Importance of protein-metabolites interactions in biological systems
Proteins act in complex networks (interactomes) with other macromolecules (other proteins, DNA, RNA) or with metabolites. Such networks are essential to all biological functions and their alteration can often lead to disease.
Protein-metabolite interactomes are poorly characterized and the current challenge is to map, on a large scale, protein networks in a spatial and temporal manner and to further analyze
1) how they are differently regulated in various physiological processes and
2) how they are altered in diseases.
To learn more about protein-lipid interactomes, check our book chapter on "Functional Proteomics: Mapping Lipid-Protein Interactomes" published in the book entitled Integrative Proteomics, 2012:
Lipid Signalling and Function in the Nucleus
Our lab focuses on protein-phospholipid interaction networks and in particular on the functionnal elucidation of nuclear protein-phosphoinositide complexes.
Phosphoinositides (PIs) are lipid signalling molecules regulating numerous cellular functions via their interaction with diverse proteins. Most research has focused on their cytoplasmic functions. PIs are also present in the nucleus but their functions are still poorly understood.
News
- Master exam Marianne Goris - Thurs 27th June 2013 - 12:15 (14.06.2013)
- Master exam Hilde Kristin Grung-Berle (09.12.2012)
- Amanda Edson's master exam Tues 27th Nov (21.11.2012)
- A new PhD student in the lab! (23.10.2012)
- new PhD position available (26.06.2012)