Cellular Networks
The main focus of CELLNET is to understand the molecular mechanism behind angiogenesis. The cell-cell communication and interaction is central for the angiogenic process in both normal and pathological condition.
We aim to investigate the impact of the cellular environment on the fundamental biochemical and biological pathways necessary for normal cellular communication in both homeostasis and disease in order to develop new anti-angiogenic therapeutic approaches.
To model angiogenesis we developed an in vitro assay comprised of the main components of blood vessels: endothelial cells, mural cells and a basement membrane. Endothelial cells co-seeded with vSMC (mural cells) results in spontaneous endothelial capillary-like network formation and deposition of a complex basement membrane leading to an endothelial VEGF-independent phenotype. (Lasse Evensen)
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NEWS
Cancer research with nanotechnology
Professor James Lorens and his group use nanotechnology to study tissue production and cancer development.