In living cells, proteins are molecules that are the end-products of a long process that begins with genes. The cellular machinery generates proteins with specific shapes. The protein shapes are not static; they are flexible and move to perform its role. Mistakes that impact the structure and flexibility of proteins can be disease-causing.
Computational methods are an integral part of the modern molecular biology tool-box. In the Reuter group, we develop, validate and apply computational methods to investigate the structure and dynamics of proteins.
Molecular modelling of protein dynamics
Through the use of computational and experimental methods, we examine the dynamic properties that allow proteins to selectively associate with cellular membranes, lipids or ligands, as well as the conservation of flexibility through evolution.