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Olav Tenstad's picture

Olav Tenstad

Professor
The Department of Biomedicine
  • E-mailOlav.Tenstad@uib.no
  • Phone+47 55 58 64 09
  • Visitor Address
    Jonas Lies vei 91
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) (2023). VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats. Cardiovascular Research (CVR). 1553-1567.
  • Show author(s) (2023). Isolation of lymph shows dysregulation of STAT3 and CREB pathways in the spleen and liver during leukemia development in a rat model. Microcirculation. 15 pages.
  • Show author(s) (2022). Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats. Journal of Physiology. 2293-2309.
  • Show author(s) (2022). Genetic engineering of lymphangiogenesis in skin does not affect blood pressure in mouse models of salt-sensitive hypertension. Hypertension. 2451-2462.
  • Show author(s) (2021). Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease. Scientific Reports.
  • Show author(s) (2021). Pharmacokinetics and pharmacodynamics of t-cell bispecifics in the tumour interstitial fluid. Pharmaceutics.
  • Show author(s) (2021). Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat. Pflügers Archiv: European Journal of Physiology.
  • Show author(s) (2020). The Liver and Kidneys mediate clearance of cardiac troponin in the rat. Scientific Reports.
  • Show author(s) (2020). Novel clearance of muscle proteins by muscle cells. European Journal of Cell Biology.
  • Show author(s) (2020). Interstitial fluid drainage from rat apical area takes place via vessels in the mandibular canal. European Journal of Oral Sciences.
  • Show author(s) (2020). Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions. Acta Physiologica.
  • Show author(s) (2020). CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model . EBioMedicine. 1-12.
  • Show author(s) (2019). Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier. Molecular Cancer Therapeutics. 2171-2181.
  • Show author(s) (2018). High-Salt Diet Causes Expansion of the Lymphatic Network and Increased Lymph Flow in Skin and Muscle of Rats. Arteriosclerosis, Thrombosis and Vascular Biology. 2054-2064.
  • Show author(s) (2017). Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration. Arteriosclerosis, Thrombosis and Vascular Biology. 2128-2135.
  • Show author(s) (2017). Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches. Journal of Physiology. 7311-7330.
  • Show author(s) (2017). Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiologica. 441-452.
  • Show author(s) (2017). High-salt diet causes osmotic gradients and hyperosmolality in skin without affecting interstitial fluid and lymph. Hypertension. 660-668.
  • Show author(s) (2017). GRHL2 is required for collecting duct epithelial barrier function and renal osmoregulation. Journal of the American Society of Nephrology. 857-868.
  • Show author(s) (2016). Unilateral renal ischaemia in rats induces a rapid secretion of inflammatory markers to renal lymph and increased capillary permeability. Journal of Physiology. 1709-1726.
  • Show author(s) (2016). Proteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls. Nephron. 70-80.
  • Show author(s) (2015). Extracellular matrix composition affects rat skin distribution volume of plasma proteins with different size and charge. American Journal of Physiology. Heart and Circulatory Physiology. H29-H38.
  • Show author(s) (2015). Distribution volume of macromolecules in human ovarian and endometrial cancers - effects of extracellular matrix structure . American Journal of Physiology. Heart and Circulatory Physiology. H18-H28.
  • Show author(s) (2015). Distinct protein signature of hypertension-induced damage in the renal proteome of two-kidney-one-clip (2K1C) rat model. Journal of Hypertension. 126-135.
  • Show author(s) (2014). Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood. BBA Clinical. 18-23.
  • Show author(s) (2014). Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats. Nephrology, Dialysis and Transplantation. 11 pages.
  • Show author(s) (2014). Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice. Journal of Physiology. 325-336.
  • Show author(s) (2014). Identification of a novel lytic peptide for the treatment of solid tumours. Genes & cancer. 186-200.
  • Show author(s) (2013). Interstitial fluid-a reflection of the tumor cell microenvironment and secretome. Biochimica et Biophysica Acta.
  • Show author(s) (2013). Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema. Arteriosclerosis, Thrombosis and Vascular Biology. 266-274.
  • Show author(s) (2013). Increased WD-repeat containing protein 1 in interstitial fluid from ovarian carcinomas shown by comparative proteomic analysis of malignant and healthy gynecological tissue. Biochimica et Biophysica Acta - Proteins and Proteomics. 2347-2359.
