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Methods

 

PROBE is equipped for a wide range of proteomics analysis, from the identification of proteins present in a sample to comparison of protein expression profiles between different samples.

Expertise in experimental design, sample preparation, sample analysis, bioinformatics and data interpretation is available.

PROBE offers a wide range of global shotgun quantitative proteomics methods including SILAC, iTRAQ, di-methylation and various label free approaches. Targeted quantification via Selected Reaction Monitoring (SRM) is also provided.

For a detailed overview of PROBE and the countrywide NorProteomics Consortium's methodological range, please consult this link.

  • Protein Identification

    The amino acid sequence of proteins in biological samples can be determined by the use of mass spectrometry.

  • Quantitative Proteome Profiling

    Disease states can influence the protein expression. By quantitative proteomics methods we can identify and quantify these changes. A typical example is the comparison of proteins in plasma between a control group and a patient group to find specific disease marker candidates.

  • Targeted Protein Quantification

    Protein quantification of a small set of proteins in a larger number of samples using Selected Reaction Monitoring (SRM). For example the verification of the expression differences between sample groups for disease marker candidates in a large sample set.