BBB seminar: Stefan Krauss
Wnt signalling in cortical development
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Stefan Krauss
Institute of Medical Microbiology, Rikshospitalet University Hospital, Oslo
Wnts are secreted proteins that regulate several developmental processes. Wnt signals can be mediated through at least three intracellular branches, including the canonical pathway. Using conditional beta-catenin gain-of-function and loss-of-function mouse mutants, we dissect the functions of canonical and non-canonical Wnt signalling in cortical development throughout the preneurogenic and neurogenic stages. We present models for the involvement of Wnt signalling in the specification of cortical identity, and in the formation of progenitor populations.
Host: Clive Bramham, Department of Biomedicine
| Prof. Stefan Krauss is group leader in the Section for Cellular and Genetic Therapy, Institute of Medical Microbiology at the Rikshospitalet University Hospital in Oslo. He discovered the central morphogen Sonic hedgehog (Shh) (Cell 1993, 75:1431) and has since then created several transgenic models for studying forebrain stem cell biology (e.g. Hesx1, Dach1, D6-b-cat conditional KO, D6 DA-b-cat). The long term goal of the laboratory of Stefan Krauss is to improve the understanding of the events that occur upon therapeutic stem cell transplantation from the point of cellular signalling. |
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11.03.2020