The glue that shape us and hold us together
The extracellular matrix (ECM) is an active structure taking more and more of a center stage in modern cell and cancer biology. We now know that the ECM in addition being a structural framework also can be an active structure in fluid exchange together with many other roles including: acting as storage depots for growth factors and cytokines, regulating stem cell fate and elaborating stem cell niches and thereby affect many aspects of a cell´s life and function. A major role of the ECM is still to act as “tissue glue”.
In the Matrix Biology group, consisting of four principal investigators, we study several aspects of proteoglycans, integrins and the integrated role of ECM on cell-matrix interactions and on cell and organism physiology in health and disease.