Importance of protein-metabolites interactions in biological systems
Proteins act in complex networks (interactomes) with other macromolecules (other proteins, DNA, RNA) or with metabolites. Such networks are essential to all biological functions and their alteration can often lead to disease.
Protein-metabolite interactomes are poorly characterized and the current challenge is to map, on a large scale, protein networks in a spatial and temporal manner and to further analyze
1) how they are differently regulated in various physiological processes and
2) how they are altered in diseases.
To learn more about protein-lipid interactomes, check our book chapter on "Functional Proteomics: Mapping Lipid-Protein Interactomes" published in the book entitled Integrative Proteomics, 2012:
Nuclear Phosphoinositide Signalling
Our lab focuses on protein-phospholipid interaction networks and in particular on the functionnal elucidation of nuclear protein-phosphoinositide complexes.
Phosphoinositides (PIs) are lipid signalling molecules regulating numerous cellular functions via their interaction with diverse proteins. Most research has focused on their cytoplasmic functions. PIs are also present in the nucleus but their functions are still poorly understood.
News
- BBB seminar 29.03.2012 (28.03.2012)
- New book chapter on protein-lipid interactomes (24.02.2012)
- Master exam-Thomas Karlsson-Thursday 8 December 10:00-N-term (29.11.2011)