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Selected Publications


2011

  • Bustad, H.J., Underhaug, J., Halskau, Ø., Martinez, A. (2011) The binding of 14-3-3γ to membranes studied by intrinsic fluorescence spectroscopy, FEBS lett. 585, 1163-1168 (on the cover)
  • Skjaerven, L., Martinez, A. and Reuter, N. (2011) Principal component and normal modes analysis of proteins; a quantitative comparison using the GroEL subunit. Proteins 79, 232-43.
  • Calvo, A.C., Pey, A.L., Miranda-Vizuete, A., Døskeland, A.P. and Martinez, A. (2011) Divergence in enzyme regulation between C. elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine. Biochem. J. 434, 133-141.
  • Olsson, E., Martinez, A., Teigen, K., and Jensen, V.R. (2011). Formation of the iron-oxo hydroxylating species in the catalytic cycle of aromatic amino acid hydroxylases. Chemistry 17, 3746-58
  • Skjaerven, L., Grant, B., Muga, A., Teigen, K., McCammon, J.A., Reuter, N., and Martinez, A. (2011) Conformational Sampling and Nucleotide-Dependent Transitions of the GroEL Subunit Probed by Unbiased Molecular Dynamics Simulations. PLoS Comp. Biol. 7(3): e1002004.
  • Dao, K.K., Pey, A.L., Gjerde, A.U., Teigen, K., Byeon, I.L., Døskeland, S.O., Gronenborn, A.M. and Martinez, A. (2011) The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation. PLoS ONE 6(3): e17602.
  • Skjevik ÅA, Lygre H, Haug B, and Teigen K (2011) Intramolecular hydrogen bonding in articaine can be related to superior bone tissue penetration. A molecular dynamics study. Biophys. Chem. 154, 18-25.

 

 

2010

 

  • Olsson, E., Martinez, A., Teigen, K., and Jensen, V.R. (2010). Water Dissociation and Dioxygen Binding in Phenylalanine Hydroxylase. Eur. J. Inorg. Chem. 2010, 351–356
  • Mossberg, A-K., Puchades, M., Halskau, Ø., Baumann, A., Lanekoff, I., Chao, Y., Martinez, A., Svanborg, C. and Karlsson, R. (2010) HAMLET interacts with lipid membranes and perturbs their structure and integrity. PLoS ONE, 5(2), e9384.
  • Stevens, R.C., Sancho, J. and Martinez, A. (2010) Rescue of misfolded proteins and stabilization by small molecules. Methods Mol. Biol. 648, 313-324
  • Flydal, M.I., Mohn, T.C., Pey, A.L., Siltberg-Liberles, J., Teigen, K. and Martinez, A. (2010) Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans PAH. Evolutionary implications. Amino acids 39, 1463–1475
  • Byeon, I., Dao, K.K., Jung, J., Keen, J., Leiros, I., Døskeland, S.O., Martinez, A., and Gronenborn, A.M. (2010). Allosteric Communication between cAMP Binding Sites in the RI Subunit of Protein Kinase A Revealed by NMR. J. Biol. Chem. 285, 14062-14070
  • Calvo, A.C., Scherer, T., Pey, A.L., Ying, M., Winge, I., McKinney, J., Haavik, J., Thöny, B. and Martinez, A. (2010) Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2. J. Neurochem. 114, 853-863.
  • Halskau, Ø., Volden, S., Calvo, A.C., Martinez, A. and Wilhelm, R.G. (2010) Stabilization and bioactivity of tyrosine hydroxylase on gold surfaces and nanoparticles. Prot. Pept. Lett. 17,1376-1382.
  • Ying, M., Pey, A.L., Aarsæther, N. and Martinez, A. (2010). Phenylalanine hydroxylase expression in primary rat hepatocytes is modulated by oxygen concentration. Mol. Genet. Metab. 101, 279-81
  • Olsson, E., Teigen, K., Martinez, A, and Jensen, V.R. (2010) The aromatic amino acid hydroxylase mechanism: a perspective from computational chemistry. Adv. Inorg. Chem. 62, 437-500.

