Centre for Cancer Biomarkers
CCBIOs seminarserie

CCBIO Seminar – Donald Gullberg

Velkommen til det første CCBIO-seminaret for vårsemesteret 2022! Åpent for alle i et webinar i Zoom, så du også kan delta fra hjemmekontoret.


Speaker: Donald Gullberg

Time: January 20, 2022 at 14.30

Place: Webinar in Zoom. Access code will be available here some days before.

Title: α11β1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis

Short bio: Professor Donald Gullberg has a Bsc in chemistry from Uppsala University, Sweden, and gained his PhD on a thesis entitled "Structural and functional characterization of collagen receptors on primary rat hepatocytes and cardiac fibroblasts” in 1990 under the supervision of Prof. Kristofer Rubin at the Department of Medical and Physiological Chemistry. During 1990-1992, both he and Marion Kusche-Gullberg conducted postdoctoral research with Professors John and Lisa Fessler at Molecular Biology Institute, UCLA. In his laboratory, the ITGA11 was identified and characterized in the 1990's. He is since 2004 at the Department of Biomedicine. As group leader for the Matrix Biology Group and PI at CCBIO, he continues to study ITGA11 in the context of tissue and tumor fibrosis. He has spent two inspiring sabbaticals at UCSF (with Prof. MD Dean Sheppard 2010-2011 and with Prof. PhD Valerie Weaver 2017-2018). 

Abstract: With a current focus on studying fibroblast heterogeneity in different conditions where extracellular matrix (ECM) dynamics are part of the tissue homeostasis and pathology, it is increasingly important to also understand the underlying cellular mechanism of tissue and tumor fibrosis. In this context we predict that collagen-binding integrins will turn out to play an important role in matrix remodeling in fibrotic diseases on specific fibroblast subsets.

Data from experimental cancer models has questioned the exclusive tumor-supportive function of the tumor stroma and suggested that the stroma might also act as a barrier to inhibit tumor metastasis. In the context of tissue fibrosis, a barrier function of the fibrotic ECM affects access of anti-fibrotic therapeutic reagents. In the talk the definition of fibroblast will be discussed, as well as new transcriptional profiling datasets suggesting the existence of universal fibroblasts lineages.  Experimental data on epitope mapping of new integrin mAbs as well as data suggesting a role of integrin α11β1 in matrix assembly will be presented.

All interested researchers, students and others are welcome