  • Show author(s) (2013). Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. Journal of Clinical Investigation. 2803-2815.
  • Show author(s) (2013). High-salt diet increases hormonal sensitivity in skin pre-capillary resistance vessels. Acta Physiologica. 577-581.
  • Show author(s) (2013). Effects of Hydration on Steric and Electric Charge-Induced Interstitial Volume Exclusion-a Model. Biophysical Journal. 1276-1284.
  • Show author(s) (2012). Proteomic Evaluation of Inflammatory Proteins in Rat Spleen Interstitial Fluid and Lymph during LPS-Induced Systemic Inflammation Reveals Increased Levels of ADAMST1. Journal of Proteome Research. 5338-5349.
  • Show author(s) (2012). Minimally invasive quantification of lymph flow in mice and rats by imaging depot clearance of near-infrared albumin. American Journal of Physiology. Heart and Circulatory Physiology. H391-H401.
  • Show author(s) (2012). Effect of topical anaesthetics on interstitial colloid osmotic pressure in human subcutaneous tissue sampled by wick technique. PLOS ONE. 5 pages.
  • Show author(s) (2011). The glomerular endothelial cell coat is essential for glomerular filtration. Kidney International. 1322-1330.
  • Show author(s) (2011). A new method for isolation of interstitial fluid from human solid tumors applied to proteomic analysis of ovarian carcinoma tissue. PLOS ONE. 9 pages.
  • Show author(s) (2010). Isolation of interstitial fluid in skin during volume expansion: evaluation of a method in pigs. American Journal of Physiology. Heart and Circulatory Physiology. H1546-H1553.
  • Show author(s) (2010). Interstitial fluid: the overlooked component of the tumor microenvironment? Fibrogenesis & Tissue Repair.
  • Show author(s) (2010). Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. Journal of Physiology. 325-339.
  • Show author(s) (2010). Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation. Journal of Immunology. 4547-4556.
  • Show author(s) (2009). Adriamycin Alters Glomerular Endothelium to Induce Proteinuria. Journal of the American Society of Nephrology. 114-122.
  • Show author(s) (2008). The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: Potential therapeutic consequences. Microcirculation. 283-296.
  • Show author(s) (2008). Isolation of rat trachea interstitial fluid and demonstration of local cytokine production in lipopolysaccharide-induced systemic inflammation. Journal of applied physiology. 809-820.
  • Show author(s) (2008). Glomerular charge barrier and development of proteinuria in passive Heymann nephritis. Kidney and Blood Pressure Research. 203-209.
  • Show author(s) (2006). Localization of tubular uptake segment of filtered Cystatin C and Aprotinin in the rat kidney. Acta Physiologica. 209-221.
  • Show author(s) (2006). Differential degradation of matrix proteoglycans and edema development in rabbit lung. American Journal of Physiology - Lung cellular and Molecular Physiology. L470-L477.
  • Show author(s) (2006). Cytokine signalling in rat pulp interstitial fluid and transcapillary fluid exchange during lipopolysaccharide-induced acute inflammation. Journal of Physiology. 225-236.
  • Show author(s) (2005). The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components. Journal of Physiology. 557-567.
  • Show author(s) (2005). Effect of hydration on interstitial distribution of charged albumin in rat dermis in vitro. Journal of Physiology. 631-641.
  • Show author(s) (2004). Tubular absortion of filtered cystatin-C in rat kidney. Experimental Physiology. 701-707.
  • Show author(s) (2004). The effect of AVP-V-1 receptor stimulation on local GFR in the rat kidney. Acta Physiologica Scandinavica. 197-204.
  • Show author(s) (2004). Increased glomerular albumin permeability in old spontaneously hypertensive rats. Nephrology, Dialysis and Transplantation. 1724-1731.
  • Show author(s) (2004). Glomerular charge selectivity is impaired in hypertensive nephropathy. Nephrology, Dialysis and Transplantation. 1083-1091.
  • Show author(s) (2004). Acute peritoneal dialysis in rats results in a marked reduction of interstitial colloid osmotic pressure. Journal of the American Society of Nephrology. 3111-3116.