 

 

2009

 

  • Halskau, Ø. Muga, A. and Martinez, A. (2009) Linking new paradigms in protein chemistry to reversible membrane-protein interactions. Curr. Prot. Pep. Sci. 10, 339-359.
  • Siltberg-Liberles, J. and Martinez, A. (2009) Searching distant homologs of the regulatory ACT domain in phenylalanine hydroxylase. Amino Acids 36, 235-49.
  • Dobrowolski, S.F., Pey, A. L., Koch, R., Levy, H., Ellingson, C., Naylor, E. W. and Martinez, A. (2009) Biochemical characterization of mutant phenylalanine hydroxylase enzymes and correlation with clinical presentation in hyperphenylalaninaemic patients. J. Inherit. Metab. Dis. 32, 10–21.
  • Pey, A.L. and Martinez, A. (2009) Iron binding effects on the kinetic stability and unfolding energetics of a thermophilic phenylalanine hydroxylase from Chloroflexus aurantiacus. J. Biol. Inorg. Chem. 14, 521-31.
  • Skjevik, Å.A, Teigen, K. and Martinez, A. (2009) Overview of computational methods employed in early-stage drug discovery. Future Med. Chem. 1, 49-63.
  • Halskau, Ø., Ying, M., Baumann, A., Kleppe, R., Rodriguez-Larrea, D., Almås, B., Haavik, J. and Martinez, A. (2009) Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase and negatively charged membranes. J. Biol. Chem. 284, 32758–32769.

 

 

2008

 

  • Martinez, A., Calvo, A., Teigen, K. and Pey, A.L. (2008) Rescuing proteins of low kinetic stability by chaperones and natural ligands; phenylketonuria, a case study. In: Progress in Molecular Biology and Translational Sciences 83, 89-134.
  • Siltberg-Liberles, J., Steen, I.H., Svebak, R. and Martinez, A. (2008) The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene 427, 86-92.
  • Pey, A,L., Ying, M., Cremades, N., Velazquez-Campoy, A., Scherer, T., Thöny, B., Sancho, J. and Martinez, A. (2008) Pharmacological chaperones as therapeutic agents to treat phenylketonuria. J. Clin. Invest. 118, 2858-2867.
  • Thöny, B., Calvo, A.C., Scherer, T., Svebak, R.M., Haavik, J., Blau, N. and Martinez, A. (2008) Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase. J. Neurochem. 106, 672-681.
  • Halskau, Ø, Perez-Jimenez, R., Ibarra-Molero, B., Underhaug, J., Muñoz, V., Martinez, A. and Sanchez-Ruiz, J.M. (2008) Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics Proc. Natl. Acad Sci. USA 105, 8625-8630.
  • Calvo, Ana C., Pey, A,L., Ying, M., Loer, C.M. and Martinez, A. (2008) Anabolic function of phenylalanine hydroxylase in Caenhorabditis elegans. FASEB J. 22, 3046-3058.

 

 

2007

 

  • Pey, A.L., Stricher, F., Serrano, L. and Martinez, A. (2007) Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm for misfolding diseases. Am. J. Hum. Genet. 81, 1006-1024.
  • Pey, A.L. and Martinez, A. (2007). Tetrahydrobiopterin for patients with phenylketonuria. The Lancet 370, 462-463.
  • Fedøy A.-E., Yang, N., Martinez, A., Leiros, H-K. S., and, Steen I. H. (2007) Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila. J. Mol. Biol. 372, 130-49.
  • Leiros, H.S., Pey, A.L., Innselset, M., Moe, E., Leiros, I., Steen, I.H. and Martinez, A. (2007) Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H; a monomeric cold active enzyme with local flexibility around the active site and high overall stability. J. Biol. Chem. 282, 21973-21986.
  • Teigen, K., McKinney, J.A., Haavik, J., and Martínez, A. (2007) Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr. Med. Chem. 14, 455-467
  • Hodneland E, Teigen K. (2007). A simple method to calculate the accessible volume of protein-bound ligands: Application for ligand selectivity. J. Mol. Graph. Model. 26, 429-433.

 

 

Last updated 16.3.2012