Mikrobiologi, immunologi og virologi
Mål og innhald
The course focuses on bacterial and viral infections relevant to dentistry. Infection mechanisms such as virus replication, biofilm formation, cell-to-cell communication, other virulence factors, genetic aspects, host defence systems to bacterial and viral infections, and bacterial and viral evasion of the microbial host defence will be discussed. Dental caries, periodontitis and endodontic infection are initiated by specific bacteria and modified by host and environmental factors. The microbiology and novel bacterial phylotypes of these infections and a brief update on chemotherapy of viral hepatitis and HIV-infection will also be given.
After having passed the course, the participants should be able to use a molecular microbiological approach for a better understanding of the host-microbe interactions with regard to health and disease in general and oral infections in particular. The application of information about factors that influence disease can be used to improve disease prevention and management. A brief update on chemotherapy of viral hepatitis and HIV-infection will also be given.
Undervisningsformer og omfang av organisert undervisning
The didactic components of the course involve lectures, integrated bacterial-immunological teaching, demonstrations (virology), self-study, students' presentation of selected literature (virology), knowledge check during the course and a final written exam (grades: passed/not passed).
Final exam: written (grades: passed/not passed).
Wilson M, McNab R, Henderson B. Bacterial Disease Mechanisms. An introduction to cellular microbiology. Cambridge University Press 2002. ISBN 0 521 79689 X.
Abbas AK, Lichtman AH. Basic Immunology. Functions and disorders of the immune system. Saunders. Second edition 2004. ISBN 0 7216 -0241-X.
NairPNR. Pathogenesis of apical periodontitis and the causes of endodontoc failures. Crit Rev Oral Biol Med 2004; 15(6):348-381.
Siqueira JF et al. Novel bacterial phylotypes in endodontic infections. J Dent Res 2005; 84(6):565-569.
Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000. 2005; 38: 135-187.
Chhour KL et al. Molecular analysis of microbial diversity in advanced caries. J Clin Microbiol 2005; 43(2): 843-849.
Professor: Vidar Bakken
Seniorkonsulent Christine Endal Kronenberger