  • Show author(s) (2003). Renal hemodynamics in young and old spontaneously hypertensive rats during intrarenal infusion of arginine vasopressin. Kidney and Blood Pressure Research. 176-184.
  • Show author(s) (2003). Isolation of interstitial fluid from rat mammary tumors by a centrifugation method. American Journal of Physiology. Heart and Circulatory Physiology. H416-24.
  • Show author(s) (2003). Interstitial exclusion of albumin in rabbit lung measured with the continuous infusion method in combination with the wick technique. Microcirculation. 153-65.
  • Show author(s) (2003). Interstitial exclusion of albumin in rabbit lung during development of pulmonary oedema. Journal of Physiology. 907-17.
  • Show author(s) (2003). In vivo determination of steric and electrostatic exclusion of albumin in rat skin and skeletal muscle. Journal of Physiology. 907-16.
  • Show author(s) (2003). Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys. American Journal of Physiology - Renal, fluid and electrolyte physiology. F1226-F1234.
  • Show author(s) (2003). Effect of charge on interstitial distribution of albumin in rat dermis in vitro. Journal of Physiology. 505-14.
  • Show author(s) (2003). Aprotinin uptake in the proximal tubules in the rat kidney I. Lenght of proximal tubular uptake segment. Journal of Structural Biology. 402-408.
  • Show author(s) (2003). Aprotinin uptake in proximal tubules in the rat kidney II. Uptake site relative to glomerulus. Journal of Structural Biology. 409-415.
  • Show author(s) (2002). Renal hemodynamics during development of hypertension in young spontaneously hypertensive rats. Kidney and Blood Pressure Research. 322-328.
  • Show author(s) (2001). Renal hemodynamics in young and old spontaneously hypertensive rats during intrarenal infusion of arginine vasopressin. Kidney and Blood Pressure Research. 176-184.
  • Show author(s) (2001). Renal hemodynamics in young and old spontaneously hypertensive rats during intrarenal infusion of arginine vasopressin. Kidney and Blood Pressure Research. 176-184.
  • Show author(s) (2001). Interstitial exclusion of positively and negatively charged IgG in rat skin and muscle. American Journal of Physiology. Heart and Circulatory Physiology. H1505-H1512.
  • Show author(s) (2001). Drainage of plasma proteins from renal medullary interstitium in rats. Journal of Physiology. 533-539.
  • Show author(s) (2001). Distribution spaces for hyaluronan and albumin in rat tail tendons. American Journal of Physiology. Heart and Circulatory Physiology. H1589-H1597.
  • Show author(s) (2000). Renal Hemodynamics in Young Spontaneously Hypertensive Rats (SHR) during Development of Hypertension. Journal of the American Society of Nephrology. 332A.
  • Show author(s) (2000). Lactoferrin and anti-lactoferrin antibodies: Effects of ironloading of lactoferrin on albumin extravasation in different tissues in rats. Acta Physiologica Scandinavica. 11-19.
  • Show author(s) (2000). Interstitial fluid pressure, composition of interstitium, and interstitial exclusion of albumin in hypothyroid rats. American Journal of Physiology. Heart and Circulatory Physiology. H1627-H1639.
  • Show author(s) (1997). Interstitial exclusion of macromolecules studied by graded centrifugation. American Journal of Physiology. Heart and Circulatory Physiology. H2794-H2803.
  • Show author(s) (1996). Renal handling of radiolabelled human cystatin C in the rat. Scandinavian Journal of Clinical and Laboratory Investigation. 409-414.
  • Show author(s) (1995). Effect of furosemide on local and zonal glomerular filtration rate in the rat kidney. Acta Physiologica Scandinavica. 99-107.
  • Show author(s) (1994). Repeatable measurement of local and zonal GFR in the rat kidney with aprotinin. Acta Physiologica Scandinavica. 21-31.
  • Show author(s) (1994). Glomerular filtration and tubular absorption of the basic polypeptide aprotinin. Acta Physiologica Scandinavica. 33-50.
  • Show author(s) (1994). Glomerular filtration and tubular absorption of the basic polypeptide aprotinin. Acta Physiologica Scandinavica. 33-50.
Popular scientific lecture
  • Show author(s) (1997). Glomerular filtration of lysozyme in the rat kidney - effect of varying net molecular charge and plasma protein concentration.
