CCBIO Seminar – Martin Götte
Velkommen til CCBIOs seminarserie for vårsemesteret 2023. Åpent for alle i auditorium 4, BBB. Foreleser er Dr. Martin Götte, University of Münster, Tyskland. Ikke nødvendig med påmelding. Bli også gjerne med på uformell mingling over pizza i hallen utenfor etter seminaret!
Speaker: Dr. Martin Götte, University of Münster, Germany
Title: The multifunctional nature of Syndecan-1 in breast cancer
Host: Donald Gullberg
Where: Auditorium 4, BB-building
When: March 30, 2023 at 14.30-15.30
No registration necessary. Join us also for the informal pizza get-together in the hall following the talk!
Abstract: The transmembrane proteoglycan syndecan-1 modulates a multitude of physiological processes via binding of its heparan sulfate carbohydrate chains to numerous ligands relevant to tumor progression and inflammation. Syndecan-1 is a classical coreceptor for growth factors, angiogenic factors and chemokines, and acts as a cell and matrix adhesion receptor. It modulates integrin function, proteolysis and tumor angiogenesis. The striking resistance of syndecan-1-deficient mice to mammary tumorigenesis has been linked to a potential role in cancer stem cell function, and we could provide evidence for a role for syndecan-1 in human tumor-initiating cells. New data from our laboratory provide a link of syndecan-1 to radiation resistance in breast cancer. In this seminar, I will present recent data which demonstrate a role for syndecan-1 in the inflammatory microenvironment, and possible molecular mechanisms linked to therapeutic resistance and recurrence.