmental toxicology

Title: Researcher

Phone: +47 55 58 43 79

Cellphone: +47 55 58 44 00


Visiting address: 3. etasje Høyteknologisenteret, Bioblokka, Thormøhlensgate 55, 5008 Bergen

Room number: Rom 325C1/326C1

Environmental toxicology, insulin resistance syndrome, type 2 diabetes, obesity, nutrition, and public health



2014             : Researcher (PI). 

 Environmental toxicology, Department of Biology, University of Bergen, Bergen, Norway.


2011-2013      : Researcher (PI). 

 Environmental toxicology, Department of Biology, University of Bergen, Bergen, Norway.


2011-2013      : Post Doctoral researcher 2 (PI). 

 Environmental toxicology, Department of Biology, University of Bergen, Bergen, Norway.


2008-2011: Post Doctoral researcher 1 (PI). 

 National Institute of Nutrition and Seafood Research, Bergen, Norway.


2006-2007: Post-doctoral fellow. 

 University Hospital Research Center, and Institute of Nutraceuticals and Fonctional

Foods, Quebec, Canada (Supervisor: Pr. A. Marette).


2001-2005: Doctor Scientiarum.

 Department of Physiology, National Institute of Occupational Health and University

of Sports, Oslo, Norway.

Cellular mechanisms for insulin resistance in skeletal muscles and effects of

contraction: Studies in rats fed with carbohydrate solutions or treated with

dexamethasone” (Supervisor: Dr. J. Jensen).




Publications in Cristin







Jacobs DR Jr, Ruzzin J, Lee DH. Environmental pollutants: downgrading the fish food stock affects chronic disease risk. J Intern Med. Jan 21. doi: 10.1111/joim.12205, 2014

M. M. Ibrahim, E. Fjære, E.-J. Lock, L. Frøyland, N. Jessen, S. Lund, H. Vidal, J. Ruzzin. Metabolic impacts of high dietary exposure to persistent organic pollutants in mice. Toxicology Letters Nov 23;215(1):8-15, 2012.

Jérôme Ruzzin and David R. Jacobs Jr. The secret story of fish: decreasing nutritional value due to pollution? British Journal of Nutrition,2012. doi:10.1017/S0007114512002048

 Jérôme Ruzzin. Public heath concern behind the exposure to persistent organic pollutants and the risk of metabolic diseases. BMC Public Health 12:298 doi:10.1186/1471-2458-12-298, 2012.

Jérôme Ruzzin, Duk-Hee Lee, David O Carpenter, David R. Jacobs Jr. Reconsidering metabolic diseases: The impacts of persistent organic pollutants. Atherosclerosis, 2012. DOI: 10.1016/j.atherosclerosis.2012.02.039

M. M. Ibrahim, E. Fjære, E.-J. Lock, D. Naville, H. Amlund, E.Meugnier, B. Le Magueresse Battistoni, L. Frøyland, L. Madsen, N. Jessen, S. Lund, H. Vidal, J. Ruzzin. Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice. PLoS ONE 6(9): e25170. doi:10.1371/journal.pone.0025170, 2011 

G. Pilon, J.Ruzzin, L.E. Rioux, C. Lavigne, P.J. White, L. Frøyland, H. Jacques, L. Beaulieu,  and A. Marette. Differential effects of various fish proteins in altering body weight, inflammatory status, and insulin sensitivity in high-fat-fed rats.Metabolism doi:10.1016/j.metabol.2010.12.005, 2011

J. Ruzzin, R. Petersen, E. Meugnier, L. Madsen, E.J. Lock, H. Lillefosse, T. Ma, S. Pesenti, S. Brask Sonne, T.T. Marstrand, M.K. Malde, Z.Y. Du, C. Chavey, L. Fajas, A.K. Lundebye, C.L. Brand, H. Vidal, K. Kristiansen, L. Frøyland. Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome.Environmental Health Perspectives 118 (4):465-471, 2010

J. Ruzzin, S. Turcotte, V. Leblanc, C. Lavigne, L. Froyland, T. R. Remman and A. Marette. Dietary salmon protein improves insulin sensitivity in high-fat fed obese rats. Annals of Nutrition & Metabolism 51, p347, 2007. 

Jensen J, Jebens E, Brennesvik EO, Ruzzin J, Soos MA, Engebretsen EM, O'Rahilly S, and Whitehead JP. Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signalling. American Journal Physiology Endocrinol Metab 290: E154-E162, 2006.

Ruzzin J, Wagman AS, and Jensen J. Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signalling and the effects of a selective glycogen synthase kinase-3 inhibitor. Diabetologia 48 (10): 2119-30, 2005

 Brennesvik EO, Ktori C, Ruzzin J, Jebens E, Shepherd PR, and Jensen J.Adrenaline potentiates insulin stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline. Cellular Signaling 17 (12):1551-9, 2005

 Jensen J, Ruzzin J, Jebens E, Brennesvik EO, and Knardahl S. Improved insulin-stimulated glucose uptake and glycogen synthase activation in rat skeletal muscles after adrenaline infusion: role of glycogen content and PKB phosphorylation. Acta Physiol Scand 184: 121-130, 2005

Ruzzin J and Jensen J. Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats. American Journal PhysiologyEndocrinol Metab 289: E241-E250, 2005

Ruzzin J, Lai YC, and Jensen J.  Consumption of carbohydrate solutions enhances energy intake without increased body weight and impaired insulin action in rat skeletal muscles. Diabetes Metabolism 31: 178-188, 2005

 Ruzzin J, Peronnet F, Tremblay J, Massicotte D, and Lavoie C. Breath [13CO2] recovery from an oral glucose load during exercise: comparison between [U-13C] and [1,2-13C]glucose. J Appl Physiol.Aug;95(2):477-82, 2003














BIO206 Toxicology

BIO316 Selected topics in environmental toxicology



On-going research activities 

Role of Xenobiotics in Metabolic Diseases: A Translational Approach. Principal Investigator. Financed by Research Council of Norway (RCN) -FRIMEDBIO "Young Research Talents"

 ·       "Signaling impairments GeNerated by Endocrine Disruptors". Principal investigator. Financed by Research Council of Norway (RCN) (2013-2016).

·       "Endocrine disruptors and obesity". Principal investigator.


Previous research activities 

·       “Searching the origin of the insulin resistance syndrome”. Principal investigator. Financed by RCN (2011-2013).

·       “Role of marine food to fight metabolic syndrome: evaluating the benefits and risks”. Principal investigator and PhD supervisor. Financed by RCN (2009-2012).

·      “Salmon oil and contaminants: impacts on insulin sensitivity and metabolic diseases”. Principal investigator. Financed by RCN (2008-2011).