Norsk A A A

Methods

We use complementary biochemical and biophysical methodology (notably NMR and calorimetry), structural bioinformatics and cellular studies, focusing on the structure, properties and function of phospholipidic membranes and proteins, in particular enzymes of the aromatic amino acid hydroxylase family and their complexes with ligands. We aim to investigate novel therapeutic approaches for correction of associated metabolic and neurological malfunctions.

  • Mutation-dependent destabilization represented on the dimeric structure.

    Protein Stability and Biomolecular Interactions

    Protein conformation and stability are mainly studied by differential scanning calorimetry (DSC) and thermal dependent circular dichroism (CD).

  • Caenorhabditis elegans

    Animal Models

    At present setting up Caenorhabditis elegans as a model organism to investigate aromatic amino acid hydroxylase function, regulation and evolution.