The glue that shape us and hold us together
The extracellular matrix (ECM) is an active structure taking more and more of a center stage in modern cell and cancer biology. We now know that the ECM in addition being a structural framework also can be an active structure in fluid exchange together with many other roles including: acting as storage depots for growth factors and cytokines, regulating stem cell fate and elaborating stem cell niches and thereby affect many aspects of a cell´s life and function. A major role of the ECM is still to act as “tissue glue”.
In the Matrix Biology group, consisting of 4 principal investigators, we study several aspects of proteoglycans, integrins and the integrated role of ECM on cell-matrix interactions and on cell and organism physiology in health and disease.