Department of Biological Sciences (BIO)

MBI researcher receives 25 million Toppforsk grant

The Norwegian research council announced the "Toppforsk" grants 25. January. MBI researcher Thomas Arnesen got a 25 million NOK grant for his project «N-terminal acetylation as a key physiological regulation mechanism».

Portrett av Thomas Arnesen ved lab-benken
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Regulation of peptide hormones

In the project, the research group will investigate how specific peptide hormones are regulated by post-translational modification.


Medical significance

The peptide hormones to be studied regulate physiological processes such as appetite, metabolism, sexual behaviour and pain.  They play a significant role in the pathophysiology of metabolic diseases such as obesity.  When the identity of the peptide hormone acetyltransferase is known, in-depth studies of the enzyme's role in peptid hormone related diseases will be undertaken.  The project aims to utilize the knowledge generated in an alternative approach for development of next generation drugs against obesity and other metabolic diseases.


A great achievement - for the researcher and the Department

- I am very glad and very proud that Thomas is receiving the Toppforsk grant, says Department head Rein Aasland.

- We have since long known of Thomas' qualities as a researcher, but it is great to see this confirmed by him winning this very competitive grant.  So this is obviously a milestone in Thomas' career, but also very valuable and much appreciated by the Department.  And we are also ever so little proud that Thomas was actually ranked first on the UiB's priority list for the FRIMEDBIO Toppforsk grants.

- I would also like to congratulate our colleagues at the Department of Physics and Technology, the Department of Mathematics, the Department of Biomedicine and the Sars centre on their Toppforsk-grants, Aasland says.