Within the field of matrix biology we have two major areas of interest.
One concerns the function of cellular interactions with collagen. The project spans from interest in gene regulation of collagen receptor expression to functional studies of collagen receptors in vitro and in vivo.
Another concerns the structure, biosynthesis and function of heparan sulfate proteoglycans, complex molecules found in abundance at cell surfaces and in the extracellular matrix, where they bind to other matrix- and cell -associated molecules.
Our projects include studies of the regulation of the structure and function of heparan sulfate proteoglycans on a cellular and molecular level.
The matrix biology group investigates mechanisms of cell adhesion to collagen and the importance of proteoglycan synthesis for cellular function. The projects are within the research areas of cell biology, tumor-stroma interactions and developmental biology. Our work aims at developing new prognostic and therapeutic tools for tumor biology and connective tissue disorders.