Academic lecture
  • Show author(s) (2007). Assessment of the glomerular charge barrier in vivo.
  • Show author(s) (2000). Exclusion of positively and negatively charged IgG in rat skin and muscle interstitium.
  • Show author(s) (1998). Glomerular filtration of lysozyme in the rat kidney - effect of varying net molecular charge and plasma protein concentration.
  • Show author(s) (1997). Glomerular filtration and tubular uptake of Cystatin C (Cy) in the rat kidney.
  • Show author(s) (1993). Extracellular space in the inner renal medulla.
Masters thesis
  • Show author(s) (2014). Characterization of the renal function in Epac1 (RapGef3) knockout mice.
  • Show author(s) (2011). Characterization of the protein contents of the tumour microenvironment of human gynaecological carcinomas.
  • Show author(s) (2011). An in vivo study of the glomerular sieving of endogenous proteins in rats.
  • Show author(s) (2006). Effekt av ischemi på funksjon av glomerulær filtrasjon og proximal tubulus i rottenyre.
  • Show author(s) (2005). Cardiac output in development of genetic hypertension in rats. The use of thermodilution method in small animals; Validity and application.
Doctoral dissertation
  • Show author(s) (2017). Role of the microenvironment and lymphatics in cancer development.
  • Show author(s) (2015). Vascular function and the mechanism of proteinuria in hypertensive kidney disease.
  • Show author(s) (1995). Regional glomerular filtration (dr.med.).
Academic chapter/article/Conference paper
  • Show author(s) (1995). Renal interstitium, lymph and capillary uptake of tubular reabsorbate. 12 pages.
Abstract
  • Show author(s) (2013). Renal ischemia-reperfusion (I/R) injury induces a rapid activation of local inflammatory markers and causes increased peritubular permeability. The FASEB Journal. 1 pages.
  • Show author(s) (2013). Proteomic analysis of outer and juxtamedullary cortex of non-clipped kidneys in 2K1C hypertensive rats. The FASEB Journal. 1 pages.
  • Show author(s) (2013). Increased interstitial osmolality in skin of rats on a high salt diet. The FASEB Journal. 1 pages.
  • Show author(s) (2013). Attenuated contractility in afferent arterioles during development of proteinuria in two-kidney, one-clip hypertensive rats. The FASEB Journal. 1 pages.
  • Show author(s) (2011). Treatment of Solid Cancers Using a New Cationic Cytolytic Peptide. European Journal of Cancer. S148-S148.
  • Show author(s) (2011). Salt-sensitive hypertension is paralleled by sodium storage, interstitial hypertonicity, and increased interstitial fluid pressure in the skin. Hypertension. E59-E59.
  • Show author(s) (2010). ISOLATION AND IDENTIFICATION OF INFLAMMATORY SPECIFIC PROTEINS IN INTERSTITIAL FLUID IN SKIN DURING ACUTE OVERHYDRATION. Intensive Care Medicine. S407-S407.
  • Show author(s) (2006). Isolation of interstitial fluid and identification inflammatory mediators in rat trachea. Journal of Vascular Research. 69-69.
  • Show author(s) (2006). Interstitial colloid osmotic pressures after chronic endothelial no production contributes to peritoneal dialysis. Journal of Vascular Research. 61-61.
  • Show author(s) (2005). Extracellular distribution of monoclonal antibodies and other macromolecules in tumors. The FASEB Journal.
Poster
  • Show author(s) (2019). Protein-rich fluid dynamics from the periapical mandibular area in rats.
  • Show author(s) (2018). Lymphatic transport route from the dental pulp.
  • Show author(s) (2001). Proteinuria in passive Heymann Nephrithis, Importance of the glomerular charge barrier.
Academic literature review
  • Show author(s) (2022). The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation. Journal of Internal Medicine. 293-308.
  • Show author(s) (2013). Interstitial fluid-A reflection of the tumor cell microenvironment and secretome. Biochimica et Biophysica Acta - Proteins and Proteomics. 2336-2346.
  • Show author(s) (2004). The contribution of sterical and electrostatical factors on distribution of macromolecules in the interstitial space. Physiology News. 29-30.

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