CCBIO-seminar 19. februar 2026 – Donald Gullberg
Velkommen til CCBIOs seminarserie i vårsemesteret 2026! Foreleser denne gangen er professor Donald Gullberg som vil snakke om "Novel integrin models to study tissue and tumor fibrosis". Åpent for alle i auditorium 4, BBB. Påmelding er ikke nødvendig, bare møt opp. Velkommen!
Hovedinnhold
Foreleser: Professor Donald Gullberg, CCBIO og Institutt for biomedisin, UiB.
Tittel: Novel integrin models to study tissue and tumor fibrosis
Vert: Carina Strell
Sted: Auditorium 4, BB-bygget
Når: 19. februar 2026 kl. 14.30–15.30
Påmelding er ikke nødvendig. Merk derimot at hvis du er student og trenger studiepoeng for oppmøte, må du ha meldt deg opp i Studentweb for dette emnet for gjeldende semester.
Abstract: In recent years, there has been an increased interest in understanding the role of extracellular matrix (ECM) remodelling in tissue -and tumor fibrosis. Integrins constitute a major group of receptors for various ECM components, including the fibrotic collagens (1,2). The Gullberg group has identified and characterized the integrin α11β1 (gene name ITGA11), which is a major fibroblast receptor involved in collagen assembly in tissue and tumor fibrosis (3,4). In the context of tumor fibrosis, the α11 subunit is a biomarker expressed on a matrix-producing subset of cancer-associated fibroblasts. The α11 subunit is also believed to be an anti-fibrotic tumor-restraining target on this subset of cells. In this seminar, we will introduce recent progress in α11 integrin research, including the generation of a novel humanized ITGA11 mouse strain, a novel integrin Itga11 Cre-reporter mouse strain, and progress in α11 integrin antibody characterization and humanization.
References cited:
- Zeltz, C., Kusche-Gullberg, M., Heljasvaara, R., and Gullberg, D. (2023) Novel roles for cooperating collagen receptor families in fibrotic niches. Curr Opin Cell Biol 85, 102273
- Farndale, R., Sonnenberg, A., DiPersio, C. M., Eble, J. A., Heino, J., and Gullberg, D. (2023) What does it take to be a collagen receptor? Matrix Biol 115, 128-132
- Velling, T., Kusche-Gullberg, M., Sejersen, T., and Gullberg, D. (1999) cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, β1-associated integrin α-chain present in muscle tissues. J Biol Chem 274, 25735-25742
- Musiime, M., Erusappan, P. M., Cukierman, E., Chang, J., Molven, A., Hansen, U., Zeltz, C., and Gullberg, D. (2024) Fibroblast integrin alpha11beta1 is a collagen assembly receptor in mechanoregulated fibrillar adhesions. Matrix Biol 134, 144-161